業績｜論文・出版物｜目次｜ALL

ウイルスベクターと遺伝子治療

水口裕之, 櫻井文教

化学療法の領域, 医薬ジャーナル社, 27, 867-873 (2011)

WebSite

ヒトES/iPS細胞から肝細胞への高効率分化誘導と毒性評価系への応用

稲村充, 高山和雄, 川端健二, 水口裕之

生産と技術, 63, 67-69 (2011)

WebSite

iPS細胞分化誘導によるHCV培養モデル

水口裕之, 近藤昌夫, 八木清仁

肝胆膵, 63, 919-924 (2011)

WebSite

スーパー特区研究『ヒトiPS細胞を用いた新規in vitro 毒性評価系の構築』の概要

水口裕之

動物実験代替法学会News Letter, 40, 21-22 (2011)

Induction of type I interferon by adenovirus-encoded small RNAs

Yamaguchi T., Kawabata K., Kouyama E., Ishii K.J., Katayama K., Suzuki T., Kurachi S., Sakurai F., Akira S., Mizuguchi H.

Proc. Natl. Acad. Sci. USA, 107, 17286-17291 (2010)

PubMed

Adenovirus serotype 35 vector-induced innate immune responses in dendritic cells derived from wild-type and human CD46-transgenic mice: Comparison with a fiber-substituted Ad vector containing fiber proteins of Ad serotype 35

Sakurai, F., Nakashima, K., Yamaguchi, T., Ichinose, T., Kawabata, K., Hayakawa, T., and Mizuguchi, H.

J. Control. Release, 148, 212-218 (2010)

PubMed

Adenovirus vector-mediated efficient transduction into human embryonic and induced pluripotent stem cells

Tashiro K., Kawabata K., Inamura M., Takayama K., Furukawa N., Sakurai F., Katayama K., Hayakawa H., Furue-Kusuda M., Mizuguchi H.

Cell. Reprogram., 12, 501-507 (2010)

PubMed

Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer

Eto Y., Yoshioka Y., Ishida T., Yao X., Morishige T., Narimatsu S., Mizuguchi H., Mukai Y., Okada N., Kiwada H., Nakagawa S.

Biol. Pharm. Bull., 33, 1540-1544 (2010)

PubMed

Prevention of hepatic ischemia-reperfusion injury by pre-administration of catalase-expressing adenovirus vectors

Ushitora M., Sakurai F., Yamaguchi T., Nakamura S-I., Kondoh M., Yagi K., Kawabata K., Mizuguchi H.

J. Control. Release, 142, 431-437 (2010)

PubMed

A novel translational approach for human malignant pleural mesothelioma: heparanase-assisted dual virotherapy

Watanabe Y., Kojima T., Kagawa S., Uno F., Hashimoto Y., Kyo S., Mizuguchi H., Tanaka N., Kawamura H., Ichimaru D., Urata Y., Fujiwara T.

Oncogene, 29, 1145-1154 (2010)

PubMed

A fiber modified adenovirus vector that targets to the EphrinA2 receptor reveals enhanced gene transfer to ex vivo pancreatic cancer

Van Geer M.A., Brevoord D., Kuhlmann K.F., Bakker C.T., Mizuguchi H., Wesseling J.G., Ten Kate F.J., Gouma D.J., Oude Elferink R.P., Bosma P.J.

Int. J. Oncol., 36, 233-44 (2010)

PubMed

Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models

Morishige T., Yoshioka Y., Tanabe A., Yao X., Mizuguchi H., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S.

Int. Immunopharmacol., 10, 26-33 (2010)

PubMed

In vivo biological purging for lymph node metastasis of human colorectal cancer by telomerase-specific oncolytic virotherapy

Kojima T., Watanabe Y., Hashimoto Y., Kuroda S., Yamasaki Y., Yano S., Ouchi M., Tazawa H., Uno F., Kagawa S., Kyo S., Mizuguchi H., Urata Y., Tanaka N., Fujiwara T.

Ann. Surg., 251, 1079-1086 (2010)

PubMed

Particle tracking of intracellular trafficking of octaarginine-modified liposomes: a comparative study with adenovirus

Akita H., Enoto K., Masuda T., Mizuguchi H., Tani T., Harashima H.

Mol. Ther., 18, 955-964 (2010)

PubMed

Co-administration of viral vector-based vaccines suppresses antigen-specific effector CD8 T cells

Yashima S., Yoshizaki S., Shinoda K., Yoshida A., Kondo A., Mizuguchi H., Ryo A., Okuda K., Shimada M.

Vaccine, 28, 3257-3264 (2010)

PubMed

Claudin-4-targeting of diphtheria toxin fragment A using a C-terminal fragment of Clostridium perfringens enterotoxin

Kakutani H., Kondoh M., Saeki R., Fujii M., Watanabe Y., Mizuguchi H., Yagi K.

Eur. J. Pharm. Biopharm., 75, 213-217 (2010)

PubMed

Adenovirus vector covalently conjugated to polyethylene glycol with a cancer-specific promoter suppresses the tumor growth through systemic administration

Yao X., Yoshioka Y., Morishige T., Eto Y., Narimatsu S., Mizuguchi H., Mukai Y., Okada N., Nakagawa S.

Biol. Pharm. Bull., 35, 1073-1076 (2010)

PubMed

マイクロRNAによる遺伝子発現制御システムを搭載した遺伝子組換えアデノウイルスの開発

櫻井文教, 水口裕之

薬学雑誌, 日本薬学会, 130, 1497-1504 (2010)

J-STAGE

iPS細胞への遺伝子導入を用いた分化誘導の最適化

川端健二, 田代克久, 水口裕之

薬学雑誌, 日本薬学会, 130, 1527-1534 (2010)

J-STAGE

次世代アデノウイルスベクターの開発と生命科学研究への応用