業績|論文・出版物|目次
 

2021

Generation of hepatocytes from human ES/iPS cells for regenerative medicine

Yamashita T., Takayama K., Mizuguchi H.

Springer Book: Cell-Inspired Materials and Engineering, Springer, 3-26 (2021)

Comparison of culture media for human intestinal organoids from the viewpoint of pharmacokinetic studies.

Yokota J., Yamashita T., Inui T., Nomoto R., Kishimoto W., Nakase H., Mizuguchi H.

Biochem. Biophys. Res. Commun., 566, 115-122 (2021)

A selective cytotoxic adenovirus vector for concentration of pluripotent stem cells in human pluripotent stem cell-derived neural progenitor cells.

Hirai T., Kono K., Sawada R., Kuroda T., Yasuda S., Matsuyama S., Matsuyama A., Koizumi N., Utoguchi N., Mizuguchi H., Sato Y.

Sci. Rep., 11, 11407 (2021)

Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system.

Ichikawa M., Akamine H., Murata M., Ito S., Takayama K., Mizuguchi H.

Sci. Rep., 11, 11670 (2021)

Adenovirus Vector-Induced IL-6 Promotes Leaky Adenoviral Gene Expression, Leading to Acute Hepatotoxicity

Shimizu K., Sakurai F., Iizuka S., Ono R., Tsukamoto T., Nishimae F., Nakamura SI., Nishinaka T., Terada T., Fujio Y., Mizuguchi H.

J. Immunol., 206, 410-421 (2021)

A TGF-b signaling inhibitor, SB431542, inhibits reovirus-mediated lysis of human hepatocellular carcinoma cells in a TGF-b-independent manner.

Ishigami I., Shuwari N., Kaminade T., Mizuguchi H., Sakurai F.

Anticancer Res., 4, 2431-2440 (2021)

Vinblastine treatment decreases the undifferentiated cell contamination of human iPSC-derived intestinal epithelial-like cells

Ichikawa M.#, Negoro R.#, Kawai K., Yamashita T., Takayama K., Mizuguchi H. #These authors equally contributed to this work.

Mol. Ther. Methods Clin. Dev., 20, 463-472 (2021)

The infectivity of progeny adenovirus in the presence of neutralizing antibody.

Hirai T., Sato A., Koizumi N., Kurioka Y., Suzuki Y., Kano J., Yamakawa M., Nomura T., Fujii M., Sakurai F., Mizuguchi H., Watanabe Y., Utoguchi N.

J. Gen. Virol., 102, 001590 (2021)

Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 35

Ono R., Takayama K., Sakurai F., Mizuguchi H.

Mol. Ther. Oncolytics, 20, 399-409 (2021)

In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology.

Deguchi S., Shintani T., Harada K., Okamoto T., Takemura A., Hirata K., Ito K., Takayama K., Mizuguchi H.

Hepatol.?Commun., 5, 1385-1399 (2021)

Asymmetric profiles of infection and innate immunological responses in human iPS cell-derived small intestinal epithelial-like cell monolayers following infection with mammalian reovirus

Inoue C., Negoro R., Takayama K., Mizuguchi H., Sakurai F.

Virus Res., 296, 198334 (2021)

Optimization of an E1A gene expression cassette in an oncolytic adenovirus for efficient tumor cell killing activity

Sakurai F., Nishimae F., Takayama K., Mizuguchi H.

Anticancer Res., 41, 773-782 (2021)

Fiber-knob region of adenovirus type 5 vector promotes migration of A549 cells

Kano J., Koizumi N., Terada A., Matsuoka A., Hirai T., Nomura T., Mizuguchi H., Utoguchi N.

BPB Reports, 4, 17-21 (2021)

In vivo gene expression profile of human intestinal epithelial cells: from the viewpoint of drug metabolism and pharmacokinetics

Takayama K., Ito K., Matsui A., Yamashita T., Kawakami K., Hirayama D., Kishimoto W., Nakase H., Mizuguchi H.

Drug Metab. Dispos., 49, 221-232 (2021)

ゲノム編集モデルの医薬品評価への応用とその課題

鳥羽由希子, 水口裕之

ゲノム編集技術の産業応用技術〜研究動向、課題とその解決、トラブル対策〜 , 株式会社 技術情報協会, 339-345 (2021)