top of page

 
業績|論文・出版物|目次|ALL
 

Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration

Tomita K., Sakurai F., Iizuka S., Hemmi M., Wakabayashi K., Tachibana M., Katayama K., Kamada H., Mizuguchi H.

Sci. Rep., 8, 12315 (2018)

Generation of the adenovirus vector-mediated CRISPR/Cpf1 system and the application for primary human hepatocytes prepared from humanized mice with chimeric liver

Tsukamoto T., Sakai E., Iizuka S., Taracena-Gándara M., Sakurai F., Mizuguchi H.

Biol. Pharm. Bull., 41, 1089-1095 (2018)

Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research

Takayama K., Hagihara Y., Toba Y., Sekiguchi K., Sakurai F., Mizuguchi H.

Biomaterials, 161, 24-32 (2018)

Oncolytic reovirus inhibits immunosuppressive activity of myeloid-derived suppressor cells in a TLR3-dependent manner

Katayama Y., Tachibana M., Kurisu N., Oya Y., Terasawa Y., Goda H., Kobiyama K., Ishii K., Akira S., Mizuguchi H., Sakurai F.

J. Immunol., 200, 2987-2999 (2018)

Nanaomycin A treatment promotes hepatoblast differentiation from human iPS cells

Nakamae S.#, Toba Y.#, Takayama K., Sakurai F., Mizuguchi H. #These authors equally contributed to this work.

Stem Cells Dev., 27, 405-414 (2018)

Billion-scale production of hepatocyte-like cells from human iPS cells

Yamashita T., Takayama K., Sakurai F., Mizuguchi H.

Biochem. Biophys. Res. Commun., 496, 1269–1275 (2018)

Occludin as a functional marker of vascular endothelial cells on tube-forming activity

Kanayasu-Toyoda T., Ishii-Watabe A., Kikuchi Y., Kitagawa H., Suzuki H., Tamura H., Tada M., Suzuki T., Mizuguchi H., Yamaguchi T.

J. Cell. Physiol., 233, 1700-1711 (2018)

Generation of optogenetically modified adenovirus vector for spatiotemporally controllable gene therapy

Takayama K., Mizuguchi H.

ACS Chem. Biol., 13, 449–454 (2018)

Detection of CTCs in cervical cancer using a conditionally replicative adenovirus targeting telomerase-positive cells

Takakura M., Matsumoto T., Nakamura M., Mizumoto Y., Myojyo S., Yamazaki R., Iwadare J., Bono Y., Orisaka S., Obata T., Izuka T., Kagami K., Nakayama K., Hayakawa H., Sakurai F., Mizuguchi H., Urata Y., Fujiwara T., Kyo S., Sasagawa T., Fujiwara H.

Cancer Sci., 109, 231-240 (2018)

Human iPS cell-based liver-like tissue engineering at extrahepatic sites in mice as a new cell therapy for hemophilia B

Okamoto R.#, Takayama K.#, Akita N.#, Nagamoto Y., Hosokawa D., Iizuka S., Sakurai F., Suemizu H., Ohashi K., Mizuguchi H. #These authors equally contributed to this work.

Cell Transplant., 27, 299-309 (2018)

アデノウイルスベクター

水口裕之, 早川堯夫

バイオロジクスの開発と品質・安全性確保, エル・アイ・シー (2018)

組換えアデノウイルス ―特性と最近の話題―

水口裕之, 邊見昌久

医学のあゆみ, 351-358 (2018)

粘膜免疫誘導型ワクチンとしてのアデノウイルスベクター

立花雅史, 邊見昌久, 水口裕之

ドラッグデリバリーシステム, シーエムシー出版 (2018)

ヒトiPS細胞由来肝細胞の創出と創薬研究への応用

三谷成二, 高山和雄, 水口裕之

PHARM STAGE, 技術情報協会 (2018)

Generation of safe and therapeutically effective human iPS cell-derived hepatocyte-like cells for regenerative medicine

Takayama K.#, Akita N.#, Mimura N., Akahira R., Taniguchi Y., Ikeda M., Sakurai F., Ohara O., Morio T., Sekiguchi K., Mizuguchi H. #These authors equally contributed to this work.

Hepatol. Commun., 1, 1058-1069 (2017)

Th17 Promotes Induction of antigen-specific gut-mucosal CTLs following adenovirus vector vaccination

Hemmi M.#, Tachibana M.#, Fujimoto N., Shoji M., Sakurai F., Kobiyama K., Ishii K.J., Akira S., Mizuguchi H. #These authors equally contributed to this work.

Front. Immunol., 8, 1456 (2017)

Suppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB

Machitani M., Sakurai F., Wakabayashi K., Nakatani K., Tachibana M., Kato N., Fujiwara T., Mizuguchi H.

Mol. Ther. Oncolytics, 7, 76-85 (2017)

Human ES/iPS cell-derived hepatocyte-like cells achieve zone-specific hepatic properties by modulation of WNT signaling

Mitani S.#, Takayama K.#, Nagamoto Y., Imagawa K., Sakurai F., Tachibana M., Sumazaki R., Mizuguchi H. #These authors equally contributed to this work.

Mol. Ther., 25, 1420-1433 (2017)

Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells

Sakurai F.#, Kunito T.#, Takayama K., Hashimoto R., Tachibana M., Sakamoto N., Wakita T., Mizuguchi H. #These authors equally contributed to this work.

Virus Res., 242, 7-15 (2017)

Neonatal gene therapy for hemophilia B by a novel adenovirus vector showing sustained transgene expression via a reduction in the leaky expression of viral genes

Iizuka S., Sakurai F., Tachibana M., Ohashi K., Mizuguchi H.

Mol. Ther. Methods Clin. Dev., 6, 183-193 (2017)

大阪大学大学院 薬学研究科 分子生物学分野 

〒565-0871 大阪府吹田市山田丘1-6 大阪大学 大学院薬学研究科・薬学部 1号館 4階

TEL: 06-6879-8185 FAX: 06-6879-8187

Copyright© Laboratory of Biochemistry and Molecular Biology, Graduate School and School of Pharmaceutical Sciences, Osaka University

directed by Prof. Hiroyuki Mizuguchi

  • 分子生物学分野 | 阪大 | 薬学 | 生化 twitter
bottom of page