Modified adenoviral vectors ablated for coxsackievirus-adenovirus receptor, αv integrin, and heparan sulfate binding reduce in vivo tissue transduction and toxicity

Koizumi N., Kawabata K., Sakurai F., Watanebe Y., Hayakawa T., Mizuguchi H.

Hum. Gene Ther., 17, 264-279 (2006)

Adenovirus serotype 35 vector-mediated transduction into human CD46-transgenic mice

Sakurai F., Kawabata K., Koizumi N., Inoue N., Okabe M., Yamaguchi T., Hayakawa T., Mizuguchi H.

Gene Ther., 13, 1118-1126 (2006)

The short consensus repeats 1 and 2, not the cytoplasmic domain, of human CD46 are crucial for infection of subgroup B adenovirus serotype 35

Sakurai F., Murakami S., Kawabata K., Okada N., Yamamoto A., Seya T., Hayakawa T., Mizuguchi H.

J. Control. Release, 113, 271-278 (2006)

Adenovirus vector-mediated gene transfer into stem cells

Kawabata K., Sakurai F., Koizumi N., Hayakawa T., Mizuguchi H.

Mol. Pharmaceutics, 3, 95-103 (2006)

Efficient gene transfer into differentiated human trophoblast cells with adenovirus vector containing RGD motif in the fiber protein

Koizumi N., Mizuguchi H., Kondoh M., Fujii M., Nakanishi T., Utoguchi N., Watanabe Y.

Biol. Pharm. Bull., 29, 1297-1299 (2006)

In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus

Kishimoto H., Kojima T., Watanabe Y., Kagawa S., Fujiwara T., Uno F., Teraishi F., Kyo S., Mizuguchi H., Hashimoto Y., Urata Y., Tanaka N., Fujiwara T.

Nature Med., 12, 1213-1219 (2006)

Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity

Uno K., Katagiri H., Yamada T., Ishigaki Y., Ogihara T., Imai J., Hasegawa Y., Gao J., Kaneko K., Iwasaki H., Ishihara H., Sasano H., Inukai K., Mizuguchi H., Asano T., Shiota M., Nakazato M., Oka Y.

Science, 312, 1656-1659 (2006)

Regulation of IL-27p28 gene by lipopolysacchraide in dendritic DC24 cells

Kamakura M., Morisawa K., Komi H., Tomatani A., Saito F., Konishi Y., Jin Y., Manabe T., Kuroda M., Imai S., Mizuguchi H., Taniguchi T.

Biochem. Biophys. Res. Commun., 349, 1372-1377 (2006)

Characteristics of transcription-regulatory elements for gene expression from plasmid vectors in human trophoblast cell lines

Komiya E., Kondoh M., Mizuguchi H., Fujii M., Utoguchi N., Nakanishi T., Watanabe Y.

Placenta, 27, 934-938 (2006)

Impact of convective flow on the cellular uptake and transfection activity of lipoplex and adenovirus

Fujiwara T., Akita H., Furukawa K., Ushida T., Mizuguchi H., Harashima H.

Biol. Pharm. Bull., 29, 1511-1515 (2006)

Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors

Nukiwa M., Andarini S., Zaini J., Xin H., Kanehira M., Suzuki T., Fukuhara T., Mizuguchi H., Hayakawa T., Saijo Y., Nukiwa T., Kikuchi T.

Eur. J. Immunol., 109, 1019-1027 (2006)

Centrifugation enhances integrin-mediated transduction of dendritic cells by conventional and RGD-modified adenoviral vectors

Harui A., Roth MD., Sanghvi M., Vira D., Mizuguchi H., Basak SK.

J. Immunol. Methods, 312, 94-104 (2006)

Adenoviral-encoded antigens are presented by a subset of dendritic cells expressing alpha-v/beta-3 integrins

Harui A., Roth MD., Vira D., Sanghvi M., Mizuguchi H., Basak SK.

J. Leukocyte. Biol., 79, 1271-1278 (2006)

Design and synthesis of a Tat-related gene transporter: a tool for carrying the adenovirus vector into cells

Kida S., Maeda M., Hojo K., Eto Y., Gao J.Q., Kurachi S., Mizuguchi H., Hayakawa T., Mayumi T., Nakagawa S., Kawasaki K.

Bioorg. Med. Chem. Lett., 16, 743-735 (2006)

Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems

Hama S., Akita H., Ito R., Mizuguchi H., Hayakawa T., Harashima H.

Mol. Ther., 13, 786-794 (2006)

Preparation of a claudin-targeting molecule using a C-terminal fragment of Clostridium perfringens enterotoxin

Ebihara C., Kondoh M., Hasuike N., Harada M., Mizuguchi H., Horiguchi Y., Fujii M., Watanabe Y.

J. Pharmacol. Exp. Ther., 316, 255-260 (2006)

Tumor suppressive efficacy through augmentation of tumor-infiltrating immune cells by intratumoral injection of chemokine-expressing adenoviral vector

Okada N., Sasaki A., Niwa M., Okada Y., Hatanaka Y., Tani Y., Mizuguchi H., Nakagawa S., Fujita T., Yamamoto A.

Cancer Gene Ther., 13, 393-405 (2006)

Gene expression of tumor cells both in vitro and in vivo enhanced by integrin-targeting adenovirus

Gao J-Q., Chen H-L., Nakagawa S., Mizuguchi H., Liang W-Q.

Acta Pharmaceutica Sinica, 41, 1116-1120 (2006)

Recent Advance of Development of Viral and Non-viral Vectors for Gene Therapy

Mizuguchi H.

Yakugaku Zasshi, 126, 1011 (2006)

Characterization of adenovirus serotype 35 vectors using genetically modified animals and nonhuman primates

Sakurai F., Kawabata K., Mizuguchi H.

Yakugaku Zasshi, 126, 1013-1019 (2006)