業績|論文・出版物|

2001

A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob

Mizuguchi H., Koizumi N., Hosono T., Utoguchi N., Watanabe Y., Kay MA., Hayakawa T.
Gene Ther., 8, 730-735 (2001)

In vitro ligation-based cloning of foreign DNAs into the E3 and E1 deletion regions for generation of recombinant adenovirus vectors

Mizuguchi H., Kay MA., Hayakawa T.
BioTechniques, 30, 1112-1114-1116 (2001)

Characteristics of adenovirus-mediated tetracycline-controllable expression system

Mizuguchi H., Hayakawa T.
Biochim. Biophys. Acta, 1568, 21-29 (2001)

Efficient gene transfer by fiber-mutant adenoviral vectors containing RGD peptide

Koizumi N., Mizuguchi H., Hosono T., Ishii-Watabe A., Uchida E., Utoguchi N., Watanabe Y., Hayakawa T.
Biochim. Biophys. Acta, 1568, 13-20 (2001)

Optimization of transcriptional regulatory elements for constructing plasmid vectors

Xu ZL., Mizuguchi H., Ishii-Watabe A., Uchida E., Mayumi T., Hayakawa T.
Gene, 272, 149-156 (2001)

Approaches for generating recombinant adenovirus vectors

Mizuguchi H., Kay M.A., Hayakawa T.
Adv. Drug. Deli. Rev., 52, 165-176 (2001)

Adenovirus-mediated MUC1 gene transduction into human blood-derived dendritic cells

Maruyama K., Akiyama Y., Nara-Ashizawa N., Hojo T., Cheng JY., Mizuguchi H., Hayakawa T., Yamaguchi K.
J. Immunother., 24, 345-353 (2001)

Efficient antigen gene transduction using Arg-Gly-Asp fiber-mutant adenovirus vectors can potentiate antitumor vaccine efficacy and maturation of murine dendritic cells

Okada N., Saito T., Masunaga Y., Tsukada Y., Nakagawa S., Mizuguchi H., Mori K., Okada Y., Fujita T., Hayakawa T., Mayumi T., Yamamoto A.
Cancer Res., 61, 7913-7919 (2001)

Efficient gene delivery into dendritic cells by fiber-mutant adenovirus vectors

Okada N., Tsukada Y., Nakagawa S., Mizuguchi H., Mori K., Saito T., Fujita T., Yamamoto A., Hayakawa T., Mayumi T.
Biochem. Biophys. Res. Commun., 282, 173-179 (2001)

Involvement of a calcium-independent pathway in plasmin-induced platelet shape change

Ishii-Watabe A., Uchida E., Mizuguchi H., Hayakawa T.
Life Science, 69, 945-960 (2001)

Targeting the replication of adenovirus to p53-defective thyroid carcinoma with a p53-regulated cre/loxP system

Nagayama Y., Nishihara E., Namba H., Yokoi H., Hasegawa M., Mizuguchi H., Hayakawa T., Hamada H., Yamashita S., Niwa M.
Cancer Gene Ther., 8, 36-44 (2001)

Nuclear targeting of DNA

Nakanishi M., Akuta T., Nagoshi E., Eguchi A., Mizuguchi H., Senda T.
Eur. J. Pharm. Sci., 13, 17-24 (2001)

Effects of erythrocytes and serum proteins on lung accumulation of lipoplexes containing cholesterol or DOPE as a helper lipid in the single-pass rat lung perfusion system

Sakurai F, Nishioka T, Yamashita F, Takakura Y, and Hashida M.
Eur. J. Pharm. Biopharm., 52, 165-172 (2001)

Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid

Sakurai F, Nishioka T, Saito H, Baba T, Okuda A, Matsumoto O, Taga T, Yamashita F, Takakura Y, and Hashida M.
Gene Ther., 8, 677-686 (2001)

The earliest stages of B cell development require a chemokine stromal cell-derived factor/pre-B cell growth-stimulating factor

Egawa T, Kawabata K, Kawamoto H, Amada K, Okamoto R, Fujii N, Kishimoto T, Katsura Y, Nagasawa T.
Immunity, 15, 323-334 (2001)

プラスミド構築に基づいた組換えアデノウイルスベクター作製技術

水口裕之, 早川堯夫
BIO INDUSTRY, シーエムシー出版, 18, 5-14 (2001)

遺伝子治療用医薬品の実用化と一層の進展に向けて-新世代アデノウイルスベクターの開発-

早川堯夫, 水口裕之
医薬ジャーナル, 医薬ジャーナル社, 37, 101-107 (2001)

アデノウイルスベクター

水口裕之, 早川堯夫
バイオ医薬品の品質・安全性評価, エル・アイ・シー, 383-393 (2001)

DDSの夢 (ベランダ)

猪狩康孝, 菊地寛, 高倉喜信, 水口裕之, 奥平和穂 (司会)
ファルマシア, 日本薬学会, 37, 369-374 (2001)