業績|論文・出版物|

2008

miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy

Suzuki T., Sakurai F., Nakamura S-I., Kouyama E., Kawabata K., kondoh M., Yagi K., Mizuguchi H.
Mol. Ther., 16, 1719-1726 (2008)

Adenoviral expression of suppressor of cytokine signaling-1 reduces adenovirus vector-induced innate immune response

Sakurai H., Tashiro K., Kawabata K., Yamaguchi T., Sakurai F., Nakagawa S., Mizuguchi H.
J. Immunol., 180, 4931-4938 (2008)

Transduction properties of adenovirus serotype 35 vectors after intravenous administration into nonhuman primates

Sakurai F., Nakamura S-I., Akitomo K., Shibata H., Terao K., Kawabata K., Hayakawa T., Mizuguchi H.
Mol. Ther., 16, 726-733 (2008)

Efficient adenovirus vector-mediated PPAR gamma gene transfer into mouse embryoid bodies promotes adipocyte differentiation, J

Tashiro K., Kawabata K., Sakurai H., Kurachi S., Sakurai F., Yamanishi K., Mizuguchi H.
Gene Med., 10, 498-507 (2008)

Efficient gene delivery in human and rodent mast cells using adenovirus vectors

Nakashima K., Sakurai F., Kawabata K., Mizuguchi H.
J. Control. Release, 129, 215-222 (2008)

Innate immune response induced by gene delivery vectors

Sakurai H., Kawabata K., Sakurai F., Nakagawa S., Mizuguchi H.
Int. J. Pharm., 354, 9-15 (2008)

Modification of pIX or hexon based on fiberless Ad vectors is not effective for targeted Ad vectors

Kurachi S., Koizumi N., Tashiro K., Sakurai H., Sakurai F., Kawabata K., Nakagawa S., Mizuguchi H.
J. Control. Release, 127, 88-95 (2008)

Engineering of highly immunogenic long-lived DC vaccines by antiapoptotic protein gene transfer to enhance cancer vaccine potency

Yoshikawa T., Niwa T., Okada N., Mizuguchi H., Nakagawa S.
Gene Ther., 15, 1321-1329 (2008)

Combination of two fiber-mutant adenovirus vectors, one encoding the chemokine FKN and another encoding cytokine interleukin 12, elicits notably enhanced anti-tumor responses

Gao J-Q., Kanagawa N., Xu D-H., Han M., Sugita T., Hatanaka Y., Tani Y., Mizuguchi H., Tsutsumi Y., Mayumi T., Okada N., Nakagawa S.
Cancer Immunol. Immunother., 57, 1657-64 (2008)

Evaluation of promoter strength in mouse and rat primary hepatocytes using adenovirus vectors

Arita E., Kondoh M., Isoda K., Nishimori H., Yoshida T., Mizuguchi H., Yagi K.
Eur. J. Pharm. Biopharm., 70, 1-6 (2008)

Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis

Takahashi A., Komiya E., Kakutani H., Yoshida T., Fujii M., Horiguchi Y., Mizuguchi H., Tsutsumi Y., Tsunoda S-I., Koizumi N., Isoda K., Yagi K., Watanabe Y., Kondoh M.
Biochem. Pharmacol., 75, 1639-1648 (2008)

Factors involved in the maturation of murine dendritic cells transduced with adenoviral vector variants

Kanagawa N., Koretomo R., Murakami S., Sakurai F., Mizuguchi H., Nakagawa S., Fujita T., Yamamoto A., Okada N.
Virology, 374, 411-420 (2008)

Tat conjugation of adenovirus vector broadens tropism and enhances transduction efficiency

Yoshioka Y., Asavatanabodee R., Eto Y., Watanabe H., Morishige T., Yao X., Kida S., Maeda M., Mukai Y., Mizuguchi H., Kawasaki K., Okada N., Nakagawa S.
Life Science, 83, 747-755 (2008)

Downregulation of CD46 during muscle differentiation: implications for gene transfer to human skeletal muscle using group B adenoviruses

Larochelle N., Deol J., Srivastava V., Allen C., Mizuguchi H., Karpati G., Holland P., Nalbantoglu J.
Hum. Gene Ther., 19, 133-142 (2008)

Development and evaluation of a novel gene delivery vehicle composed of adenovirus serotype 35

Sakurai F.
Biol. Pharm. Bull., 31, 1819-1825 (2008)

Development of a replication-incompetent adenovirus vector derived from subgroup B adenovirus serotype 35

Sakurai F.
Yakugaku Zasshi, 128, 1751-1761 (2008)

標的指向性を有するバイオコンジュゲート化アデノウイルスベクターの開発

衛藤佑介, 吉岡靖雄, Asavatanabodee R, 水口裕之, 向洋平, 岡田直貴, 中川晋作
薬学雑誌, 日本薬学会, 128, 1733-1742 (2008)

遺伝子治療研究の動向

水口裕之
医薬ジャーナル新薬展望2008, 44, 235-242 (2008)

ウイルスベクター

水口裕之
ウイルスハンドブック, 日本医学館, 6-7 (2008)

アデノウイルスベクター

水口裕之
機能性DDSキャリアの製剤設計, シーエムシー出版, 133-141 (2008)