業績|論文・出版物|

2005

Efficient gene transfer into mouse embryonic stem cells with adenovirus vectors

Kawabata K., Sakurai F., Yamaguchi T., Hayakawa T., Mizuguchi H.
Mol. Ther.
12
547-554
2005

Optimization of adenovirus serotype 35 vectors for efficient transduction in human hematopoietic progenitors: comparison of promoter activities

Sakurai F., Kawabata K., Yamaguchi T., Hayakawa T., Mizuguchi H.
Gene Ther.
12
1424-1433
2005

Fiber-modified adenovirus vectors mediate efficient gene transfer into undifferentiated and adipogenic-differentiated human mesenchymal stem cell

Mizuguchi H., Sasaki T., Kawabata K., Sakurai F., Hayakawa T.
Biochem. Biophys. Res. Commun.
332
1101-1106
2005

A trial of somatic gene targeting in vivo with an adenovirus vector

Ino A., Naito Y., Mizuguchi H., Handa N., Hayakawa T., Kobayashi I.
Genet. Vaccines Ther.
3
8
2005

Efficient regulation of gene expression using self-contained fiber-modified adenovirus vectors containing the tet-off system

Mizuguchi H., Xu Z-L., Sakurai F., Kawabata K., Yamaguchi T., Hayakawa T.
J. Control. Release
110
202-211
2005

Prime-boost vaccination with plasmid DNA and a chimeric adenovirus type 5 vector with type 35 fiber induces protective immunity against HIV

Xin K-Q., Jounai N., Someya K., Honma K., Mizuguchi H., Naganawa S., Kitamura K., Hayakawa T., Saha S., Takeshita F., Okuda K., Honda M., Klinman D.M., Okuda K.
Gene Ther.
12
1769-1777
2005

Role of C-terminal regions of the C-terminal fragment of Clostridium perfringens enterotoxin in its interaction with claudin-4

Takahashi A., Kondoh M., Masuyama A., Fujii M., Mizuguchi H., Horiguchi Y., Watanabe Y.
J. Control. Release
108
56-62
2005

Role of N-terminal amino acids in the absorption-enhancing effects of the C-terminal fragment of Clostridium Perfringens enterotoxin

Masuyama A., Kondoh M., Seguchi H., Takahashi A., Harada M., Fujii M., Mizuguchi H., Horiguchi Y., Watanabe Y.
J. Pharmacol. Exp. Ther.
314
789-795
2005

Anti-tumor responses induced by chemokine CCL19 transfected into an ovarian carcinoma model via fiber-mutant adenovirus vector

Gao J-Q, Sugita T., Kanagawa N., Iida K., Okada N., Mizuguchi H., Nakayama T., Yoshie O., Tsutsumi Y., Mayumi T., Nakagawa S.
Biol. Pharm. Bull.
28
1066-1070
2005

Transcriptional targeting of RGD fiber-mutant adenovirus vectors can improve the safety of suicide gene therapy for murine melanoma

Okada Y., Okada N., Mizuguchi H., Hayakawa T., Nakagawa S., Mayumi T.
Cancer Gene Ther.
12
608-616
2005

Comparison of transgene expression mediated by several fiber-modified adenovirus vectors in trophoblast cells

Koizumi, N., Kondoh, M., Mizuguchi H., Nakanishi, T., Masuyama, A., Ida, F., Fujii, M., Hayakawa, T., Nakashima, E., Tanaka, K., Watanabe, Y.
Placenta
26
729-734
2005

PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody evasion ability

Eto Y., Gao J-Q., Sekiguchi F., Kurachi S., Katayama K., Mizuguchi H., Hayakawa T., Maeda, M., Kawasaki K., Tsutsumi Y., Mayumi T., Nakagawa S.
J. Gene Med.
7
604-612
2005

Enhanced oncolysis by a tropism-modified telomerase-specific replication-selective adenoviral agent OBP-405 ('Telomelysin-RGD')

Taki M., Kagawa S., Nishizaki M., Mizuguchi H., Hayakawa T., Kyo S., Nagai K., Urata Y., Tanaka N., Fujiwara T.
Oncogene
24
3130-3140
2005

Design and synthesis of a peptide-PEG transporter tool for carrying adenovirus vector into cells

Maeda M., Kida S., Hojo K., Eto Y., Gao J-Q, Kurachi S., Sekiguchi F., Mizuguchi H., Hayakawa T., Mayumi T., Nakagawa S., Kawasaki K.
Bioorg. Med. Chem. Lett.
15
621-624
2005

A single intratumoral injection of a fiber-mutant adenoviral vector encoding interleukin 12 induces remarkable anti-tumor and anti-metastatic activity in mice with Meth-A fibrosarcoma

