Fiber-modified adenovirus vectors decrease liver toxicity through reduced interleukin 6 production

Koizumi N., Yamaguchi T., Kawabata K., Sakurai F., Sasaki T., Watanabe Y., Hayakawa T., Mizuguchi H.

J. Immunol., 178, 1767-1773 (2007)

Characterization of capsid-modified adenovirus vectors containing heterologous peptides in the fiber knob, protein IX, or hexon

Kurachi S., Koizumi N., Sakurai F., Kawabata K., Sakurai H., Nakagawa S., Hayakawa T., Mizuguchi H.

Gene Ther., 14, 266-274 (2007)

Rapid construction of small interfering RNA-expressing adenovirus vectors on the basis of direct cloning of short hairpin RNA-coding DNAs

Mizuguchi H., Funakoshi N., Hosono T., Sakurai F., Kawabata K., Yamaguchi T., Hayakawa T.

Hum. Gene Ther., 18, 74-80 (2007)

Comparison of gene expression efficiency and innate immune response induced by Ad vector and lipoplex

Sakurai H., Sakurai F., Kawabata K., Sasaki T., Koizumi N., Huang H., Tashiro K., Kurachi S., Nakagawa S., Mizuguchi H.

J. Control. Release, 117, 430-437 (2007)

Role of tyrosine residues in modulation of claudin-4 by the C-terminal fragment of Clostridium perfringens enterotoxin

Harada M., Kondoh M., Ebihara C., Takahashi A., Komiya E., Fujii M., Mizuguchi H., Tsunoda S-I., Horiguchi Y., Yagi K., Watanabe Y.

Biochem. Pharmacol., 73, 206-214 (2007)

Role of Tyr306 in the C-terminal fragment of Clostridium perfringens enterotoxin for modulation of tight junction

Ebihara C., Kondoh M., Harada M., Fujii M., Mizuguchi H., Tsunoda S-I., Horiguchi Y., Yagi K., Watanabe Y.

Biochem. Pharmacol., 73, 824-830 (2007)

Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex

Hama S., Akita H., Iida S., Mizuguchi H., Harashima H.

Nuc. Acid Res., 35, 1533-1543 (2007)

Induction of human adiponectin gene transcription by telmisartan, angiotensin receptor blocker, independently on PPAR-gamma activation

Moriuchi A., Yamasaki H., Shimamura M., Kita A., Kuwahara H., Fujishima K., Satoh T., Fukushima K., Fukushima T., Hayakawa T., Mizuguchi H., Nagayama Y., Abiru N., Kawasaki E., Eguchi K.

Biochem. Biophys. Res. Commun., 356, 1024-1030 (2007)

Efficient gene transfer into murine pancreatic islets using adenovirus vectors

Mukai E., Fujimoto S., Sakurai F., Kawabata K., Yamashita M., Inagaki N., Mizuguchi H.

J. Control. Release, 119, 136-141 (2007)

Downregulation of human CD46 by adenovirus serotype 35 vectors

Sakurai F., Akitomo K., Kawabata K., Hayakawa T., Mizuguchi H.

Gene Ther., 14, 912-919 (2007)

Chimeric adenovirus 5/35 vector containing the clade C HIV gag gene induces a cross-reactive immune response against HIV

Xin K-Q., Sekimoto Y., Takahashi T., Mizuguchi H., Ichino M., Yoshida A., Okuda K.

Vaccine, 25, 3809-3815 (2007)

Cotransduction of CCL27 gene can improve the efficacy and safety of IL-12 gene therapy for cancer

Gao J-Q., Kanagawa N., Motomura Y., Yanagawa T., Sugita T., Hatanaka Y., Tani Y., Mizuguchi H., Tsutsumi Y., Mayumi T., Okada N., Nakagawa S.

Gene Ther., 14, 491-502 (2007)

Expression of coxsackie and adenovirus receptor reduces the lung metastatic potential of murine tumor cells

Yamashita M., Ino A., Kawabata K., Sakurai F., Mizuguchi H.

Int. J. Cancer, 121, 1690-1696 (2007)

Fiber-modified adenovirus vectors containing the TAT peptide derived from human immunodeficiency virus in the fiber knob have efficient gene transfer activity

Kurachi S., Tashiro K., Sakurai F., Sakurai H., Kawabata K., Yayama K., Okamoto H., Nakagawa S., Hayakawa T., Mizuguchi H.

Gene Ther., 14, 1160-1165 (2007)

Positive and negative regulation of adenovirus infection by CAR-like soluble protein, CLSP

Kawabata K., Tashiro K., Sakurai F., Osada N., Kusuda J., Hayakawa T., Yamanishi K., Mizuguchi H.

Gene Ther., 14, 1199-1207 (2007)

Role of MyD88 and TLR9 in the innate immune response elicited by serotype 5 adenoviral vectors

Yamaguchi T.#, Kawabata K.#, Koizumi N., Sakurai F., Nakashima K., Sasaki T., Okada N, Mizuguchi H. #These authors equally contributed to this work.

Hum. Gene Ther., 18, 753-762 (2007)

Targeted-delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells

Xin H., Kanehira M., Mizuguchi H., Hayakawa T., Kikuchi T., Nukiwa T., Saijo Y.

Stem Cells, 25, 1618-1626 (2007)

Adenovirus vectors composed of subgroup B adenoviruses

Sakurai F., Kawabata K., Mizuguchi H.

Curr. Gene Ther., 7, 229-238 (2007)

Chimeric adenovirus type 5/35 vector encoding SIV gag and HIV env genes affords protective immunity against the simian/human immunodeficiency virus in monkeys

Someya K., Xin K-Q., Ami Y., Izumi Y., Mizuguchi H., Ohta S., Yamamoto N., Honda M., Okuda K.

Virology, 367, 390-397 (2007)

Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration

Gao J-Q., Eto Y., Yoshioka Y., Sekiguchi F, Kurachi S., Morishige T., Yao X., Watanabe H., Asavatanabodee R., Sakurai F., Mizuguchi H., Okada Y., Mukai Y., Tsutsumi Y., Mayumi T., Okada N., Nakagawa S.

J. Control. Release, 122, 102-110 (2007)