業績｜論文・出版物｜目次｜ALL

Adenovirus vector-mediated macrophage erythroblast attacher (MAEA) overexpression in primary mouse hepatocytes attenuates hepatic gluconeogenesis

Shimizu K., Okamoto M., Terada T., Sakurai F., Mizuguchi H., Tomita K., Nishinaka T.

Biochem. Biophys. Rep., 10, 192-197 (2017)

PubMed

A mammalian mirtron miR-1224 promotes tube-formation of human primary endothelial cells by targeting anti-angiogenic factor epsin2

Sakai E., Miura Y., Suzuki-Kouyama E., Oka K., Tachibana M., Kawabata K., Sakurai F., Mizuguchi H.

Sci. Rep., 7, 5541 (2017)

PubMed

Sensitive detection of viable circulating tumor cells using a novel conditionally telomerase-selective replicating adenovirus in non-small cell lung cancer patients

Togo S., Katagiri N., Namba Y., Tulafu M., Nagahama K., Kadoya K., Takamochi K., Oh S., Suzuki K., Sakurai F., Mizuguchi H., Urata Y., Takahashi K.

Oncotarget, 8, 34884-34895 (2017)

PubMed

Overexpression of miR-27b negatively regulates expression of pluripotency-associated genes and hepatic differentiation in human induced pluripotent stem cells

Lim J., Sakai E., Takayama K., Sakurai F., Mizuguchi H.

Stem Cell Res. Ther., 2, 88-97 (2017)

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Cationic liposome-mediated delivery of reovirus enhances the tumor cell-killing efficiencies of reovirus in reovirus-resistant tumor cells

Sakurai F., Inoue S., Kaminade T., Hotani T., Katayama Y., Hosoyamada E., Terasawa Y., Tachibana M., Mizuguchi H.

Int. J. Pharm., 524, 238-247 (2017)

PubMed

Generation of a bile salt export pump deficiency model using patient-specific iPSC-derived hepatocyte-like cells

Imagawa K., Takayama K., Isoyama S., Tanikawa K., Shinkai M., Harada K., Tachibana M., Sakurai F., Noguchi E., Hirata K., Kage M., Kawabata K., Sumazaki R., Mizuguchi H.

Sci. Rep., 7, 41806 (2017)

PubMed

MicroRNA miR-27 inhibits adenovirus infection by suppressing the expression of SNAP25 and TXN2

Machitani M., Sakurai F., Wakabayashi K., Nakatani K., Tachibana M., Mizuguchi H.

J. Virol., 91, e00159-17 (2017)

PubMed

Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection

Sakurai F.#, Mitani S.#, Yamamoto T.#, Takayama K., Tachibana M., Watashi K., Wakita T., Iijima S., Tanaka Y., Mizuguchi H. #These authors equally contributed to this work.

Sci. Rep., 7, 45698 (2017)

PubMed

Inhibition of CRISPR/Cas9-mediated genome engineering by a type I interferon-induced reduction in guide RNA expression

Machitani M.#, Sakurai F.#, Wakabayashi K., Nakatani K., Takayama K., Tachibana M., Mizuguchi H. #These authors equally contributed to this work. (Highlighted paper selected by Editor-in-Chief)

Biol. Pharm. Bull., 40, 272-277 (2017)

PubMed

Enhanced oncolytic activities of the telomerase-specific replication-competent adenovirus expressing short-hairpin RNA against Dicer

Machitani M.#, Sakurai F.#, Wakabayashi K., Tachibana M., Fujiwara T., Mizuguchi H. #These authors equally contributed to this work.

Mol. Cancer Ther., 16, 251-259 (2017)

PubMed

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction

Nakamori D.#, Akamine H.#, Takayama K.#, Sakurai F., Mizuguchi H. #These authors equally contributed to this work.

Sci. Rep., 7, 16675 (2017)

PubMed

Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions

Fukuda T., Takayama K., Hirata M., Liu Y-J, Yanagihara K., Suga M., Mizuguchi H., Furue M.K.

Exp. Cell Res., 352, 333-345 (2017)

PubMed

Identification of adenovirus-derived cell-penetrating peptide

Hirai T., Yamagishi Y., Koizumi N., Nonaka M., Mochida R., Shida K., Nomura T., Fujii M., Sakurai F., Mizuguchi H., Watanabe Y., Utoguchi N.

Biol. Pharm. Bull., 40, 195-204 (2017)

PubMed

Eradication of melanoma in vitro and in vivo via targeting with a Killer-Red-containing telomerase-dependent adenovirus

Takehara K., Yano S., Tazawa H., Okada N., Kishimoto H., Narii N., Mizuguchi H., Urata Y., Kagawa S., Fujiwara T., Hoffman R.M.

Cell Cycle, 16, 1502-1508 (2017)

PubMed

Highly efficient biallelic genome editing of human ES/iPS cells Using a CRISPR/Cas9 or TALEN system

Takayama K., Igai K., Hagihara Y., Hashimoto R., Hanawa M., Sakuma T., Tachibana M., Sakurai F., Yamamoto T., Mizuguchi H.

Nuc. Acid Res., 45, 5198-5207 (2017)

PubMed

Type I interferons impede short-hairpin RNA-mediated RNA interference via inhibition of dicer-mediated processing to small interfering RNA

Machitani M.#, Sakurai F.#, Wakabayashi K., Takayama K., Tachibana M., Mizuguchi H. #These authors equally contributed to this work.

Mol. Ther. Nucleic Acids, 6, 173-182 (2017)

PubMed

Hepatocyte Nuclear Factor 4 alpha promotes definitive endoderm differentiation from human induced pluripotent stem cells

Hanawa M., Takayama K., Sakurai F., Tachibana M., Mizuguchi H.

Stem Cell Rev., 13, 542-551 (2017)

PubMed

Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening

Takayama K., Mizuguchi H.

Drug Metab. Pharmacokinet., 32, 12-20 (2017)

PubMed

zone特異的性質を有するヒトES/iPS細胞由来肝細胞の作製法の開発

三谷成二, 高山和雄, 水口裕之

肝細胞研究会HP・研究交流 (2017)

WebSite

Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure

Nagamoto Y., Takayama K., Ohashi K., Okamoto R., Sakurai F., Tachibana M., Kawabata K., Mizuguchi H.

J. Hepatol., 64, 1068-1075 (2016)

PubMed

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大阪大学大学院薬学研究科分子生物学分野

Laboratory of Biochemistry and Molecular Biology

Graduate School of Pharmaceutical Sciences, Osaka University

業績｜論文・出版物｜目次｜ALL