論文・出版物 - ALL

Kawai K., Negoro R., Ichikawa M., Yamashita T., Deguchi S., Harada K., Hirata K., Takayama K., Mizuguchi H. Establishment of SLC15A1/PEPT1-knockout human induced pluripotent stem cell line for intestinal drug absorption studies. Mol. Ther. Methods Clin. Dev., in press.

Tsukamoto T., Sakai E., Nishimae F., Sakurai F., Mizuguchi H. Efficient generation of adenovirus vectors carrying the Clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR associated proteins (Cas)12a system by suppressing Cas12a expression in packaging cells. J. Biotech., 304, 1-9 (2019) PubMed

Takayama K., Negoro R., Yamashita T., Kawai K., Ichikawa M., Mori T., Nakatsu N., Harada K., Ito S., Yamada H., Yamaura Y., Hirata K., Ishida S., Mizuguchi H. Generation of human iPS cell-derived intestinal epithelial cell monolayers by CDX2 transduction. Cell. Mol. Gastroenterol. Hepatol., 8, 513-526 (2019) PubMed

Sakurai F. #, Hashimoto R. #, Inoue C., Wakabayashi K., Tsukamoto T., Taracena-Gándara M., Imaizumi T., Sakai E., Itsuki K., Sakamoto N., Wakita T., Mizuguchi H. miR-27b-mediated suppression of aquaporin-11 expression in hepatocytes reduces HCV genomic RNA levels but not viral titers. Virology Journal, 16, 58 (2019) # These authors contributed equally to this work. PubMed

Deguchi S., Yamashita T., Igai K., Harada K., Toba Y., Hirata K., Takayama K., Mizuguchi H. Modeling of hepatic drug metabolism and responses in CYP2C19 poor metabolizer using genetically manipulated human iPS cells. Drug Metab. Dispos., 47, 632-638 (2019) PubMed

Toba Y., Kiso A., Nakamae S., Sakurai F., Takayama K., Mizuguchi H. FGF signal is not required for hepatoblast differentiation of human iPS cells. Sci. Rep., 9, 3713 (2019) PubMed

Kono K., Sawada R., Kuroda T., Yasuda S., Matsuyama S., Matsuyama A., Mizuguchi H., Sato Y. Development of selective cytotoxic viral vectors for concentration of undifferentiated cells in cardiomyocytes derived from human induced pluripotent stem cells. Sci. Rep., 9, 3630 (2019) PubMed

Wakabayashi K. #, Machitani M. #, Tachibana M., Sakurai F., Mizuguchi H. A microRNA derived from adenovirus virus-associated RNAII promotes virus infection via post-transcriptional gene silencing. J.Virology, 93, e01265-18 (2019) # These authors contributed equally to this work. PubMed

Yamashita T., Takayama K., Hori M., Harada-Shiba M., Mizuguchi H. Pharmaceutical research for inherited metabolic disorders of the liver using human induced pluripotent stem cell and genome editing technologies. Biol. Pharm. Bull., 42, 312-318 (2019) PubMed

Deguchi S., Takayama K., Mizuguchi H., Generation of human iPS cell-derived hepatocyte-like cells for cellular medicine. Biol. Pharm. Bull., in press.

Hotani T., Mizuguchi H., Sakurai F. Systemically administered reovirus-induced down-regulation of hypoxia inducible factor-1α in subcutaneous tumors. Mol. Ther. Oncolytics, 12, 162-172 (2018) PubMed

Negoro R., Takayama K., Kawai K., Harada K., Sakurai F., Hirata K., Mizuguchi H. Efficient generation of small intestinal epithelial-like cells from human iPS cells for drug absorption and metabolism studies. Stem Cell Reports, 11(6), 1539-1550 (2018) PubMed

Matoba N. #, Yamashita T. #, Takayama K., Sakurai F., Mizuguchi H. Optimal human iPS cell culture method for efficient hepatic differentiation. Differentiation, 104, 13-21 (2018) # These authors contributed equally to this work. PubMed

Morikawa N., Tachibana M., Ago Y., Goda H., Sakurai F., Mizuguchi H. LY341495, an mGluR2/3 antagonist, regulates the immunosuppressive function of myeloid-derived suppressor cells and inhibits melanoma tumor growth. Biol. Pharm. Bull., 41(12), 1866-1869 (2018) PubMed

Tomita K., Sakurai F., Iizuka S., Hemmi M., Wakabayashi K., Tachibana M., Katayama K., Kamada H., Mizuguchi H. Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration. Sci. Rep., 8(1), 12315 (2018) PubMed

 

Tsukamoto T., Sakai E., Iizuka S., Taracena-Gándara M., Sakurai F., Mizuguchi H. Generation of the adenovirus vector-mediated CRISPR/Cpf1 system and the application for primary human hepatocytes prepared from humanized mice with chimeric liver. Biol. Pharm. Bull., 41(7), 1089-1095 (2018) PubMed

Takayama K., Hagihara Y., Toba Y., Sekiguchi K., Sakurai F., Mizuguchi H. Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research. Biomaterials, 161, 24-32 (2018) PubMed

Katayama Y., Tachibana M., Kurisu N., Oya Y., Terasawa Y., Goda H., Kobiyama K., Ishii K., Akira S., Mizuguchi H., Sakurai F. Oncolytic reovirus inhibits immunosuppressive activity of myeloid-derived suppressor cells in a TLR3-dependent manner. J.Immunol., 200(8), 2987-2999 (2018) PubMed

Nakamae S. #, Toba Y. #, Takayama K., Sakurai F., Mizuguchi H. Nanaomycin A treatment promotes hepatoblast differentiation from human iPS cells. Stem Cells Dev., 27(6), 405-414 (2018) # These authors contributed equally to this work. PubMed

Yamashita T., Takayama K., Sakurai F., Mizuguchi H. Billion-scale production of hepatocyte-like cells from human iPS cells. Biochem. Biophys. Res. Commun., 496(4), 1269–1275 (2018) PubMed

Kanayasu-Toyoda T., Ishii-Watabe A., Kikuchi Y., Kitagawa H., Suzuki H., Tamura H., Tada M., Suzuki T., Mizuguchi H., Yamaguchi T. Occludin as a functional marker of vascular endothelial cells on tube-forming activity. J. Cell. Physiol., 233, 1700-1711 (2018) PubMed

Takayama K., Mizuguchi H. Generation of optogenetically modified adenovirus vector for spatiotemporally controllable gene therapy. ACS Chem. Biol., 13(2), 449–454 (2018) PubMed

Takakura M., Matsumoto T., Nakamura M., Mizumoto Y., Myojyo S., Yamazaki R., Iwadare J., Bono Y., Orisaka S., Obata T., Izuka T., Kagami K., Nakayama K., Hayakawa H., Sakurai F., Mizuguchi H., Urata Y., Fujiwara T., Kyo S., Sasagawa T., Fujiwara H. Detection of CTCs in cervical cancer using a conditionally replicative adenovirus targeting telomerase-positive cells. Cancer Sci., 109(1), 231-240 (2018) PubMed

Okamoto R. #, Takayama K. #, Akita N.#, Nagamoto Y., Hosokawa D., Iizuka S., Sakurai F., Suemizu H., Ohashi K., Mizuguchi H. Human iPS cell-based liver-like tissue engineering at extrahepatic sites in mice as a new cell therapy for hemophilia B. Cell Transplant., 27(2), 299-309 (2018) # These authors contributed equally to this work. PubMed

水口裕之・早川堯夫;アデノウイルスベクター、バイオロジクスの開発と品質・安全性確保 ―バイオ医薬品、再生医療等製品、その他のバイオロジクスー、早川堯夫監修、エル・アイ・シー、印刷中

水口裕之、邊見 昌久;組換えアデノウイルス ―特性と最近の話題―、医学のあゆみ、351-358 (2018) WebSite

立花雅史、邊見昌久、水口裕之;粘膜免疫誘導型ワクチンとしてのアデノウイルスベクター、ドラッグデリバリーシステム、シーエムシー出版、(2018) WebSite
 
三谷成二、高山和雄、水口裕之;ヒトiPS細胞由来肝細胞の創出と創薬研究への応用、PHARM STAGE、技術情報協会、(2018) WebSite

Takayama K. #, Akita N. #, Mimura N., Akahira R., Taniguchi Y., Ikeda M., Sakurai F., Ohara O., Morio T., Sekiguchi K., Mizuguchi H. Generation of safe and therapeutically effective human iPS cell-derived hepatocyte-like cells for regenerative medicine. Hepatol. Commun., 1, 1058-1069 (2017) #These authors equally contributed to this work. PubMed

 

Hemmi M. #, Tachibana M. #, Fujimoto N., Shoji M., Sakurai F., Kobiyama K., Ishii K.J., Akira S., Mizuguchi H. Th17 Promotes Induction of antigen-specific gut-mucosal CTLs following adenovirus vector vaccination. Front Immunol., 8, 1456 (2017) #These authors equally contributed to this work. PubMed

 

Machitani M., Sakurai F., Wakabayashi K., Nakatani K., Tachibana M., Kato N., Fujiwara T., Mizuguchi H. Suppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB. Mol. Ther. Oncolysis., 7, 76-85 (2017) PubMed

 

Mitani S. #, Takayama K. #, Nagamoto Y., Imagawa K., Sakurai F., Tachibana M., Sumazaki R., Mizuguchi H. Human ES/iPS cell-derived hepatocyte-like cells achieve zone-specific hepatic properties by modulation of WNT signaling. Mol. Ther., 25, 1420-1433 (2017) #These authors equally contributed to this work. PubMed

 

Sakurai F. #, Kunito T. #, Takayama K., Hashimoto R., Tachibana M., Sakamoto N., Wakita T., Mizuguchi H. Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells. Virus Res., 242, 7-15 (2017) #These authors equally contributed to this work. PubMed

