業績｜論文・出版物｜目次｜

2018

Systemically administered reovirus-induced down-regulation of hypoxia inducible factor-1α in subcutaneous tumors

Hotani T., Mizuguchi H., Sakurai F.

Mol. Ther. Oncolytics, 12, 162-172 (2018)

Efficient generation of small intestinal epithelial-like cells from human iPS cells for drug absorption and metabolism studies

Negoro R., Takayama K., Kawai K., Harada K., Sakurai F., Hirata K., Mizuguchi H.

Stem Cell Rep., 11, 1539-1550 (2018)

PubMed

Optimal human iPS cell culture method for efficient hepatic differentiation

Matoba N.#, Yamashita T.#, Takayama K., Sakurai F., Mizuguchi H. #These authors equally contributed to this work.

Differentiation, 104, 13-21 (2018)

PubMed

LY341495, an mGluR2/3 antagonist, regulates the immunosuppressive function of myeloid-derived suppressor cells and inhibits melanoma tumor growth

Morikawa N., Tachibana M., Ago Y., Goda H., Sakurai F., Mizuguchi H.

Biol. Pharm. Bull., 41, 1866-1869 (2018)

PubMed

Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration

Tomita K., Sakurai F., Iizuka S., Hemmi M., Wakabayashi K., Tachibana M., Katayama K., Kamada H., Mizuguchi H.

Sci. Rep., 8, 12315 (2018)

PubMed

Generation of the adenovirus vector-mediated CRISPR/Cpf1 system and the application for primary human hepatocytes prepared from humanized mice with chimeric liver

Tsukamoto T., Sakai E., Iizuka S., Taracena-Gándara M., Sakurai F., Mizuguchi H.

Biol. Pharm. Bull., 41, 1089-1095 (2018)

PubMed

Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research

Takayama K., Hagihara Y., Toba Y., Sekiguchi K., Sakurai F., Mizuguchi H.

Biomaterials, 161, 24-32 (2018)

PubMed

Oncolytic reovirus inhibits immunosuppressive activity of myeloid-derived suppressor cells in a TLR3-dependent manner

Katayama Y., Tachibana M., Kurisu N., Oya Y., Terasawa Y., Goda H., Kobiyama K., Ishii K., Akira S., Mizuguchi H., Sakurai F.

J. Immunol., 200, 2987-2999 (2018)

PubMed

Nanaomycin A treatment promotes hepatoblast differentiation from human iPS cells

Nakamae S.#, Toba Y.#, Takayama K., Sakurai F., Mizuguchi H. #These authors equally contributed to this work.

Stem Cells Dev., 27, 405-414 (2018)

PubMed

Billion-scale production of hepatocyte-like cells from human iPS cells

Yamashita T., Takayama K., Sakurai F., Mizuguchi H.

Biochem. Biophys. Res. Commun., 496, 1269–1275 (2018)

PubMed

Occludin as a functional marker of vascular endothelial cells on tube-forming activity

Kanayasu-Toyoda T., Ishii-Watabe A., Kikuchi Y., Kitagawa H., Suzuki H., Tamura H., Tada M., Suzuki T., Mizuguchi H., Yamaguchi T.

J. Cell. Physiol., 233, 1700-1711 (2018)

PubMed

Generation of optogenetically modified adenovirus vector for spatiotemporally controllable gene therapy

Takayama K., Mizuguchi H.

ACS Chem. Biol., 13, 449–454 (2018)

PubMed

Detection of CTCs in cervical cancer using a conditionally replicative adenovirus targeting telomerase-positive cells

Takakura M., Matsumoto T., Nakamura M., Mizumoto Y., Myojyo S., Yamazaki R., Iwadare J., Bono Y., Orisaka S., Obata T., Izuka T., Kagami K., Nakayama K., Hayakawa H., Sakurai F., Mizuguchi H., Urata Y., Fujiwara T., Kyo S., Sasagawa T., Fujiwara H.

Cancer Sci., 109, 231-240 (2018)

PubMed

Human iPS cell-based liver-like tissue engineering at extrahepatic sites in mice as a new cell therapy for hemophilia B

Okamoto R.#, Takayama K.#, Akita N.#, Nagamoto Y., Hosokawa D., Iizuka S., Sakurai F., Suemizu H., Ohashi K., Mizuguchi H. #These authors equally contributed to this work.

Cell Transplant., 27, 299-309 (2018)

PubMed

アデノウイルスベクター

水口裕之, 早川堯夫

バイオロジクスの開発と品質・安全性確保, エル・アイ・シー (2018)

WebSite

組換えアデノウイルス　―特性と最近の話題―

水口裕之, 邊見昌久

医学のあゆみ, 351-358 (2018)

WebSite

粘膜免疫誘導型ワクチンとしてのアデノウイルスベクター

立花雅史, 邊見昌久, 水口裕之