業績|論文・出版物|

2014

Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes

Takayama K., Morisaki Y., Kuno S., Nagamoto Y., Harada K., Furukawa N., Ohtaka M., Nishimura K., Imagawa K., Sakurai F., Tachibana M., Sumazaki R., Noguchi E., Nakanishi M., Hirata K., Kawabata K., Mizuguchi H.
Proc. Natl. Acad. Sci. USA, 111, 16772-16777 (2014)

Protective mucosal immunity mediated by epithelial CD1d and IL-10

Olszak T., Neves J., Dowds M., Baker K.K., Glickman J., Davidson N., Lin C-Y., Jobin C., Brand S., Sotlar K., Wada K., Katayama K., Nakajima A., Mizuguchi H., Kawasaki K., Nagata K., Müller W., Snapper S., Schreiber S., Kaser A., Zeissig S., Blumberg RS.
Nature, 509, 497-502 (2014)

The Early Activation of CD8(+) T Cells is dependent on type I IFN Ssignaling following intramuscular vaccination of adenovirus vector

Hemmi M.#, Tachibana M.#, Tsuzuki S., Shoji M., Sakurai F., Kawabata K., Kobiyama K., Ishii K.J., Akira S., Mizuguchi H. #These authors equally contributed to this work.
BioMed Res. Int., 158128 (2014)

CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determine the hepatoblast fate decision

Takayama K., Kawabata K., Nagamoto Y., Inamura M., Ohashi K., Okuno H., Yamaguchi T., Tashiro K., Sakurai F., Hayakawa T., Okano T., Furue MK., Mizuguchi H.
Development, 141, 91-100 (2014)

Development of mice exhibiting hepatic microsomal activity of human CYP3A4 comparable to that in human liver microsomes by intravenous administration of an adenovirus vector expressing human CYP3A4

Kuno S., Sakurai F., Shimizu K., Matsumura N., Kim S., Watanabe H., Tashiro K., Tachibana M., Yokoi T., Mizuguchi H.
Drug Metab. Pharmacokinet., 29, 296-304 (2014)

HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin

Watanabe H.#, Takayama K.#, Inamura M., Tachibana M., Mimura N., Tashiro K., Nagamoto Y., Sakurai F., Kawabata K., Furue MK., Mizuguchi H. #These authors equally contributed to this work.
PLoS One, 9, e90791 (2014)

Enhanced expression of the β4-galactosyltransferase 2 gene impairs mammalian tumor growth

Tagawa M., Shirane K., Yu L., Sato T., Furukawa S., Mizuguchi H., Kuji R., Kawamura K., Takahashi N., Kato K., Hayakawa S., Sawada S., Furukawa K.
Cancer Gene Ther., 21, 219-227 (2014)

Polyethyleneimine-coating enhances adenoviral transduction of mesenchymal stem cells

Yao X, Zhou N, Wan L, Su X, Sun Z, Mizuguchi H., Yoshioka Y, Nakagawa S, Zhao RC, Gao JQ.
Biochem. Biophys. Res. Commun., 447, 383-387 (2014)

Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome

Shimizu K., Sakurai F., Tomita K., Nagamoto Y., Nakamura S., Katayama K., Tachibana M., Kawabata K., Mizuguchi H.
Mol. Ther. Methods Clin. Dev., 1, 14035 (2014)

Plasma elevation of vascular endothelial growth factor leads to the reduction of mouse hematopoietic and mesenchymal stem/progenitor cells in the bone marrow

Tashiro K.#, Nonaka A.#, Hirata N., Yamaguchi T., Mizuguchi H., Kawabata K. #These authors equally contributed to this work.
Stem Cells Dev., 23, 2202-2210 (2014)

Hepatic differentiation of human embryonic stem cells and induced pluripotent stem cells by two- and three-dimensional culture systems in vitro

Higuchi M., Mizuguchi H.
Engineered Cell Manipulation for Biomedical Application, Springer, 147-158 (2014)

3次元組織化技術を利用したヒトES/iPS細胞から肝細胞への分化誘導法

長基康人, 高山和雄, 水口裕之
遺伝子医学MOOK別冊 細胞の3次元組織化 -その最先端技術と材料技術, メディカルドゥ, 244-248 (2014)

Upregulation of RECK gene expression by small double-stranded RNA targeting the promoter region

Sakurai F.#, Nanjo Y.#, Okamoto S., Tachibana M., Mizuguchi H. #These authors equally contributed to this work.
Cancer Gene Ther., 21, 219-227 (2014)

iPS細胞由来組織細胞を用いた毒性試験

水口裕之, 高山和雄
実験医学別冊 ES・iPS細胞実験スタンダード, 羊土社, 345-350 (2014)