業績｜論文・出版物｜目次｜ALL

Small extracellular vesicles carrying reovirus, tumor antigens, interferon-β, and damage-associated molecular patterns for efficient tumor treatment

Shuwari N., Inoue C., Ishigami I., Jingushi K., Kamiya M., Kawakami S., Tsujikawa K., Tachibana M., Mizuguchi H., Sakurai F.

J Control Release, 374, 89-102 (2024)

Efficient hepatocyte differentiation of primary human hepatocyte-derived organoids using three dimensional nanofibers (HYDROX) and their possible application in hepatotoxicity research

Tong Y., Ueyama-Toba Y., Yokota Y., Matsui H., Kanai M., Mizuguchi H.

Sci. Rep., 14, 10846 (2024)

Development of an Improved Adenovirus Vector and Its Application to the Treatment of Lifestyle-Related Diseases

Shimzu K.

Biol Pharm Bull., 47, 886-894 (2024)

Functional intestinal monolayers from organoids derived from human iPS cells for drug discovery research

Inui T., Uraya Y., Yokota J., Yamashita T., Kawai K., Okada K., Ueyama-Toba Y., Mizuguchi H.

Stem Cell Research & Therapy, 15, 57 (2024)

Heterogenous gene expression of bicellular and tricellular tight junction-sealing components in the human intestinal tract.

Tachibana K., Bai L., Sugimura S., Fujioka H., Kishimoto W., Mizuguchi H., Nakase H., Kondoh M.

Biol. Pharm. Bull., 47, 1209-1217 (2024)

A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT).

Hanaoka K., Ikeno T., Iwaki S., Deguchi S., Takayama K., Mizuguchi H., Tao F., Kojima N., Ohno H., Sasaki E., Komatsu T., Ueno T., Maeda K., Kusuhara H., Urano Y.

Sci. Adv., 10, eadi8847 (2024)

Overexpression of lysophospholipid acyltransferase, LPLAT10/LPCAT4/LPEAT2, in the mouse liver increases glucose-stimulated insulin secretion.

Shimizu K., Ono M., Mikamoto T., Urayama Y., Yoshida S., Hase T., Michinaga S., Nakanishi H., Iwasaki M., Terada T., Sakurai F., Mizuguchi H., Shindou H., Tomita K., Nishinaka T.

FASEB J., 38, e23425 (2024)

Establishment of human intestinal organoids derived from commercially available cryopreserved intestinal epithelium and evaluation for pharmacokinetic study

Okada K., Yokota J., Yamashita T., Inui T., Kishimoto W., Nakase H., Mizuguchi H.,

Drug Metab Pharmacokinet., 54, 100532 (2024)

Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation.

Shintani T.#, Imamura C.#,?Ueyama-Toba Y.,?Inui J., Watanabe A.,?Mizuguchi H. #These authors equally contributed to this work.

Mol. Ther. Methods Clin. Dev., 30, 429-442 (2023)

Quantitative analysis of mRNA and protein expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in the human intestine.

Hirosawa K., Fujioka H., Morinaga G., Fukami T., Ishiguro N., Kishimoto W., Nakase H., Mizuguchi H., Nakajima M.

Drug Metab Dispos., 51, 1569-1577 (2023)

Novel conditionally replicating adenovirus-mediated efficient detection of circulating tumor cells in lung cancer patients.

Ikemoto S., Sakurai F., Tokuoka S., Yamashita T., Takayama K., Hoshi K., Okabe T., Sumiyoshi I., Togo S., Takahashi K., Tachibana M., Mizuguchi H.

PLoS ONE, 18, e0286323 (2023)

Involvement of protein kinase R in double-stranded RNA-induced proteasomal degradation of hypoxia inducible factor-1a.

Hotani T., Nakagawa K., Tsukamoto T., Mizuguchi H., Sakurai F.

Inflammation, 46, 2332-2342 (2023)

miR-27b targets MAIP1 to mediate lipid accumulation in cultured human and mouse hepatic cells.

Sakai E., Imaizumi T., Suzuki R., Taracena-G?ndara M., Fujimoto T., Sakurai F., Mizuguchi H.

Communi. Biol., 6 (2023)

WebSite

Label-free evaluation of maturation and hepatotoxicity of human iPSC-derived hepatocytes using hyperspectral Raman imaging.

Li M., Ueyama-Toba Y., Lindley M., Kongklad G., Nawa Y., Kumamoto Y., Ishida S., Kanda Y., Fujita S., Mizuguchi H., Fujita, K.

Anal. Chem., 95, 9252-9262 (2023)

PubMed

Treatment of human pancreatic cancers following local and systemic administration of oncolytic adenovirus serotype 35.

Ono R., Takayama K., Onishi R., Tokuoka S., Sakurai F., Mizuguchi H.

Anticancer Res., 43, 537-546 (2023)

PubMed

Development of a method of passaging and freezing human iPS cell-derived hepatocytes to improve their functions.

Inui J., Ueyama-Toba Y., Mitani S., Mizuguchi H.

PLoS ONE, 18, e0285783 (2023)

WebSite

Regional transcriptomics and proteomics of pharmacokinetics-related genes in human intestine.

Murata M., Fujioka H., Yokota J., Okada K., Yamashita T., Hirayama D., Kawakami K., Morinaga G., Saito A., Nakase H., Kishimoto W., Mizuguchi H.

Mol. Pharm., 20, 2876-2890 (2023)

PubMed

Biliary epithelial cell differentiation of bipotent human liver-derived organoids by 2D and 3D culture.

Tong Y., Ueyama-Toba Y., Mizuguchi H.

Biochem. Biophys. Rep., 33, 101432 (2023)

PubMed

Pre-treatment of oncolytic reovirus improves tumor accumulation and intratumoral distribution of PEG-liposomes.

Eguchi M., Hirata S., Ishigami I., Shuwari N., Ono R., Tachibana M., Tanuma M., Kasai A., Hashimoto H., Ogawara KI., Mizuguchi H., Sakurai F.

J. Cont. Rel., 354, 35-44 (2023)

PubMed

Establishment of MDR1-knockout human enteroids for pharmaceutical application

Inui T., Nomoto R., Yokota J., Yamashita T., Okada K., Kishimoto W., Nakase H., Mizuguchi H.

Drug Metab Pharmacokinet., 48, 100476 (2023)

PubMed

目次に戻る

大阪大学大学院薬学研究科分子生物学分野

Laboratory of Biochemistry and Molecular Biology

Graduate School of Pharmaceutical Sciences, Osaka University

業績｜論文・出版物｜目次｜ALL