業績｜論文・出版物｜目次｜ALL

ヒトiPS 細胞由来分化誘導肝細胞を用いた薬物毒性評価系の開発

川端健二, 高山和雄, 水口裕之

BIO INDUSTRY, シーエムシー出版, 30, 19-24 (2013)

WebSite

遺伝子治療におけるDDS　ウイルスベクター

水口裕之

応用が拡がるDDS　人体環境から農業・家電まで, NTS (日本ハイコム (株)), 180-187 (2013)

WebSite

ヒトiPS細胞由来肝細胞を用いた毒性評価

水口裕之, 高山和雄, 川端健二

In vitro毒性・動態評価の最前線, シーエムシー出版, 63-70 (2013)

WebSite

Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction

Takayama K., Inamura M., Kawabata K., Sugawara M., Kikuchi K., Higuchi M., Nagamoto Y., Watanabe H., Tashiro K., Sakurai F., Hayakawa T., Furue MK., Mizuguchi H.

J. Hepatol., 57, 628-636 (2012)

PubMed

Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction

Takayama K., Inamura M., Kawabata K., Katayama K., Higuchi M., Tashiro K., Nonaka A., Sakurai F., Hayakawa T., Furue MK., Mizuguchi H.

Mol. Ther., 20, 127-137 (2012)

PubMed

Intramuscular DNA immunization with in vivo electroporation induces antigen-specific cellular and humoral immune responses in both systemic and gut-mucosal compartments

Shoji M., Katayama K., Tachibana M., Tomita K., Sakurai F., Kawabata K., Mizuguchi H.

Vaccine, 30, 7278-7285 (2012)

PubMed

Type-I IFN signaling is required for the induction of antigen-specific CD8＋ T cell responses by adenovirus vector vaccine in the gut-mucosa

Shoji M., Tachibana M., Katayama K., Tomita K., Tsuzuki S., Sakurai F., Ishii K.J., Akira S., Mizuguchi H.

Biochem. Biophys. Res. Commun., 425, 89-93 (2012)

PubMed

Promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets

Nagamoto Y., Tashiro K., Takayama K., Ohashi K., Kawabata K., Sakurai F., Tachibana M., Hayakawa T., Furue MK., Mizuguchi H.

Biomaterials, 33, 4526-4534 (2012)

PubMed

A hexon-specific PEGylated adenovirus vector utilizing blood coagulation factor X

Matsui H., Sakurai F., Katayama K., Yamaguchi T., Okamoto S., Takahira K., Tachibana M., Nakagawa S., Mizuguchi H.

Biomaterials, 33, 3743-3755 (2012)

PubMed

Inhibition of Lnk in mouse induced pluripotent stem cells promotes hematopoietic cell generation

Tashiro K., Omori M., Kawabata K., Hirata N., Yamaguchi T., Sakurai F., Takaki S., Mizuguchi H.

Stem Cell Dev., 21, 3381-3390 (2012)

PubMed

Improved Gene Transfer into Bladder Cancer Cells Using Adenovirus Vector Containing RGD Motif

Hiwasa K., Nagaya H., Terao S., Acharya B., Hamada K., Mizuguchi H., Gotoh A.

Anticancer Res., 32, 3137-3140 (2012)

PubMed

Promotion of hematopoietic differentiation from mouse induced pluripotent stem cells by transient HoxB4 transduction

Tashiro K., Kawabata K., Omori M., Yamaguchi T., Sakurai F., Katayama K., Hayakawa H., Mizuguchi H.

Stem Cell Res., 8, 300-311 (2012)

PubMed

Correlation between adenovirus-neutralizing antibody titer and adenovirus vector-mediated transduction efficiency following intratumoral injection

Tomita K., Sakurai F., Tachibana M., Mizuguchi H.

Anticancer Res., 32, 1145-1152 (2012)

PubMed

Immunogenic Comparison of Chimeric Adenovirus 5/35 Vector Carrying Optimized Human Immunodeficiency Virus Clade C Genes and Various Promoters

Shoji M., Yoshizaki S., Mizuguchi H., Okuda K., Shimada M.

PLoS One, 7, e30302 (2012)

PubMed

Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-122a

Sakurai F., Furukawa N., Higuchi M., Okamoto S., Ono K., Yoshida T., Kondoh M., Yagi K., Sakamoto N., Katayama K., Mizuguchi H.

Virus Res., 165, 214-218 (2012)

PubMed

Optimization and internalization mechanisms of PEGylated adenovirus vector with targeting peptide for cancer gene therapy

Yao X.L., Yoshioka Y., Ruan G.X., Chen Y.Z., Mizuguchi H., Mukai Y., Okada N., Gao J.Q., Nakagawa S.

Biomacromolecules, 13, 2402-2409 (2012)

PubMed

Efficient antitumor effects of carrier cells loaded with a fiber-substituted conditionally replicating adenovirus on CAR-negative tumor cells

Iguchi K., Sakurai F., Tomita K., Katayama K., Yamaguchi T., Tagawa M., Kawabata M., Shirakawa T., Mizuguchi H.

Cancer Gene Ther., 19, 118-125 (2012)

PubMed

A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression

Yamasaki Y., Tazawa H., Hashimoto Y., Kojima T., Kuroda S., Yano S., Yoshida R., Uno F., Mizuguchi H., Ohtsuru A., Urata Y., Kagawa S., Fujiwara T.

Eur. J. Cancer, 48, 2282-2291 (2012)

PubMed

Efficient hepatic differentiation from human iPS cells by gene transfer

Kawabata K., Inamura M., Mizuguchi H.

Methods Mol. Biol., 826, 115-124 (2012)

PubMed

Further reduction in adenovirus vector-mediated liver transduction without largely affecting transgene expression in target organ by exploiting microRNA-mediated regulation and the Cre-loxP recombination system

Bennett D., Sakurai F., Shimizu K., Matsui H., Tomita K., Suzuki T., Katayama K., Kawabata K., Mizuguchi H.

Mol. Pharm., 9, 3452-63 (2012)

PubMed

目次に戻る

大阪大学大学院薬学研究科分子生物学分野

Laboratory of Biochemistry and Molecular Biology

Graduate School of Pharmaceutical Sciences, Osaka University

業績｜論文・出版物｜目次｜ALL