 

Iizuka S., Sakurai F., Tachibana M., Ohashi K., Mizuguchi H. Neonatal gene therapy for hemophilia B by a novel adenovirus vector showing sustained transgene expression via a reduction in the leaky expression of viral genes. Mol.Ther.Methods.Clin.Dev., 6, 183-193 (2017) PubMed

 

Shimizu K., Okamoto M., Terada T., Sakurai F., Mizuguchi H., Tomita K., Nishinaka T. Adenovirus vector-mediated macrophage erythroblast attacher (MAEA) overexpression in primary mouse hepatocytes attenuates hepatic gluconeogenesis. Biochem. Biophys. Rep., 10, 192-197 (2017) PubMed

 

Sakai E., Miura Y., Suzuki-Kouyama E., Oka K., Tachibana M., Kawabata K., Sakurai F., Mizuguchi H. A mammalian mirtron miR-1224 promotes tube-formation of human primary endothelial cells by targeting anti-angiogenic factor epsin2. Sci. Rep., 7, 5541 (2017) PubMed

 

Togo S., Katagiri N., Namba Y., Tulafu M., Nagahama K., Kadoya K., Takamochi K., Oh S., Suzuki K., Sakurai F., Mizuguchi H., Urata Y., Takahashi K. Sensitive detection of viable circulating tumor cells using a novel conditionally telomerase-selective replicating adenovirus in non-small cell lung cancer patients. Oncotarget, 8, 34884-34895 (2017) PubMed

 

Lim J., Sakai E., Takayama K., Sakurai F., Mizuguchi H. Overexpression of miR-27b negatively regulates expression of pluripotency-associated genes and hepatic differentiation in human induced pluripotent stem cells. Stem Cell Res. Ther., 2, 88-97 (2017) WebSite

 

Sakurai F., Inoue S., Kaminade T., Hotani T., Katayama Y., Hosoyamada E., Terasawa Y., Tachibana M., Mizuguchi H. Cationic liposome-mediated delivery of reovirus enhances the tumor cell-killing efficiencies of reovirus in reovirus-resistant tumor cells. Int. J. Pharm., 524, 238-247 (2017) PubMed

 

Imagawa K., Takayama K., Isoyama S., Tanikawa K., Shinkai M., Harada K., Tachibana M., Sakurai F., Noguchi E., Hirata K., Kage M., Kawabata K., Sumazaki R., Mizuguchi H. Generation of a bile salt export pump deficiency model using patient-specific iPSC-derived hepatocyte-like cells. Sci. Rep., 7, 41806 (2017) PubMed

 

Machitani M., Sakurai F., Wakabayashi K., Nakatani K., Tachibana M., Mizuguchi H. MicroRNA miR-27 inhibits adenovirus infection by suppressing the expression of SNAP25 and TXN2. J. Virol., 91, e00159-17 (2017) PubMed

 

Sakurai F. #, Mitani S. #, Yamamoto T. #, Takayama K., Tachibana M., Watashi K., Wakita T., Iijima S., Tanaka Y., Mizuguchi H. Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection. Sci. Rep., 7, 45698 (2017) #These authors equally contributed to this work. PubMed

 

Machitani M. #, Sakurai F. #, Wakabayashi K., Nakatani K., Takayama K., Tachibana M., Mizuguchi H. Inhibition of CRISPR/Cas9-mediated genome engineering by a type I interferon-induced reduction in guide RNA expression. Biol. Pharm. Bull., 40, 272-277 (2017) Highlighted paper selected by Editor-in-Chief PubMed

 

Machitani M. #, Sakurai F. #, Wakabayashi K., Tachibana M., Fujiwara T., Mizuguchi H. Enhanced oncolytic activities of the telomerase-specific replication-competent adenovirus expressing short-hairpin RNA against Dicer. Mol. Cancer Ther., 16, 251-259 (2017) #These authors contributed equally to this work. PubMed

 

Nakamori D. #, Akamine H. #, Takayama K. #, Sakurai F., Mizuguchi H. Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction. Sci. Rep., 7(1), 16675 (2017) #These authors contributed equally to this work. PubMed

 

Fukuda T., Takayama K., Hirata M., Liu Y-J, Yanagihara K., Suga M., Mizuguchi H., Furue M.K. Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions. Exp. Cell Res., 352, 333-345 (2017) PubMed

 

Hirai T., Yamagishi Y., Koizumi N., Nonaka M., Mochida R., Shida K., Nomura T., Fujii M., Sakurai F., Mizuguchi H., Watanabe Y., Utoguchi N. Identification of adenovirus-derived cell-penetrating peptide. Biol. Pharm. Bull., 40, 195-204 (2017) PubMed

 

Takehara K., Yano S., Tazawa H., Okada N., Kishimoto H., Narii N., Mizuguchi H., Urata Y., Kagawa S., Fujiwara T., Hoffman R.M. Eradication of melanoma in vitro and in vivo via targeting with a Killer-Red-containing telomerase-dependent adenovirus. Cell Cycle, 16, 1502-1508 (2017) PubMed

 

Takayama K., Igai K., Hagihara Y., Hashimoto R., Hanawa M., Sakuma T., Tachibana M., Sakurai F., Yamamoto T., Mizuguchi H. Highly efficient biallelic genome editing of human ES/iPS cells Using a CRISPR/Cas9 or TALEN system. Nuc. Acid Res., 45, 5198-5207 (2017) PubMed

 

Machitani M. #, Sakurai F. #, Wakabayashi K., Takayama K., Tachibana M., Mizuguchi H. Type I interferons impede short-hairpin RNA-mediated RNA interference via inhibition of dicer-mediated processing to small interfering RNA. Mol. Ther. Nucleic Acids, 6, 173-182 (2017)  #These authors contributed equally to this work. PubMed

 

Hanawa M., Takayama K., Sakurai F., Tachibana M., Mizuguchi H. Hepatocyte Nuclear Factor 4 alpha promotes definitive endoderm differentiation from human induced pluripotent stem cells. Stem Cell Rev., 13, 542-551 (2017) PubMed

 

Takayama K., Mizuguchi H. Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening. cells. Drug. Metab. Pharmacokinet., 32, 12-20 (2017) PubMed

 

Yamashita T., Takayama K., Mizuguchi H. Generation of hepatocytes from human ES/iPS cells for regenerative medicine, Springer Book: Cell-Inspired Materials and Engineering (edited by Dr. Dan Ohtan Wang), in press.

 

三谷成二、高山和雄、水口裕之;zone特異的性質を有するヒトES/iPS細胞由来肝細胞の作製法の開発、肝細胞研究会HP・研究交流http://hepato.umin.jp/kouryu/kouryu42.html)(2017)

 

Nagamoto Y., Takayama K., Ohashi K., Okamoto R., Sakurai F., Tachibana M., Kawabata K., Mizuguchi H. Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure. J. Hepatol., 64, 1068-1075 (2016) PubMed

 

Machitani M. #, Sakurai F. #, Wakabayashi K., Nakatani K., Shimizu K., Tachibana M., Mizuguchi H. NF-kB promotes leaky expression of adenovirus genes in a replication-incompetent adenovirus vector. Sci. Rep., 6, 19922 (2016) # These authors contributed equally to this work. PubMed

 

Sakurai F., Narii N., Tomita K., Togo S., Takahashi K., Machitani M., Tachibana M., Ouchi M., Katagiri N., Urata Y., Fujiwara T., Mizuguchi H. Efficient detection of human circulating tumor cells without significant production of false-positive cells by a novel conditionally replicating adenovirus. Mol.Ther.Methods.Clin.Dev., 3, 16001 (2016) PubMed

 

Machitani M. #, Sakurai F. #, Wakabayashi K., Tomita K., Tachibana M., Mizuguchi H. Dicer functions as an antiviral system against human adenoviruses via cleavage of adenovirus-encoded noncoding RNA. Sci. Rep., 6, 27598 (2016)  # These authors contributed equally to this work. PubMed

 

Takayama K. #, Mitani S. #, Nagamoto Y., Sakurai F., Tachibana M., Taniguchi Y., Sakaguchi K., Mizuguchi H. Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells. Biochem. Biophys. Res. Commun., 474, 91-96 (2016) # These authors contributed equally to this work. PubMed

 

Negoro R. #, Takayama K. #, Nagamoto Y., Sakurai F., Tachibana M., Mizuguchi H. Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells. Biochem. Biophys. Res. Commun., 472, 631-636 (2016) # These authors contributed equally to this work. PubMed

 

Nakamori D. #, Takayama K. #, Nagamoto Y., Mitani S., Sakurai F., Tachibana M., Mizuguchi H. Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBPα, and PROX1 transduction. Biochem. Biophys. Res. Commun., 469, 424-429 (2016) # These authors contributed equally to this work. PubMed

 

Tsuzuki S. #, Tachibana M. #, Hemmi M., Yamaguchi T., Shoji M., Sakurai F., Kobiyama K., Kawabata K., Ishii K.J., Akira S., Mizuguchi H. TANK-binding kinase 1-dependent or -independent signaling elicits the cell type-specific innate immune responses induced by the adenovirus vector. Int. Immunol., 28, 105-115 (2016) # These authors contributed equally to this work. PubMed

 

Kita A., Hino N., Higashi S., Hirota K., Narumi R., Adachi J., Takafuji K., Ishimoto K., Okada Y., Sakamoto K., Tomonaga T., Takashima S., Mizuguchi H., Doi T. Adenovirus vector-based incorporation of a photo-cross-linkable amino acid into proteins in human primary cells and cancerous cell lines. Sci. Rep., 6, 36946 (2016) PubMed

