業績|論文・出版物|

2011

Efficient generation of hepatoblastsfrom human ES cells and iPS cells by transient overexpression of homeobox gene HEX

Inamura M., Kawabata K., Takayama K., Tashiro K., Sakurai F., Katayama K., Toyoda M., Akutsu H., Miyagawa Y.,Okita H., Kiyokawa N., Umezawa A., Hayakawa T., Furue MK., Mizuguchi H.
Mol. Ther.
19
400-407
2011

Efficient and directive generation of two distinct endoderm lineages from human ES and iPS cells by differentiation stage-specific SOX17 transduction

Takayama K., Inamura M., Kawabata K., Tashiro K., Katayama K., Hayakawa T., Furue MK., Mizuguchi H.
PLoS One
6
e21780
2011

Enhanced safety profiles of the telomerase-specific replication-competent adenovirus by incorporation of normal cell-specific microRNA-targeted sequences

Sugio K., Sakurai F., Katayama K., Matsui H., Kawabata K., Kawase A., Iwaki M., Hayakawa T., Fujiwara T., Mizuguchi H.
Clin. Cancer Res.
17
2807-2818
2011

Hexon-specific PEGylated adenovirus vectors utilizing avidin-biotin interaction

Suzuki-Kouyama E., Katayama K., Sakurai F., Yamaguchi T., Kurachi S., Kawabata K., Nakagawa S., Mizuguchi H.
Biomaterials
32
1724-1730
2011

Enhanced transduction efficiency of fiber-substituted adenovirus vectors by the incorporation of RGD peptides in two distinct regions of the adenovirus serotype 35 fiber knob

Matsui H., Sakurai F., Katayama K., Kurachi S., Tashiro K., Sugio K., Kawabata K., Mizuguchi H.
Virus Res.
155
48-54
2011

Development of a recombinant adenovirus vector production system free of replication-competent adenovirus by utilizing a packaging size limit of the viral genome

Suzuki T., Sasaki T., Yano K., Sakurai F., Kawabata K., Kondoh M., Hayakawa T., Yagi K., Mizuguchi H.
Virus Res.
158
154-160
2011

Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection

Yoshida T.#, Takayama K.#, Kondoh M.*, Sakurai F., Tani H., Sakamoto N., Matsuura Y., Mizuguchi H*., Yagi K*.
Biochem. Biophys. Res. Commun.
416
119-124
2011

An effective gene-knockdown using multiple shRNA-expressing adenovirus vectors

Motegi Y., Katayama K., Sakurai F., Kato T., Yamaguchi T., Matsui H., Takahashi M., Kawabata K., Mizuguchi H.
J. Control. Release
153
149-153
2011

Quantitative analysis of the leaky expression of adenovirus genes in cells transduced with a replication-incompetent adenovirus vector

Shimizu K., Sakurai F., Machitani M., Katayama K., Mizuguchi H.
Mol. Pharmaceutics
8
1430-1435
2011

Development of an adenovirus vector lacking the expression of virus-associated RNAs

Machitani M., Katayama K., Sakurai F., Matsui H., Yamaguchi T., Suzuki T., Miyoshi H., Kawabata K., Mizuguchi H.
J. Control. Release
154
285-289
2011

Enhanced in vivo gene transfer into the placenta using RGD fiber-mutant adenovirus vector

Katayama K., Furuki R., Yokoyama H., Kaneko M., Tachibana M., Yoshida I., Nagase H., Tanaka K., Sakurai F., Mizuguchi H., Nakagawa S., Nakanishi T.
Biomaterials
32
4185-4193
2011

Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma

Iwahori K., Serada S., Fujimoto M., Nomura S., Osaki T., Lee C.M., Mizuguchi H., Takahashi T., Ripley B., Okumura M., Kawase I., Kishimoto T., Naka T.
Int. J. Cancer
129
993-1005
2011

Adenovirus vector-mediated assay system for Hepatitis C virus replication

Yoshida T., Kondoh M., Ojima M., Mizuguchi H., Yamagishi Y., Sakamoto N., Yagi K.
Nuc. Acid Res.
39
e64
2011

Optimization of a microRNA expression vector for function analysis of microRNA

Furukawa N., Sakurai F., Katayama K., Seki N., Kawabata K., Mizuguchi H.
J. Control. Release
150
94-101
2011

EpCAM- and EGFR- targeted selective gene therapy for biliary cancers using Z33-fiber modified adenovirus

Kawashima R., Abei M., Fukuda K., Nakamura K., Murata T., Wakayama M., Seo E., Hasegawa N., Mizuguchi H., Obata Y., Hyodo I., Hamada H., Yokoyama K.K.
Int. J. Cancer
129
1244-53
2011

Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors

Iwata-Kajihara T., Sumimoto H., Kawamura N., Ueda R., Takahashi T., Mizuguchi H., Miyagishi M., Takeda K., Kawakami Y.
J. Immunol.
187
27-36
2011

Tumor vascular targeted delivery of polymer-conjugated adenovirus vector for cancer gene therapy

Yao X., Yoshioka Y., Morishige T., Eto Y., Narimatsu S., Kawai Y., Mizuguchi H., Gao J.Q., Mukai Y., Okada N., Nakagawa S.
Mol. Ther.
19
1619-1625
2011

Adenovirus vector-derived VA-RNA-mediated innate immune responses

Machitani M., Yamaguchi T., Shimizu K., Sakurai F., Katayama K., Kawabata K., Mizuguchi H.
Pharmaceutics
3
38-353
2011

MicroRNA-regulated transgene expression system for gene therapy and virotherapy

Sakurai F., Katayama K., Mizuguchi H.
Front. Biosci.
17
2389-2401
2011

改良型アデノウイルスベクターの開発と神経系細胞への遺伝子導入

松井勇人, 櫻井文教, 形山和史, 水口裕之
日本薬理学会雑誌
137
70-74
2011

ウイルスベクターと遺伝子治療

水口裕之, 櫻井文教
化学療法の領域
27
867-873
2011

ヒトES/iPS細胞から肝細胞への高効率分化誘導と毒性評価系への応用

稲村充, 高山和雄, 川端健二, 水口裕之
生産と技術
63
67-69
2011

iPS細胞分化誘導によるHCV培養モデル

水口裕之, 近藤昌夫, 八木清仁
肝胆膵
63
919-924
2011

スーパー特区研究『ヒトiPS細胞を用いた新規in vitro 毒性評価系の構築』の概要

水口裕之
動物実験代替法学会News Letter
40
21-22
2011