Systemically administered reovirus-induced down-regulation of hypoxia inducible factor-1α in subcutaneous tumors

Hotani T., Mizuguchi H., Sakurai F.

Mol. Ther. Oncolytics, 12, 162-172 (2018)

Efficient generation of small intestinal epithelial-like cells from human iPS cells for drug absorption and metabolism studies

Negoro R., Takayama K., Kawai K., Harada K., Sakurai F., Hirata K., Mizuguchi H.

Stem Cell Rep., 11, 1539-1550 (2018)

Optimal human iPS cell culture method for efficient hepatic differentiation

Matoba N.#, Yamashita T.#, Takayama K., Sakurai F., Mizuguchi H. #These authors equally contributed to this work.

Differentiation, 104, 13-21 (2018)

LY341495, an mGluR2/3 antagonist, regulates the immunosuppressive function of myeloid-derived suppressor cells and inhibits melanoma tumor growth

Morikawa N., Tachibana M., Ago Y., Goda H., Sakurai F., Mizuguchi H.

Biol. Pharm. Bull., 41, 1866-1869 (2018)

Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration

Tomita K., Sakurai F., Iizuka S., Hemmi M., Wakabayashi K., Tachibana M., Katayama K., Kamada H., Mizuguchi H.

Sci. Rep., 8, 12315 (2018)

Generation of the adenovirus vector-mediated CRISPR/Cpf1 system and the application for primary human hepatocytes prepared from humanized mice with chimeric liver

Tsukamoto T., Sakai E., Iizuka S., Taracena-Gándara M., Sakurai F., Mizuguchi H.

Biol. Pharm. Bull., 41, 1089-1095 (2018)

Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research

Takayama K., Hagihara Y., Toba Y., Sekiguchi K., Sakurai F., Mizuguchi H.

Biomaterials, 161, 24-32 (2018)

Oncolytic reovirus inhibits immunosuppressive activity of myeloid-derived suppressor cells in a TLR3-dependent manner

Katayama Y., Tachibana M., Kurisu N., Oya Y., Terasawa Y., Goda H., Kobiyama K., Ishii K., Akira S., Mizuguchi H., Sakurai F.

J. Immunol., 200, 2987-2999 (2018)

Nanaomycin A treatment promotes hepatoblast differentiation from human iPS cells

Nakamae S.#, Toba Y.#, Takayama K., Sakurai F., Mizuguchi H. #These authors equally contributed to this work.

Stem Cells Dev., 27, 405-414 (2018)

Billion-scale production of hepatocyte-like cells from human iPS cells

Yamashita T., Takayama K., Sakurai F., Mizuguchi H.

Biochem. Biophys. Res. Commun., 496, 1269–1275 (2018)

Occludin as a functional marker of vascular endothelial cells on tube-forming activity

Kanayasu-Toyoda T., Ishii-Watabe A., Kikuchi Y., Kitagawa H., Suzuki H., Tamura H., Tada M., Suzuki T., Mizuguchi H., Yamaguchi T.

J. Cell. Physiol., 233, 1700-1711 (2018)

Generation of optogenetically modified adenovirus vector for spatiotemporally controllable gene therapy

Takayama K., Mizuguchi H.

ACS Chem. Biol., 13, 449–454 (2018)

Detection of CTCs in cervical cancer using a conditionally replicative adenovirus targeting telomerase-positive cells

Takakura M., Matsumoto T., Nakamura M., Mizumoto Y., Myojyo S., Yamazaki R., Iwadare J., Bono Y., Orisaka S., Obata T., Izuka T., Kagami K., Nakayama K., Hayakawa H., Sakurai F., Mizuguchi H., Urata Y., Fujiwara T., Kyo S., Sasagawa T., Fujiwara H.

Cancer Sci., 109, 231-240 (2018)

Human iPS cell-based liver-like tissue engineering at extrahepatic sites in mice as a new cell therapy for hemophilia B

Okamoto R.#, Takayama K.#, Akita N.#, Nagamoto Y., Hosokawa D., Iizuka S., Sakurai F., Suemizu H., Ohashi K., Mizuguchi H. #These authors equally contributed to this work.

Cell Transplant., 27, 299-309 (2018)

アデノウイルスベクター

水口裕之, 早川堯夫

バイオロジクスの開発と品質・安全性確保, エル・アイ・シー (2018)

組換えアデノウイルス　―特性と最近の話題―

水口裕之, 邊見昌久

医学のあゆみ, 351-358 (2018)

粘膜免疫誘導型ワクチンとしてのアデノウイルスベクター

立花雅史, 邊見昌久, 水口裕之

ドラッグデリバリーシステム, シーエムシー出版 (2018)

ヒトiPS細胞由来肝細胞の創出と創薬研究への応用

三谷成二, 高山和雄, 水口裕之

PHARM STAGE, 技術情報協会 (2018)