 

Yanagihara K., Liu Y., Kanie K., Takayama K., Kokunugi M., Hirata M., Fukuda T., Suga M., Nikawa H., Mizuguchi H., Kato R., Furue M.K. Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells. Stem Cells Dev. 25, 1884-1897 (2016) PubMed

 

Wan L., Yao X., Faiola F., Liu B., Zhang T., Tabata Y., Mizuguchi H., Nakagawa S., Gao J.Q, Zhao R.C. Coating with Spermine-Pullulan Polymer Enhances Adenoviral Transduction of Mesenchymal Stem Cells. Int. J. Nanomed., 11, 6763-6769 (2016) PubMed

 

Onishi T., Tazawa H., Hashimoto Y., Takeuchi M., Otani T., Nakamura S., Sakurai F., Mizuguchi H., Kishimoto H., Umeda Y., Shirakawa Y., Urata Y., Kagawa S., Fujiwara T. Tumor-specific delivery of biologics by a novel T-cell line HOZOT. Sci Rep., 6, 38060 (2016) PubMed

 

Okamoto M., Asamura A., Tanaka K., Soeda T., Watanabe K., Mizuguchi H., Ikeda T. Expression of HIF-1α ODD domain fused canine caspase 3 by EGFR promoter-driven adenovirus vector induces cytotoxicity in canine breast tumor cells under hypoxia. Vet. Res. Commun., 40, 131-139 (2016) PubMed

 

Takehara K., Tazawa H., Okada N., Hashimoto Y., Kikuchi S., Kuroda S., Kishimoto H., Shirakawa Y., Narii N., Mizuguchi H., Urata Y., Kagawa S., Fujiwara T. Targeted photodynamic virotherapy armed with a genetically encoded photosensitizer. Mol. Cancer Ther., 15, 199-208 (2016) PubMed

 

Hemmi M, Mizuguchi H. Adenoviral Vector Construction II: Bacterial Systems, Adenoviral Vectors for Gene Therapy, Second Edition, Elsevier, David Curiel (eds.), (2016) WebSite

 

水口裕之、高山和雄;ヒトiPS細胞から肝細胞への分化誘導と毒性評価系への応用、SCAS NEWS 2016-Ⅱ、株式会社住化分析センター、3-7 (2016) Website

 

水口裕之、高山和雄;ヒトiPS細胞を用いた薬剤評価のための肝細胞の作製、iPS細胞、技術情報協会、124-130 (2016)

 

水口裕之、高山和雄;薬物毒性評価、臨床薬学テキストシリーズ、中山書店、乾賢一監修、233-239 (2016)

 

町谷充洋、水口裕之;標的化アデノウイルスベクターの開発、遺伝子医学MOOK 30 今、着実に実り始めた遺伝子治療~最新研究と今後の展望、金田安史編集、63-73 (2016) Website

 

Ozawa T., Takayama K., Okamoto R., Negoro R., Sakurai F., Tachibana M., Kawabata K., Mizuguchi H. Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine. Sci. Rep., 5:16479, (2015) PubMed

 

Mori J., Kawabata A., Tang H., Tadagaki K., Mizuguchi H., Kuroda K., Mori Y.. Human Herpesvirus-6 U14 induces cell-cycle arrest in G2/M phase by associating with a cellular protein, EDD. PLoS One, 10, e0137420 (2015) PubMed

 

Koizumi N., Yamagishi Y., Hirai T., Fujii M., Mizuguchi H., Watanabe Y. Efficient Adenovirus gene transfer methods in human colonic Caco-2 epithelial cells using capric acid. Biol. Pharm. Bull., 38, 1240-1244 (2015) PubMed

 

Tashiro K., Hirata N., Okada A., Yamaguchi T., Takayama K., Mizuguchi H., Kawabata K. Expression of coxsackievirus and adenovirus receptor separates hematopoietic and cardiac progenitor cells in Flk1-expressing mesoderm. Stem Cells Transl. Med., 4, 424-436 (2015) PubMed

 

Terasawa Y., Hotani T., Katayama Y., Tachibana M., Mizuguchi H., Sakurai F. Activity levels of cathepsins B and L in tumor cells are a biomarker for efficacy of reovirus-mediated tumor cell killing. Cancer Gene Ther., 22, 188-97 (2015) PubMed

 

Wakabayashi K., Machitani M., Shimizu K., Tachibana M., Sakurai F., Mizuguchi H. Quantitative analysis of virus-associated RNAI expression following transduction with a replication-incompetent adenovirus vector in vitro and in vivo. J. Mol. Genet. Med., 9:169 (2015) WebSite

 

Minami H., Tashiro K., Okada A., Hirata N., Yamaguchi T., Takayama K., Mizuguchi H., Kawabata K. Generation of brain microvascular endothelial-like cells from human induced pluripotent stem cells by co-culture with C6 glioma cells. PLOS ONE, 10, e0128890 (2015) PubMed

 

Iizuka S., Sakurai F., Shimizu K., Ohashi K., Nakamura S-I., Tachibana M., Mizuguchi H. Evaluation of transduction properties of an adenovirus vector in neonatal mice. BioMed Res.Int., Article ID 685374 (2015) PubMed

 

Hotani T., Tachibana M., Mizuguchi H., Sakurai F. Reovirus double-stranded RNA genomes and polyI:C induce down-regulation of hypoxia-inducible factor-alpha. Biochem. Biophys. Res. Commun., 460, 1041-1046 (2015) PubMed

 

Nagamoto Y., Takayama K., Tashiro K., Tateno C., Sakurai F., Tachibana M., Kawabata K., Ikeda K., Tanaka Y., Mizuguchi H. Efficient engraftment of human iPS cell-derived hepatocyte-like cells in uPA/SCID mice by overexpression of FNK, a Bcl-xLmutant gene. Cell Transplant., 24, 1127-1138 (2015) PubMed

 

Katayama Y., Terasawa Y., Tachibana M., Mizuguchi H., Sakurai F. Proteolytic disassembly of viral outer capsid proteins is crucial for reovirus-mediated type-I interferon induction in both reovirus-susceptible and reovirus-refractory tumor cells. BioMed Res.Int., Article ID 468457 (2015) PubMed

 

水口裕之;ヒトiPS細胞から肝細胞への高効率分化誘導法の開発とその実用化に関する研究、バイオサイエンスとインダストリー、73, 104-109 (2015)

 

高山和雄、水口裕之;ヒトiPS細胞由来肝細胞の創薬研究・非臨床試験への応用を目指して、薬剤学、75, 369-373(2015) J-STAGE

 

Takayama K., Morisaki Y., Kuno S., Nagamoto Y., Harada K., Furukawa N., Ohtaka M., Nishimura K., Imagawa K., Sakurai F., Tachibana M., Sumazaki R., Noguchi E., Nakanishi M., Hirata K., Kawabata K., Mizuguchi H. Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes. Proc. Natl. Acad. Sci. USA., 111, 16772-16777 (2014) PubMed

 

Olszak T., Neves J., Dowds M., Baker K.K., Glickman J., Davidson N., Lin C-Y., Jobin C., Brand S., Sotlar K., Wada K., Katayama K., Nakajima A., Mizuguchi H., Kawasaki K., Nagata K., Müller W., Snapper S., Schreiber S., Kaser A., Zeissig S., Blumberg RS. Protective mucosal immunity mediated by epithelial CD1d and IL-10, Nature, 509, 497-502 (2014) PubMed

 

Hemmi M. #, Tachibana M. #, Tsuzuki S., Shoji M., Sakurai F., Kawabata K., Kobiyama K., Ishii K.J., Akira S., Mizuguchi H. The Early Activation of CD8(+) T Cells is dependent on type I IFN Ssignaling following intramuscular vaccination of adenovirus vector. Biomed Res Int., 158128 (2014) # These authors equally contributed to this work. PubMed

 

Sakurai F. #, Nanjo Y. #, Okamoto S., Tachibana M., Mizuguchi H. Upregulation of RECK gene expression by small double-stranded RNA targeting the promoter region. Cancer Gene Ther., 21, 219-227 (2014) # These authors equally contributed to this work. PubMed

 

Takayama K., Kawabata K., Nagamoto Y., Inamura M., Ohashi K., Okuno H., Yamaguchi T., Tashiro K., Sakurai F., Hayakawa T., Okano T., Furue MK., Mizuguchi H. CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determine the hepatoblast fate decision. Development, 141, 91-100 (2014) PubMed

 

Kuno S., Sakurai F., Shimizu K., Matsumura N., Kim S., Watanabe H., Tashiro K., Tachibana M., Yokoi T., Mizuguchi H. Development of mice exhibiting hepatic microsomal activity of human CYP3A4 comparable to that in human liver microsomes by intravenous administration of an adenovirus vector expressing human CYP3A4. Drug Metab. Pharmacokinet., 29, 296-304 (2014) PubMed

 

Watanabe H. #, Takayama K. #, Inamura M., Tachibana M., Mimura N., Tashiro K., Nagamoto Y., Sakurai F., Kawabata K., Furue MK., Mizuguchi H. HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin. PLoS One, 9, e90791 (2014) # These authors equally contributed to this work. PubMed

 

Tagawa M., Shirane K., Yu L., Sato T., Furukawa S., Mizuguchi H., Kuji R., Kawamura K., Takahashi N., Kato K., Hayakawa S., Sawada S., Furukawa K. Enhanced expression of the β4-galactosyltransferase 2 gene impairs mammalian tumor growth. Cancer Gene Ther., 21, 219-227 (2014) PubMed

 

Yao X, Zhou N, Wan L, Su X, Sun Z, Mizuguchi H., Yoshioka Y, Nakagawa S, Zhao RC, Gao JQ. Polyethyleneimine-coating enhances adenoviral transduction of mesenchymal stem cells. Biochem. Biophys. Res. Commun., 447, 383-387 (2014) PubMed

