業績｜論文・出版物｜目次｜ALL

Two-dimensionally cultured functional hepatocytes generated from human induced pluripotent stem cell-derived hepatic organoids for pharmaceutical research.

Inui J., Ueyama-Toba Y., Nagai W., Asano R., Mizuguchi H.

Biomaterials (in press)

Air–liquid interface culture alters the characteristics and functions of monolayers generated from human iPS cell‑derived enterocyte‑like cell organoids

Inui T., Uraya Y., Ueyama-Toba Y., Mizuguchi H.

Eur. J. Cell Biol. (in press)

Evaluation of the correlation between nuclear localization levels and genome editing efficiencies of Cas12a fused with nuclear localization signals.

Tsukamoto T., Mizuta H., Sakai E., Sakurai F., Mizuguchi H.

J. Pharm. Sci. (in press)

Adenoviral Vector Construction II: Bacterial Systems

Hemmi M, Mizuguchi H.

Adenoviral Vectors for Gene Therapy (Third Edition) (in press)

ヒト肝臓オルガノイドの創薬研究への応用

植山（鳥羽）由希子、仝嫣然、水口裕之

薬学雑誌 (in press)

ヒト腸管オルガノイドを用いた医薬品開発プラットフォーム

乾達也、水口裕之

創薬研究における細胞培養の今 (in press)

植山（鳥羽）由希子、水口裕之

薬剤学 (in press)

Generation and application of CES1-knockout Tet-Off-regulated CYP3A4 and UGT1A1-expressing Caco-2 cells.

Murata M., Okada K., Takahashi M., Ueyama-Toba Y., Ito S., Mizuguchi H.

Toxicol Lett., 401, 158-169 (2024)

Development of a hepatic differentiation method in 2D culture from primary human hepatocyte-derived organoids for pharmaceutical research.

Ueyama-Toba Y., Tong Y., Yokota J., Murai K., Hikita H., Eguchi H., Takehara T., Mizuguchi H.

iScience, 27, 110778 (2024)

Development of a novel adenovirus serotype 35 vector vaccine possessing an RGD peptide in the fiber knob and the E4 orf 4, 6, and 6/7 regions of adenovirus serotype 5

Onishi R., Ikemoto S., Shiota A., Tsukamoto T., Asayama A., Tachibana M., Sakurai F., Mizuguchi H.

Int J Pharm., 662, 124480 (2024)

Transplacental delivery of factor IX Fc-fusion protein ameliorates bleeding phenotype of newborn hemophilia B mice

Sakurai F., Iizuka S., Tsukamoto T., Shiota A., Shimizu K., Ohashi K., Mizuguchi H.

J Control Release, 374, 415-424 (2024)

Small extracellular vesicles carrying reovirus, tumor antigens, interferon-β, and damage-associated molecular patterns for efficient tumor treatment

Shuwari N., Inoue C., Ishigami I., Jingushi K., Kamiya M., Kawakami S., Tsujikawa K., Tachibana M., Mizuguchi H., Sakurai F.

J Control Release, 374, 89-102 (2024)

Efficient hepatocyte differentiation of primary human hepatocyte-derived organoids using three dimensional nanofibers (HYDROX) and their possible application in hepatotoxicity research

Tong Y., Ueyama-Toba Y., Yokota Y., Matsui H., Kanai M., Mizuguchi H.

Sci. Rep., 14, 10846 (2024)

Development of an Improved Adenovirus Vector and Its Application to the Treatment of Lifestyle-Related Diseases

Shimzu K.

Biol Pharm Bull., 47, 886-894 (2024)

Functional intestinal monolayers from organoids derived from human iPS cells for drug discovery research

Inui T., Uraya Y., Yokota J., Yamashita T., Kawai K., Okada K., Ueyama-Toba Y., Mizuguchi H.

Stem Cell Research & Therapy, 15, 57 (2024)

Heterogenous gene expression of bicellular and tricellular tight junction-sealing components in the human intestinal tract.

Tachibana K., Bai L., Sugimura S., Fujioka H., Kishimoto W., Mizuguchi H., Nakase H., Kondoh M.

Biol. Pharm. Bull., 47, 1209-1217 (2024)

A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT).

Hanaoka K., Ikeno T., Iwaki S., Deguchi S., Takayama K., Mizuguchi H., Tao F., Kojima N., Ohno H., Sasaki E., Komatsu T., Ueno T., Maeda K., Kusuhara H., Urano Y.

Sci. Adv., 10, eadi8847 (2024)

Overexpression of lysophospholipid acyltransferase, LPLAT10/LPCAT4/LPEAT2, in the mouse liver increases glucose-stimulated insulin secretion.

Shimizu K., Ono M., Mikamoto T., Urayama Y., Yoshida S., Hase T., Michinaga S., Nakanishi H., Iwasaki M., Terada T., Sakurai F., Mizuguchi H., Shindou H., Tomita K., Nishinaka T.

FASEB J., 38, e23425 (2024)

Establishment of human intestinal organoids derived from commercially available cryopreserved intestinal epithelium and evaluation for pharmacokinetic study

Okada K., Yokota J., Yamashita T., Inui T., Kishimoto W., Nakase H., Mizuguchi H.,

Drug Metab Pharmacokinet., 54, 100532 (2024)

Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation.

Shintani T.#, Imamura C.#,?Ueyama-Toba Y.,?Inui J., Watanabe A.,?Mizuguchi H. #These authors equally contributed to this work.

Mol. Ther. Methods Clin. Dev., 30, 429-442 (2023)

目次に戻る

大阪大学大学院薬学研究科分子生物学分野

Laboratory of Biochemistry and Molecular Biology

Graduate School of Pharmaceutical Sciences, Osaka University

業績｜論文・出版物｜目次｜ALL