業績｜論文・出版物｜目次｜

2006

Modified adenoviral vectors ablated for coxsackievirus-adenovirus receptor, αv integrin, and heparan sulfate binding reduce in vivo tissue transduction and toxicity

Koizumi N., Kawabata K., Sakurai F., Watanebe Y., Hayakawa T., Mizuguchi H.

Hum. Gene Ther., 17, 264-279 (2006)

PubMed

Adenovirus serotype 35 vector-mediated transduction into human CD46-transgenic mice

Sakurai F., Kawabata K., Koizumi N., Inoue N., Okabe M., Yamaguchi T., Hayakawa T., Mizuguchi H.

Gene Ther., 13, 1118-1126 (2006)

PubMed

The short consensus repeats 1 and 2, not the cytoplasmic domain, of human CD46 are crucial for infection of subgroup B adenovirus serotype 35

Sakurai F., Murakami S., Kawabata K., Okada N., Yamamoto A., Seya T., Hayakawa T., Mizuguchi H.

J. Control. Release, 113, 271-278 (2006)

PubMed

Adenovirus vector-mediated gene transfer into stem cells

Kawabata K., Sakurai F., Koizumi N., Hayakawa T., Mizuguchi H.

Mol. Pharmaceutics, 3, 95-103 (2006)

PubMed

Efficient gene transfer into differentiated human trophoblast cells with adenovirus vector containing RGD motif in the fiber protein

Koizumi N., Mizuguchi H., Kondoh M., Fujii M., Nakanishi T., Utoguchi N., Watanabe Y.

Biol. Pharm. Bull., 29, 1297-1299 (2006)

PubMed

In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus

Kishimoto H., Kojima T., Watanabe Y., Kagawa S., Fujiwara T., Uno F., Teraishi F., Kyo S., Mizuguchi H., Hashimoto Y., Urata Y., Tanaka N., Fujiwara T.

Nature Med., 12, 1213-1219 (2006)

PubMed

Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity

Uno K., Katagiri H., Yamada T., Ishigaki Y., Ogihara T., Imai J., Hasegawa Y., Gao J., Kaneko K., Iwasaki H., Ishihara H., Sasano H., Inukai K., Mizuguchi H., Asano T., Shiota M., Nakazato M., Oka Y.

Science, 312, 1656-1659 (2006)

PubMed

Regulation of IL-27p28 gene by lipopolysacchraide in dendritic DC24 cells

Kamakura M., Morisawa K., Komi H., Tomatani A., Saito F., Konishi Y., Jin Y., Manabe T., Kuroda M., Imai S., Mizuguchi H., Taniguchi T.

Biochem. Biophys. Res. Commun., 349, 1372-1377 (2006)

PubMed

Characteristics of transcription-regulatory elements for gene expression from plasmid vectors in human trophoblast cell lines

Komiya E., Kondoh M., Mizuguchi H., Fujii M., Utoguchi N., Nakanishi T., Watanabe Y.

Placenta, 27, 934-938 (2006)

PubMed

Impact of convective flow on the cellular uptake and transfection activity of lipoplex and adenovirus

Fujiwara T., Akita H., Furukawa K., Ushida T., Mizuguchi H., Harashima H.

Biol. Pharm. Bull., 29, 1511-1515 (2006)

PubMed

Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors

Nukiwa M., Andarini S., Zaini J., Xin H., Kanehira M., Suzuki T., Fukuhara T., Mizuguchi H., Hayakawa T., Saijo Y., Nukiwa T., Kikuchi T.

Eur. J. Immunol., 109, 1019-1027 (2006)

PubMed

Centrifugation enhances integrin-mediated transduction of dendritic cells by conventional and RGD-modified adenoviral vectors

Harui A., Roth MD., Sanghvi M., Vira D., Mizuguchi H., Basak SK.

J. Immunol. Methods, 312, 94-104 (2006)

PubMed

Adenoviral-encoded antigens are presented by a subset of dendritic cells expressing alpha-v/beta-3 integrins

Harui A., Roth MD., Vira D., Sanghvi M., Mizuguchi H., Basak SK.

J. Leukocyte. Biol., 79, 1271-1278 (2006)

PubMed

Design and synthesis of a Tat-related gene transporter: a tool for carrying the adenovirus vector into cells

Kida S., Maeda M., Hojo K., Eto Y., Gao J.Q., Kurachi S., Mizuguchi H., Hayakawa T., Mayumi T., Nakagawa S., Kawasaki K.

Bioorg. Med. Chem. Lett., 16, 743-735 (2006)

PubMed

Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems

Hama S., Akita H., Ito R., Mizuguchi H., Hayakawa T., Harashima H.

Mol. Ther., 13, 786-794 (2006)

PubMed

Preparation of a claudin-targeting molecule using a C-terminal fragment of Clostridium perfringens enterotoxin

Ebihara C., Kondoh M., Hasuike N., Harada M., Mizuguchi H., Horiguchi Y., Fujii M., Watanabe Y.

J. Pharmacol. Exp. Ther., 316, 255-260 (2006)

PubMed

Tumor suppressive efficacy through augmentation of tumor-infiltrating immune cells by intratumoral injection of chemokine-expressing adenoviral vector

Okada N., Sasaki A., Niwa M., Okada Y., Hatanaka Y., Tani Y., Mizuguchi H., Nakagawa S., Fujita T., Yamamoto A.

Cancer Gene Ther., 13, 393-405 (2006)

PubMed

Gene expression of tumor cells both in vitro and in vivo enhanced by integrin-targeting adenovirus

Gao J-Q., Chen H-L., Nakagawa S., Mizuguchi H., Liang W-Q.

Acta Pharmaceutica Sinica, 41, 1116-1120 (2006)

PubMed

Recent Advance of Development of Viral and Non-viral Vectors for Gene Therapy

Mizuguchi H.

Yakugaku Zasshi, 126, 1011 (2006)

PubMed

Characterization of adenovirus serotype 35 vectors using genetically modified animals and nonhuman primates