 

Shimizu K., Sakurai F., Tomita K., Nagamoto Y., Nakamura S., Katayama K., Tachibana M., Kawabata K., Mizuguchi H. Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome. Mol. Ther. Methods Clin. Dev., 1, 14035 (2014) PubMed

 

Tashiro K. #, Nonaka A. #, Hirata N., Yamaguchi T., Mizuguchi H., Kawabata K. Plasma elevation of vascular endothelial growth factor leads to the reduction of mouse hematopoietic and mesenchymal stem/progenitor cells in the bone marrow. Stem Cells Dev., 23, 2202-2210 (2014) # These authors equally contributed to this work.  PubMed

 

Higuchi M, Mizuguchi H. Hepatic differentiation of human embryonic stem cells and induced pluripotent stem cells by two- and three-dimensional culture systems in vitro. Engineered Cell Manipulation for Biomedical Application, the Springer publishing, 147-158, 2014, In: M. Akashi, T. Akagi, M. Matsusaki (eds.) WebSite

 

長基康人、高山和雄、水口裕之;3次元組織化技術を利用したヒトES/iPS細胞から肝細胞への分化誘導法、遺伝子医学MOOK別冊 細胞の3次元組織化 –その最先端技術と材料技術、田畑泰彦編集、244-248 (2014) WebSite

 

水口裕之、高山和雄;iPS細胞由来組織細胞を用いた毒性試験、実験医学別冊 ES・iPS細胞実験スタンダード、羊土社、中辻憲夫監修、末盛博文編集、345-350 (2014) WebSite

Takayama K., Nagamoto Y., Mimura N., Tashiro K., Sakurai F., Tachibana M., Hayakawa T., Kawabata K., Mizuguchi H. Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human Laminin 111-coated dishes. Stem Cell Rep.,1,322-335 (2013) PubMed

 

Matsui H., Sakurai F., Katayama K., Abe Y., Machitani M., Kurachi S., Tachibana M., Mizuguchi H. A targeted adenovirus vector displaying a human fibronectin type III domain-based monobody in a fiber protein. Biomaterials, 34, 4191-4201 (2013) PubMed

 

Machitani M., Sakurai F., Katayama K., Tachibana M., Suzuki T., Matsui H., Yamaguchi T., Mizuguchi H. Improving adenovirus vector-mediated RNAi efficiency by lacking the expression of virus-associated RNAs. Virus Res., 178, 357-363 (2013) PubMed

 

Matsuura M., Somboonthum P., Murakami K., Ota M., Shoji M., Kawabata K., Mizuguchi H., Gomi Y., Yamanishi K., Mori Y. Novel polyvalent live vaccine against varicella-zoster and mumps virus infections. Microbiol Immunol., 57, 704-714 (2013) PubMed

 

Ikeda M., Tsuno S., Sugiyama T., Hashimoto A., Yamoto K., Takeuchi K., Kishi H., Mizuguchi H., Kohsaka S-I, Yoshioka T. Ca2+ spiking activity caused by the activation of store-operated Ca2+ channels mediates TNF-α release from microglial cells under chronic purinergic stimulation. Biochim. Biophys. Acta., 1833, 2573-2585 (2013) PubMed

 

Nakashima-Kaneda K., Matsuda A., Mizuguchi H., Sasaki-Sakamoto T., Saito H., Ra C., Okayama Y. Regulation of IgE-dependent zinc release from human mast cells. Int. Arch. Allergy. Immunol., 161, 44-51 (2013) PubMed

 

Takayama K., Kawabata K., Nagamoto Y., Kishimoto K., Tashiro K., Sakurai F., Tachibana M., Kanda K.,Hayakawa T., Furue MK., Mizuguchi H. 3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing. Biomaterials, 34, 1781-1789 (2013) PubMed

 

Naoe M., Ogawa Y., Hasebe Y., Iwamoto S., Mizuguchi H., Aoi T., Terao S. Gamma-delta T cells may function as carrier vehicles in adenovirus vector-based gene therapy. J. Cancer Sci. Ther., 5, 384-390 (2013) WebSite

 

Uchibori R., Tsukahara T., Mizuguchi H., Saga Y., Urabe M., Mizukami H., Kume A., Ozawa K. NF-κB activity regulates mesenchymal stem cell accumulation at tumor sites. Cancer Res., 73, 364-372 (2013) PubMed

 

Iwahori K., Serada S., Fujimoto M., Ripley B., Nomura S., Mizuguchi H., Shimada K., Takahashi T., Kawase I., Kishimoto T., Naka T. SOCS-1 gene delivery cooperates with cisplatin plus pemetrexed to exhibit preclinical antitumor activity against malignant pleural mesothelioma. Int. J. Cancer, 132, 459-471 (2013) PubMed

 

Yamaguchi T., Tashiro K., Tanaka S., Katayama S., Ishida W., Fukuda K., Fukushima A., Araki R., Abe M., Mizuguchi H., Kawabata K. Two-step differentiation of mast cells from induced pluripotent stem cells. Stem Cell Dev., 22, 726-34 (2013) PubMed

 

吉田孟史、近藤昌夫、水口裕之、八木清仁;アデノウイルスベクターを利用したC型肝炎研究の新展開、薬学雑誌、133, 305-311(2013) J-STAGE

 

櫻井文教、藤原俊義、水口裕之;次世代型制限増殖アデノウイルスを利用した血中循環がん細胞検出法の開発、薬学雑誌、133, 291-296 (2013) J-STAGE

高山和雄、川端健二、水口裕之;ヒト多能性幹細胞から肝細胞への分化誘導法の開発とその毒性評価系への応用、Tiss. Cult. Res. Commun., 32, 183–187 (2013) J-STAGE

高山和雄、川端健二、水口裕之;ヒトES/iPS細胞から肝細胞への高効率分化誘導法の開発とその創薬応用、最新医学、68、141-144 (2013)

川端健二、高山和雄、水口裕之;ヒトiPS 細胞由来分化誘導肝細胞を用いた薬物毒性評価系の開発;BIO INDUSTRY、シーエムシー出版、30、19-24 (2013) WebSite

水口裕之;遺伝子治療におけるDDS ウイルスベクター、応用が拡がるDDS 人体環境から農業・家電まで、寺田弘、中川晋作、辻孝三、牧野公子、絹田精鎮、西野敦編集、NTS(日本ハイコム(株))、180-187 (2013) WebSite

 

水口裕之、高山和雄、川端健二;ヒトiPS細胞由来肝細胞を用いた毒性評価、In vitro毒性・動態評価の最前線、シーエムシー出版、小島肇夫監修、63-70 (2013) WebSite

Takayama K., Inamura M., Kawabata K., Sugawara M., Kikuchi K., Higuchi M., Nagamoto Y., Watanabe H., Tashiro K., Sakurai F., Hayakawa T., Furue MK., Mizuguchi H. Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction. J. Hepatol., 57, 628-636 (2012) PubMed

 

Takayama K., Inamura M., Kawabata K., Katayama K., Higuchi M., Tashiro K., Nonaka A., Sakurai F., Hayakawa T., Furue MK., Mizuguchi H. Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction. Mol. Ther., 20, 127-137 (2012) PubMed

 

Shoji M., Katayama K., Tachibana M., Tomita K., Sakurai F., Kawabata K., Mizuguchi H. Intramuscular DNA immunization with in vivo electroporation induces antigen-specific cellular and humoral immune responses in both systemic and gut-mucosal compartments. Vaccine, 30, 7278-7285 (2012) PubMed

 

Shoji M., Tachibana M., Katayama K., Tomita K., Tsuzuki S., Sakurai F., Ishii K.J., Akira S., Mizuguchi H. Type-I IFN signaling is required for the induction of antigen-specific CD8+ T cell responses by adenovirus vector vaccine in the gut-mucosa. Biochem. Biophys. Res. Commun., 425, 89-93 (2012) PubMed

 

Nagamoto Y., Tashiro K., Takayama K., Ohashi K., Kawabata K., Sakurai F., Tachibana M., Hayakawa T., Furue MK., Mizuguchi H. Promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets. Biomaterials, 33, 4526-4534 (2012) PubMed

 

Matsui H., Sakurai F., Katayama K., Yamaguchi T., Okamoto S., Takahira K., Tachibana M., Nakagawa S., Mizuguchi H. A hexon-specific PEGylated adenovirus vector utilizing blood coagulation factor X. Biomaterials, 33, 3743-3755 (2012) PubMed

 

Tashiro K., Omori M., Kawabata K., Hirata N., Yamaguchi T., Sakurai F., Takaki S., Mizuguchi H. Inhibition of Lnk in mouse induced pluripotent stem cells promotes hematopoietic cell generation. Stem Cell Dev., 21, 3381-3390 (2012) PubMed

 

Hiwasa K., Nagaya H., Terao S., Acharya B., Hamada K., Mizuguchi H., Gotoh A. Improved Gene Transfer into Bladder Cancer Cells Using Adenovirus Vector Containing RGD Motif. Anticancer Res., 32, 3137-3140 (2012) PubMed

 

Tashiro K., Kawabata K., Omori M., Yamaguchi T., Sakurai F., Katayama K., Hayakawa H., Mizuguchi H. Promotion of hematopoietic differentiation from mouse induced pluripotent stem cells by transient HoxB4 transduction. Stem Cell Res., 8, 300-311 (2012) PubMed

 

Tomita K., Sakurai F., Tachibana M., Mizuguchi H. Correlation between adenovirus-neutralizing antibody titer and adenovirus vector-mediated transduction efficiency following intratumoral injection. Anticancer Res., 32, 1145-1152 (2012) PubMed

