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業績｜論文・出版物｜目次｜
 

2021

Generation of hepatocytes from human ES/iPS cells for regenerative medicine

Yamashita T., Takayama K., Mizuguchi H.

Springer Book: Cell-Inspired Materials and Engineering, Springer, 3-26 (2021)

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Development of a 3D Cell Culture System Using Amphiphilic Polydepsipeptides and Its Application to Hepatic Differentiation.

Enomoto J., Toba Y., Yamazaki H., Kanai M., Mizuguchi H., Matsui H.

ACS Applied Bio Materials., 4, 7290-7299 (2021)

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Oncolytic reovirus-mediated killing of mouse cancer-associated fibroblasts.

Kurisu N., Kaminade T., Eguchi M., Ishigami I., Mizuguchi H., Sakurai F.

Int. J. Pharmaceut, 610, 121269 (2021)

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Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research

Yamashita T., Inui T., Yokota J., Kawakami K., Morinaga G., Takatani M., Hirayama D., Nomoto R., Ito K., Cui Y., Ruez S., Harada K., Kishimoto W., Nakase H., Mizuguchi H.

Mol. Ther. Methods Clin. Dev., 22, 263-278 (2021)

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miR-27b antagonizes BMP signaling in early differentiation of human induced pluripotent stem cells.

Lim J., Sakai E., Sakurai F., Mizuguchi H.

Sci. Rep., 11, 19820 (2021)

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Transduction properties of an adenovirus vector containing sequences complementary to a liver-specific microRNA, miR-122a, in the 3'-untranslated region of the E4 gene in human hepatocytes from chimeric mice with humanized liver.

Sakurai F., Tsukamoto T., Ono R., Nishimae F., Shiota A., Iizuka S., Shimizu K., Sakai E., Ishida Y., Tateno C., Chayama K., Mizuguchi H.

Biol. Pharm. Bull., 44, 1506-1513 (2021)

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Generation of Tetrafluoroethylene-Propylene Elastomer-Based Microfluidic Devices for Drug Toxicity and Metabolism Studies.

Sano E., Deguchi S., Matsuoka N., Tsuda M., Wang M., Kosugi K., Mori C., Yagi K., Wada A., Yamasaki S., Kawai T., Yodogawa M, Mizuguchi H., Nakazawa N., Yamashita F., Torisawa Y.S., Takayama K.

ACS omega, 6, 24859-24865 (2021)

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Usability of Polydimethylsiloxane-Based Microfluidic Devices in Pharmaceutical Research Using Human Hepatocytes.

Deguchi S., Tsuda M., Kosugi K., Sakamoto A., Mimura N., Negoro R., Sano E., Nobe T., Maeda K., Kusuhara H., Mizuguchi H., Yamashita F., Torisawa Y.S., Takayama K.

ACS Biomater. Sci. Eng., 7, 3648-3657 (2021)

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Comparison of culture media for human intestinal organoids from the viewpoint of pharmacokinetic studies.

Yokota J., Yamashita T., Inui T., Nomoto R., Kishimoto W., Nakase H., Mizuguchi H.

Biochem. Biophys. Res. Commun., 566, 115-122 (2021)

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A selective cytotoxic adenovirus vector for concentration of pluripotent stem cells in human pluripotent stem cell-derived neural progenitor cells.

Hirai T., Kono K., Sawada R., Kuroda T., Yasuda S., Matsuyama S., Matsuyama A., Koizumi N., Utoguchi N., Mizuguchi H., Sato Y.

Sci. Rep., 11, 11407 (2021)

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Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system.

Ichikawa M., Akamine H., Murata M., Ito S., Takayama K., Mizuguchi H.

Sci. Rep., 11, 11670 (2021)

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Adenovirus Vector-Induced IL-6 Promotes Leaky Adenoviral Gene Expression, Leading to Acute Hepatotoxicity

Shimizu K., Sakurai F., Iizuka S., Ono R., Tsukamoto T., Nishimae F., Nakamura SI., Nishinaka T., Terada T., Fujio Y., Mizuguchi H.

J. Immunol., 206, 410-421 (2021)

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A TGF-b signaling inhibitor, SB431542, inhibits reovirus-mediated lysis of human hepatocellular carcinoma cells in a TGF-b-independent manner.

Ishigami I., Shuwari N., Kaminade T., Mizuguchi H., Sakurai F.

Anticancer Res., 4, 2431-2440 (2021)

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Vinblastine treatment decreases the undifferentiated cell contamination of human iPSC-derived intestinal epithelial-like cells

Ichikawa M.#, Negoro R.#, Kawai K., Yamashita T., Takayama K., Mizuguchi H. #These authors equally contributed to this work.

Mol. Ther. Methods Clin. Dev., 20, 463-472 (2021)

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The infectivity of progeny adenovirus in the presence of neutralizing antibody.

Hirai T., Sato A., Koizumi N., Kurioka Y., Suzuki Y., Kano J., Yamakawa M., Nomura T., Fujii M., Sakurai F., Mizuguchi H., Watanabe Y., Utoguchi N.

J. Gen. Virol., 102, 001590 (2021)

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Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 35

Ono R., Takayama K., Sakurai F., Mizuguchi H.

Mol. Ther. Oncolytics, 20, 399-409 (2021)

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In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology.

Deguchi S., Shintani T., Harada K., Okamoto T., Takemura A., Hirata K., Ito K., Takayama K., Mizuguchi H.

Hepatol.?Commun., 5, 1385-1399 (2021)

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Asymmetric profiles of infection and innate immunological responses in human iPS cell-derived small intestinal epithelial-like cell monolayers following infection with mammalian reovirus

Inoue C., Negoro R., Takayama K., Mizuguchi H., Sakurai F.

Virus Res., 296, 198334 (2021)

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Optimization of an E1A gene expression cassette in an oncolytic adenovirus for efficient tumor cell killing activity

Sakurai F., Nishimae F., Takayama K., Mizuguchi H.

Anticancer Res., 41, 773-782 (2021)

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Fiber-knob region of adenovirus type 5 vector promotes migration of A549 cells

Kano J., Koizumi N., Terada A., Matsuoka A., Hirai T., Nomura T., Mizuguchi H., Utoguchi N.

BPB Reports, 4, 17-21 (2021)

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