業績｜論文・出版物｜目次｜ALL

Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications of myeloid-derived suppressor cells and NO production

Tachibana M., Watanabe N., Koda Y., Oya Y., Kaminuma O., Katayama K., Fan Z., Sakurai F., Kawabata K., Hiroi T., Mizuguchi H.

Int. Immunol., 32, 187-201 (2020)

PubMed

Generation of human induced pluripotent stem cell-derived hepatocyte-like cells for cellular medicine

Deguchi S., Takayama K., Mizuguchi H.

Biol. Pharm. Bull., 43, 608-615 (2020)

PubMed

Aspects of gene therapy products using current genome-editing technology in Japan

Yamaguchi T., Uchida E., Okada T., Ozawa K., Onodera M., Kume A., Shimada T., Takahashi S., Tani K., Nasu Y., Mashimo T., Mizuguchi H., Mitani K., Maki K.

Hum. Gene Ther., 31, 1043-1053 (2020)

PubMed

ヒトiPS細胞由来肝細胞のB型肝炎ウイルス感染評価系への応用

櫻井文教, 水口裕之

ファルマシア, 日本薬学会, 56, 1099-1103 (2020)

J-STAGE

薬物動態評価系としてのヒトiPS細胞由来腸管上皮細胞の可能性

山下智起, 横田純平, 乾達也, 水口裕之

Drug Delivery System, 日本DDS学会, 35, 309-318 (2020)

J-STAGE

CHOPCHOP v3を用いたCRISPR-Cas9の標的配列検索方法

塚本智仁, 酒井英子, 櫻井文教, 水口裕之

Drug Delivery System, 日本DDS学会, 35, 257-259 (2020)

J-STAGE

Establishment of SLC15A1/PEPT1-knockout human induced pluripotent stem cell line for intestinal drug absorption studies

Kawai K., Negoro R., Ichikawa M., Yamashita T., Deguchi S., Harada K., Hirata K., Takayama K., Mizuguchi H.

Mol. Ther. Methods Clin. Dev., 17, 49-57 (2019)

PubMed

Efficient generation of adenovirus vectors carrying the Clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR associated proteins (Cas)12a system by suppressing Cas12a expression in packaging cells

Tsukamoto T., Sakai E., Nishimae F., Sakurai F., Mizuguchi H.

J. Biotech., 304, 1-9 (2019)

PubMed

Generation of human iPS cell-derived intestinal epithelial cell monolayers by CDX2 transduction

Takayama K., Negoro R., Yamashita T., Kawai K., Ichikawa M., Mori T., Nakatsu N., Harada K., Ito S., Yamada H., Yamaura Y., Hirata K., Ishida S., Mizuguchi H.

Cell. Mol. Gastroenterol. Hepatol., 8, 513-526 (2019)

PubMed

miR-27b-mediated suppression of aquaporin-11 expression in hepatocytes reduces HCV genomic RNA levels but not viral titers

Sakurai F.#, Hashimoto R.#, Inoue C., Wakabayashi K., Tsukamoto T., Taracena-Gándara M., Imaizumi T., Sakai E., Itsuki K., Sakamoto N., Wakita T., Mizuguchi H. #These authors equally contributed to this work.

Virology Journal, 16, 58 (2019)

PubMed

Modeling of hepatic drug metabolism and responses in CYP2C19 poor metabolizer using genetically manipulated human iPS cells

Deguchi S., Yamashita T., Igai K., Harada K., Toba Y., Hirata K., Takayama K., Mizuguchi H.

Drug Metab. Dispos., 47, 632-638 (2019)

PubMed

FGF signal is not required for hepatoblast differentiation of human iPS cells

Toba Y., Kiso A., Nakamae S., Sakurai F., Takayama K., Mizuguchi H.

Sci. Rep., 9, 3713 (2019)

PubMed

Development of selective cytotoxic viral vectors for concentration of undifferentiated cells in cardiomyocytes derived from human induced pluripotent stem cells

Kono K., Sawada R., Kuroda T., Yasuda S., Matsuyama S., Matsuyama A., Mizuguchi H., Sato Y.

Sci. Rep., 9, 3630 (2019)

PubMed

A microRNA derived from adenovirus virus-associated RNAII promotes virus infection via post-transcriptional gene silencing

Wakabayashi K.#, Machitani M.#, Tachibana M., Sakurai F., Mizuguchi H. #These authors equally contributed to this work.

J. Virol., 93, e01265-18 (2019)

PubMed

Pharmaceutical research for inherited metabolic disorders of the liver using human induced pluripotent stem cell and genome editing technologies

Yamashita T., Takayama K., Hori M., Harada-Shiba M., Mizuguchi H.

Biol. Pharm. Bull., 42, 312-318 (2019)

PubMed

アデノウイルス由来小分子RNAによるウイルス増殖促進機構の解明と遺伝子組換えウイルスへの応用

若林圭作, 櫻井文教, 水口裕之

生産と技術, 71, 10-14 (2019)

WebSite

Systemically administered reovirus-induced down-regulation of hypoxia inducible factor-1α in subcutaneous tumors

Hotani T., Mizuguchi H., Sakurai F.

Mol. Ther. Oncolytics, 12, 162-172 (2018)

PubMed

Efficient generation of small intestinal epithelial-like cells from human iPS cells for drug absorption and metabolism studies

Negoro R., Takayama K., Kawai K., Harada K., Sakurai F., Hirata K., Mizuguchi H.

Stem Cell Rep., 11, 1539-1550 (2018)

PubMed

Optimal human iPS cell culture method for efficient hepatic differentiation

Matoba N.#, Yamashita T.#, Takayama K., Sakurai F., Mizuguchi H. #These authors equally contributed to this work.

Differentiation, 104, 13-21 (2018)

PubMed

LY341495, an mGluR2/3 antagonist, regulates the immunosuppressive function of myeloid-derived suppressor cells and inhibits melanoma tumor growth

Morikawa N., Tachibana M., Ago Y., Goda H., Sakurai F., Mizuguchi H.

Biol. Pharm. Bull., 41, 1866-1869 (2018)

PubMed

目次に戻る

大阪大学大学院薬学研究科分子生物学分野

Laboratory of Biochemistry and Molecular Biology

Graduate School of Pharmaceutical Sciences, Osaka University

業績｜論文・出版物｜目次｜ALL