 

Shoji M., Yoshizaki S., Mizuguchi H., Okuda K., Shimada M. Immunogenic Comparison of Chimeric Adenovirus 5/35 Vector Carrying Optimized Human Immunodeficiency Virus Clade C Genes and Various Promoters. PLoS One, 7, e30302 (2012) PubMed

 

Sakurai F., Furukawa N., Higuchi M., Okamoto S., Ono K., Yoshida T., Kondoh M., Yagi K., Sakamoto N., Katayama K., Mizuguchi H. Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-122a. Virus Res., 165, 214-218 (2012) PubMed

Yao X.L., Yoshioka Y., Ruan G.X., Chen Y.Z., Mizuguchi H., Mukai Y., Okada N., Gao J.Q., Nakagawa S. Optimization and internalization mechanisms of PEGylated adenovirus vector with targeting peptide for cancer gene therapy. Biomacromolecules, 13, 2402-2409 (2012) PubMed

 

Iguchi K., Sakurai F., Tomita K., Katayama K., Yamaguchi T., Tagawa M., Kawabata M., Shirakawa T., Mizuguchi H. Efficient antitumor effects of carrier cells loaded with a fiber-substituted conditionally replicating adenovirus on CAR-negative tumor cells. Cancer Gene Ther., 19, 118-125 (2012) PubMed

 

Yamasaki Y., Tazawa H., Hashimoto Y., Kojima T., Kuroda S., Yano S., Yoshida R., Uno F., Mizuguchi H., Ohtsuru A., Urata Y., Kagawa S., Fujiwara T. A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression. Eur. J. Cancer, 48, 2282-2291 (2012) PubMed

 

Kawabata K., Inamura M., Mizuguchi H. Efficient hepatic differentiation from human iPS cells by gene transfer. Methods Mol. Biol., 826, 115-124 (2012) PubMed

 

Bennett D., Sakurai F., Shimizu K., Matsui H., Tomita K., Suzuki T., Katayama K., Kawabata K., Mizuguchi H. Further reduction in adenovirus vector-mediated liver transduction without largely affecting transgene expression in target organ by exploiting microRNA-mediated regulation and the Cre-loxP recombination system. Mol. Pharm., 9, 3452-63 (2012) PubMed

 

Kawabata K., Takayama K., Nagamoto Y., Saldon M.S., Higuchi M., Mizuguchi H. Endodermal and hepatic differentiation from human embryonic stem cells and human induced pluripotent stem cells. J. Stem Cell Res. Ther., S10 (2012) PubMed

清水かほり、櫻井文教、立花雅史、水口 裕之;マイクロRNAを利用してウイルス遺伝子の非特異的な発現を抑制可能な新規アデノウイルスベクターの開発、薬学雑誌、132, 1407-1412 (2012) J-STAGE

水口裕之、高山和雄、長基康人、川端健二;ヒトiPS細胞から肝細胞への分化誘導の現状と創薬応用、医薬品医療機器レギュラトリーサイエンス、医薬品医療機器レギュラトリーサイエンス財団、43、982-987 (2012) WebSite

早川堯夫、水口裕之;ヒトiPS細胞の再生医療及び創薬研究への応用の現状と展望、Brain and Nerve、64, 47-57 (2012) WebSite

水口裕之、櫻井文教;ウイルスベクターと遺伝子治療、新編ウイルスの今日的意味、柳雄介・堤裕幸編集、医薬ジャーナル、101-108 (2012) WebSite

高山和雄、川端健二、水口裕之;多能性幹細胞から肝細胞への分化誘導、再生医療業書、日本再生医療学会監修、後藤満一・大橋一夫編集、朝倉書店、110-116 (2012)

水口裕之;iPS細胞研究の道しるべ 遺伝子治療研究の貢献と教訓、ファルマシア、日本薬学会、48、827 (2012) J-STAGE

櫻井文教、水口裕之; microRNAによる遺伝子発現制御システムを搭載した遺伝子発現ベクター、ドラッグデリバリーシステムの新展開II―核酸医薬・抗体医薬・ワクチン医療を支えるDDS技術―、シーエムシー出版、47-53(278) (2012) WebSite

Inamura M., Kawabata K., Takayama K., Tashiro K., Sakurai F., Katayama K., Toyoda M., Akutsu H., Miyagawa Y.,Okita H., Kiyokawa N., Umezawa A., Hayakawa T., Furue MK., Mizuguchi H. Efficient generation of hepatoblastsfrom human ES cells and iPS cells by transient overexpression of homeobox gene HEX. Mol. Ther.,19, 400-407 (2011) PubMed

 

Takayama K., Inamura M., Kawabata K., Tashiro K., Katayama K., Hayakawa T., Furue MK., Mizuguchi H. Efficient and directive generation of two distinct endoderm lineages from human ES and iPS cells by differentiation stage-specific SOX17 transduction. PLoS One, 6, e21780 (2011) PubMed

 

Sugio K., Sakurai F., Katayama K., Matsui H., Kawabata K., Kawase A., Iwaki M., Hayakawa T., Fujiwara T., Mizuguchi H. Enhanced safety profiles of the telomerase-specific replication-competent adenovirus by incorporation of normal cell-specific microRNA-targeted sequences. Clin. Cancer Res., 17, 2807-2818 (2011) PubMed

 

Suzuki-Kouyama E., Katayama K., Sakurai F., Yamaguchi T., Kurachi S., Kawabata K., Nakagawa S., Mizuguchi H. Hexon-specific PEGylated adenovirus vectors utilizing avidin-biotin interaction. Biomaterials, 32, 1724-1730 (2011) PubMed

 

Matsui H., Sakurai F., Katayama K., Kurachi S., Tashiro K., Sugio K., Kawabata K., Mizuguchi H. Enhanced transduction efficiency of fiber-substituted adenovirus vectors by the incorporation of RGD peptides in two distinct regions of the adenovirus serotype 35 fiber knob. Virus Res., 155, 48-54 (2011) PubMed

 

Suzuki T., Sasaki T., Yano K., Sakurai F., Kawabata K., Kondoh M., Hayakawa T., Yagi K., Mizuguchi H. Development of a recombinant adenovirus vector production system free of replication-competent adenovirus by utilizing a packaging size limit of the viral genome. Virus Res., 158, 154-160 (2011) PubMed

 

Yoshida T., Takayama K. (Co-first author), Kondoh M. (Co-corresponding author), Sakurai F., Tani H., Sakamoto N., Matsuura Y., Mizuguchi H. (Co-corresponding author), Yagi K. Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection. Biochem. Biophys. Res. Commun., 416, 119-124 (2011) PubMed

 

Motegi Y., Katayama K., Sakurai F., Kato T., Yamaguchi T., Matsui H., Takahashi M., Kawabata K., Mizuguchi H. An effective gene-knockdown using multiple shRNA-expressing adenovirus vectors. J. Cont. Rel., 153, 149-153 (2011) PubMed

 

Shimizu K., Sakurai F., Machitani M., Katayama K., Mizuguchi H. Quantitative analysis of the leaky expression of adenovirus genes in cells transduced with a replication-incompetent adenovirus vector. Mol. Pharmaceutics, 8, 1430-1435 (2011) PubMed

 

Machitani M., Katayama K., Sakurai F., Matsui H., Yamaguchi T., Suzuki T., Miyoshi H., Kawabata K., Mizuguchi H. Development of an adenovirus vector lacking the expression of virus-associated RNAs. J. Cont. Rel., 154, 285-289 (2011) PubMed

 

Katayama K., Furuki R., Yokoyama H., Kaneko M., Tachibana M., Yoshida I., Nagase H., Tanaka K., Sakurai F., Mizuguchi H., Nakagawa S., Nakanishi T. Enhanced in vivo gene transfer into the placenta using RGD fiber-mutant adenovirus vector. Biomaterials, 32, 4185-4193 (2011) PubMed

 

Iwahori K., Serada S., Fujimoto M., Nomura S., Osaki T., Lee C.M., Mizuguchi H. , Takahashi T., Ripley B., Okumura M., Kawase I., Kishimoto T., Naka T. Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma. Int. J. Cancer, 129, 993-1005 (2011) PubMed

 

Yoshida T., Kondoh M., Ojima M., Mizuguchi H., Yamagishi Y., Sakamoto N., Yagi K. Adenovirus vector-mediated assay system for Hepatitis C virus replication. Nucleic. Acid Res., 39, e64 (2011) PubMed

 

Furukawa N., Sakurai F., Katayama K., Seki N., Kawabata K., Mizuguchi H. Optimization of a microRNA expression vector for function analysis of microRNA. J. Cont. Rel., 150, 94-101 (2011) PubMed

 

Kawashima R., Abei M., Fukuda K., Nakamura K., Murata T., Wakayama M., Seo E., Hasegawa N., Mizuguchi H., Obata Y., Hyodo I., Hamada H., Yokoyama K.K. EpCAM- and EGFR- targeted selective gene therapy for biliary cancers using Z33-fiber modified adenovirus. Int. J. Cancer, 129, 1244-53 (2011) PubMed

 

Iwata-Kajihara T., Sumimoto H., Kawamura N., Ueda R., Takahashi T., Mizuguchi H., Miyagishi M., Takeda K., Kawakami Y. Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors. J. Immunol., 187, 27-36 (2011) PubMed

 

Yao X., Yoshioka Y., Morishige T., Eto Y., Narimatsu S., Kawai Y., Mizuguchi H., Gao J.Q., Mukai Y., Okada N., Nakagawa S. Tumor vascular targeted delivery of polymer-conjugated adenovirus vector for cancer gene therapy. Mol. Ther., 19, 1619-1625 (2011) PubMed

 

