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大阪大学大学院薬学研究科分子生物学分野

Laboratory of Biochemistry and Molecular Biology

Graduate School of Pharmaceutical Sciences, Osaka University

業績｜論文・出版物｜目次｜ALL

Evaluation of promoter strength in mouse and rat primary hepatocytes using adenovirus vectors

Arita E., Kondoh M., Isoda K., Nishimori H., Yoshida T., Mizuguchi H., Yagi K.

Eur. J. Pharm. Biopharm., 70, 1-6 (2008)

Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis

Takahashi A., Komiya E., Kakutani H., Yoshida T., Fujii M., Horiguchi Y., Mizuguchi H., Tsutsumi Y., Tsunoda S-I., Koizumi N., Isoda K., Yagi K., Watanabe Y., Kondoh M.

Biochem. Pharmacol., 75, 1639-1648 (2008)

Factors involved in the maturation of murine dendritic cells transduced with adenoviral vector variants

Kanagawa N., Koretomo R., Murakami S., Sakurai F., Mizuguchi H., Nakagawa S., Fujita T., Yamamoto A., Okada N.

Virology, 374, 411-420 (2008)

Tat conjugation of adenovirus vector broadens tropism and enhances transduction efficiency

Yoshioka Y., Asavatanabodee R., Eto Y., Watanabe H., Morishige T., Yao X., Kida S., Maeda M., Mukai Y., Mizuguchi H., Kawasaki K., Okada N., Nakagawa S.

Life Science, 83, 747-755 (2008)

Downregulation of CD46 during muscle differentiation: implications for gene transfer to human skeletal muscle using group B adenoviruses

Larochelle N., Deol J., Srivastava V., Allen C., Mizuguchi H., Karpati G., Holland P., Nalbantoglu J.

Hum. Gene Ther., 19, 133-142 (2008)

Development and evaluation of a novel gene delivery vehicle composed of adenovirus serotype 35

Sakurai F.

Biol. Pharm. Bull., 31, 1819-1825 (2008)

Development of a replication-incompetent adenovirus vector derived from subgroup B adenovirus serotype 35

Sakurai F.

Yakugaku Zasshi, 128, 1751-1761 (2008)

標的指向性を有するバイオコンジュゲート化アデノウイルスベクターの開発

衛藤佑介, 吉岡靖雄, Asavatanabodee R, 水口裕之, 向洋平, 岡田直貴, 中川晋作

薬学雑誌, 日本薬学会, 128, 1733-1742 (2008)

遺伝子治療研究の動向

水口裕之

医薬ジャーナル新薬展望2008, 44, 235-242 (2008)

ウイルスベクター

水口裕之

ウイルスハンドブック, 日本医学館, 6-7 (2008)

アデノウイルスベクター

水口裕之

機能性DDSキャリアの製剤設計, シーエムシー出版, 133-141 (2008)

Fiber-modified adenovirus vectors decrease liver toxicity through reduced interleukin 6 production

Koizumi N., Yamaguchi T., Kawabata K., Sakurai F., Sasaki T., Watanabe Y., Hayakawa T., Mizuguchi H.

J. Immunol., 178, 1767-1773 (2007)

Characterization of capsid-modified adenovirus vectors containing heterologous peptides in the fiber knob, protein IX, or hexon

Kurachi S., Koizumi N., Sakurai F., Kawabata K., Sakurai H., Nakagawa S., Hayakawa T., Mizuguchi H.

Gene Ther., 14, 266-274 (2007)

Rapid construction of small interfering RNA-expressing adenovirus vectors on the basis of direct cloning of short hairpin RNA-coding DNAs

Mizuguchi H., Funakoshi N., Hosono T., Sakurai F., Kawabata K., Yamaguchi T., Hayakawa T.

Hum. Gene Ther., 18, 74-80 (2007)

Comparison of gene expression efficiency and innate immune response induced by Ad vector and lipoplex

Sakurai H., Sakurai F., Kawabata K., Sasaki T., Koizumi N., Huang H., Tashiro K., Kurachi S., Nakagawa S., Mizuguchi H.

J. Control. Release, 117, 430-437 (2007)

Role of tyrosine residues in modulation of claudin-4 by the C-terminal fragment of Clostridium perfringens enterotoxin

Harada M., Kondoh M., Ebihara C., Takahashi A., Komiya E., Fujii M., Mizuguchi H., Tsunoda S-I., Horiguchi Y., Yagi K., Watanabe Y.

Biochem. Pharmacol., 73, 206-214 (2007)

Role of Tyr306 in the C-terminal fragment of Clostridium perfringens enterotoxin for modulation of tight junction

Ebihara C., Kondoh M., Harada M., Fujii M., Mizuguchi H., Tsunoda S-I., Horiguchi Y., Yagi K., Watanabe Y.

Biochem. Pharmacol., 73, 824-830 (2007)

Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex

Hama S., Akita H., Iida S., Mizuguchi H., Harashima H.

Nuc. Acid Res., 35, 1533-1543 (2007)

Induction of human adiponectin gene transcription by telmisartan, angiotensin receptor blocker, independently on PPAR-gamma activation

Moriuchi A., Yamasaki H., Shimamura M., Kita A., Kuwahara H., Fujishima K., Satoh T., Fukushima K., Fukushima T., Hayakawa T., Mizuguchi H., Nagayama Y., Abiru N., Kawasaki E., Eguchi K.

Biochem. Biophys. Res. Commun., 356, 1024-1030 (2007)

Efficient gene transfer into murine pancreatic islets using adenovirus vectors

Mukai E., Fujimoto S., Sakurai F., Kawabata K., Yamashita M., Inagaki N., Mizuguchi H.

J. Control. Release, 119, 136-141 (2007)

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