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業績｜論文・出版物｜目次｜ALL
 

Heterogenous gene expression of bicellular and tricellular tight junction-sealing components in the human intestinal tract.

Tachibana K., Bai L., Sugimura S., Fujioka H., Kishimoto W., Mizuguchi H., Nakase H., Kondoh M.

Biol. Pharm. Bull. (in press)

Functional intestinal monolayers from organoids derived from human iPS cells for drug discovery research

Inui T., Uraya Y., Yokota J., Yamashita T., Kawai K., Okada K., Ueyama-Toba Y., Mizuguchi H.

Stem Cell Research & Therapy, 15, 57 (2024)

A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT).

Hanaoka K., Ikeno T., Iwaki S., Deguchi S., Takayama K., Mizuguchi H., Tao F., Kojima N., Ohno H., Sasaki E., Komatsu T., Ueno T., Maeda K., Kusuhara H., Urano Y.

Sci. Adv., 10, eadi8847 (2024)

Overexpression of lysophospholipid acyltransferase, LPLAT10/LPCAT4/LPEAT2, in the mouse liver increases glucose-stimulated insulin secretion.

Shimizu K., Ono M., Mikamoto T., Urayama Y., Yoshida S., Hase T., Michinaga S., Nakanishi H., Iwasaki M., Terada T., Sakurai F., Mizuguchi H., Shindou H., Tomita K., Nishinaka T.

FASEB J., 38, e23425 (2024)

Establishment of human intestinal organoids derived from commercially available cryopreserved intestinal epithelium and evaluation for pharmacokinetic study

Okada K., Yokota J., Yamashita T., Inui T., Kishimoto W., Nakase H., Mizuguchi H.,

Drug Metab Pharmacokinet., 54, 100532 (2024)

Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation.

Shintani T.#, Imamura C.#,?Ueyama-Toba Y.,?Inui J., Watanabe A.,?Mizuguchi H. #These authors equally contributed to this work.

Mol. Ther. Methods Clin. Dev., 30, 429-442 (2023)

Quantitative analysis of mRNA and protein expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in the human intestine.

Hirosawa K., Fujioka H., Morinaga G., Fukami T., Ishiguro N., Kishimoto W., Nakase H., Mizuguchi H., Nakajima M.

Drug Metab Dispos., 51, 1569-1577 (2023)

Novel conditionally replicating adenovirus-mediated efficient detection of circulating tumor cells in lung cancer patients.

Ikemoto S., Sakurai F., Tokuoka S., Yamashita T., Takayama K., Hoshi K., Okabe T., Sumiyoshi I., Togo S., Takahashi K., Tachibana M., Mizuguchi H.

PLoS ONE, 18, e0286323 (2023)

Involvement of protein kinase R in double-stranded RNA-induced proteasomal degradation of hypoxia inducible factor-1a.

Hotani T., Nakagawa K., Tsukamoto T., Mizuguchi H., Sakurai F.

Inflammation, 46, 2332-2342 (2023)

miR-27b targets MAIP1 to mediate lipid accumulation in cultured human and mouse hepatic cells.

Sakai E., Imaizumi T., Suzuki R., Taracena-G?ndara M., Fujimoto T., Sakurai F., Mizuguchi H.

Communi. Biol., 6 (2023)

WebSite

Label-free evaluation of maturation and hepatotoxicity of human iPSC-derived hepatocytes using hyperspectral Raman imaging.

Li M., Ueyama-Toba Y., Lindley M., Kongklad G., Nawa Y., Kumamoto Y., Ishida S., Kanda Y., Fujita S., Mizuguchi H., Fujita, K.

Anal. Chem., 95, 9252-9262 (2023)

PubMed

Treatment of human pancreatic cancers following local and systemic administration of oncolytic adenovirus serotype 35.

Ono R., Takayama K., Onishi R., Tokuoka S., Sakurai F., Mizuguchi H.

Anticancer Res., 43, 537-546 (2023)

PubMed

Development of a method of passaging and freezing human iPS cell-derived hepatocytes to improve their functions.

Inui J., Ueyama-Toba Y., Mitani S., Mizuguchi H.

PLoS ONE, 18, e0285783 (2023)

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Regional transcriptomics and proteomics of pharmacokinetics-related genes in human intestine.

Murata M., Fujioka H., Yokota J., Okada K., Yamashita T., Hirayama D., Kawakami K., Morinaga G., Saito A., Nakase H., Kishimoto W., Mizuguchi H.

Mol. Pharm., 20, 2876-2890 (2023)

PubMed

Biliary epithelial cell differentiation of bipotent human liver-derived organoids by 2D and 3D culture.

Tong Y., Ueyama-Toba Y., Mizuguchi H.

Biochem. Biophys. Rep., 33, 101432 (2023)

PubMed

Pre-treatment of oncolytic reovirus improves tumor accumulation and intratumoral distribution of PEG-liposomes.

Eguchi M., Hirata S., Ishigami I., Shuwari N., Ono R., Tachibana M., Tanuma M., Kasai A., Hashimoto H., Ogawara KI., Mizuguchi H., Sakurai F.

J. Cont. Rel., 354, 35-44 (2023)

PubMed

Establishment of MDR1-knockout human enteroids for pharmaceutical application

Inui T., Nomoto R., Yokota J., Yamashita T., Okada K., Kishimoto W., Nakase H., Mizuguchi H.

Drug Metab Pharmacokinet., 48, 100476 (2023)

PubMed

Comparison of human biopsy-derived and human iPS cell-derived intestinal organoids established from a single individual

Inui T., Yamashita T., Tomita J., Yokota J., Kishimoto W., Nakase H., Mizuguchi H.

Drug Metab Pharmacokinet., 48, 100482 (2023)

WebSite

Y-27632

植山（鳥羽）由希子、水口裕之

消化器病学サイエンス, 7, 162 (2023)

新規アデノウイルス製剤　～非増殖型ベクターと腫瘍溶解性ウイルス～

水口裕之

医学のあゆみ, 285, 310-316 (2023)

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