Machitani M., Yamaguchi T., Shimizu K., Sakurai F., Katayama K., Kawabata K., Mizuguchi H. Adenovirus vector-derived VA-RNA-mediated innate immune responses. Pharmaceutics, 3,338-353 (2011) PubMed

 

Sakurai F., Katayama K., Mizuguchi H. MicroRNA-regulated transgene expression system for gene therapy and virotherapy. Frontier in Bioscience., 17, 2389-2401 (2011) PubMed

 

松井勇人、櫻井文教、形山和史、水口裕之;改良型アデノウイルスベクターの開発と神経系細胞への遺伝子導入、日本薬理学会雑誌、137、70-74 (2011) J-STAGE

 

水口裕之、櫻井文教;ウイルスベクターと遺伝子治療、化学療法の領域、医薬ジャーナル社、27、867-873 (2011) WebSite

 

稲村充、高山和雄、川端健二、水口裕之;ヒトES/iPS細胞から肝細胞への高効率分化誘導と毒性評価系への応用、生産と技術、63、67-69 (2011)

水口裕之、近藤昌夫、八木清仁;iPS細胞分化誘導によるHCV培養モデル、肝胆膵、63、919-924 (2011)

 

水口裕之;スーパー特区研究『ヒトiPS細胞を用いた新規in vitro 毒性評価系の構築』の概要、動物実験代替法学会News Letter、40、21-22 (2011)

Yamaguchi, T., Kawabata, K., Kouyama, E., Ishii, K. J., Katayama, K., Suzuki, T., Kurachi, S., Sakurai, F., Akira, S., and Mizuguchi, H. Induction of type I interferon by adenovirus-encoded small RNAs. Proc. Natl. Acad. Sci. USA, 107, 17286-17291 (2010) PubMed

 

Sakurai, F., Nakashima, K., Yamaguchi, T., Ichinose, T., Kawabata, K., Hayakawa, T., and Mizuguchi, H. Adenovirus serotype 35 vector-induced innate immune responses in dendritic cells derived from wild-type and human CD46-transgenic mice: Comparison with a fiber-substituted Ad vector containing fiber proteins of Ad serotype 35. J. Control. Rel., 148, 212-218 (2010) PubMed

 

Tashiro K., Kawabata K., Inamura M., Takayama K., Furukawa N., Sakurai F., Katayama K., Hayakawa H., Furue-Kusuda M., Mizuguchi H., Adenovirus vector-mediated efficient transduction into human embryonic and induced pluripotent stem cells. Cell Reprogram., 12, 501-507 (2010) PubMed

 

Eto Y., Yoshioka Y., Ishida T., Yao X., Morishige T., Narimatsu S., Mizuguchi H., Mukai Y., Okada N., Kiwada H., Nakagawa S. Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer. Biol. Pharm. Bull., 33, 1540-1544 (2010) PubMed

 

Ushitora M., Sakurai F., Yamaguchi T., Nakamura S-I., Kondoh M., Yagi K., Kawabata K., Mizuguchi H. Prevention of hepatic ischemia-reperfusion injury by pre-administration of catalase-expressing adenovirus vectors. J. Control. Rel., 142, 431-437 (2010) PubMed

 

Watanabe Y., Kojima T., Kagawa S., Uno F., Hashimoto Y., Kyo S., Mizuguchi H., Tanaka N., Kawamura H., Ichimaru D., Urata Y., Fujiwara T. A novel translational approach for human malignant pleural mesothelioma: heparanase-assisted dual virotherapy. Oncogene, 29, 1145-1154 (2010) PubMed

 

Van Geer M.A., Brevoord D., Kuhlmann K.F., Bakker C.T., Mizuguchi H., Wesseling J.G., Ten Kate F.J., Gouma D.J., Oude Elferink R.P., Bosma P.J. A fiber modified adenovirus vector that targets to the EphrinA2 receptor reveals enhanced gene transfer to ex vivo pancreatic cancer. Int. J. Oncol., 36, 233-44 (2010) PubMed

 

Morishige T., Yoshioka Y., Tanabe A., Yao X., Mizuguchi H., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S. Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models. Int. Immunopharmacol., 10, 26-33 (2010) PubMed

 

Kojima T., Watanabe Y., Hashimoto Y., Kuroda S., Yamasaki Y., Yano S., Ouchi M., Tazawa H., Uno F., Kagawa S., Kyo S., Mizuguchi H., Urata Y., Tanaka N., Fujiwara T. In vivo biological purging for lymph node metastasis of human colorectal cancer by telomerase-specific oncolytic virotherapy. Ann. Surg., 251, 1079-1086 (2010) PubMed

 

Akita H., Enoto K., Masuda T., Mizuguchi H., Tani T., Harashima H., Particle tracking of intracellular trafficking of octaarginine-modified liposomes: a comparative study with adenovirus. Mol. Ther., 18, 955-964 (2010) PubMed

 

Yashima S., Yoshizaki S., Shinoda K., Yoshida A., Kondo A., Mizuguchi H., Ryo A., Okuda K., Shimada M. Co-administration of viral vector-based vaccines suppresses antigen-specific effector CD8 T cells. Vaccine, 28, 3257-3264 (2010) PubMed

 

Kakutani H., Kondoh M., Saeki R., Fujii M., Watanabe Y., Mizuguchi H., Yagi K. Claudin-4-targeting of diphtheria toxin fragment A using a C-terminal fragment of Clostridium perfringens enterotoxin. Eur. J. Pharm. Biopharm., 75, 213-217 (2010) PubMed

 

Yao X., Yoshioka Y., Morishige T., Eto Y., Narimatsu S., Mizuguchi H., Mukai Y., Okada N., Nakagawa S. Adenovirus vector covalently conjugated to polyethylene glycol with a cancer-specific promoter suppresses the tumor growth through systemic administration. Biol. Pharm. Bull., 35, 1073-1076 (2010) PubMed

 

櫻井文教、水口裕之;マイクロRNAによる遺伝子発現制御システムを搭載した遺伝子組換えアデノウイルスの開発 、薬学雑誌、130、1497-1504 (2010) J-STAGE

 

川端健二、田代克久、水口裕之;iPS細胞への遺伝子導入を用いた分化誘導の最適化 、薬学雑誌、130、1527-1534 (2010) J-STAGE

 

水口裕之;次世代アデノウイルスベクターの開発と生命科学研究への応用、Drug Delivery System、25, 493-503 (2010)

Matsui H., Sakurai F., Kurachi S., Tashiro K., Sugio K., Kawabata K., Yamanishi K., Mizuguchi H. Development of fiber-substituted adenovirus vectors containing foreign peptides in the adenovirus serotype 35 fiber knob. Gene Ther., 16, 1050-1057 (2009) PubMed

 

Tashiro K., Inamura M., Kawabata K., Sakurai F., Yamanishi K., Hayakawa T., Mizuguchi H. Efficient adipocyte and osteoblast differentiation from mouse induced pluripotent stem cells by adenoviral transduction. Stem Cells, 27, 102-1811 (2009) PubMed

 

Yao X., Yoshioka Y., Morishige T., Eto Y., Watanabe H., Okada Y., Mizuguchi H., Mukai Y., Okada N., Nakagawa S. Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis. Gene Ther., 16, 1395-404 (2009) PubMed

Kojima T., Hashimoto Y., Watanabe Y., Kagawa S., Uno F., Kuroda S., Tazawa H., Kyo S., Mizuguchi H., Urata Y., Tanaka N., Fujiwara T. A simple biological imaging system for detecting viable human circulating tumor cells. J. Clin. Invest., 119(10):3172-3181 (2009) PubMed

 

Xin H., Sun R., Kanehira M., Takahata T., Itoh J., Mizuguchi H., Saijo Y. Intratracheal delivery of CX3CL1-expressing mesenchymal stem cells to multiple lung tumors. Mol. Med., 15, 321-327 (2009) PubMed

 

Terao S., Acharya B., Suzuki T., Aoi T., Naoe M., Hamada K., Mizuguchi H., Gotoh A. Improved gene transfer into renal carcinoma cells using adenovirus vector containing RGD motif. Anticancer Res., 29, 2997-3001 (2009) PubMed

 

Eto Y., Yoshioka Y., Asavatanabodee R., Kida S., Maeda M., Mukai Y., Mizuguchi H., Kawasaki K., Okada N., Nakagawa S. Transduction of adenovirus vectors modified with cell penetrating peptides. Peptides, 30, 1548-1552 (2009) PubMed

Van Geer M.A., Bakker C.T., Koizumi N., Mizuguchi H., Wesseling J.G., Oude Elferink R.P.J., Bosma P.J., Ephrin A2 receptor targeting does not increase adenoviral pancreatic cancer transduction in vivo. World J. Gastroenterol., 15, 2754-2762 (2009) PubMed

Kurihara Y., Watanabe Y., Onimatsu H., Kojima T., Shirota T., Hatori M., Liu D., Kyo S., Mizuguchi H., Urata Y., Shintani S., Fujiwara T. Telomerase-Specific Virotheranostics for Human Head and Neck Cancer. Clin. Cancer Res., 15, 2335-2343 (2009) PubMed

 

Sakurai F., Nakamura S-I., Akitomo K., Shibata H., Terao K., Kawabata K., Hayakawa T., Mizuguchi H. Adenovirus serotype 35 vector-mediated transduction following direct administration into organs of nonhuman primates. Gene Ther., 16, 297-302 (2009) PubMed

 

Tashiro K., Kondo A., Kawabata K., Sakurai H., Sakurai F., Yamanishi K., Hayakawa T., Mizuguchi H. Efficient osteoblast differentiation from mouse bone marrow stromal cells with polylysin-modified adenovirus vectors. Biochem. Biophys. Res. Commun., 379, 127-132 (2009) PubMed

