業績|論文・出版物|ALL

Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 35

Ono R., Takayama K., Sakurai F., Mizuguchi H.
Mol. Ther. Oncolytics
in press.

Generation of hepatocytes from human ES/iPS cells for regenerative medicine

Yamashita T., Takayama K., Mizuguchi H.
Springer Book: Cell-Inspired Materials and Engineering
in press.

In vivo gene expression profile of human intestinal epithelial cells: from the viewpoint of drug metabolism and pharmacokinetics

Takayama K., Ito K., Matsui A., Yamashita T., Kawakami K., Hirayama D., Kishimoto W., Nakase H., Mizuguchi H.
Drug Metab. Dispos.
in press.

Asymmetric profiles of infection and innate immunological responses in human iPS cell-derived small intestinal epithelial-like cell monolayers following infection with mammalian reovirus

Inoue C., Negoro R., Takayama K., Mizuguchi H., Sakurai F.
Virus Res.
in press.

ゲノム編集モデルの医薬品評価への応用とその課題

鳥羽由希子, 水口裕之
ゲノム編集技術の産業応用技術〜研究動向、課題とその解決、トラブル対策〜
in press.

Fiber-knob region of adenovirus type 5 vector promotes migration of A549 cells

Kano J., Koizumi N., Terada A., Matsuoka A., Hirai T., Nomura T., Mizuguchi H., Utoguchi N.
BPB Reports
in press.

Optimization of an E1A gene expression cassette in an oncolytic adenovirus for efficient tumor cell killing activity

Sakurai F., Nishimae F., Takayama K., Mizuguchi H.
Anticancer Res.
41
773-782
2021

Vinblastine treatment decreases the undifferentiated cell contamination of human iPSC-derived intestinal epithelial-like cells

Ichikawa M.#, Negoro R.#, Kawai K., Yamashita T., Takayama K., Mizuguchi H.
Mol. Ther. Methods Clin. Dev.
20
463-472
2021

Adenovirus Vector-Induced IL-6 Promotes Leaky Adenoviral Gene Expression, Leading to Acute Hepatotoxicity

Shimizu K., Sakurai F., Iizuka S., Ono R., Tsukamoto T., Nishimae F., Nakamura SI., Nishinaka T., Terada T., Fujio Y., Mizuguchi H.
J. Immunol.
206
410-421
2021

Tolloid-like 1 negatively regulates hepatic differentiation of human iPS cells through transforming growth factor beta signaling

Kiso A., Toba Y., Tsutsumi S., Deguchi S., Igai K., Koshino S., Tanaka Y., Takayama K., Mizuguchi H.
Hepatol. Commun.
4
255-267
2020

Photoactivatable oncolytic adenovirus for optogenetic cancer therapy

Hagihara Y., Sakamoto A., Tokuda T., Yamashita T., Ikemoto S., Kimura A., Haruta M., Sasagawa K., Ohta J., Takayama K., Mizuguchi H.
Cell Death Dis.
11
570
2020

Establishment of MDR1-knockout human induced pluripotent stem cell line

Negoro R., Kawai K., Ichikawa M., Deguchi S., Takayama K., Mizuguchi H.
Drug Metab. Pharmacokinet.
35
288-296
2020

Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer

Koujima T., Tazawa H., Ieda T., Araki H., Fushimi T., Shoji R., Kuroda S., Kikuchi S., Yoshida R., Umeda Y., Teraishi F., Urata Y., Mizuguchi H., Fujiwara T.
Mol. Ther. Oncolytics
17
107-117
2020

Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance

Toba Y., Deguchi S., Mimura N., Sakamoto A., Harada K., Hirata K., Takayama K., Mizuguchi H.
PLoS One
15
e0229654
2020

Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody

Kanaya N., Kuroda S., Kakiuchi Y., Kumon K., Tsumura T., Hashimoto M., Morihiro T., Kubota T., Aoyama K., Kikuchi S., Nishizaki M., Kagawa S., Tazawa H., Mizuguchi H., Urata Y., Fujiwara T.
Mol. Ther.
28
794-804
2020

Development of a Novel Oncolytic Adenovirus Expressing a Short-hairpin RNA Against Cullin 4A

Wakabayashi K., Sakurai F., Ono R., Fujiwara T., Mizuguchi H.
Anticancer Res.
40
161-168
2020

Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications of myeloid-derived suppressor cells and NO production

Tachibana M., Watanabe N., Koda Y., Oya Y., Kaminuma O., Katayama K., Fan Z., Sakurai F., Kawabata K., Hiroi T., Mizuguchi H.
Int. Immunol.
32
187-201
2020

Generation of human induced pluripotent stem cell-derived hepatocyte-like cells for cellular medicine

Deguchi S., Takayama K., Mizuguchi H.
Biol. Pharm. Bull.
43
608-615
2020

Aspects of gene therapy products using current genome-editing technology in Japan

Yamaguchi T., Uchida E., Okada T., Ozawa K., Onodera M., Kume A., Shimada T., Takahashi S., Tani K., Nasu Y., Mashimo T., Mizuguchi H., Mitani K., Maki K.
Hum. Gene Ther.
31
1043-1053
2020

