業績｜論文・出版物｜目次｜ALL

Efficient generation of hepatoblastsfrom human ES cells and iPS cells by transient overexpression of homeobox gene HEX

Inamura M., Kawabata K., Takayama K., Tashiro K., Sakurai F., Katayama K., Toyoda M., Akutsu H., Miyagawa Y.,Okita H., Kiyokawa N., Umezawa A., Hayakawa T., Furue MK., Mizuguchi H.

Mol. Ther., 19, 400-407 (2011)

PubMed

Efficient and directive generation of two distinct endoderm lineages from human ES and iPS cells by differentiation stage-specific SOX17 transduction

Takayama K., Inamura M., Kawabata K., Tashiro K., Katayama K., Hayakawa T., Furue MK., Mizuguchi H.

PLoS One, 6, e21780 (2011)

PubMed

Enhanced safety profiles of the telomerase-specific replication-competent adenovirus by incorporation of normal cell-specific microRNA-targeted sequences

Sugio K., Sakurai F., Katayama K., Matsui H., Kawabata K., Kawase A., Iwaki M., Hayakawa T., Fujiwara T., Mizuguchi H.

Clin. Cancer Res., 17, 2807-2818 (2011)

PubMed

Hexon-specific PEGylated adenovirus vectors utilizing avidin-biotin interaction

Suzuki-Kouyama E., Katayama K., Sakurai F., Yamaguchi T., Kurachi S., Kawabata K., Nakagawa S., Mizuguchi H.

Biomaterials, 32, 1724-1730 (2011)

PubMed

Enhanced transduction efficiency of fiber-substituted adenovirus vectors by the incorporation of RGD peptides in two distinct regions of the adenovirus serotype 35 fiber knob

Matsui H., Sakurai F., Katayama K., Kurachi S., Tashiro K., Sugio K., Kawabata K., Mizuguchi H.

Virus Res., 155, 48-54 (2011)

PubMed

Development of a recombinant adenovirus vector production system free of replication-competent adenovirus by utilizing a packaging size limit of the viral genome

Suzuki T., Sasaki T., Yano K., Sakurai F., Kawabata K., Kondoh M., Hayakawa T., Yagi K., Mizuguchi H.

Virus Res., 158, 154-160 (2011)

PubMed

Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection

Yoshida T.#, Takayama K.#, Kondoh M.*, Sakurai F., Tani H., Sakamoto N., Matsuura Y., Mizuguchi H*., Yagi K*. #These authors equally contributed to this work. *Co-corresponding author.

Biochem. Biophys. Res. Commun., 416, 119-124 (2011)

PubMed

An effective gene-knockdown using multiple shRNA-expressing adenovirus vectors

Motegi Y., Katayama K., Sakurai F., Kato T., Yamaguchi T., Matsui H., Takahashi M., Kawabata K., Mizuguchi H.

J. Control. Release, 153, 149-153 (2011)

PubMed

Quantitative analysis of the leaky expression of adenovirus genes in cells transduced with a replication-incompetent adenovirus vector

Shimizu K., Sakurai F., Machitani M., Katayama K., Mizuguchi H.

Mol. Pharmaceutics, 8, 1430-1435 (2011)

PubMed

Development of an adenovirus vector lacking the expression of virus-associated RNAs

Machitani M., Katayama K., Sakurai F., Matsui H., Yamaguchi T., Suzuki T., Miyoshi H., Kawabata K., Mizuguchi H.

J. Control. Release, 154, 285-289 (2011)

PubMed

Enhanced in vivo gene transfer into the placenta using RGD fiber-mutant adenovirus vector

Katayama K., Furuki R., Yokoyama H., Kaneko M., Tachibana M., Yoshida I., Nagase H., Tanaka K., Sakurai F., Mizuguchi H., Nakagawa S., Nakanishi T.

Biomaterials, 32, 4185-4193 (2011)

PubMed

Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma

Iwahori K., Serada S., Fujimoto M., Nomura S., Osaki T., Lee C.M., Mizuguchi H., Takahashi T., Ripley B., Okumura M., Kawase I., Kishimoto T., Naka T.

Int. J. Cancer, 129, 993-1005 (2011)

PubMed

Adenovirus vector-mediated assay system for Hepatitis C virus replication

Yoshida T., Kondoh M., Ojima M., Mizuguchi H., Yamagishi Y., Sakamoto N., Yagi K.

Nuc. Acid Res., 39, e64 (2011)

PubMed

Optimization of a microRNA expression vector for function analysis of microRNA

Furukawa N., Sakurai F., Katayama K., Seki N., Kawabata K., Mizuguchi H.

J. Control. Release, 150, 94-101 (2011)

PubMed

EpCAM- and EGFR- targeted selective gene therapy for biliary cancers using Z33-fiber modified adenovirus

Kawashima R., Abei M., Fukuda K., Nakamura K., Murata T., Wakayama M., Seo E., Hasegawa N., Mizuguchi H., Obata Y., Hyodo I., Hamada H., Yokoyama K.K.

Int. J. Cancer, 129, 1244-53 (2011)

PubMed

Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors

Iwata-Kajihara T., Sumimoto H., Kawamura N., Ueda R., Takahashi T., Mizuguchi H., Miyagishi M., Takeda K., Kawakami Y.

J. Immunol., 187, 27-36 (2011)

PubMed

Tumor vascular targeted delivery of polymer-conjugated adenovirus vector for cancer gene therapy

Yao X., Yoshioka Y., Morishige T., Eto Y., Narimatsu S., Kawai Y., Mizuguchi H., Gao J.Q., Mukai Y., Okada N., Nakagawa S.

Mol. Ther., 19, 1619-1625 (2011)

PubMed

Adenovirus vector-derived VA-RNA-mediated innate immune responses

Machitani M., Yamaguchi T., Shimizu K., Sakurai F., Katayama K., Kawabata K., Mizuguchi H.

Pharmaceutics, 3, 38-353 (2011)

PubMed

MicroRNA-regulated transgene expression system for gene therapy and virotherapy