業績｜論文・出版物｜目次｜ALL

Inhibition of CRISPR/Cas9-mediated genome engineering by a type I interferon-induced reduction in guide RNA expression

Machitani M.#, Sakurai F.#, Wakabayashi K., Nakatani K., Takayama K., Tachibana M., Mizuguchi H. #These authors equally contributed to this work. (Highlighted paper selected by Editor-in-Chief)

Biol. Pharm. Bull., 40, 272-277 (2017)

PubMed

Enhanced oncolytic activities of the telomerase-specific replication-competent adenovirus expressing short-hairpin RNA against Dicer

Machitani M.#, Sakurai F.#, Wakabayashi K., Tachibana M., Fujiwara T., Mizuguchi H. #These authors equally contributed to this work.

Mol. Cancer Ther., 16, 251-259 (2017)

PubMed

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction

Nakamori D.#, Akamine H.#, Takayama K.#, Sakurai F., Mizuguchi H. #These authors equally contributed to this work.

Sci. Rep., 7, 16675 (2017)

PubMed

Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions

Fukuda T., Takayama K., Hirata M., Liu Y-J, Yanagihara K., Suga M., Mizuguchi H., Furue M.K.

Exp. Cell Res., 352, 333-345 (2017)

PubMed

Identification of adenovirus-derived cell-penetrating peptide

Hirai T., Yamagishi Y., Koizumi N., Nonaka M., Mochida R., Shida K., Nomura T., Fujii M., Sakurai F., Mizuguchi H., Watanabe Y., Utoguchi N.

Biol. Pharm. Bull., 40, 195-204 (2017)

PubMed

Eradication of melanoma in vitro and in vivo via targeting with a Killer-Red-containing telomerase-dependent adenovirus

Takehara K., Yano S., Tazawa H., Okada N., Kishimoto H., Narii N., Mizuguchi H., Urata Y., Kagawa S., Fujiwara T., Hoffman R.M.

Cell Cycle, 16, 1502-1508 (2017)

PubMed

Highly efficient biallelic genome editing of human ES/iPS cells Using a CRISPR/Cas9 or TALEN system

Takayama K., Igai K., Hagihara Y., Hashimoto R., Hanawa M., Sakuma T., Tachibana M., Sakurai F., Yamamoto T., Mizuguchi H.

Nuc. Acid Res., 45, 5198-5207 (2017)

PubMed

Type I interferons impede short-hairpin RNA-mediated RNA interference via inhibition of dicer-mediated processing to small interfering RNA

Machitani M.#, Sakurai F.#, Wakabayashi K., Takayama K., Tachibana M., Mizuguchi H. #These authors equally contributed to this work.

Mol. Ther. Nucleic Acids, 6, 173-182 (2017)

PubMed

Hepatocyte Nuclear Factor 4 alpha promotes definitive endoderm differentiation from human induced pluripotent stem cells

Hanawa M., Takayama K., Sakurai F., Tachibana M., Mizuguchi H.

Stem Cell Rev., 13, 542-551 (2017)

PubMed

Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening

Takayama K., Mizuguchi H.

Drug Metab. Pharmacokinet., 32, 12-20 (2017)

PubMed

zone特異的性質を有するヒトES/iPS細胞由来肝細胞の作製法の開発

三谷成二, 高山和雄, 水口裕之

肝細胞研究会HP・研究交流 (2017)

WebSite

Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure

Nagamoto Y., Takayama K., Ohashi K., Okamoto R., Sakurai F., Tachibana M., Kawabata K., Mizuguchi H.

J. Hepatol., 64, 1068-1075 (2016)

PubMed

NF-kB promotes leaky expression of adenovirus genes in a replication-incompetent adenovirus vector

Machitani M.#, Sakurai F.#, Wakabayashi K., Nakatani K., Shimizu K., Tachibana M., Mizuguchi H. #These authors equally contributed to this work.

Sci. Rep., 6, 19922 (2016)

PubMed

Efficient detection of human circulating tumor cells without significant production of false-positive cells by a novel conditionally replicating adenovirus

Sakurai F., Narii N., Tomita K., Togo S., Takahashi K., Machitani M., Tachibana M., Ouchi M., Katagiri N., Urata Y., Fujiwara T., Mizuguchi H.

Mol. Ther. Methods Clin. Dev., 3, 16001 (2016)

PubMed

Dicer functions as an antiviral system against human adenoviruses via cleavage of adenovirus-encoded noncoding RNA

Machitani M.#, Sakurai F.#, Wakabayashi K., Tomita K., Tachibana M., Mizuguchi H. #These authors equally contributed to this work.

Sci. Rep., 6, 27598 (2016)

PubMed

Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells

Takayama K.#, Mitani S.#, Nagamoto Y., Sakurai F., Tachibana M., Taniguchi Y., Sakaguchi K., Mizuguchi H. #These authors equally contributed to this work.

Biochem. Biophys. Res. Commun., 474, 91-96 (2016)

PubMed

Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells

Negoro R.#, Takayama K.#, Nagamoto Y., Sakurai F., Tachibana M., Mizuguchi H. #These authors equally contributed to this work.

Biochem. Biophys. Res. Commun., 472, 631-636 (2016)

PubMed

Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction

Nakamori D.#, Takayama K.#, Nagamoto Y., Mitani S., Sakurai F., Tachibana M., Mizuguchi H. #These authors equally contributed to this work.

Biochem. Biophys. Res. Commun., 469, 424-429 (2016)

PubMed

TANK-binding kinase 1-dependent or -independent signaling elicits the cell type-specific innate immune responses induced by the adenovirus vector

Tsuzuki S.#, Tachibana M.#, Hemmi M., Yamaguchi T., Shoji M., Sakurai F., Kobiyama K., Kawabata K., Ishii K.J., Akira S., Mizuguchi H. #These authors equally contributed to this work.

Int. Immunol., 28, 105-115 (2016)

PubMed

Adenovirus vector-based incorporation of a photo-cross-linkable amino acid into proteins in human primary cells and cancerous cell lines

Kita A., Hino N., Higashi S., Hirota K., Narumi R., Adachi J., Takafuji K., Ishimoto K., Okada Y., Sakamoto K., Tomonaga T., Takashima S., Mizuguchi H., Doi T.

Sci. Rep., 6, 36946 (2016)

PubMed

目次に戻る

大阪大学大学院薬学研究科分子生物学分野

Laboratory of Biochemistry and Molecular Biology

Graduate School of Pharmaceutical Sciences, Osaka University

業績｜論文・出版物｜目次｜ALL