Efficient generation of hepatoblastsfrom human ES cells and iPS cells by transient overexpression of homeobox gene HEX

Inamura M., Kawabata K., Takayama K., Tashiro K., Sakurai F., Katayama K., Toyoda M., Akutsu H., Miyagawa Y.,Okita H., Kiyokawa N., Umezawa A., Hayakawa T., Furue MK., Mizuguchi H.

Mol. Ther., 19, 400-407 (2011)

Efficient and directive generation of two distinct endoderm lineages from human ES and iPS cells by differentiation stage-specific SOX17 transduction

Takayama K., Inamura M., Kawabata K., Tashiro K., Katayama K., Hayakawa T., Furue MK., Mizuguchi H.

PLoS One, 6, e21780 (2011)

Enhanced safety profiles of the telomerase-specific replication-competent adenovirus by incorporation of normal cell-specific microRNA-targeted sequences

Sugio K., Sakurai F., Katayama K., Matsui H., Kawabata K., Kawase A., Iwaki M., Hayakawa T., Fujiwara T., Mizuguchi H.

Clin. Cancer Res., 17, 2807-2818 (2011)

Hexon-specific PEGylated adenovirus vectors utilizing avidin-biotin interaction

Suzuki-Kouyama E., Katayama K., Sakurai F., Yamaguchi T., Kurachi S., Kawabata K., Nakagawa S., Mizuguchi H.

Biomaterials, 32, 1724-1730 (2011)

Enhanced transduction efficiency of fiber-substituted adenovirus vectors by the incorporation of RGD peptides in two distinct regions of the adenovirus serotype 35 fiber knob

Matsui H., Sakurai F., Katayama K., Kurachi S., Tashiro K., Sugio K., Kawabata K., Mizuguchi H.

Virus Res., 155, 48-54 (2011)

Development of a recombinant adenovirus vector production system free of replication-competent adenovirus by utilizing a packaging size limit of the viral genome

Suzuki T., Sasaki T., Yano K., Sakurai F., Kawabata K., Kondoh M., Hayakawa T., Yagi K., Mizuguchi H.

Virus Res., 158, 154-160 (2011)

Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection

Yoshida T.#, Takayama K.#, Kondoh M.*, Sakurai F., Tani H., Sakamoto N., Matsuura Y., Mizuguchi H*., Yagi K*. #These authors equally contributed to this work. *Co-corresponding author.

Biochem. Biophys. Res. Commun., 416, 119-124 (2011)

An effective gene-knockdown using multiple shRNA-expressing adenovirus vectors

Motegi Y., Katayama K., Sakurai F., Kato T., Yamaguchi T., Matsui H., Takahashi M., Kawabata K., Mizuguchi H.

J. Control. Release, 153, 149-153 (2011)

Quantitative analysis of the leaky expression of adenovirus genes in cells transduced with a replication-incompetent adenovirus vector

Shimizu K., Sakurai F., Machitani M., Katayama K., Mizuguchi H.

Mol. Pharmaceutics, 8, 1430-1435 (2011)

Development of an adenovirus vector lacking the expression of virus-associated RNAs

Machitani M., Katayama K., Sakurai F., Matsui H., Yamaguchi T., Suzuki T., Miyoshi H., Kawabata K., Mizuguchi H.

J. Control. Release, 154, 285-289 (2011)

Enhanced in vivo gene transfer into the placenta using RGD fiber-mutant adenovirus vector

Katayama K., Furuki R., Yokoyama H., Kaneko M., Tachibana M., Yoshida I., Nagase H., Tanaka K., Sakurai F., Mizuguchi H., Nakagawa S., Nakanishi T.

Biomaterials, 32, 4185-4193 (2011)

Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma

Iwahori K., Serada S., Fujimoto M., Nomura S., Osaki T., Lee C.M., Mizuguchi H., Takahashi T., Ripley B., Okumura M., Kawase I., Kishimoto T., Naka T.

Int. J. Cancer, 129, 993-1005 (2011)

Adenovirus vector-mediated assay system for Hepatitis C virus replication

Yoshida T., Kondoh M., Ojima M., Mizuguchi H., Yamagishi Y., Sakamoto N., Yagi K.

Nuc. Acid Res., 39, e64 (2011)

Optimization of a microRNA expression vector for function analysis of microRNA

Furukawa N., Sakurai F., Katayama K., Seki N., Kawabata K., Mizuguchi H.

J. Control. Release, 150, 94-101 (2011)

EpCAM- and EGFR- targeted selective gene therapy for biliary cancers using Z33-fiber modified adenovirus

Kawashima R., Abei M., Fukuda K., Nakamura K., Murata T., Wakayama M., Seo E., Hasegawa N., Mizuguchi H., Obata Y., Hyodo I., Hamada H., Yokoyama K.K.

Int. J. Cancer, 129, 1244-53 (2011)

Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors

Iwata-Kajihara T., Sumimoto H., Kawamura N., Ueda R., Takahashi T., Mizuguchi H., Miyagishi M., Takeda K., Kawakami Y.

J. Immunol., 187, 27-36 (2011)

Tumor vascular targeted delivery of polymer-conjugated adenovirus vector for cancer gene therapy

Yao X., Yoshioka Y., Morishige T., Eto Y., Narimatsu S., Kawai Y., Mizuguchi H., Gao J.Q., Mukai Y., Okada N., Nakagawa S.

Mol. Ther., 19, 1619-1625 (2011)

Adenovirus vector-derived VA-RNA-mediated innate immune responses

Machitani M., Yamaguchi T., Shimizu K., Sakurai F., Katayama K., Kawabata K., Mizuguchi H.

Pharmaceutics, 3, 38-353 (2011)

MicroRNA-regulated transgene expression system for gene therapy and virotherapy

Sakurai F., Katayama K., Mizuguchi H.

Front. Biosci., 17, 2389-2401 (2011)

改良型アデノウイルスベクターの開発と神経系細胞への遺伝子導入

松井勇人, 櫻井文教, 形山和史, 水口裕之

日本薬理学会雑誌, 日本薬理学会, 137, 70-74 (2011)