業績｜論文・出版物｜目次｜ALL

ゲノム解析と遺伝子DDSの設計・評価

水口裕之

Pharm Tech Japan, 25(13) (2009)

WebSite

組換えウイルスキャリア－遺伝子治療・ワクチン応用への新展開－

水口裕之

Drug Delivery System, 日本DDS学会, 24, 569 (2009)

CiNii

遺伝子組換えウイルスの安全性向上に向けた遺伝子改変～microRNAによる遺伝子発現制御システムを搭載した組換えウイルスの開発～

櫻井文教, 川端健二, 水口裕之

Drug Delivery System, 日本DDS学会, 24, 572-581 (2009)

J-STAGE

miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy

Suzuki T., Sakurai F., Nakamura S-I., Kouyama E., Kawabata K., kondoh M., Yagi K., Mizuguchi H.

Mol. Ther., 16, 1719-1726 (2008)

PubMed

Adenoviral expression of suppressor of cytokine signaling-1 reduces adenovirus vector-induced innate immune response

Sakurai H., Tashiro K., Kawabata K., Yamaguchi T., Sakurai F., Nakagawa S., Mizuguchi H.

J. Immunol., 180, 4931-4938 (2008)

PubMed

Transduction properties of adenovirus serotype 35 vectors after intravenous administration into nonhuman primates

Sakurai F., Nakamura S-I., Akitomo K., Shibata H., Terao K., Kawabata K., Hayakawa T., Mizuguchi H.

Mol. Ther., 16, 726-733 (2008)

PubMed

Efficient adenovirus vector-mediated PPAR gamma gene transfer into mouse embryoid bodies promotes adipocyte differentiation, J

Tashiro K., Kawabata K., Sakurai H., Kurachi S., Sakurai F., Yamanishi K., Mizuguchi H.

Gene Med., 10, 498-507 (2008)

PubMed

Efficient gene delivery in human and rodent mast cells using adenovirus vectors

Nakashima K., Sakurai F., Kawabata K., Mizuguchi H.

J. Control. Release, 129, 215-222 (2008)

PubMed

Innate immune response induced by gene delivery vectors

Sakurai H., Kawabata K., Sakurai F., Nakagawa S., Mizuguchi H.

Int. J. Pharm., 354, 9-15 (2008)

PubMed

Modification of pIX or hexon based on fiberless Ad vectors is not effective for targeted Ad vectors

Kurachi S., Koizumi N., Tashiro K., Sakurai H., Sakurai F., Kawabata K., Nakagawa S., Mizuguchi H.

J. Control. Release, 127, 88-95 (2008)

PubMed

Engineering of highly immunogenic long-lived DC vaccines by antiapoptotic protein gene transfer to enhance cancer vaccine potency

Yoshikawa T., Niwa T., Okada N., Mizuguchi H., Nakagawa S.

Gene Ther., 15, 1321-1329 (2008)

PubMed

Combination of two fiber-mutant adenovirus vectors, one encoding the chemokine FKN and another encoding cytokine interleukin 12, elicits notably enhanced anti-tumor responses

Gao J-Q., Kanagawa N., Xu D-H., Han M., Sugita T., Hatanaka Y., Tani Y., Mizuguchi H., Tsutsumi Y., Mayumi T., Okada N., Nakagawa S.

Cancer Immunol. Immunother., 57, 1657-64 (2008)

PubMed

Evaluation of promoter strength in mouse and rat primary hepatocytes using adenovirus vectors

Arita E., Kondoh M., Isoda K., Nishimori H., Yoshida T., Mizuguchi H., Yagi K.

Eur. J. Pharm. Biopharm., 70, 1-6 (2008)

PubMed

Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis

Takahashi A., Komiya E., Kakutani H., Yoshida T., Fujii M., Horiguchi Y., Mizuguchi H., Tsutsumi Y., Tsunoda S-I., Koizumi N., Isoda K., Yagi K., Watanabe Y., Kondoh M.

Biochem. Pharmacol., 75, 1639-1648 (2008)

PubMed

Factors involved in the maturation of murine dendritic cells transduced with adenoviral vector variants

Kanagawa N., Koretomo R., Murakami S., Sakurai F., Mizuguchi H., Nakagawa S., Fujita T., Yamamoto A., Okada N.

Virology, 374, 411-420 (2008)

PubMed

Tat conjugation of adenovirus vector broadens tropism and enhances transduction efficiency

Yoshioka Y., Asavatanabodee R., Eto Y., Watanabe H., Morishige T., Yao X., Kida S., Maeda M., Mukai Y., Mizuguchi H., Kawasaki K., Okada N., Nakagawa S.

Life Science, 83, 747-755 (2008)

PubMed

Downregulation of CD46 during muscle differentiation: implications for gene transfer to human skeletal muscle using group B adenoviruses

Larochelle N., Deol J., Srivastava V., Allen C., Mizuguchi H., Karpati G., Holland P., Nalbantoglu J.

Hum. Gene Ther., 19, 133-142 (2008)

PubMed

Development and evaluation of a novel gene delivery vehicle composed of adenovirus serotype 35

Sakurai F.

Biol. Pharm. Bull., 31, 1819-1825 (2008)

PubMed

Development of a replication-incompetent adenovirus vector derived from subgroup B adenovirus serotype 35

Sakurai F.