業績｜論文・出版物｜目次｜ALL

Generation of human iPS cell-derived intestinal epithelial cell monolayers by CDX2 transduction

Takayama K., Negoro R., Yamashita T., Kawai K., Ichikawa M., Mori T., Nakatsu N., Harada K., Ito S., Yamada H., Yamaura Y., Hirata K., Ishida S., Mizuguchi H.

Cell. Mol. Gastroenterol. Hepatol., 8, 513-526 (2019)

PubMed

miR-27b-mediated suppression of aquaporin-11 expression in hepatocytes reduces HCV genomic RNA levels but not viral titers

Sakurai F.#, Hashimoto R.#, Inoue C., Wakabayashi K., Tsukamoto T., Taracena-Gándara M., Imaizumi T., Sakai E., Itsuki K., Sakamoto N., Wakita T., Mizuguchi H. #These authors equally contributed to this work.

Virology Journal, 16, 58 (2019)

PubMed

Modeling of hepatic drug metabolism and responses in CYP2C19 poor metabolizer using genetically manipulated human iPS cells

Deguchi S., Yamashita T., Igai K., Harada K., Toba Y., Hirata K., Takayama K., Mizuguchi H.

Drug Metab. Dispos., 47, 632-638 (2019)

PubMed

FGF signal is not required for hepatoblast differentiation of human iPS cells

Toba Y., Kiso A., Nakamae S., Sakurai F., Takayama K., Mizuguchi H.

Sci. Rep., 9, 3713 (2019)

PubMed

Development of selective cytotoxic viral vectors for concentration of undifferentiated cells in cardiomyocytes derived from human induced pluripotent stem cells

Kono K., Sawada R., Kuroda T., Yasuda S., Matsuyama S., Matsuyama A., Mizuguchi H., Sato Y.

Sci. Rep., 9, 3630 (2019)

PubMed

A microRNA derived from adenovirus virus-associated RNAII promotes virus infection via post-transcriptional gene silencing

Wakabayashi K.#, Machitani M.#, Tachibana M., Sakurai F., Mizuguchi H. #These authors equally contributed to this work.

J. Virol., 93, e01265-18 (2019)

PubMed

Pharmaceutical research for inherited metabolic disorders of the liver using human induced pluripotent stem cell and genome editing technologies

Yamashita T., Takayama K., Hori M., Harada-Shiba M., Mizuguchi H.

Biol. Pharm. Bull., 42, 312-318 (2019)

PubMed

アデノウイルス由来小分子RNAによるウイルス増殖促進機構の解明と遺伝子組換えウイルスへの応用

若林圭作, 櫻井文教, 水口裕之

生産と技術, 71, 10-14 (2019)

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Systemically administered reovirus-induced down-regulation of hypoxia inducible factor-1α in subcutaneous tumors

Hotani T., Mizuguchi H., Sakurai F.

Mol. Ther. Oncolytics, 12, 162-172 (2018)

PubMed

Efficient generation of small intestinal epithelial-like cells from human iPS cells for drug absorption and metabolism studies

Negoro R., Takayama K., Kawai K., Harada K., Sakurai F., Hirata K., Mizuguchi H.

Stem Cell Rep., 11, 1539-1550 (2018)

PubMed

Optimal human iPS cell culture method for efficient hepatic differentiation

Matoba N.#, Yamashita T.#, Takayama K., Sakurai F., Mizuguchi H. #These authors equally contributed to this work.

Differentiation, 104, 13-21 (2018)

PubMed

LY341495, an mGluR2/3 antagonist, regulates the immunosuppressive function of myeloid-derived suppressor cells and inhibits melanoma tumor growth

Morikawa N., Tachibana M., Ago Y., Goda H., Sakurai F., Mizuguchi H.

Biol. Pharm. Bull., 41, 1866-1869 (2018)

PubMed

Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration

Tomita K., Sakurai F., Iizuka S., Hemmi M., Wakabayashi K., Tachibana M., Katayama K., Kamada H., Mizuguchi H.

Sci. Rep., 8, 12315 (2018)

PubMed

Generation of the adenovirus vector-mediated CRISPR/Cpf1 system and the application for primary human hepatocytes prepared from humanized mice with chimeric liver

Tsukamoto T., Sakai E., Iizuka S., Taracena-Gándara M., Sakurai F., Mizuguchi H.

Biol. Pharm. Bull., 41, 1089-1095 (2018)

PubMed

Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research

Takayama K., Hagihara Y., Toba Y., Sekiguchi K., Sakurai F., Mizuguchi H.

Biomaterials, 161, 24-32 (2018)

PubMed

Oncolytic reovirus inhibits immunosuppressive activity of myeloid-derived suppressor cells in a TLR3-dependent manner

Katayama Y., Tachibana M., Kurisu N., Oya Y., Terasawa Y., Goda H., Kobiyama K., Ishii K., Akira S., Mizuguchi H., Sakurai F.

J. Immunol., 200, 2987-2999 (2018)

PubMed

Nanaomycin A treatment promotes hepatoblast differentiation from human iPS cells

Nakamae S.#, Toba Y.#, Takayama K., Sakurai F., Mizuguchi H. #These authors equally contributed to this work.

Stem Cells Dev., 27, 405-414 (2018)

PubMed

Billion-scale production of hepatocyte-like cells from human iPS cells

Yamashita T., Takayama K., Sakurai F., Mizuguchi H.

Biochem. Biophys. Res. Commun., 496, 1269–1275 (2018)

PubMed

Occludin as a functional marker of vascular endothelial cells on tube-forming activity

Kanayasu-Toyoda T., Ishii-Watabe A., Kikuchi Y., Kitagawa H., Suzuki H., Tamura H., Tada M., Suzuki T., Mizuguchi H., Yamaguchi T.

J. Cell. Physiol., 233, 1700-1711 (2018)

PubMed

Generation of optogenetically modified adenovirus vector for spatiotemporally controllable gene therapy

Takayama K., Mizuguchi H.

ACS Chem. Biol., 13, 449–454 (2018)

PubMed

目次に戻る

大阪大学大学院薬学研究科分子生物学分野

Laboratory of Biochemistry and Molecular Biology

Graduate School of Pharmaceutical Sciences, Osaka University

業績｜論文・出版物｜目次｜ALL