業績|論文・出版物|

2012

Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction

Takayama K., Inamura M., Kawabata K., Sugawara M., Kikuchi K., Higuchi M., Nagamoto Y., Watanabe H., Tashiro K., Sakurai F., Hayakawa T., Furue MK., Mizuguchi H.
J. Hepatol., 57, 628-636 (2012)

Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction

Takayama K., Inamura M., Kawabata K., Katayama K., Higuchi M., Tashiro K., Nonaka A., Sakurai F., Hayakawa T., Furue MK., Mizuguchi H.
Mol. Ther., 20, 127-137 (2012)

Intramuscular DNA immunization with in vivo electroporation induces antigen-specific cellular and humoral immune responses in both systemic and gut-mucosal compartments

Shoji M., Katayama K., Tachibana M., Tomita K., Sakurai F., Kawabata K., Mizuguchi H.
Vaccine, 30, 7278-7285 (2012)

Type-I IFN signaling is required for the induction of antigen-specific CD8+ T cell responses by adenovirus vector vaccine in the gut-mucosa

Shoji M., Tachibana M., Katayama K., Tomita K., Tsuzuki S., Sakurai F., Ishii K.J., Akira S., Mizuguchi H.
Biochem. Biophys. Res. Commun., 425, 89-93 (2012)

Promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets

Nagamoto Y., Tashiro K., Takayama K., Ohashi K., Kawabata K., Sakurai F., Tachibana M., Hayakawa T., Furue MK., Mizuguchi H.
Biomaterials, 33, 4526-4534 (2012)

A hexon-specific PEGylated adenovirus vector utilizing blood coagulation factor X

Matsui H., Sakurai F., Katayama K., Yamaguchi T., Okamoto S., Takahira K., Tachibana M., Nakagawa S., Mizuguchi H.
Biomaterials, 33, 3743-3755 (2012)

Inhibition of Lnk in mouse induced pluripotent stem cells promotes hematopoietic cell generation

Tashiro K., Omori M., Kawabata K., Hirata N., Yamaguchi T., Sakurai F., Takaki S., Mizuguchi H.
Stem Cell Dev., 21, 3381-3390 (2012)

Improved Gene Transfer into Bladder Cancer Cells Using Adenovirus Vector Containing RGD Motif

Hiwasa K., Nagaya H., Terao S., Acharya B., Hamada K., Mizuguchi H., Gotoh A.
Anticancer Res., 32, 3137-3140 (2012)

Promotion of hematopoietic differentiation from mouse induced pluripotent stem cells by transient HoxB4 transduction

Tashiro K., Kawabata K., Omori M., Yamaguchi T., Sakurai F., Katayama K., Hayakawa H., Mizuguchi H.
Stem Cell Res., 8, 300-311 (2012)

Correlation between adenovirus-neutralizing antibody titer and adenovirus vector-mediated transduction efficiency following intratumoral injection

Tomita K., Sakurai F., Tachibana M., Mizuguchi H.
Anticancer Res., 32, 1145-1152 (2012)

Immunogenic Comparison of Chimeric Adenovirus 5/35 Vector Carrying Optimized Human Immunodeficiency Virus Clade C Genes and Various Promoters

Shoji M., Yoshizaki S., Mizuguchi H., Okuda K., Shimada M.
PLoS One, 7, e30302 (2012)

Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-122a

Sakurai F., Furukawa N., Higuchi M., Okamoto S., Ono K., Yoshida T., Kondoh M., Yagi K., Sakamoto N., Katayama K., Mizuguchi H.
Virus Res., 165, 214-218 (2012)

Optimization and internalization mechanisms of PEGylated adenovirus vector with targeting peptide for cancer gene therapy

Yao X.L., Yoshioka Y., Ruan G.X., Chen Y.Z., Mizuguchi H., Mukai Y., Okada N., Gao J.Q., Nakagawa S.
Biomacromolecules, 13, 2402-2409 (2012)

Efficient antitumor effects of carrier cells loaded with a fiber-substituted conditionally replicating adenovirus on CAR-negative tumor cells

Iguchi K., Sakurai F., Tomita K., Katayama K., Yamaguchi T., Tagawa M., Kawabata M., Shirakawa T., Mizuguchi H.
Cancer Gene Ther., 19, 118-125 (2012)

A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression

Yamasaki Y., Tazawa H., Hashimoto Y., Kojima T., Kuroda S., Yano S., Yoshida R., Uno F., Mizuguchi H., Ohtsuru A., Urata Y., Kagawa S., Fujiwara T.
Eur. J. Cancer, 48, 2282-2291 (2012)

Efficient hepatic differentiation from human iPS cells by gene transfer

Kawabata K., Inamura M., Mizuguchi H.
Methods Mol. Biol., 826, 115-124 (2012)

Further reduction in adenovirus vector-mediated liver transduction without largely affecting transgene expression in target organ by exploiting microRNA-mediated regulation and the Cre-loxP recombination system

Bennett D., Sakurai F., Shimizu K., Matsui H., Tomita K., Suzuki T., Katayama K., Kawabata K., Mizuguchi H.
Mol. Pharm., 9, 3452-63 (2012)

Endodermal and hepatic differentiation from human embryonic stem cells and human induced pluripotent stem cells

Kawabata K., Takayama K., Nagamoto Y., Saldon M.S., Higuchi M., Mizuguchi H.
J. Stem Cell Res. Ther., S10 (2012)

マイクロRNAを利用してウイルス遺伝子の非特異的な発現を抑制可能な新規アデノウイルスベクターの開発

清水かほり, 櫻井文教, 立花雅史, 水口裕之
薬学雑誌, 日本薬学会, 132, 1407-1412 (2012)

ヒトiPS細胞から肝細胞への分化誘導の現状と創薬応用

水口裕之, 高山和雄, 長基康人, 川端健二
医薬品医療機器レギュラトリーサイエンス, 医薬品医療機器レギュラトリーサイエンス財団, 43, 982-987 (2012)