業績｜論文・出版物｜目次｜ALL

改良型アデノウイルスベクターを用いた肝臓内の脂質の量と種類の制御による糖尿病の遺伝子治療法の開発

清水かほり

Drug Delivery System, 40, 82-83 (2025)

ヒト腸管オルガノイドを用いた医薬品開発プラットフォーム

乾達也、水口裕之

創薬研究における細胞培養の今, 116-123 (2025)

肝臓内のリン脂質プロファイルに着目した、糖尿病に対する遺伝子治療法の開発

清水かほり

生産と技術, 77, 31-33 (2025)

ヒトiPS細胞由来肝オルガノイドの樹立とその二次元培養による肝細胞の成熟化

乾純平、植山（鳥羽）由希子、水口裕之

肝細胞研究会　研究交流 (2025)

Generation and application of CES1-knockout Tet-Off-regulated CYP3A4 and UGT1A1-expressing Caco-2 cells.

Murata M., Okada K., Takahashi M., Ueyama-Toba Y., Ito S., Mizuguchi H.

Toxicol Lett., 401, 158-169 (2024)

Development of a hepatic differentiation method in 2D culture from primary human hepatocyte-derived organoids for pharmaceutical research.

Ueyama-Toba Y., Tong Y., Yokota J., Murai K., Hikita H., Eguchi H., Takehara T., Mizuguchi H.

iScience, 27, 110778 (2024)

Development of a novel adenovirus serotype 35 vector vaccine possessing an RGD peptide in the fiber knob and the E4 orf 4, 6, and 6/7 regions of adenovirus serotype 5

Onishi R., Ikemoto S., Shiota A., Tsukamoto T., Asayama A., Tachibana M., Sakurai F., Mizuguchi H.

Int J Pharm., 662, 124480 (2024)

Transplacental delivery of factor IX Fc-fusion protein ameliorates bleeding phenotype of newborn hemophilia B mice

Sakurai F., Iizuka S., Tsukamoto T., Shiota A., Shimizu K., Ohashi K., Mizuguchi H.

J Control Release, 374, 415-424 (2024)

Small extracellular vesicles carrying reovirus, tumor antigens, interferon-β, and damage-associated molecular patterns for efficient tumor treatment

Shuwari N., Inoue C., Ishigami I., Jingushi K., Kamiya M., Kawakami S., Tsujikawa K., Tachibana M., Mizuguchi H., Sakurai F.

J Control Release, 374, 89-102 (2024)

Efficient hepatocyte differentiation of primary human hepatocyte-derived organoids using three dimensional nanofibers (HYDROX) and their possible application in hepatotoxicity research

Tong Y., Ueyama-Toba Y., Yokota Y., Matsui H., Kanai M., Mizuguchi H.

Sci. Rep., 14, 10846 (2024)

Development of an Improved Adenovirus Vector and Its Application to the Treatment of Lifestyle-Related Diseases

Shimzu K.

Biol Pharm Bull., 47, 886-894 (2024)

Functional intestinal monolayers from organoids derived from human iPS cells for drug discovery research

Inui T., Uraya Y., Yokota J., Yamashita T., Kawai K., Okada K., Ueyama-Toba Y., Mizuguchi H.

Stem Cell Research & Therapy, 15, 57 (2024)

Heterogenous gene expression of bicellular and tricellular tight junction-sealing components in the human intestinal tract.

Tachibana K., Bai L., Sugimura S., Fujioka H., Kishimoto W., Mizuguchi H., Nakase H., Kondoh M.

Biol. Pharm. Bull., 47, 1209-1217 (2024)

A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT).

Hanaoka K., Ikeno T., Iwaki S., Deguchi S., Takayama K., Mizuguchi H., Tao F., Kojima N., Ohno H., Sasaki E., Komatsu T., Ueno T., Maeda K., Kusuhara H., Urano Y.

Sci. Adv., 10, eadi8847 (2024)

Overexpression of lysophospholipid acyltransferase, LPLAT10/LPCAT4/LPEAT2, in the mouse liver increases glucose-stimulated insulin secretion.

Shimizu K., Ono M., Mikamoto T., Urayama Y., Yoshida S., Hase T., Michinaga S., Nakanishi H., Iwasaki M., Terada T., Sakurai F., Mizuguchi H., Shindou H., Tomita K., Nishinaka T.

FASEB J., 38, e23425 (2024)

Establishment of human intestinal organoids derived from commercially available cryopreserved intestinal epithelium and evaluation for pharmacokinetic study

Okada K., Yokota J., Yamashita T., Inui T., Kishimoto W., Nakase H., Mizuguchi H.,

Drug Metab Pharmacokinet., 54, 100532 (2024)

Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation.

Shintani T.#, Imamura C.#,?Ueyama-Toba Y.,?Inui J., Watanabe A.,?Mizuguchi H. #These authors equally contributed to this work.

Mol. Ther. Methods Clin. Dev., 30, 429-442 (2023)

Quantitative analysis of mRNA and protein expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in the human intestine.

Hirosawa K., Fujioka H., Morinaga G., Fukami T., Ishiguro N., Kishimoto W., Nakase H., Mizuguchi H., Nakajima M.

Drug Metab Dispos., 51, 1569-1577 (2023)

Novel conditionally replicating adenovirus-mediated efficient detection of circulating tumor cells in lung cancer patients.

Ikemoto S., Sakurai F., Tokuoka S., Yamashita T., Takayama K., Hoshi K., Okabe T., Sumiyoshi I., Togo S., Takahashi K., Tachibana M., Mizuguchi H.

PLoS ONE, 18, e0286323 (2023)

Involvement of protein kinase R in double-stranded RNA-induced proteasomal degradation of hypoxia inducible factor-1a.

Hotani T., Nakagawa K., Tsukamoto T., Mizuguchi H., Sakurai F.

Inflammation, 46, 2332-2342 (2023)

目次に戻る

大阪大学大学院薬学研究科分子生物学分野

Laboratory of Biochemistry and Molecular Biology

Graduate School of Pharmaceutical Sciences, Osaka University

業績｜論文・出版物｜目次｜ALL