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大阪大学大学院薬学研究科分子生物学分野

Laboratory of Biochemistry and Molecular Biology

Graduate School of Pharmaceutical Sciences, Osaka University

業績｜論文・出版物｜目次｜ALL

Transduction properties of an adenovirus vector containing sequences complementary to a liver-specific microRNA, miR-122a, in the 3'-untranslated region of the E4 gene in human hepatocytes from chimeric mice with humanized liver.

Sakurai F., Tsukamoto T., Ono R., Nishimae F., Shiota A., Iizuka S., Shimizu K., Sakai E., Ishida Y., Tateno C., Chayama K., Mizuguchi H.

Biol. Pharm. Bull. (in press)

Involvement of protein kinase R in double-stranded RNA-induced proteasomal degradation of hypoxia inducible factor-1a.

Hotani T., Nakagawa K., Tsukamoto T., Mizuguchi H., Sakurai F.

Inflammation (in press)

Quantitative analysis of mRNA and protein expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in the human intestine.

Hirosawa K., Fujioka H., Morinaga G., Fukami T., Ishiguro N., Kishimoto W., Nakase H., Mizuguchi H., Nakajima M.

Drug Metab Dispos. (in press)

Establishment of human intestinal organoids derived from commercially available cryopreserved intestinal epithelium and evaluation for pharmacokinetic study

Okada K., Yokota J., Yamashita T., Inui T., Kishimoto W., Nakase H., Mizuguchi H.,

Drug Metab Pharmacokinet., 100532 (in press)

Novel conditionally replicating adenovirus-mediated efficient detection of circulating tumor cells in lung cancer patients.

Ikemoto S., Sakurai F., Tokuoka S., Yamashita T., Takayama K., Hoshi K., Okabe T., Sumiyoshi I., Togo S., Takahashi K., Tachibana M., Mizuguchi H.

PLoS ONE, 18, e0286323 (2023)

Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation.

Shintani T.#, Imamura C.#, Ueyama-Toba Y., Inui J., Watanabe A., Mizuguchi H. #These authors equally contributed to this work.

Mol. Ther. Methods Clin. Dev., 30, 429-442 (2023)

miR-27b targets MAIP1 to mediate lipid accumulation in cultured human and mouse hepatic cells.

Sakai E., Imaizumi T., Suzuki R., Taracena-Gandara M., Fujimoto T., Sakurai F., Mizuguchi H.

Communi. Biol., 6 (2023)

Label-free evaluation of maturation and hepatotoxicity of human iPSC-derived hepatocytes using hyperspectral Raman imaging.

Li M., Ueyama-Toba Y., Lindley M., Kongklad G., Nawa Y., Kumamoto Y., Ishida S., Kanda Y., Fujita S., Mizuguchi H., Fujita, K.

Anal. Chem., 95, 9252-9262 (2023)

Treatment of human pancreatic cancers following local and systemic administration of oncolytic adenovirus serotype 35.

Ono R., Takayama K., Onishi R., Tokuoka S., Sakurai F., Mizuguchi H.

Anticancer Res., 43, 537-546 (2023)

Development of a method of passaging and freezing human iPS cell-derived hepatocytes to improve their functions.

Inui J., Ueyama-Toba Y., Mitani S., Mizuguchi H.

PLoS ONE, 18, e0285783 (2023)

Regional transcriptomics and proteomics of pharmacokinetics-related genes in human intestine.

Murata M., Fujioka H., Yokota J., Okada K., Yamashita T., Hirayama D., Kawakami K., Morinaga G., Saito A., Nakase H., Kishimoto W., Mizuguchi H.

Mol. Pharm., 20, 2876-2890 (2023)

Biliary epithelial cell differentiation of bipotent human liver-derived organoids by 2D and 3D culture.

Tong Y., Ueyama-Toba Y., Mizuguchi H.

Biochem. Biophys. Rep., 33, 101432 (2023)

Pre-treatment of oncolytic reovirus improves tumor accumulation and intratumoral distribution of PEG-liposomes.

Eguchi M., Hirata S., Ishigami I., Shuwari N., Ono R., Tachibana M., Tanuma M., Kasai A., Hashimoto H., Ogawara KI., Mizuguchi H., Sakurai F.

J. Cont. Rel., 354, 35-44 (2023)

Establishment of MDR1-knockout human enteroids for pharmaceutical application

Inui T., Nomoto R., Yokota J., Yamashita T., Okada K., Kishimoto W., Nakase H., Mizuguchi H.

Drug Metab Pharmacokinet., 48, 100476 (2023)

Comparison of human biopsy-derived and human iPS cell-derived intestinal organoids established from a single individual

Inui T., Yamashita T., Tomita J., Yokota J., Kishimoto W., Nakase H., Mizuguchi H.

Drug Metab Pharmacokinet., 48, 100482 (2023)

新規アデノウイルス製剤　～非増殖型ベクターと腫瘍溶解性ウイルス～

水口裕之

医学のあゆみ, 285, 310-316 (2023)

ヒトiPS細胞を用いた食の評価系　～ヒトiPS細胞から分化誘導した腸管上皮細胞～

水口裕之

実験医学, 41, 1584-1588 (2023)

腫瘍溶解性ウイルスによる抗腫瘍免疫の活性化とがん免疫療法との併用

櫻井文教、水口裕之

ドラックデリバリーシステム, 38, 24-30 (2023)

アデノウイルスベクター

水口裕之

遺伝子細胞治療ハンドブック, 株式会社エヌ・ティー・エス, 2, 30-36 (2023)

Y-27632

植山（鳥羽）由希子、水口裕之

消化器病学サイエンス, 7, 162 (2023)

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