 

Ura T., Yoshida A., Xin K-Q., Yoshizaki S., Yashima S., Abe S, Mizuguchi H. Okuda K. Designed recombinant adenovirus type 5 vector induced env-specific CD8+ cytotoxic T lymphocytes and cross-reactive neutralizing antibodies against human immunodeficiency virus type 1. J. Gene Med., 11, 139-149 (2009) PubMed

 

Abe S., Okuda K., Ura T., Kondo A., Yoshida A., Yoshizaki S., Mizuguchi H., Klinman D., Shimada M. Adenovirus type 5 with modified hexons induces robust transgene-specific immune responses in mice with pre-existing immunity against adenovirus type 5. J. Gene Med., 11, 570-579 (2009) PubMed

Huang H., Sakurai F., Higuchi Y., Kawakami S., Hashida M., Kawabata K., Hayakawa T., Mizuguchi H. Suppressive effects of sugar-modified cationic liposome/NF-κB decoy complexes on adenovirus vector-induced innate immune responses. J. Control. Rel., 133, 139-145 (2009) PubMed

 

Gao J-Q., Tsuda Y., Han M., Xu D-H., Kanagawa N., Hatanaka Y., Tani Y., Mizuguchi H., Tsutsumi Y., Mayumi T., Okada N., Nakagawa S. NK cells are migrated and indispensable in the anti-tumor activity induced by CCL27 gene therapy. Cancer Immunol. Immunother., 58, 291-299 (2009) PubMed

 

Shimada M, Wang H-B., Ino A., Xu X-P., Yoshida A., Shinoda K., Ura T., Mizuguchi H., Klinman D., Luo J-L., Bai H., Okuda K. Effect of therapeutic immunization using Ad5/35 and MVA vectors on SIV-infection of rhesus monkeys undergoing anti-retroviral therapy. Gene Ther., 16, 218-228 (2009) PubMed

 

水口裕之;改良型アデノウイルスベクター開発の最前線、脳21、金芳堂、12(1)、123-131 (2009) WebSite

 

水口裕之;アデノウイルスベクターの作製・増幅・精製法、脳21、金芳堂、12(2)、246-251 (2009) WebSite

 

古江-楠田美保、山田弘、水口裕之;iPS細胞を活用した安全性・有効性評価系の構築、iPS細胞の産業的応用技術、シーエムシー出版、pp218~224 WebSite

 

水口裕之、櫻井文教、川端健二;アデノウイルスベクターのDDS、Pharm Tech Japan、25、2618-2624 (2009)

水口裕之;ゲノム解析と遺伝子DDSの設計・評価、Pharm Tech Japan、25(13) (2009) WebSite

 

水口裕之;組換えウイルスキャリア-遺伝子治療・ワクチン応用への新展開-、DDS、24(6)、569 (2009)

 

櫻井文教、川端健二、水口裕之;遺伝子組換えウイルスの安全性向上に向けた遺伝子改変~microRNAによる遺伝子発現制御システムを搭載した組換えウイルスの開発~、DDS、24(6)、572-581 (2009)

Suzuki T., Sakurai F., Nakamura S-I., Kouyama E., Kawabata K., kondoh M., Yagi K., Mizuguchi H. miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy. Mol. Ther., 16, 1719-1726 (2008) PubMed

Sakurai H., Tashiro K., Kawabata K., Yamaguchi T., Sakurai F., Nakagawa S., Mizuguchi H. Adenoviral expression of suppressor of cytokine signaling-1 reduces adenovirus vector-induced innate immune response. J. Immunol., 180, 4931-4938 (2008) PubMed

 

Sakurai F., Nakamura S-I., Akitomo K., Shibata H., Terao K., Kawabata K., Hayakawa T., Mizuguchi H. Transduction properties of adenovirus serotype 35 vectors after intravenous administration into nonhuman primates. Mol. Ther., 16, 726-733 (2008) PubMed

 

Tashiro K., Kawabata K., Sakurai H., Kurachi S., Sakurai F., Yamanishi K., Mizuguchi H. Efficient adenovirus vector-mediated PPAR gamma gene transfer into mouse embryoid bodies promotes adipocyte differentiation, J. Gene Med., 10, 498-507 (2008) PubMed

 

Nakashima K., Sakurai F., Kawabata K., Mizuguchi H. Efficient gene delivery in human and rodent mast cells using adenovirus vectors. J. Control. Rel., 129, 215-222 (2008) PubMed

 

Sakurai H., Kawabata K., Sakurai F., Nakagawa S., Mizuguchi H. Innate immune response induced by gene delivery vectors. Int. J. Pharm., 354, 9-15 (2008) PubMed

 

Kurachi S., Koizumi N., Tashiro K., Sakurai H., Sakurai F., Kawabata K., Nakagawa S., Mizuguchi H. Modification of pIX or hexon based on fiberless Ad vectors is not effective for targeted Ad vectors. J. Control. Rel., 127, 88-95 (2008) PubMed

 

Yoshikawa T., Niwa T., Okada N., Mizuguchi H., Nakagawa S. Engineering of highly immunogenic long-lived DC vaccines by antiapoptotic protein gene transfer to enhance cancer vaccine potency. Gene Ther., 15, 1321-1329 (2008) PubMed

 

Gao J-Q., Kanagawa N., Xu D-H., Han M., Sugita T., Hatanaka Y., Tani Y., Mizuguchi H., Tsutsumi Y., Mayumi T., Okada N., Nakagawa S. Combination of two fiber-mutant adenovirus vectors, one encoding the chemokine FKN and another encoding cytokine interleukin 12, elicits notably enhanced anti-tumor responses. Cancer Immunol. Immunother., 57, 1657-64 (2008) PubMed

 

Arita E., Kondoh M., Isoda K., Nishimori H., Yoshida T., Mizuguchi H., Yagi K. Evaluation of promoter strength in mouse and rat primary hepatocytes using adenovirus vectors. Eur. J. Pharm. Biopharm., 70, 1-6 (2008) PubMed

 

Takahashi A., Komiya E., Kakutani H., Yoshida T., Fujii M., Horiguchi Y., Mizuguchi H., Tsutsumi Y., Tsunoda S-I., Koizumi N., Isoda K., Yagi K., Watanabe Y., Kondoh M. Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis. Biochem. Pharmacol., 75, 1639-1648 (2008) PubMed

 

Kanagawa N., Koretomo R., Murakami S., Sakurai F., Mizuguchi H., Nakagawa S., Fujita T., Yamamoto A., Okada N. Factors involved in the maturation of murine dendritic cells transduced with adenoviral vector variants. Virology, 374, 411-420 (2008) PubMed

 

Yoshioka Y., Asavatanabodee R., Eto Y., Watanabe H., Morishige T., Yao X., Kida S., Maeda M., Mukai Y., Mizuguchi H., Kawasaki K., Okada N., Nakagawa S. Tat conjugation of adenovirus vector broadens tropism and enhances transduction efficiency. Life Science, 83, 747-755 (2008) PubMed

 

Larochelle N., Deol J., Srivastava V., Allen C., Mizuguchi H., Karpati G., Holland P., Nalbantoglu J. Downregulation of CD46 during muscle differentiation: implications for gene transfer to human skeletal muscle using group B adenoviruses. Hum. Gene Ther., 19, 133-142 (2008) PubMed

 

Sakurai F. Development and evaluation of a novel gene delivery vehicle composed of adenovirus serotype 35. Biol. Pharm. Bull., 31, 1819-1825 (2008) PubMed

Sakurai F. Development of a replication-incompetent adenovirus vector derived from subgroup B adenovirus serotype 35. Yakugaku Zasshi, 128, 1751-1761 (2008) PubMed

 

衛藤佑介、吉岡靖雄、Asavatanabodee R、水口裕之、向洋平、岡田直貴、中川晋作;標的指向性を有するバイオコンジュゲート化アデノウイルスベクターの開発、薬学雑誌、128、1733-1742 (2008) J-STAGE

水口裕之;遺伝子治療研究の動向;医薬ジャーナル新薬展望2008、44、235-242 (2008) WebSite

水口裕之;ウイルスベクター;ウイルスハンドブック、日本医学館、6-7 (2008)

水口裕之;アデノウイルスベクター;機能性DDSキャリアの製剤設計、シーエムシー出版、岡田弘晃監修、133-141 (2008) WebSite

Koizumi N., Yamaguchi T., Kawabata K., Sakurai F., Sasaki T., Watanabe Y., Hayakawa T., Mizuguchi H. Fiber-modified adenovirus vectors decrease liver toxicity through reduced interleukin 6 production. J. Immunol., 178, 1767-1773 (2007) PubMed

 

Kurachi S., Koizumi N., Sakurai F., Kawabata K., Sakurai H., Nakagawa S., Hayakawa T., Mizuguchi H. Characterization of capsid-modified adenovirus vectors containing heterologous peptides in the fiber knob, protein IX, or hexon. Gene Ther., 14, 266-274 (2007) PubMed

 

Mizuguchi H., Funakoshi N., Hosono T., Sakurai F., Kawabata K., Yamaguchi T., Hayakawa T. Rapid construction of small interfering RNA-expressing adenovirus vectors on the basis of direct cloning of short hairpin RNA-coding DNAs. Hum. Gene Ther., 18, 74-80 (2007) PubMed

 

Sakurai H., Sakurai F., Kawabata K., Sasaki T., Koizumi N., Huang H., Tashiro K., Kurachi S., Nakagawa S., Mizuguchi H. Comparison of gene expression efficiency and innate immune response induced by Ad vector and lipoplex, J. Control. Release., 117, 430-437 (2007) PubMed

 

