業績|論文・出版物|

2003

Antitumor effect by interleukin-11 receptor alpha-locus chemokine/CCL27, introduced into tumor cells through a recombinant adenovirus vector

Gao J-Q, Tsuda Y., Katayama K., Nakayama T., Hatanaka Y., Tani Y., Mizuguchi H., Hayakawa T., Yoshie O., Tsutsumi Y., Mayumi T., Nakagawa S.
Cancer Res.
63
4420-4425
2003

Efficient gene transfer into human CD34+ cells by an adenovirus type 35 vector

Sakurai F., Mizuguchi H., Hayakawa T.
Gene Ther.
10
1041-1048
2003

Generation of fiber-modified adenovirus vectors containing heterologous peptides in both the HI loop and C terminus of the fiber knob

Koizumi N., Mizuguchi H., Utoguchi N., Watanabe Y., Hayakawa T.
J. Gene Med.
5
267-276
2003

Regulated gene expression from adenovirus vectors: a systematic comparison of various inducible systems

Xu Z.L., Mizuguchi H., Mayumi T., Hayakawa T.
Gene
309
145-151
2003

Woodchuck hepatitis virus post-transcriptional regulation element enhances transgene expression from adenovirus vectors

Xu Z.L., Mizuguchi H., Mayumi T., Hayakawa T.
Biochim. Biophys. Acta
1621
266-271
2003

A soluble CAR-SCF fusion protein improves adenoviral vector-mediated gene transfer to c-Kit-positive hematopoietic cells

Itoh A., Okada T., Mizuguchi H., Hayakawa T., Mizukami H., Kume A., Takatoku M., Komatsu A., Hanazono Y., Ozawa K.
J. Gene Med.
5
929-940
2003

Dendritic cells transduced with gp100 gene by RGD fiber-mutant adenovirus vectors are highly efficacious in generating anti-B16BL6 melanoma immunity in mice

Okada N., Masunaga Y., Okada Y., Mizuguchi H., Iiyama S., Mori N., Sasaki A., Nakagawa S., Mayumi T., Hayakawa T., Fujita T., Yamamoto A.
Gene Ther.
10
1891-1902
2003

Vanadate enhances leptin-induced activation of JAK/STAT pathway in CHO cells

Kita A., Uotani S., Kuwahara H., Takahashi R., Oshima K., Yamasaki H., Mizuguchi H., Hayakawa T., Nagayama Y., Yamaguchi Y., Eguchi K.
Biochem. Biophys. Res. Commun.
302
805-809
2003

Postinfarction treatment with an adenoviral vector expressing hepatocyte growth factor relieves chronic left ventricular remodeling and dysfunction in mice

Li Y., Takemura G., Kosai K.I., Yuge K., Nagano S., Esaki M., Goto K., Takahashi T., Hayakawa K., Koda M., Kawase Y., Maruyama R., Okada H., Minatoguchi S., Mizuguchi H., Fujiwara T., Fujiwara H.
Circulation
107
2499-2506
2003

Thyroid cancer immuno-therapy with retroviral and adenoviral vectors expressing granulocyte macrophage colony stimulating factor and interleukin-12 in a rat model

Tanaka K., Towata S., Nakao K., Mizuguchi H., Hayakawa T., Niwa M., Ishii N., Nagayama Y.
Clin. Endocrinol.
59
734-742
2003

Prevention of autoantibody-mediated Graves'-like hyperthyroidism in mice with IL-4, a Th2 cytokine

Nagayama Y, Mizuguchi H., Hayakawa T., Niwa M., McLachlan SM., Rapoport B.
J. Immunol.
170
3522-3527
2003

Enhanced antitumor effect of combined replicative adenovirus and nonreplicative adenovirus expressing interleukin-12 in an immunocompetent mouse model

Nagayama Y., Nakao, K., Mizuguchi H., Hayakawa T., Niwa M.
Gene Ther.
10
1400-1403
2003

Role of H1-calponin in pancreatic AR42J cell differentiation into insulin-producing cells

Morioka T., Koyama H., Yamamura H., Tanaka S., Fujimoto, S., Emoto M., Mizuguchi H., Hayakawa T., Kojima I., Takahashi K., Nishizawa Y.
Diabetes
52
760-766
2003

A novel T7 system utilizing mRNA coding for T7 RNA polymerase

Nakano R., Nakagawa T., Imazu S., Katayama K., Mizuguchi H., Hayakawa T., Tsutsumi Y., Nakagawa S., Mayumi T.
Biochem. Biophys. Res. Commun.
301
974-978
2003

