Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure

Nagamoto Y., Takayama K., Ohashi K., Okamoto R., Sakurai F., Tachibana M., Kawabata K., Mizuguchi H.

J. Hepatol., 64, 1068-1075 (2016)

NF-kB promotes leaky expression of adenovirus genes in a replication-incompetent adenovirus vector

Machitani M.#, Sakurai F.#, Wakabayashi K., Nakatani K., Shimizu K., Tachibana M., Mizuguchi H. #These authors equally contributed to this work.

Sci. Rep., 6, 19922 (2016)

Efficient detection of human circulating tumor cells without significant production of false-positive cells by a novel conditionally replicating adenovirus

Sakurai F., Narii N., Tomita K., Togo S., Takahashi K., Machitani M., Tachibana M., Ouchi M., Katagiri N., Urata Y., Fujiwara T., Mizuguchi H.

Mol. Ther. Methods Clin. Dev., 3, 16001 (2016)

Dicer functions as an antiviral system against human adenoviruses via cleavage of adenovirus-encoded noncoding RNA

Machitani M.#, Sakurai F.#, Wakabayashi K., Tomita K., Tachibana M., Mizuguchi H. #These authors equally contributed to this work.

Sci. Rep., 6, 27598 (2016)

Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells

Takayama K.#, Mitani S.#, Nagamoto Y., Sakurai F., Tachibana M., Taniguchi Y., Sakaguchi K., Mizuguchi H. #These authors equally contributed to this work.

Biochem. Biophys. Res. Commun., 474, 91-96 (2016)

Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells

Negoro R.#, Takayama K.#, Nagamoto Y., Sakurai F., Tachibana M., Mizuguchi H. #These authors equally contributed to this work.

Biochem. Biophys. Res. Commun., 472, 631-636 (2016)

Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction

Nakamori D.#, Takayama K.#, Nagamoto Y., Mitani S., Sakurai F., Tachibana M., Mizuguchi H. #These authors equally contributed to this work.

Biochem. Biophys. Res. Commun., 469, 424-429 (2016)

TANK-binding kinase 1-dependent or -independent signaling elicits the cell type-specific innate immune responses induced by the adenovirus vector

Tsuzuki S.#, Tachibana M.#, Hemmi M., Yamaguchi T., Shoji M., Sakurai F., Kobiyama K., Kawabata K., Ishii K.J., Akira S., Mizuguchi H. #These authors equally contributed to this work.

Int. Immunol., 28, 105-115 (2016)

Adenovirus vector-based incorporation of a photo-cross-linkable amino acid into proteins in human primary cells and cancerous cell lines

Kita A., Hino N., Higashi S., Hirota K., Narumi R., Adachi J., Takafuji K., Ishimoto K., Okada Y., Sakamoto K., Tomonaga T., Takashima S., Mizuguchi H., Doi T.

Sci. Rep., 6, 36946 (2016)

Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells

Yanagihara K., Liu Y., Kanie K., Takayama K., Kokunugi M., Hirata M., Fukuda T., Suga M., Nikawa H., Mizuguchi H., Kato R., Furue M.K.

Stem Cells Dev., 25, 1884-1897 (2016)

Coating with Spermine-Pullulan Polymer Enhances Adenoviral Transduction of Mesenchymal Stem Cells

Wan L., Yao X., Faiola F., Liu B., Zhang T., Tabata Y., Mizuguchi H., Nakagawa S., Gao J.Q, Zhao R.C.

Int. J. Nanomed., 11, 6763-6769 (2016)

Tumor-specific delivery of biologics by a novel T-cell line HOZOT

Onishi T., Tazawa H., Hashimoto Y., Takeuchi M., Otani T., Nakamura S., Sakurai F., Mizuguchi H., Kishimoto H., Umeda Y., Shirakawa Y., Urata Y., Kagawa S., Fujiwara T.

Sci. Rep., 6, 38060 (2016)

Expression of HIF-1α ODD domain fused canine caspase 3 by EGFR promoter-driven adenovirus vector induces cytotoxicity in canine breast tumor cells under hypoxia

Okamoto M., Asamura A., Tanaka K., Soeda T., Watanabe K., Mizuguchi H., Ikeda T.

Vet. Res. Commun., 40, 131-139 (2016)

Targeted photodynamic virotherapy armed with a genetically encoded photosensitizer

Takehara K., Tazawa H., Okada N., Hashimoto Y., Kikuchi S., Kuroda S., Kishimoto H., Shirakawa Y., Narii N., Mizuguchi H., Urata Y., Kagawa S., Fujiwara T.

Mol. Cancer Ther., 15, 199-208 (2016)

Adenoviral Vector Construction II: Bacterial Systems

Hemmi M., Mizuguchi H.

Adenoviral Vectors for Gene Therapy (Second Edition), Academic Press, 113-137 (2016)

ヒトiPS細胞から肝細胞への分化誘導と毒性評価系への応用

水口裕之, 高山和雄

SCAS NEWS 2016-Ⅱ, 株式会社住化分析センター, 3-7 (2016)

ヒトiPS細胞を用いた薬剤評価のための肝細胞の作製

水口裕之, 高山和雄

iPS細胞の安全・高品質な作製技術, 技術情報協会, 124-130 (2016)

薬物毒性評価

水口裕之, 高山和雄

臨床薬学テキストシリーズ, 中山書店, 233-239 (2016)

標的化アデノウイルスベクターの開発

町谷充洋, 水口裕之

遺伝子医学MOOK 30 今、着実に実り始めた遺伝子治療～最新研究と今後の展望, メディカルドゥ, 63-73 (2016)