業績|論文・出版物|

2012

Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-122a

Sakurai F., Furukawa N., Higuchi M., Okamoto S., Ono K., Yoshida T., Kondoh M., Yagi K., Sakamoto N., Katayama K., Mizuguchi H.
Virus Res.
165
214-218
2012

Optimization and internalization mechanisms of PEGylated adenovirus vector with targeting peptide for cancer gene therapy

Yao X.L., Yoshioka Y., Ruan G.X., Chen Y.Z., Mizuguchi H., Mukai Y., Okada N., Gao J.Q., Nakagawa S.
Biomacromolecules
13
2402-2409
2012

Efficient antitumor effects of carrier cells loaded with a fiber-substituted conditionally replicating adenovirus on CAR-negative tumor cells

Iguchi K., Sakurai F., Tomita K., Katayama K., Yamaguchi T., Tagawa M., Kawabata M., Shirakawa T., Mizuguchi H.
Cancer Gene Ther.
19
118-125
2012

A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression

Yamasaki Y., Tazawa H., Hashimoto Y., Kojima T., Kuroda S., Yano S., Yoshida R., Uno F., Mizuguchi H., Ohtsuru A., Urata Y., Kagawa S., Fujiwara T.
Eur. J. Cancer
48
2282-2291
2012

Efficient hepatic differentiation from human iPS cells by gene transfer

Kawabata K., Inamura M., Mizuguchi H.
Methods Mol. Biol.
826
115-124
2012

Further reduction in adenovirus vector-mediated liver transduction without largely affecting transgene expression in target organ by exploiting microRNA-mediated regulation and the Cre-loxP recombination system

Bennett D., Sakurai F., Shimizu K., Matsui H., Tomita K., Suzuki T., Katayama K., Kawabata K., Mizuguchi H.
Mol. Pharm.
9
3452-63
2012

Endodermal and hepatic differentiation from human embryonic stem cells and human induced pluripotent stem cells

Kawabata K., Takayama K., Nagamoto Y., Saldon M.S., Higuchi M., Mizuguchi H.
J. Stem Cell Res. Ther.
S10
2012

マイクロRNAを利用してウイルス遺伝子の非特異的な発現を抑制可能な新規アデノウイルスベクターの開発

清水かほり, 櫻井文教, 立花雅史, 水口裕之
薬学雑誌
132
1407-1412
2012

ヒトiPS細胞から肝細胞への分化誘導の現状と創薬応用

水口裕之, 高山和雄, 長基康人, 川端健二
医薬品医療機器レギュラトリーサイエンス
43
982-987
2012

ヒトiPS細胞の再生医療及び創薬研究への応用の現状と展望

早川堯夫, 水口裕之
Brain and Nerve
64
47-57
2012

ウイルスベクターと遺伝子治療

水口裕之, 櫻井文教
新編ウイルスの今日的意味
101-108
2012

多能性幹細胞から肝細胞への分化誘導

高山和雄, 川端健二, 水口裕之
再生医療業書
110-116
2012

iPS細胞研究の道しるべ 遺伝子治療研究の貢献と教訓

水口裕之
ファルマシア
48
827
2012

microRNAによる遺伝子発現制御システムを搭載した遺伝子発現ベクター

櫻井文教, 水口裕之
ドラッグデリバリーシステムの新展開II―核酸医薬・抗体医薬・ワクチン医療を支えるDDS技術―
278
47-53
2012

Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction

Takayama K., Inamura M., Kawabata K., Sugawara M., Kikuchi K., Higuchi M., Nagamoto Y., Watanabe H., Tashiro K., Sakurai F., Hayakawa T., Furue MK., Mizuguchi H.
J. Hepatol.
57
628-636
2012

Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction

Takayama K., Inamura M., Kawabata K., Katayama K., Higuchi M., Tashiro K., Nonaka A., Sakurai F., Hayakawa T., Furue MK., Mizuguchi H.
Mol. Ther.
20
127-137
2012

Intramuscular DNA immunization with in vivo electroporation induces antigen-specific cellular and humoral immune responses in both systemic and gut-mucosal compartments

Shoji M., Katayama K., Tachibana M., Tomita K., Sakurai F., Kawabata K., Mizuguchi H.
Vaccine
30
7278-7285
2012

Type-I IFN signaling is required for the induction of antigen-specific CD8+ T cell responses by adenovirus vector vaccine in the gut-mucosa

Shoji M., Tachibana M., Katayama K., Tomita K., Tsuzuki S., Sakurai F., Ishii K.J., Akira S., Mizuguchi H.
Biochem. Biophys. Res. Commun.
425
89-93
2012

Promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets

Nagamoto Y., Tashiro K., Takayama K., Ohashi K., Kawabata K., Sakurai F., Tachibana M., Hayakawa T., Furue MK., Mizuguchi H.
Biomaterials
33
4526-4534
2012

A hexon-specific PEGylated adenovirus vector utilizing blood coagulation factor X

Matsui H., Sakurai F., Katayama K., Yamaguchi T., Okamoto S., Takahira K., Tachibana M., Nakagawa S., Mizuguchi H.
Biomaterials
33
3743-3755
2012

Inhibition of Lnk in mouse induced pluripotent stem cells promotes hematopoietic cell generation

Tashiro K., Omori M., Kawabata K., Hirata N., Yamaguchi T., Sakurai F., Takaki S., Mizuguchi H.
Stem Cell Dev.
21
3381-3390
2012

Improved Gene Transfer into Bladder Cancer Cells Using Adenovirus Vector Containing RGD Motif

Hiwasa K., Nagaya H., Terao S., Acharya B., Hamada K., Mizuguchi H., Gotoh A.
Anticancer Res.
32
3137-3140
2012

Promotion of hematopoietic differentiation from mouse induced pluripotent stem cells by transient HoxB4 transduction

Tashiro K., Kawabata K., Omori M., Yamaguchi T., Sakurai F., Katayama K., Hayakawa H., Mizuguchi H.
Stem Cell Res.
8
300-311
2012

Correlation between adenovirus-neutralizing antibody titer and adenovirus vector-mediated transduction efficiency following intratumoral injection

Tomita K., Sakurai F., Tachibana M., Mizuguchi H.
Anticancer Res.
32
1145-1152
2012

Immunogenic Comparison of Chimeric Adenovirus 5/35 Vector Carrying Optimized Human Immunodeficiency Virus Clade C Genes and Various Promoters

Shoji M., Yoshizaki S., Mizuguchi H., Okuda K., Shimada M.
PLoS One
7
e30302
2012

 大阪大学大学院 薬学研究科 分子生物学分野 

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Copyright© Laboratory of Biochemistry and Molecular Biology, Graduate School and School of Pharmaceutical Sciences, Osaka University

directed by Prof. Hiroyuki Mizuguchi

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