ヒトiPS細胞由来肝細胞のB型肝炎ウイルス感染評価系への応用

櫻井文教, 水口裕之
ファルマシア
56
1099-1103
2020

薬物動態評価系としてのヒトiPS細胞由来腸管上皮細胞の可能性

山下智起, 横田純平, 乾達也, 水口裕之
Drug Delivery System
35
309-318
2020

CHOPCHOP v3を用いたCRISPR-Cas9の標的配列検索方法

塚本智仁, 酒井英子, 櫻井文教, 水口裕之
Drug Delivery System
35
257-259
2020

Establishment of SLC15A1/PEPT1-knockout human induced pluripotent stem cell line for intestinal drug absorption studies

Kawai K., Negoro R., Ichikawa M., Yamashita T., Deguchi S., Harada K., Hirata K., Takayama K., Mizuguchi H.
Mol. Ther. Methods Clin. Dev.
17
49-57
2019

Efficient generation of adenovirus vectors carrying the Clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR associated proteins (Cas)12a system by suppressing Cas12a expression in packaging cells

Tsukamoto T., Sakai E., Nishimae F., Sakurai F., Mizuguchi H.
J. Biotech.
304
1-9
2019

Generation of human iPS cell-derived intestinal epithelial cell monolayers by CDX2 transduction

Takayama K., Negoro R., Yamashita T., Kawai K., Ichikawa M., Mori T., Nakatsu N., Harada K., Ito S., Yamada H., Yamaura Y., Hirata K., Ishida S., Mizuguchi H.
Cell. Mol. Gastroenterol. Hepatol.
8
513-526
2019

miR-27b-mediated suppression of aquaporin-11 expression in hepatocytes reduces HCV genomic RNA levels but not viral titers

Sakurai F.#, Hashimoto R.#, Inoue C., Wakabayashi K., Tsukamoto T., Taracena-Gándara M., Imaizumi T., Sakai E., Itsuki K., Sakamoto N., Wakita T., Mizuguchi H.
Virology Journal
16
58
2019

Modeling of hepatic drug metabolism and responses in CYP2C19 poor metabolizer using genetically manipulated human iPS cells

Deguchi S., Yamashita T., Igai K., Harada K., Toba Y., Hirata K., Takayama K., Mizuguchi H.
Drug Metab. Dispos.
47
632-638
2019

FGF signal is not required for hepatoblast differentiation of human iPS cells

Toba Y., Kiso A., Nakamae S., Sakurai F., Takayama K., Mizuguchi H.
Sci. Rep.
9
3713
2019

Development of selective cytotoxic viral vectors for concentration of undifferentiated cells in cardiomyocytes derived from human induced pluripotent stem cells

Kono K., Sawada R., Kuroda T., Yasuda S., Matsuyama S., Matsuyama A., Mizuguchi H., Sato Y.
Sci. Rep.
9
3630
2019

A microRNA derived from adenovirus virus-associated RNAII promotes virus infection via post-transcriptional gene silencing

Wakabayashi K.#, Machitani M.#, Tachibana M., Sakurai F., Mizuguchi H.
J. Virol.
93
e01265-18
2019

Pharmaceutical research for inherited metabolic disorders of the liver using human induced pluripotent stem cell and genome editing technologies

Yamashita T., Takayama K., Hori M., Harada-Shiba M., Mizuguchi H.
Biol. Pharm. Bull.
42
312-318
2019

アデノウイルス由来小分子RNAによるウイルス増殖促進機構の解明と遺伝子組換えウイルスへの応用

若林圭作, 櫻井文教, 水口裕之
生産と技術
71
10-14
2019

Systemically administered reovirus-induced down-regulation of hypoxia inducible factor-1α in subcutaneous tumors

Hotani T., Mizuguchi H., Sakurai F.
Mol. Ther. Oncolytics
12
162-172
2018

Efficient generation of small intestinal epithelial-like cells from human iPS cells for drug absorption and metabolism studies

Negoro R., Takayama K., Kawai K., Harada K., Sakurai F., Hirata K., Mizuguchi H.
Stem Cell Rep.
11
1539-1550
2018

Optimal human iPS cell culture method for efficient hepatic differentiation

Matoba N.#, Yamashita T.#, Takayama K., Sakurai F., Mizuguchi H.
Differentiation
104
13-21
2018

LY341495, an mGluR2/3 antagonist, regulates the immunosuppressive function of myeloid-derived suppressor cells and inhibits melanoma tumor growth

Morikawa N., Tachibana M., Ago Y., Goda H., Sakurai F., Mizuguchi H.
Biol. Pharm. Bull.
41
1866-1869
2018

Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration

Tomita K., Sakurai F., Iizuka S., Hemmi M., Wakabayashi K., Tachibana M., Katayama K., Kamada H., Mizuguchi H.
Sci. Rep.
8
12315
2018

Generation of the adenovirus vector-mediated CRISPR/Cpf1 system and the application for primary human hepatocytes prepared from humanized mice with chimeric liver

Tsukamoto T., Sakai E., Iizuka S., Taracena-Gándara M., Sakurai F., Mizuguchi H.
Biol. Pharm. Bull.
41
1089-1095
2018

Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research

Takayama K., Hagihara Y., Toba Y., Sekiguchi K., Sakurai F., Mizuguchi H.
Biomaterials
161
24-32
2018

Oncolytic reovirus inhibits immunosuppressive activity of myeloid-derived suppressor cells in a TLR3-dependent manner

Katayama Y., Tachibana M., Kurisu N., Oya Y., Terasawa Y., Goda H., Kobiyama K., Ishii K., Akira S., Mizuguchi H., Sakurai F.
J. Immunol.
200
2987-2999
2018