Generation of safe and therapeutically effective human iPS cell-derived hepatocyte-like cells for regenerative medicine

Takayama K.#, Akita N.#, Mimura N., Akahira R., Taniguchi Y., Ikeda M., Sakurai F., Ohara O., Morio T., Sekiguchi K., Mizuguchi H. #These authors equally contributed to this work.

Hepatol. Commun., 1, 1058-1069 (2017)

Th17 Promotes Induction of antigen-specific gut-mucosal CTLs following adenovirus vector vaccination

Hemmi M.#, Tachibana M.#, Fujimoto N., Shoji M., Sakurai F., Kobiyama K., Ishii K.J., Akira S., Mizuguchi H. #These authors equally contributed to this work.

Front. Immunol., 8, 1456 (2017)

Suppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB

Machitani M., Sakurai F., Wakabayashi K., Nakatani K., Tachibana M., Kato N., Fujiwara T., Mizuguchi H.

Mol. Ther. Oncolytics, 7, 76-85 (2017)

Human ES/iPS cell-derived hepatocyte-like cells achieve zone-specific hepatic properties by modulation of WNT signaling

Mitani S.#, Takayama K.#, Nagamoto Y., Imagawa K., Sakurai F., Tachibana M., Sumazaki R., Mizuguchi H. #These authors equally contributed to this work.

Mol. Ther., 25, 1420-1433 (2017)

Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells

Sakurai F.#, Kunito T.#, Takayama K., Hashimoto R., Tachibana M., Sakamoto N., Wakita T., Mizuguchi H. #These authors equally contributed to this work.

Virus Res., 242, 7-15 (2017)

Neonatal gene therapy for hemophilia B by a novel adenovirus vector showing sustained transgene expression via a reduction in the leaky expression of viral genes

Iizuka S., Sakurai F., Tachibana M., Ohashi K., Mizuguchi H.

Mol. Ther. Methods Clin. Dev., 6, 183-193 (2017)

Adenovirus vector-mediated macrophage erythroblast attacher (MAEA) overexpression in primary mouse hepatocytes attenuates hepatic gluconeogenesis

Shimizu K., Okamoto M., Terada T., Sakurai F., Mizuguchi H., Tomita K., Nishinaka T.

Biochem. Biophys. Rep., 10, 192-197 (2017)

A mammalian mirtron miR-1224 promotes tube-formation of human primary endothelial cells by targeting anti-angiogenic factor epsin2

Sakai E., Miura Y., Suzuki-Kouyama E., Oka K., Tachibana M., Kawabata K., Sakurai F., Mizuguchi H.

Sci. Rep., 7, 5541 (2017)

Sensitive detection of viable circulating tumor cells using a novel conditionally telomerase-selective replicating adenovirus in non-small cell lung cancer patients

Togo S., Katagiri N., Namba Y., Tulafu M., Nagahama K., Kadoya K., Takamochi K., Oh S., Suzuki K., Sakurai F., Mizuguchi H., Urata Y., Takahashi K.

Oncotarget, 8, 34884-34895 (2017)

Overexpression of miR-27b negatively regulates expression of pluripotency-associated genes and hepatic differentiation in human induced pluripotent stem cells

Lim J., Sakai E., Takayama K., Sakurai F., Mizuguchi H.

Stem Cell Res. Ther., 2, 88-97 (2017)

Cationic liposome-mediated delivery of reovirus enhances the tumor cell-killing efficiencies of reovirus in reovirus-resistant tumor cells

Sakurai F., Inoue S., Kaminade T., Hotani T., Katayama Y., Hosoyamada E., Terasawa Y., Tachibana M., Mizuguchi H.

Int. J. Pharm., 524, 238-247 (2017)

Generation of a bile salt export pump deficiency model using patient-specific iPSC-derived hepatocyte-like cells

Imagawa K., Takayama K., Isoyama S., Tanikawa K., Shinkai M., Harada K., Tachibana M., Sakurai F., Noguchi E., Hirata K., Kage M., Kawabata K., Sumazaki R., Mizuguchi H.

Sci. Rep., 7, 41806 (2017)

MicroRNA miR-27 inhibits adenovirus infection by suppressing the expression of SNAP25 and TXN2

Machitani M., Sakurai F., Wakabayashi K., Nakatani K., Tachibana M., Mizuguchi H.

J. Virol., 91, e00159-17 (2017)

Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection

Sakurai F.#, Mitani S.#, Yamamoto T.#, Takayama K., Tachibana M., Watashi K., Wakita T., Iijima S., Tanaka Y., Mizuguchi H. #These authors equally contributed to this work.

Sci. Rep., 7, 45698 (2017)

Inhibition of CRISPR/Cas9-mediated genome engineering by a type I interferon-induced reduction in guide RNA expression

Machitani M.#, Sakurai F.#, Wakabayashi K., Nakatani K., Takayama K., Tachibana M., Mizuguchi H. #These authors equally contributed to this work. (Highlighted paper selected by Editor-in-Chief)

Biol. Pharm. Bull., 40, 272-277 (2017)

Enhanced oncolytic activities of the telomerase-specific replication-competent adenovirus expressing short-hairpin RNA against Dicer

Machitani M.#, Sakurai F.#, Wakabayashi K., Tachibana M., Fujiwara T., Mizuguchi H. #These authors equally contributed to this work.

Mol. Cancer Ther., 16, 251-259 (2017)

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction

Nakamori D.#, Akamine H.#, Takayama K.#, Sakurai F., Mizuguchi H. #These authors equally contributed to this work.

Sci. Rep., 7, 16675 (2017)

Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions

Fukuda T., Takayama K., Hirata M., Liu Y-J, Yanagihara K., Suga M., Mizuguchi H., Furue M.K.

Exp. Cell Res., 352, 333-345 (2017)

Identification of adenovirus-derived cell-penetrating peptide

Hirai T., Yamagishi Y., Koizumi N., Nonaka M., Mochida R., Shida K., Nomura T., Fujii M., Sakurai F., Mizuguchi H., Watanabe Y., Utoguchi N.

Biol. Pharm. Bull., 40, 195-204 (2017)

Eradication of melanoma in vitro and in vivo via targeting with a Killer-Red-containing telomerase-dependent adenovirus

Takehara K., Yano S., Tazawa H., Okada N., Kishimoto H., Narii N., Mizuguchi H., Urata Y., Kagawa S., Fujiwara T., Hoffman R.M.

Cell Cycle, 16, 1502-1508 (2017)