Gene transduction efficiency and maturation status in mouse bone marrow-derived dendritic cells infected with conventional or RGD fiber-mutant adenovirus vectors

Okada N., Masunaga Y., Okada Y., Iiyama S., Tsuda T., Matsubara A., Mori N., Mizuguchi H., Hayakawa T., Fujita T., Yamamoto A.
Cancer Gene Ther.
10
421-431
2003

A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model

Katayama K., Wada K., Nakajima A., Yoshida S., Mizuguchi H., Hayakawa T., Nakagawa S., Kadowaki T, Nagai R., Kamisaki Y, Blumberg RS., Mayumi T.
Gastroenterology
124
1315-1324
2003

An investigation of adverse effects caused by the injection of high-dose TNFα-expressing adenovirus vector into established murine melanoma

Okada Y., Okada N., Mizuguchi H., Hayakawa T., Mayumi T., Mizuno N.
Gene Ther.
10
700-705
2003

In vivo expression of B:9-23 peptide/I-Ag7 complex may abrogate the inhibition of diabetes induced by RGD-fiber-mutant adenovirus in NOD mice

Abiru N., Sun F., Kawasaki E., Yamasaki H., Oshima K., Nagayama Y., Mizuguchi H., Hayakawa T., Miao D., Liu E., Eisenbarth G.S., Eguchi K.
Annals N.Y. Acad. Sci.
1005
218-221
2003

Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny

Ara T., Tokoyoda K., Sugiyama T., Egawa T., Kawabata K., Nagasawa T.
Immunity
19
257-267
2003

A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo

Ara T., Itoi M., Kawabata K., Egawa T., Tokoyoda K., Sugiyama T., Fujii N., Amagai T., Nagasawa T.
J. Immunol.
170
4649-4655
2003

Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-beta gene and poly I: poly C in a murine lung metastasis model

Sakurai F., Terada T., Maruyama M., Yamashita F., Takakura Y., and Hashida M.
Cancer Gene Ther.
10
661-668
2003

次世代遺伝子治療薬の開発基盤研究

水口裕之
薬学雑誌
123
761-771
2003

アデノウイルスベクター:最近の進歩

水口裕之, 早川堯夫
分子細胞治療
2
200-207
2003

遺伝子機能解析のための遺伝子導入ベクター -ウイルスベクターを中心として-

水口裕之, 早川堯夫
蛋白質核酸酵素
48
1653-1662
2003

21世紀のDDS:発展を担う立場から

橋田充, 水口裕之, 山下富義, 横山昌幸, 原島秀吉, 米谷芳枝, 松村保広, 岡田純一, 五十嵐理慧
Drug Delivery System
18
7-20
2003

Reduction of natural adenovirus tropism to mouse liver by fiber-shaft exchange in combination with both CAR- and αv integrin-binding ablation

Koizumi N., Mizuguchi H., Sakurai F., Yamaguchi T., Watanabe Y., Hayakawa T.
J. Virol.
77
13062-13072
2003

Detection of replication-competent adenoviruses spiked into recombinant adenovirus vector products by infectivity PCR

Ishi-Watabe A., Uchida E., Iwata A., Nagata R., Satoh K., Fan K., Murata M., Mizuguchi H., Kawasaki N., Kawanishi T., Yamaguchi T., Hayakawa T.
Mol. Ther.
8
1009-1016
2003

Characterization of in vitro and in vivo gene transfer properties of adenovirus serotype 35 vector

Sakurai F., Mizuguchi H., Yamaguchi T., Hayakawa T.
Mol. Ther.
8
813-821
2003

Tight positive regulation of transgene expression by a single adenovirus vector containing the rtTA and tTS expression cassettes in separate genome regions

Mizuguchi H., Xu Z.L., Sakurai F., Mayumi T., Hayakawa T.
Hum. Gene Ther.
14
1265-1277
2003

 大阪大学大学院 薬学研究科 分子生物学分野 

〒565-0871 大阪府吹田市山田丘1-6 大阪大学 大学院薬学研究科・薬学部 1号館 4階

TEL: 06-6879-8185 FAX: 06-6879-8187

 

Copyright© Laboratory of Biochemistry and Molecular Biology, Graduate School and School of Pharmaceutical Sciences, Osaka University

directed by Prof. Hiroyuki Mizuguchi

  • 分子生物学分野 | 阪大 | 薬学 | 生化 twitter