業績|論文・出版物|

2017

Generation of safe and therapeutically effective human iPS cell-derived hepatocyte-like cells for regenerative medicine

Takayama K.#, Akita N.#, Mimura N., Akahira R., Taniguchi Y., Ikeda M., Sakurai F., Ohara O., Morio T., Sekiguchi K., Mizuguchi H.
Hepatol. Commun.
1
1058-1069
2017

Th17 Promotes Induction of antigen-specific gut-mucosal CTLs following adenovirus vector vaccination

Hemmi M.#, Tachibana M.#, Fujimoto N., Shoji M., Sakurai F., Kobiyama K., Ishii K.J., Akira S., Mizuguchi H.
Front. Immunol.
8
1456
2017

Suppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB

Machitani M., Sakurai F., Wakabayashi K., Nakatani K., Tachibana M., Kato N., Fujiwara T., Mizuguchi H.
Mol. Ther. Oncolytics
7
76-85
2017

Human ES/iPS cell-derived hepatocyte-like cells achieve zone-specific hepatic properties by modulation of WNT signaling

Mitani S.#, Takayama K.#, Nagamoto Y., Imagawa K., Sakurai F., Tachibana M., Sumazaki R., Mizuguchi H.
Mol. Ther.
25
1420-1433
2017

Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells

Sakurai F.#, Kunito T.#, Takayama K., Hashimoto R., Tachibana M., Sakamoto N., Wakita T., Mizuguchi H.
Virus Res.
242
7-15
2017

Neonatal gene therapy for hemophilia B by a novel adenovirus vector showing sustained transgene expression via a reduction in the leaky expression of viral genes

Iizuka S., Sakurai F., Tachibana M., Ohashi K., Mizuguchi H.
Mol. Ther. Methods Clin. Dev.
6
183-193
2017

Adenovirus vector-mediated macrophage erythroblast attacher (MAEA) overexpression in primary mouse hepatocytes attenuates hepatic gluconeogenesis

Shimizu K., Okamoto M., Terada T., Sakurai F., Mizuguchi H., Tomita K., Nishinaka T.
Biochem. Biophys. Rep.
10
192-197
2017

A mammalian mirtron miR-1224 promotes tube-formation of human primary endothelial cells by targeting anti-angiogenic factor epsin2

Sakai E., Miura Y., Suzuki-Kouyama E., Oka K., Tachibana M., Kawabata K., Sakurai F., Mizuguchi H.
Sci. Rep.
7
5541
2017

Sensitive detection of viable circulating tumor cells using a novel conditionally telomerase-selective replicating adenovirus in non-small cell lung cancer patients

Togo S., Katagiri N., Namba Y., Tulafu M., Nagahama K., Kadoya K., Takamochi K., Oh S., Suzuki K., Sakurai F., Mizuguchi H., Urata Y., Takahashi K.
Oncotarget
8
34884-34895
2017

Overexpression of miR-27b negatively regulates expression of pluripotency-associated genes and hepatic differentiation in human induced pluripotent stem cells

Lim J., Sakai E., Takayama K., Sakurai F., Mizuguchi H.
Stem Cell Res. Ther.
2
88-97
2017

Cationic liposome-mediated delivery of reovirus enhances the tumor cell-killing efficiencies of reovirus in reovirus-resistant tumor cells

Sakurai F., Inoue S., Kaminade T., Hotani T., Katayama Y., Hosoyamada E., Terasawa Y., Tachibana M., Mizuguchi H.
Int. J. Pharm.
524
238-247
2017

Generation of a bile salt export pump deficiency model using patient-specific iPSC-derived hepatocyte-like cells

Imagawa K., Takayama K., Isoyama S., Tanikawa K., Shinkai M., Harada K., Tachibana M., Sakurai F., Noguchi E., Hirata K., Kage M., Kawabata K., Sumazaki R., Mizuguchi H.
Sci. Rep.
7
41806
2017

MicroRNA miR-27 inhibits adenovirus infection by suppressing the expression of SNAP25 and TXN2

Machitani M., Sakurai F., Wakabayashi K., Nakatani K., Tachibana M., Mizuguchi H.
J. Virol.
91
e00159-17
2017

Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection

Sakurai F.#, Mitani S.#, Yamamoto T.#, Takayama K., Tachibana M., Watashi K., Wakita T., Iijima S., Tanaka Y., Mizuguchi H.
Sci. Rep.
7
45698
2017

Inhibition of CRISPR/Cas9-mediated genome engineering by a type I interferon-induced reduction in guide RNA expression

Machitani M.#, Sakurai F.#, Wakabayashi K., Nakatani K., Takayama K., Tachibana M., Mizuguchi H.
Biol. Pharm. Bull.
40
272-277
2017

Enhanced oncolytic activities of the telomerase-specific replication-competent adenovirus expressing short-hairpin RNA against Dicer

Machitani M.#, Sakurai F.#, Wakabayashi K., Tachibana M., Fujiwara T., Mizuguchi H.
Mol. Cancer Ther.
16
251-259
2017

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction

Nakamori D.#, Akamine H.#, Takayama K.#, Sakurai F., Mizuguchi H.
Sci. Rep.
7
16675
2017

Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions

Fukuda T., Takayama K., Hirata M., Liu Y-J, Yanagihara K., Suga M., Mizuguchi H., Furue M.K.
Exp. Cell Res.
352
333-345
2017

Identification of adenovirus-derived cell-penetrating peptide

Hirai T., Yamagishi Y., Koizumi N., Nonaka M., Mochida R., Shida K., Nomura T., Fujii M., Sakurai F., Mizuguchi H., Watanabe Y., Utoguchi N.
Biol. Pharm. Bull.
40
195-204
2017

Eradication of melanoma in vitro and in vivo via targeting with a Killer-Red-containing telomerase-dependent adenovirus

Takehara K., Yano S., Tazawa H., Okada N., Kishimoto H., Narii N., Mizuguchi H., Urata Y., Kagawa S., Fujiwara T., Hoffman R.M.
Cell Cycle
16
1502-1508
2017

Highly efficient biallelic genome editing of human ES/iPS cells Using a CRISPR/Cas9 or TALEN system

Takayama K., Igai K., Hagihara Y., Hashimoto R., Hanawa M., Sakuma T., Tachibana M., Sakurai F., Yamamoto T., Mizuguchi H.
Nuc. Acid Res.
45
5198-5207
2017

Type I interferons impede short-hairpin RNA-mediated RNA interference via inhibition of dicer-mediated processing to small interfering RNA

Machitani M.#, Sakurai F.#, Wakabayashi K., Takayama K., Tachibana M., Mizuguchi H.
Mol. Ther. Nucleic Acids
6
173-182
2017

Hepatocyte Nuclear Factor 4 alpha promotes definitive endoderm differentiation from human induced pluripotent stem cells

Hanawa M., Takayama K., Sakurai F., Tachibana M., Mizuguchi H.
Stem Cell Rev.
13
542-551
2017

Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening

Takayama K., Mizuguchi H.
Drug Metab. Pharmacokinet.
32
12-20
2017

zone特異的性質を有するヒトES/iPS細胞由来肝細胞の作製法の開発

三谷成二, 高山和雄, 水口裕之
肝細胞研究会HP・研究交流
2017

 大阪大学大学院 薬学研究科 分子生物学分野 

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Copyright© Laboratory of Biochemistry and Molecular Biology, Graduate School and School of Pharmaceutical Sciences, Osaka University

directed by Prof. Hiroyuki Mizuguchi

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