Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research

Yamashita T., Inui T., Yokota J., Kawakami K., Morinaga G., Takatani M., Hirayama D., Nomoto R., Ito K., Cui Y., Ruez S., Harada K., Kishimoto W., Nakase H., Mizuguchi H.
Mol. Ther. Methods Clin. Dev., in press.

Comparison of culture media for human intestinal organoids from the viewpoint of pharmacokinetic studies.

Yokota J., Yamashita T., Inui T., Nomoto R., Kishimoto W., Nakase H., Mizuguchi H.
Biochem. Biophys. Res. Commun., in press.

In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology.

Deguchi S., Shintani T., Harada K., Okamoto T., Takemura A., Hirata K., Ito K., Takayama K., Mizuguchi H.
Hepatol. Commun., in press.

ZFAND3 overexpression in the mouse liver improves glucose tolerance and hepatic insulin resistance.

Shimizu K., Ogiya Y., Yoshinaga K., Kimura H., Michinaga S., Ono M., Taketomi A., Terada T., Sakurai F., Mizuguchi H., Tomita K., Nishinaka T.
Exp. Clin. Endocrinol. Diabetes., in press.

Asymmetric profiles of infection and innate immunological responses in human iPS cell-derived small intestinal epithelial-like cell monolayers following infection with mammalian reovirus

Inoue C., Negoro R., Takayama K., Mizuguchi H., Sakurai F.
Virus Res., 296, 198334, in press.

Generation of hepatocytes from human ES/iPS cells for regenerative medicine

Yamashita T., Takayama K., Mizuguchi H.
Springer Book: Cell-Inspired Materials and Engineering, Springer, 3-26 (2021)

Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system.

Ichikawa M., Akamine H., Murata M., Ito S., Takayama K., Mizuguchi H.
Sci. Rep., 11, 11670 (2021)

Adenovirus Vector-Induced IL-6 Promotes Leaky Adenoviral Gene Expression, Leading to Acute Hepatotoxicity

Shimizu K., Sakurai F., Iizuka S., Ono R., Tsukamoto T., Nishimae F., Nakamura SI., Nishinaka T., Terada T., Fujio Y., Mizuguchi H.
J. Immunol., 206, 410-421 (2021)

A TGF-b signaling inhibitor, SB431542, inhibits reovirus-mediated lysis of human hepatocellular carcinoma cells in a TGF-b-independent manner.

Ishigami I., Shuwari N., Kaminade T., Mizuguchi H., Sakurai F.
Anticancer Res., 4, 2431-2440 (2021)

Vinblastine treatment decreases the undifferentiated cell contamination of human iPSC-derived intestinal epithelial-like cells

Ichikawa M.#, Negoro R.#, Kawai K., Yamashita T., Takayama K., Mizuguchi H. #These authors equally contributed to this work.
Mol. Ther. Methods Clin. Dev., 20, 463-472 (2021)

The infectivity of progeny adenovirus in the presence of neutralizing antibody.

Hirai T., Sato A., Koizumi N., Kurioka Y., Suzuki Y., Kano J., Yamakawa M., Nomura T., Fujii M., Sakurai F., Mizuguchi H., Watanabe Y., Utoguchi N.
J. Gen. Virol., 102, 001590 (2021)

Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 35

Ono R., Takayama K., Sakurai F., Mizuguchi H.
Mol. Ther. Oncolytics, 20, 399-409 (2021)

Optimization of an E1A gene expression cassette in an oncolytic adenovirus for efficient tumor cell killing activity

Sakurai F., Nishimae F., Takayama K., Mizuguchi H.
Anticancer Res., 41, 773-782 (2021)

Fiber-knob region of adenovirus type 5 vector promotes migration of A549 cells

Kano J., Koizumi N., Terada A., Matsuoka A., Hirai T., Nomura T., Mizuguchi H., Utoguchi N.
BPB Reports, 4, 17-21 (2021)

In vivo gene expression profile of human intestinal epithelial cells: from the viewpoint of drug metabolism and pharmacokinetics

Takayama K., Ito K., Matsui A., Yamashita T., Kawakami K., Hirayama D., Kishimoto W., Nakase H., Mizuguchi H.
Drug Metab. Dispos., 49, 221-232 (2021)

ゲノム編集モデルの医薬品評価への応用とその課題

鳥羽由希子, 水口裕之
ゲノム編集技術の産業応用技術〜研究動向、課題とその解決、トラブル対策〜, 株式会社 技術情報協会, 339-345 (2021)

Tolloid-like 1 negatively regulates hepatic differentiation of human iPS cells through transforming growth factor beta signaling

Kiso A., Toba Y., Tsutsumi S., Deguchi S., Igai K., Koshino S., Tanaka Y., Takayama K., Mizuguchi H.
Hepatol. Commun., 4, 255-267 (2020)

Photoactivatable oncolytic adenovirus for optogenetic cancer therapy

Hagihara Y., Sakamoto A., Tokuda T., Yamashita T., Ikemoto S., Kimura A., Haruta M., Sasagawa K., Ohta J., Takayama K., Mizuguchi H.
Cell Death Dis., 11, 570 (2020)

Establishment of MDR1-knockout human induced pluripotent stem cell line

Negoro R., Kawai K., Ichikawa M., Deguchi S., Takayama K., Mizuguchi H.
Drug Metab. Pharmacokinet., 35, 288-296 (2020)

Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer

Koujima T., Tazawa H., Ieda T., Araki H., Fushimi T., Shoji R., Kuroda S., Kikuchi S., Yoshida R., Umeda Y., Teraishi F., Urata Y., Mizuguchi H., Fujiwara T.
Mol. Ther. Oncolytics, 17, 107-117 (2020)

 

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