業績|論文・出版物|

2005

Efficient gene transfer into mouse embryonic stem cells with adenovirus vectors

Kawabata K., Sakurai F., Yamaguchi T., Hayakawa T., Mizuguchi H.
Mol. Ther., 12, 547-554 (2005)

Optimization of adenovirus serotype 35 vectors for efficient transduction in human hematopoietic progenitors: comparison of promoter activities

Sakurai F., Kawabata K., Yamaguchi T., Hayakawa T., Mizuguchi H.
Gene Ther., 12, 1424-1433 (2005)

Fiber-modified adenovirus vectors mediate efficient gene transfer into undifferentiated and adipogenic-differentiated human mesenchymal stem cell

Mizuguchi H., Sasaki T., Kawabata K., Sakurai F., Hayakawa T.
Biochem. Biophys. Res. Commun., 332, 1101-1106 (2005)

A trial of somatic gene targeting in vivo with an adenovirus vector

Ino A., Naito Y., Mizuguchi H., Handa N., Hayakawa T., Kobayashi I.
Genet. Vaccines Ther., 3, 8 (2005)

Efficient regulation of gene expression using self-contained fiber-modified adenovirus vectors containing the tet-off system

Mizuguchi H., Xu Z-L., Sakurai F., Kawabata K., Yamaguchi T., Hayakawa T.
J. Control. Release, 110, 202-211 (2005)

Prime-boost vaccination with plasmid DNA and a chimeric adenovirus type 5 vector with type 35 fiber induces protective immunity against HIV

Xin K-Q., Jounai N., Someya K., Honma K., Mizuguchi H., Naganawa S., Kitamura K., Hayakawa T., Saha S., Takeshita F., Okuda K., Honda M., Klinman D.M., Okuda K.
Gene Ther., 12, 1769-1777 (2005)

Role of C-terminal regions of the C-terminal fragment of Clostridium perfringens enterotoxin in its interaction with claudin-4

Takahashi A., Kondoh M., Masuyama A., Fujii M., Mizuguchi H., Horiguchi Y., Watanabe Y.
J. Control. Release, 108, 56-62 (2005)

Role of N-terminal amino acids in the absorption-enhancing effects of the C-terminal fragment of Clostridium Perfringens enterotoxin

Masuyama A., Kondoh M., Seguchi H., Takahashi A., Harada M., Fujii M., Mizuguchi H., Horiguchi Y., Watanabe Y.
J. Pharmacol. Exp. Ther., 314, 789-795 (2005)

Anti-tumor responses induced by chemokine CCL19 transfected into an ovarian carcinoma model via fiber-mutant adenovirus vector

Gao J-Q, Sugita T., Kanagawa N., Iida K., Okada N., Mizuguchi H., Nakayama T., Yoshie O., Tsutsumi Y., Mayumi T., Nakagawa S.
Biol. Pharm. Bull., 28, 1066-1070 (2005)

Transcriptional targeting of RGD fiber-mutant adenovirus vectors can improve the safety of suicide gene therapy for murine melanoma

Okada Y., Okada N., Mizuguchi H., Hayakawa T., Nakagawa S., Mayumi T.
Cancer Gene Ther., 12, 608-616 (2005)

Comparison of transgene expression mediated by several fiber-modified adenovirus vectors in trophoblast cells

Koizumi, N., Kondoh, M., Mizuguchi H., Nakanishi, T., Masuyama, A., Ida, F., Fujii, M., Hayakawa, T., Nakashima, E., Tanaka, K., Watanabe, Y.
Placenta, 26, 729-734 (2005)

PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody evasion ability

Eto Y., Gao J-Q., Sekiguchi F., Kurachi S., Katayama K., Mizuguchi H., Hayakawa T., Maeda, M., Kawasaki K., Tsutsumi Y., Mayumi T., Nakagawa S.
J. Gene Med., 7, 604-612 (2005)

Enhanced oncolysis by a tropism-modified telomerase-specific replication-selective adenoviral agent OBP-405 ('Telomelysin-RGD')

Taki M., Kagawa S., Nishizaki M., Mizuguchi H., Hayakawa T., Kyo S., Nagai K., Urata Y., Tanaka N., Fujiwara T.
Oncogene, 24, 3130-3140 (2005)

Design and synthesis of a peptide-PEG transporter tool for carrying adenovirus vector into cells

Maeda M., Kida S., Hojo K., Eto Y., Gao J-Q, Kurachi S., Sekiguchi F., Mizuguchi H., Hayakawa T., Mayumi T., Nakagawa S., Kawasaki K.
Bioorg. Med. Chem. Lett., 15, 621-624 (2005)

A single intratumoral injection of a fiber-mutant adenoviral vector encoding interleukin 12 induces remarkable anti-tumor and anti-metastatic activity in mice with Meth-A fibrosarcoma

Gao J-Q, Sugita T., Kanagawa N., Iida K., Eto Y., Motomura Y., Mizuguchi H., Tsutsumi Y., Hayakawa T., Mayumi T., Nakagawa S.
Biochem. Biophys. Res. Commun., 328, 1043-1050 (2005)

Eradication of Epstein-Barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1

Nasimuzzaman, M., Kuroda, M., Dohno, S., Yamamoto, T., Iwatsuki, K., Matsuzaki, S., Rashel, M., Kumita, W., Mizuguchi, H., Hayakawa, T., Nakamura, H., Taguchi, T., Wakiguchi, H., Imai, S.
Mol. Ther., 11, 578-590 (2005)

RNA interference of PPARγ using fiber-modified adenovirus vector efficiently suppresses preadipocyte-to-adipocyte differentiation in 3T3-L1 cells

Hosono T., Mizuguchi H., Katayama K., Koizumi N., Kawabata K., Yamaguchi T., Nakagawa S., Watanabe Y., Mayumi T., Hayakawa T.
Gene, 348, 157-165 (2005)

A novel strategy for the enhancement of drug absorption using a claudin modulator

Kondoh, M., Masuyama , A., Takahashi, A., Asano, N., Mizuguchi H., Koizumi, N., Fujii, M., Hayakawa, T., Horiguchi, Y., Watanabe, Y.
Mol. Pharmacol., 67, 749-756 (2005)

Gene therapy for human small cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference

Sumimoto H., Yamagata S., Shimizu A., Miyoshi H., Mizuguchi H., Hayakawa T., Miyagishi M., Taira K., Kawakami Y.
Gene Ther., 12, 95-100 (2005)

Augmentation of the migratory ability of DC-based vaccine into regionalymph nodes by efficient CCR7 gene transduction

Okada N., Mori N., Koretomo R., Okada Y., Nakayama T., Yoshie O., Mizuguchi H., Hayakawa T., Nakagawa S., Mayumi T., Fujita T., Yamamoto A.
Gene Ther., 12, 129-139 (2005)