業績｜論文・出版物｜目次｜ALL

A trial of somatic gene targeting in vivo with an adenovirus vector

Ino A., Naito Y., Mizuguchi H., Handa N., Hayakawa T., Kobayashi I.

Genet. Vaccines Ther., 3, 8 (2005)

Efficient regulation of gene expression using self-contained fiber-modified adenovirus vectors containing the tet-off system

Mizuguchi H., Xu Z-L., Sakurai F., Kawabata K., Yamaguchi T., Hayakawa T.

J. Control. Release, 110, 202-211 (2005)

PubMed

Prime-boost vaccination with plasmid DNA and a chimeric adenovirus type 5 vector with type 35 fiber induces protective immunity against HIV

Xin K-Q., Jounai N., Someya K., Honma K., Mizuguchi H., Naganawa S., Kitamura K., Hayakawa T., Saha S., Takeshita F., Okuda K., Honda M., Klinman D.M., Okuda K.

Gene Ther., 12, 1769-1777 (2005)

PubMed

Role of C-terminal regions of the C-terminal fragment of Clostridium perfringens enterotoxin in its interaction with claudin-4

Takahashi A., Kondoh M., Masuyama A., Fujii M., Mizuguchi H., Horiguchi Y., Watanabe Y.

J. Control. Release, 108, 56-62 (2005)

PubMed

Role of N-terminal amino acids in the absorption-enhancing effects of the C-terminal fragment of Clostridium Perfringens enterotoxin

Masuyama A., Kondoh M., Seguchi H., Takahashi A., Harada M., Fujii M., Mizuguchi H., Horiguchi Y., Watanabe Y.

J. Pharmacol. Exp. Ther., 314, 789-795 (2005)

PubMed

Anti-tumor responses induced by chemokine CCL19 transfected into an ovarian carcinoma model via fiber-mutant adenovirus vector

Gao J-Q, Sugita T., Kanagawa N., Iida K., Okada N., Mizuguchi H., Nakayama T., Yoshie O., Tsutsumi Y., Mayumi T., Nakagawa S.

Biol. Pharm. Bull., 28, 1066-1070 (2005)

PubMed

Transcriptional targeting of RGD fiber-mutant adenovirus vectors can improve the safety of suicide gene therapy for murine melanoma

Okada Y., Okada N., Mizuguchi H., Hayakawa T., Nakagawa S., Mayumi T.

Cancer Gene Ther., 12, 608-616 (2005)

PubMed

Comparison of transgene expression mediated by several fiber-modified adenovirus vectors in trophoblast cells

Koizumi, N., Kondoh, M., Mizuguchi H., Nakanishi, T., Masuyama, A., Ida, F., Fujii, M., Hayakawa, T., Nakashima, E., Tanaka, K., Watanabe, Y.

Placenta, 26, 729-734 (2005)

PubMed

PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody evasion ability

Eto Y., Gao J-Q., Sekiguchi F., Kurachi S., Katayama K., Mizuguchi H., Hayakawa T., Maeda, M., Kawasaki K., Tsutsumi Y., Mayumi T., Nakagawa S.

J. Gene Med., 7, 604-612 (2005)

PubMed

Enhanced oncolysis by a tropism-modified telomerase-specific replication-selective adenoviral agent OBP-405 ('Telomelysin-RGD')

Taki M., Kagawa S., Nishizaki M., Mizuguchi H., Hayakawa T., Kyo S., Nagai K., Urata Y., Tanaka N., Fujiwara T.

Oncogene, 24, 3130-3140 (2005)

PubMed

Design and synthesis of a peptide-PEG transporter tool for carrying adenovirus vector into cells

Maeda M., Kida S., Hojo K., Eto Y., Gao J-Q, Kurachi S., Sekiguchi F., Mizuguchi H., Hayakawa T., Mayumi T., Nakagawa S., Kawasaki K.

Bioorg. Med. Chem. Lett., 15, 621-624 (2005)

PubMed

A single intratumoral injection of a fiber-mutant adenoviral vector encoding interleukin 12 induces remarkable anti-tumor and anti-metastatic activity in mice with Meth-A fibrosarcoma

Gao J-Q, Sugita T., Kanagawa N., Iida K., Eto Y., Motomura Y., Mizuguchi H., Tsutsumi Y., Hayakawa T., Mayumi T., Nakagawa S.

Biochem. Biophys. Res. Commun., 328, 1043-1050 (2005)

PubMed

Eradication of Epstein-Barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1

Nasimuzzaman, M., Kuroda, M., Dohno, S., Yamamoto, T., Iwatsuki, K., Matsuzaki, S., Rashel, M., Kumita, W., Mizuguchi, H., Hayakawa, T., Nakamura, H., Taguchi, T., Wakiguchi, H., Imai, S.

Mol. Ther., 11, 578-590 (2005)

PubMed

RNA interference of PPARγ using fiber-modified adenovirus vector efficiently suppresses preadipocyte-to-adipocyte differentiation in 3T3-L1 cells

Hosono T., Mizuguchi H., Katayama K., Koizumi N., Kawabata K., Yamaguchi T., Nakagawa S., Watanabe Y., Mayumi T., Hayakawa T.

Gene, 348, 157-165 (2005)

PubMed

A novel strategy for the enhancement of drug absorption using a claudin modulator

Kondoh, M., Masuyama , A., Takahashi, A., Asano, N., Mizuguchi H., Koizumi, N., Fujii, M., Hayakawa, T., Horiguchi, Y., Watanabe, Y.

Mol. Pharmacol., 67, 749-756 (2005)

PubMed

Gene therapy for human small cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference

Sumimoto H., Yamagata S., Shimizu A., Miyoshi H., Mizuguchi H., Hayakawa T., Miyagishi M., Taira K., Kawakami Y.

Gene Ther., 12, 95-100 (2005)

PubMed

Augmentation of the migratory ability of DC-based vaccine into regionalymph nodes by efficient CCR7 gene transduction

Okada N., Mori N., Koretomo R., Okada Y., Nakayama T., Yoshie O., Mizuguchi H., Hayakawa T., Nakagawa S., Mayumi T., Fujita T., Yamamoto A.

Gene Ther., 12, 129-139 (2005)

PubMed

Immunological properties and vaccine efficacy of murine dendritic cells simultaneously expressing melanoma-associated antigen and interleukin-12

Okada N., Iiyama S., Okada Y., Mizuguchi H., Hayakawa T., Nakagawa S., Mayumi T., Fujita T., Yamamoto A.

Cancer Gene Ther., 12, 72-83 (2005)

PubMed

Constitutively active PDX1 induced efficient insulin production in adult murine liver

Imai, J., Katagiri, H., Yamada, T., Ishigaki, Y., Ogihara, T., Uno, K., Hasegawa, Y., Gao, J., Ishihara, H., Sasano, H., Mizuguchi H., Asano, T., Oka, Y.

Biochem. Biophys. Res. Commun., 326, 402-409 (2005)

PubMed

Approaches to improving the kinetics of adenovirus-delivered genes and gene products

Xu ZL., Mizuguchi H., Koizumi N., Sakurai F., Hosono T., Kawabata K., Watanabe Y., Yamaguchi T., Hayakawa T.

Adv. Drug. Deli. Rev., 57, 781-802 (2005)

PubMed

目次に戻る

大阪大学大学院薬学研究科分子生物学分野

Laboratory of Biochemistry and Molecular Biology

Graduate School of Pharmaceutical Sciences, Osaka University

業績｜論文・出版物｜目次｜ALL