Gao J-Q, Sugita T., Kanagawa N., Iida K., Eto Y., Motomura Y., Mizuguchi H., Tsutsumi Y., Hayakawa T., Mayumi T., Nakagawa S.
Biochem. Biophys. Res. Commun.
328
1043-1050
2005

Eradication of Epstein-Barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1

Nasimuzzaman, M., Kuroda, M., Dohno, S., Yamamoto, T., Iwatsuki, K., Matsuzaki, S., Rashel, M., Kumita, W., Mizuguchi, H., Hayakawa, T., Nakamura, H., Taguchi, T., Wakiguchi, H., Imai, S.
Mol. Ther.
11
578-590
2005

RNA interference of PPARγ using fiber-modified adenovirus vector efficiently suppresses preadipocyte-to-adipocyte differentiation in 3T3-L1 cells

Hosono T., Mizuguchi H., Katayama K., Koizumi N., Kawabata K., Yamaguchi T., Nakagawa S., Watanabe Y., Mayumi T., Hayakawa T.
Gene
348
157-165
2005

A novel strategy for the enhancement of drug absorption using a claudin modulator

Kondoh, M., Masuyama , A., Takahashi, A., Asano, N., Mizuguchi H., Koizumi, N., Fujii, M., Hayakawa, T., Horiguchi, Y., Watanabe, Y.
Mol. Pharmacol.
67
749-756
2005

Gene therapy for human small cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference

Sumimoto H., Yamagata S., Shimizu A., Miyoshi H., Mizuguchi H., Hayakawa T., Miyagishi M., Taira K., Kawakami Y.
Gene Ther.
12
95-100
2005

Augmentation of the migratory ability of DC-based vaccine into regionalymph nodes by efficient CCR7 gene transduction

Okada N., Mori N., Koretomo R., Okada Y., Nakayama T., Yoshie O., Mizuguchi H., Hayakawa T., Nakagawa S., Mayumi T., Fujita T., Yamamoto A.
Gene Ther.
12
129-139
2005

Immunological properties and vaccine efficacy of murine dendritic cells simultaneously expressing melanoma-associated antigen and interleukin-12

Okada N., Iiyama S., Okada Y., Mizuguchi H., Hayakawa T., Nakagawa S., Mayumi T., Fujita T., Yamamoto A.
Cancer Gene Ther.
12
72-83
2005

Constitutively active PDX1 induced efficient insulin production in adult murine liver

Imai, J., Katagiri, H., Yamada, T., Ishigaki, Y., Ogihara, T., Uno, K., Hasegawa, Y., Gao, J., Ishihara, H., Sasano, H., Mizuguchi H., Asano, T., Oka, Y.
Biochem. Biophys. Res. Commun.
326
402-409
2005

Approaches to improving the kinetics of adenovirus-delivered genes and gene products

Xu ZL., Mizuguchi H., Koizumi N., Sakurai F., Hosono T., Kawabata K., Watanabe Y., Yamaguchi T., Hayakawa T.
Adv. Drug. Deli. Rev.
57
781-802
2005

Evaluation of immune response after administration of plasmid DNA-non-viral vector complexes

Sakurai F., Takakura Y., Hashida M.
Gene Design and Delivery
Non-viral Gene Therapy
339-347
2005

目的遺伝子の抑制レベルを自由に制御するアデノウイルスベクターの開発

水口裕之
実験医学
23
2167-2172
2005

改良型アデノウイルスベクターを用いた造血幹細胞, 間葉系幹細胞, ES細胞への高効率遺伝子導入

水口裕之, 川端健二, 櫻井文教, 早川堯夫
炎症・再生
25
447-451
2005

カプシドタンパク質を改変した改良型アデノウイルスベクターによる高効率遺伝子導入

水口裕之, 早川堯夫
BIO INDUSTRY
22
16-21
2005

ウイルスベクター

水口裕之, 早川堯夫
Drug Delivery System
20
158-159
2005

高性能な遺伝子導入ベクターの開発を目指して

櫻井文教
Drug Delivery System
20
474-475
2005

ウイルスベクターのDDS

水口裕之
Drug Metabolism and Pharmacokinetics
19
30-32
2005

 大阪大学大学院 薬学研究科 分子生物学分野 

〒565-0871 大阪府吹田市山田丘1-6 大阪大学 大学院薬学研究科・薬学部 1号館 4階

TEL: 06-6879-8185 FAX: 06-6879-8187

 

Copyright© Laboratory of Biochemistry and Molecular Biology, Graduate School and School of Pharmaceutical Sciences, Osaka University

directed by Prof. Hiroyuki Mizuguchi

  • 分子生物学分野 | 阪大 | 薬学 | 生化 twitter