業績|論文・出版物|

2014

Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes

Takayama K., Morisaki Y., Kuno S., Nagamoto Y., Harada K., Furukawa N., Ohtaka M., Nishimura K., Imagawa K., Sakurai F., Tachibana M., Sumazaki R., Noguchi E., Nakanishi M., Hirata K., Kawabata K., Mizuguchi H.
Proc. Natl. Acad. Sci. USA
111
16772-16777
2014

Protective mucosal immunity mediated by epithelial CD1d and IL-10

Olszak T., Neves J., Dowds M., Baker K.K., Glickman J., Davidson N., Lin C-Y., Jobin C., Brand S., Sotlar K., Wada K., Katayama K., Nakajima A., Mizuguchi H., Kawasaki K., Nagata K., Müller W., Snapper S., Schreiber S., Kaser A., Zeissig S., Blumberg RS.
Nature
509
497-502
2014

The Early Activation of CD8(+) T Cells is dependent on type I IFN Ssignaling following intramuscular vaccination of adenovirus vector

Hemmi M.#, Tachibana M.#, Tsuzuki S., Shoji M., Sakurai F., Kawabata K., Kobiyama K., Ishii K.J., Akira S., Mizuguchi H.
BioMed Res. Int.
158128
2014

Upregulation of RECK gene expression by small double-stranded RNA targeting the promoter region

Sakurai F.#, Nanjo Y.#, Okamoto S., Tachibana M., Mizuguchi H.
Cancer Gene Ther.
21
219-227
2014

CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determine the hepatoblast fate decision

Takayama K., Kawabata K., Nagamoto Y., Inamura M., Ohashi K., Okuno H., Yamaguchi T., Tashiro K., Sakurai F., Hayakawa T., Okano T., Furue MK., Mizuguchi H.
Development
141
91-100
2014

Development of mice exhibiting hepatic microsomal activity of human CYP3A4 comparable to that in human liver microsomes by intravenous administration of an adenovirus vector expressing human CYP3A4

Kuno S., Sakurai F., Shimizu K., Matsumura N., Kim S., Watanabe H., Tashiro K., Tachibana M., Yokoi T., Mizuguchi H.
Drug Metab. Pharmacokinet.
29
296-304
2014

HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin

Watanabe H.#, Takayama K.#, Inamura M., Tachibana M., Mimura N., Tashiro K., Nagamoto Y., Sakurai F., Kawabata K., Furue MK., Mizuguchi H.
PLoS One
9
e90791
2014

Enhanced expression of the β4-galactosyltransferase 2 gene impairs mammalian tumor growth

Tagawa M., Shirane K., Yu L., Sato T., Furukawa S., Mizuguchi H., Kuji R., Kawamura K., Takahashi N., Kato K., Hayakawa S., Sawada S., Furukawa K.
Cancer Gene Ther.
21
219-227
2014

Polyethyleneimine-coating enhances adenoviral transduction of mesenchymal stem cells

Yao X, Zhou N, Wan L, Su X, Sun Z, Mizuguchi H., Yoshioka Y, Nakagawa S, Zhao RC, Gao JQ.
Biochem. Biophys. Res. Commun.
447
383-387
2014

Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome

Shimizu K., Sakurai F., Tomita K., Nagamoto Y., Nakamura S., Katayama K., Tachibana M., Kawabata K., Mizuguchi H.
Mol. Ther. Methods Clin. Dev.
1
14035
2014

Plasma elevation of vascular endothelial growth factor leads to the reduction of mouse hematopoietic and mesenchymal stem/progenitor cells in the bone marrow

Tashiro K.#, Nonaka A.#, Hirata N., Yamaguchi T., Mizuguchi H., Kawabata K.
Stem Cells Dev.
23
2202-2210
2014

Hepatic differentiation of human embryonic stem cells and induced pluripotent stem cells by two- and three-dimensional culture systems in vitro

Higuchi M., Mizuguchi H.
Engineered Cell Manipulation for Biomedical Application
147-158
2014

3次元組織化技術を利用したヒトES/iPS細胞から肝細胞への分化誘導法

長基康人, 高山和雄, 水口裕之
遺伝子医学MOOK別冊 細胞の3次元組織化 -その最先端技術と材料技術
244-248
2014

iPS細胞由来組織細胞を用いた毒性試験

水口裕之, 高山和雄
実験医学別冊 ES・iPS細胞実験スタンダード
345-350
2014

 大阪大学大学院 薬学研究科 分子生物学分野 

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Copyright© Laboratory of Biochemistry and Molecular Biology, Graduate School and School of Pharmaceutical Sciences, Osaka University

directed by Prof. Hiroyuki Mizuguchi

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