業績|論文・出版物|

2002

CAR- orαv integrin-binding ablated adenovirus vectors, but not fiber-modified vectors containing RGD peptide, do not change the systemic gene transfer properties in mice

Mizuguchi H., Koizumi N., Hosono T., Ishii-Watabe A., Uchida E., Utoguchi N., Watanabe Y., Hayakawa T.
Gene Ther.
9
769-776
2002

Enhanced antitumor effect and reduced vector dissemination with fiber-modified adenovirus vectors expressing herpes simplex virus thymidine kinase

Mizuguchi H., Hayakawa T.
Cancer Gene Ther.
9
236-242
2002

The tet-off system is more effective than the tet-on system for regulating transgene expression in a single adenovirus vector

Mizuguchi H., Hayakawa T.
J. Gene Med.
4
240-247
2002

Adenovirus vectors containing chimeric type 5 and type 35 fiber proteins exhibit altered and expanded tropism and increase the size limit of foreign genes

Mizuguchi H., Hayakawa T.
Gene
285
69-77
2002

Strength evaluation of transcriptional regulatory elements for transgene expression by adenovirus vector

Xu Z.L., Mizuguchi H., Ishii-Watabe I., Uchida E., Mayumi T., Hayakawa T.
J. Control. Release
81
155-163
2002

Comparison of the efficiency and safety of non-viral vector-mediated gene transfer into a wide range of human cells

Uchida E., Mizuguchi H., Ishi-Watabe A., Hayakawa T.
Biol. Pharm. Bull.
25
891-897
2002

Receptor-independent augmentation of adenovirus-mediated gene transfer with chitosan in vitro

Kawamata Y., Nagayama Y., Nakao K., Mizuguchi H., Hayakawa T., Sato T., Ishii N.
Biomaterials
23
4573-4579
2002

Enhancement of phage-mediated gene transfer by nuclear localization signal

Akuta T., Eguchi A., Okuyama H., Senda T., Inokuchi H., Suzuki Y., Nagoshi E., Mizuguchi H., Hayakawa T., Takeda K., Hasegawa M., Nakanishi M.
Biochem. Biophys. Res. Commun.
297
779-786
2002

Tumor necrosis factor α-gene therapy for an established murine melanoma using RGD (Arg-Gly-Asp) fiber-mutant adenovirus vectors

Okada Y., Okada N., Nakagawa S., Mizuguchi H., Takahashi K., Mizuno N., Fujita T., Yamamoto A., Hayakawa T., Mayumi T.
Jpn. J. Cancer Res.
93
436-444
2002

A Novel murine model of graves’ hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor

Nagayama Y, Kita-Furuyama M., Ando T., Nakao K., Mizuguchi H., Hayakawa T., Eguchi K., Niwa M.
J. Immunol.
168
2789-2794
2002

Modification of a fiber protein in an adenovirus vector improves in vitro gene transfer efficiency to microglial cell line

Omori M., Mizuguchi H., Ohsawa K., Kohsaka S., Hayakawa T., Abe K., Shibasaki F.
Neurosci. Lett.
324
145-148
2002

Identification of the p33ING1-regulated genes that include cyclin B1 and proto-oncogene DEK by using cDNA microarray in a mouse mammary epithelial cell line NMuMG

Takahashi M., Seki N., Ozaki T., Kato M., Kuno T., Nakagawa T., Watanabe K., Miyazaki K., Ohira M., Hayashi S., Hosoda M., Tokita H., Mizuguchi H., Hayakawa T., Todo S., Nakagawara A.
Cancer Res.
62
2203-2209
2002

Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter

Nakagawa T., Takahashi M., Ozaki T., Watanabe K., Todo S., Mizuguchi H., Hayakawa T., Nakagawara A.
Mol. Cell. Biol.
22
2575-2585
2002

Fiber-mutant technique can augment gene transduction efficacy and anti-tumor effects against established murine melanoma by cytokine-gene therapy using adenovirus vectors

Okada Y., Okada N., Nakagawa S., Mizuguchi H., Kanehira M., Nishino N., Takahashi K., Mizuno N., Hayakawa T., Mayumi T.
Cancer Lett.
177
57-63
2002

The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes

Sakurai F, Terada T, Yasuda K, Yamashita F, Takakura Y, and Hashida M.
Gene Ther.
9
1120-1126
2002

Improvement of adenovirus vectors for gene transfer

Mizuguchi H., Hayakawa T.
Animal Cell Technology: Basic & Applied Aspects
12
1-5
2002

in vitroライゲーションを利用したアデノウイルスベクターの作製・増殖法

水口裕之, 早川堯夫
実験医学
20
1799-1804
2002

遺伝子治療とDDS

水口裕之
Drug Delivery System
17
60-61
2002