業績｜論文・出版物｜目次｜ALL

Adenovirus Vector-Induced IL-6 Promotes Leaky Adenoviral Gene Expression, Leading to Acute Hepatotoxicity

Shimizu K., Sakurai F., Iizuka S., Ono R., Tsukamoto T., Nishimae F., Nakamura SI., Nishinaka T., Terada T., Fujio Y., Mizuguchi H.

J. Immunol., 206, 410-421 (2021)

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A TGF-b signaling inhibitor, SB431542, inhibits reovirus-mediated lysis of human hepatocellular carcinoma cells in a TGF-b-independent manner.

Ishigami I., Shuwari N., Kaminade T., Mizuguchi H., Sakurai F.

Anticancer Res., 4, 2431-2440 (2021)

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Vinblastine treatment decreases the undifferentiated cell contamination of human iPSC-derived intestinal epithelial-like cells

Ichikawa M.#, Negoro R.#, Kawai K., Yamashita T., Takayama K., Mizuguchi H. #These authors equally contributed to this work.

Mol. Ther. Methods Clin. Dev., 20, 463-472 (2021)

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The infectivity of progeny adenovirus in the presence of neutralizing antibody.

Hirai T., Sato A., Koizumi N., Kurioka Y., Suzuki Y., Kano J., Yamakawa M., Nomura T., Fujii M., Sakurai F., Mizuguchi H., Watanabe Y., Utoguchi N.

J. Gen. Virol., 102, 001590 (2021)

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Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 35

Ono R., Takayama K., Sakurai F., Mizuguchi H.

Mol. Ther. Oncolytics, 20, 399-409 (2021)

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In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology.

Deguchi S., Shintani T., Harada K., Okamoto T., Takemura A., Hirata K., Ito K., Takayama K., Mizuguchi H.

Hepatol.?Commun., 5, 1385-1399 (2021)

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Asymmetric profiles of infection and innate immunological responses in human iPS cell-derived small intestinal epithelial-like cell monolayers following infection with mammalian reovirus

Inoue C., Negoro R., Takayama K., Mizuguchi H., Sakurai F.

Virus Res., 296, 198334 (2021)

PubMed

Optimization of an E1A gene expression cassette in an oncolytic adenovirus for efficient tumor cell killing activity

Sakurai F., Nishimae F., Takayama K., Mizuguchi H.

Anticancer Res., 41, 773-782 (2021)

PubMed

Fiber-knob region of adenovirus type 5 vector promotes migration of A549 cells

Kano J., Koizumi N., Terada A., Matsuoka A., Hirai T., Nomura T., Mizuguchi H., Utoguchi N.

BPB Reports, 4, 17-21 (2021)

PubMed

In vivo gene expression profile of human intestinal epithelial cells: from the viewpoint of drug metabolism and pharmacokinetics

Takayama K., Ito K., Matsui A., Yamashita T., Kawakami K., Hirayama D., Kishimoto W., Nakase H., Mizuguchi H.

Drug Metab. Dispos., 49, 221-232 (2021)

PubMed

アデノウイルスベクターワクチン設計のサイエンス　～COVID-19に対するワクチン開発を中心に～

水口裕之

医学のあゆみ, 279, 999-1004 (2021)

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ゲノム編集によるヒトiPS細胞モデルの作製技術と医薬品評価への応用

鳥羽由希子、新谷友啓、水口裕之

月刊PHARMSTAGE, 株式会社技術情報協会, 21, 21-27 (2021)

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ゲノム編集モデルの医薬品評価への応用とその課題

鳥羽由希子, 水口裕之

ゲノム編集技術の産業応用技術〜研究動向、課題とその解決、トラブル対策〜, 株式会社技術情報協会, 339-345 (2021)

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Tolloid-like 1 negatively regulates hepatic differentiation of human iPS cells through transforming growth factor beta signaling

Kiso A., Toba Y., Tsutsumi S., Deguchi S., Igai K., Koshino S., Tanaka Y., Takayama K., Mizuguchi H.

Hepatol. Commun., 4, 255-267 (2020)

PubMed

Photoactivatable oncolytic adenovirus for optogenetic cancer therapy

Hagihara Y., Sakamoto A., Tokuda T., Yamashita T., Ikemoto S., Kimura A., Haruta M., Sasagawa K., Ohta J., Takayama K., Mizuguchi H.

Cell Death Dis., 11, 570 (2020)

PubMed

Establishment of MDR1-knockout human induced pluripotent stem cell line

Negoro R., Kawai K., Ichikawa M., Deguchi S., Takayama K., Mizuguchi H.

Drug Metab. Pharmacokinet., 35, 288-296 (2020)

PubMed

Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer

Koujima T., Tazawa H., Ieda T., Araki H., Fushimi T., Shoji R., Kuroda S., Kikuchi S., Yoshida R., Umeda Y., Teraishi F., Urata Y., Mizuguchi H., Fujiwara T.

Mol. Ther. Oncolytics, 17, 107-117 (2020)

PubMed

Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance

Toba Y., Deguchi S., Mimura N., Sakamoto A., Harada K., Hirata K., Takayama K., Mizuguchi H.

PLoS One, 15, e0229654 (2020)

PubMed

Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody

Kanaya N., Kuroda S., Kakiuchi Y., Kumon K., Tsumura T., Hashimoto M., Morihiro T., Kubota T., Aoyama K., Kikuchi S., Nishizaki M., Kagawa S., Tazawa H., Mizuguchi H., Urata Y., Fujiwara T.

Mol. Ther., 28, 794-804 (2020)

PubMed

Development of a Novel Oncolytic Adenovirus Expressing a Short-hairpin RNA Against Cullin 4A

Wakabayashi K., Sakurai F., Ono R., Fujiwara T., Mizuguchi H.

Anticancer Res., 40, 161-168 (2020)

PubMed

目次に戻る

大阪大学大学院薬学研究科分子生物学分野

Laboratory of Biochemistry and Molecular Biology

Graduate School of Pharmaceutical Sciences, Osaka University

業績｜論文・出版物｜目次｜ALL