業績｜論文・出版物｜目次｜ALL

遺伝子治療研究の動向

水口裕之

医薬ジャーナル新薬展望2008, 44, 235-242 (2008)

WebSite

ウイルスベクター

水口裕之

ウイルスハンドブック, 日本医学館, 6-7 (2008)

WebSite

アデノウイルスベクター

水口裕之

機能性DDSキャリアの製剤設計, シーエムシー出版, 133-141 (2008)

WebSite

Fiber-modified adenovirus vectors decrease liver toxicity through reduced interleukin 6 production

Koizumi N., Yamaguchi T., Kawabata K., Sakurai F., Sasaki T., Watanabe Y., Hayakawa T., Mizuguchi H.

J. Immunol., 178, 1767-1773 (2007)

PubMed

Characterization of capsid-modified adenovirus vectors containing heterologous peptides in the fiber knob, protein IX, or hexon

Kurachi S., Koizumi N., Sakurai F., Kawabata K., Sakurai H., Nakagawa S., Hayakawa T., Mizuguchi H.

Gene Ther., 14, 266-274 (2007)

PubMed

Rapid construction of small interfering RNA-expressing adenovirus vectors on the basis of direct cloning of short hairpin RNA-coding DNAs

Mizuguchi H., Funakoshi N., Hosono T., Sakurai F., Kawabata K., Yamaguchi T., Hayakawa T.

Hum. Gene Ther., 18, 74-80 (2007)

PubMed

Comparison of gene expression efficiency and innate immune response induced by Ad vector and lipoplex

Sakurai H., Sakurai F., Kawabata K., Sasaki T., Koizumi N., Huang H., Tashiro K., Kurachi S., Nakagawa S., Mizuguchi H.

J. Control. Release, 117, 430-437 (2007)

PubMed

Role of tyrosine residues in modulation of claudin-4 by the C-terminal fragment of Clostridium perfringens enterotoxin

Harada M., Kondoh M., Ebihara C., Takahashi A., Komiya E., Fujii M., Mizuguchi H., Tsunoda S-I., Horiguchi Y., Yagi K., Watanabe Y.

Biochem. Pharmacol., 73, 206-214 (2007)

PubMed

Role of Tyr306 in the C-terminal fragment of Clostridium perfringens enterotoxin for modulation of tight junction

Ebihara C., Kondoh M., Harada M., Fujii M., Mizuguchi H., Tsunoda S-I., Horiguchi Y., Yagi K., Watanabe Y.

Biochem. Pharmacol., 73, 824-830 (2007)

PubMed

Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex

Hama S., Akita H., Iida S., Mizuguchi H., Harashima H.

Nuc. Acid Res., 35, 1533-1543 (2007)

PubMed

Induction of human adiponectin gene transcription by telmisartan, angiotensin receptor blocker, independently on PPAR-gamma activation

Moriuchi A., Yamasaki H., Shimamura M., Kita A., Kuwahara H., Fujishima K., Satoh T., Fukushima K., Fukushima T., Hayakawa T., Mizuguchi H., Nagayama Y., Abiru N., Kawasaki E., Eguchi K.

Biochem. Biophys. Res. Commun., 356, 1024-1030 (2007)

PubMed

Efficient gene transfer into murine pancreatic islets using adenovirus vectors

Mukai E., Fujimoto S., Sakurai F., Kawabata K., Yamashita M., Inagaki N., Mizuguchi H.

J. Control. Release, 119, 136-141 (2007)

PubMed

Downregulation of human CD46 by adenovirus serotype 35 vectors

Sakurai F., Akitomo K., Kawabata K., Hayakawa T., Mizuguchi H.

Gene Ther., 14, 912-919 (2007)

PubMed

Chimeric adenovirus 5/35 vector containing the clade C HIV gag gene induces a cross-reactive immune response against HIV

Xin K-Q., Sekimoto Y., Takahashi T., Mizuguchi H., Ichino M., Yoshida A., Okuda K.

Vaccine, 25, 3809-3815 (2007)

PubMed

Cotransduction of CCL27 gene can improve the efficacy and safety of IL-12 gene therapy for cancer

Gao J-Q., Kanagawa N., Motomura Y., Yanagawa T., Sugita T., Hatanaka Y., Tani Y., Mizuguchi H., Tsutsumi Y., Mayumi T., Okada N., Nakagawa S.

Gene Ther., 14, 491-502 (2007)

PubMed

Expression of coxsackie and adenovirus receptor reduces the lung metastatic potential of murine tumor cells

Yamashita M., Ino A., Kawabata K., Sakurai F., Mizuguchi H.

Int. J. Cancer, 121, 1690-1696 (2007)

PubMed

Fiber-modified adenovirus vectors containing the TAT peptide derived from human immunodeficiency virus in the fiber knob have efficient gene transfer activity

Kurachi S., Tashiro K., Sakurai F., Sakurai H., Kawabata K., Yayama K., Okamoto H., Nakagawa S., Hayakawa T., Mizuguchi H.

Gene Ther., 14, 1160-1165 (2007)

PubMed

Positive and negative regulation of adenovirus infection by CAR-like soluble protein, CLSP

Kawabata K., Tashiro K., Sakurai F., Osada N., Kusuda J., Hayakawa T., Yamanishi K., Mizuguchi H.

Gene Ther., 14, 1199-1207 (2007)

PubMed

Role of MyD88 and TLR9 in the innate immune response elicited by serotype 5 adenoviral vectors

Yamaguchi T.#, Kawabata K.#, Koizumi N., Sakurai F., Nakashima K., Sasaki T., Okada N, Mizuguchi H. #These authors equally contributed to this work.

Hum. Gene Ther., 18, 753-762 (2007)

PubMed

Targeted-delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells

Xin H., Kanehira M., Mizuguchi H., Hayakawa T., Kikuchi T., Nukiwa T., Saijo Y.

Stem Cells, 25, 1618-1626 (2007)

PubMed

目次に戻る

大阪大学大学院薬学研究科分子生物学分野

Laboratory of Biochemistry and Molecular Biology

Graduate School of Pharmaceutical Sciences, Osaka University

業績｜論文・出版物｜目次｜ALL