Harada M., Kondoh M., Ebihara C., Takahashi A., Komiya E., Fujii M., Mizuguchi H., Tsunoda S-I., Horiguchi Y., Yagi K., Watanabe Y. Role of tyrosine residues in modulation of claudin-4 by the C-terminal fragment of Clostridium perfringens enterotoxin. Biochem Pharmacol., 73, 206-214 (2007) PubMed

Ebihara C., Kondoh M., Harada M., Fujii M., Mizuguchi H., Tsunoda S-I., Horiguchi Y., Yagi K., Watanabe Y. Role of Tyr306 in the C-terminal fragment of Clostridium perfringens enterotoxin for modulation of tight junction. Biochem. Pharmacol., 73, 824-830 (2007) PubMed

Hama S., Akita H., Iida S., Mizuguchi H., Harashima H. Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex.  Nuc. Acid Res., 35, 1533-1543 (2007) PubMed

 

Moriuchi A., Yamasaki H., Shimamura M., Kita A., Kuwahara H., Fujishima K., Satoh T., Fukushima K., Fukushima T., Hayakawa T., Mizuguchi H., Nagayama Y., Abiru N., Kawasaki E., Eguchi K. Induction of human adiponectin gene transcription by telmisartan, angiotensin receptor blocker, independently on PPAR-gamma activation. Biochem. Biophys. Res. Commun., 356, 1024-1030 (2007) PubMed

 

Mukai E., Fujimoto S., Sakurai F., Kawabata K., Yamashita M., Inagaki N., Mizuguchi H. Efficient gene transfer into murine pancreatic islets using adenovirus vectors. J. Control. Rel., 119, 136-141 (2007) PubMed

Sakurai F., Akitomo K., Kawabata K., Hayakawa T., Mizuguchi H. Downregulation of human CD46 by adenovirus serotype 35 vectors, Gene Ther., 14, 912-919 (2007) PubMed

 

Xin K-Q., Sekimoto Y., Takahashi T., Mizuguchi H., Ichino M., Yoshida A., Okuda K. Chimeric adenovirus 5/35 vector containing the clade C HIV gag gene induces a cross-reactive immune response against HIV. Vaccine, 25, 3809-3815 (2007) PubMed

 

Gao J-Q., Kanagawa N., Motomura Y., Yanagawa T., Sugita T., Hatanaka Y., Tani Y., Mizuguchi H., Tsutsumi Y., Mayumi T., Okada N., Nakagawa S. Cotransduction of CCL27 gene can improve the efficacy and safety of IL-12 gene therapy for cancer. Gene Ther., 14, 491-502 (2007) PubMed

 

Yamashita M., Ino A., Kawabata K., Sakurai F., Mizuguchi H. Expression of coxsackie and adenovirus receptor reduces the lung metastatic potential of murine tumor cells. Int. J. Cancer, 121, 1690-1696 (2007) PubMed

 

Kurachi S., Tashiro K., Sakurai F., Sakurai H., Kawabata K., Yayama K., Okamoto H., Nakagawa S., Hayakawa T., Mizuguchi H. Fiber-modified adenovirus vectors containing the TAT peptide derived from human immunodeficiency virus in the fiber knob have efficient gene transfer activity. Gene Ther., 14, 1160-1165 (2007) PubMed

 

Kawabata K., Tashiro K., Sakurai F., Osada N., Kusuda J., Hayakawa T., Yamanishi K., Mizuguchi H. Positive and negative regulation of adenovirus infection by CAR-like soluble protein, CLSP. Gene Ther., 14, 1199-1207 (2007) PubMed

 

Yamaguchi T. #, Kawabata K. #, Koizumi N., Sakurai F., Nakashima K., Sasaki T., Okada N, Mizuguchi H. Role of MyD88 and TLR9 in the innate immune response elicited by serotype 5 adenoviral vectors. Hum. Gene Ther., 18, 753-762 (2007) # These authors equally contributed to this work. PubMed

 

Xin H., Kanehira M., Mizuguchi H., Hayakawa T., Kikuchi T., Nukiwa T., Saijo Y. Targeted-delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells. Stem Cells, 25, 1618-1626 (2007) PubMed

 

Sakurai F., Kawabata K., Mizuguchi H. Adenovirus vectors composed of subgroup B adenoviruses. Curr. Gene Ther., 7, 229-238 (2007) PubMed

 

Someya K., Xin K-Q., Ami Y., Izumi Y., Mizuguchi H., Ohta S., Yamamoto N., Honda M., Okuda K. Chimeric adenovirus type 5/35 vector encoding SIV gag and HIV env genes affords protective immunity against the simian/human immunodeficiency virus in monkeys. Virology, 367, 390-397 (2007) PubMed

 

Gao J-Q., Eto Y., Yoshioka Y., Sekiguchi F, Kurachi S., Morishige T., Yao X., Watanabe H., Asavatanabodee R., Sakurai F., Mizuguchi H., Okada Y., Mukai Y., Tsutsumi Y., Mayumi T., Okada N., Nakagawa S. Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration. J. Control. Rel., 122, 102-110 (2007) PubMed

 

Murakami S. #, Sakurai F. #, Kawabata K., Okada N., Fujita T., Yamamoto A., Hayakawa T., Mizuguchi H. Interaction of penton base Arg-Gly-Asp motifs with integrins is crucial for adenovirus serotype 35 vector transduction in human hematopoietic cells.  Gene Ther., 14, 1525-1533 (2007) # These authors equally contributed to this work. PubMed

 

Yao X., Yoshioka Y., Eto Y., Morishige T., Okada Y., Mizuguchi H., Mukai Y., Okada N., Nakagawa S. TERT promoter-driven adenovirus vector for cancer gene therapy via systemic injection. Biochem. Biophys. Res. Commun., 362, 419-424 (2007) PubMed

 

Kanehira M., Xin H., Hoshino K., Maemondo M., Mizuguchi H., Hayakawa T., Matsumoto K., Nakamura T., Nukiwa T., Saijo Y. Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells. Cancer Gene Ther., 14, 894-903 (2007) PubMed

 

Kawabata K. Role of a novel protein, CAR-like soluble protein (CLSP), in adenovirus infection. Yakugaku Zasshi, 127、1091-1096 (2007) PubMed

 

水口裕之;アデノウイルスベクター開発の最前線、バイオテクノロジージャーナル、羊土社、7(2)、168-173 (2007) WebSite

 

川端健二、櫻井文教、水口裕之;改良型アデノウイルスベクターを用いた各種幹細胞への遺伝子デリバリー、Drug Delivery System、22(2)、148-154 (2007) J-STAGE

川端健二;各種幹細胞への高効率遺伝子導入法の開発とその応用、Drug Delivery System、22(6)、668-669 (2007)

水口裕之、早川堯夫;アデノウイルスベクター;バイオ医薬品の開発と品質・安全性確保、早川堯夫監修、エル・アイ・シー、pp563~577 (2007) WebSite

早川堯夫、前田大輔、水口裕之;遺伝子治療用医薬品の品質,安全性等の確保;バイオ医薬品の開発と品質・安全性確保、早川堯夫監修、エル・アイ・シー、pp551~562 (2007) WebSite

水口裕之;遺伝子導入技術開発とその応用、大阪医薬品協会会報、699(4)、21-45 (2007)

水口裕之、櫻井文教、川端健二;カプシドタンパク質改変アデノウイルスベクター、遺伝子医学MOOK別冊 絵で見てわかるナノDDS、メディカルドゥ、235-242 (2007) WebSite

Koizumi N., Kawabata K., Sakurai F., Watanebe Y., Hayakawa T., Mizuguchi H. Modified adenoviral vectors ablated for coxsackievirus-adenovirus receptor, αv integrin, and heparan sulfate binding reduce in vivo tissue transduction and toxicity. Hum. Gene Ther., 17, 264-279 (2006) PubMed

 

Sakurai F., Kawabata K., Koizumi N., Inoue N., Okabe M., Yamaguchi T., Hayakawa T., Mizuguchi H. Adenovirus serotype 35 vector-mediated transduction into human CD46-transgenic mice. Gene Ther., 13, 1118-1126 (2006) PubMed

 

Sakurai F., Murakami S., Kawabata K., Okada N., Yamamoto A., Seya T., Hayakawa T., Mizuguchi H. The short consensus repeats 1 and 2, not the cytoplasmic domain, of human CD46 are crucial for infection of subgroup B adenovirus serotype 35.  J. Control. Rel., 113, 271-278 (2006) PubMed

 

Kawabata K., Sakurai F., Koizumi N., Hayakawa T., Mizuguchi H. Adenovirus vector-mediated gene transfer into stem cells. Mol. Pharmaceutics, 3, 95-103 (2006) PubMed

 

Koizumi N., Mizuguchi H., Kondoh M., Fujii M., Nakanishi T., Utoguchi N., Watanabe Y. Efficient gene transfer into differentiated human trophoblast cells with adenovirus vector containing RGD motif in the fiber protein. Biol. Pharm. Bull., 29, 1297-1299 (2006) PubMed

 

Kishimoto H., Kojima T., Watanabe Y., Kagawa S., Fujiwara T., Uno F., Teraishi F., Kyo S., Mizuguchi H., Hashimoto Y., Urata Y., Tanaka N., Fujiwara T. In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus.  Nature Med., 12, 1213-1219 (2006) PubMed

 

Uno K., Katagiri H., Yamada T., Ishigaki Y., Ogihara T., Imai J., Hasegawa Y., Gao J., Kaneko K., Iwasaki H., Ishihara H., Sasano H., Inukai K., Mizuguchi H., Asano T., Shiota M., Nakazato M., Oka Y. Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. Science, 312, 1656-1659 (2006) PubMed

 

Kamakura M., Morisawa K., Komi H., Tomatani A., Saito F., Konishi Y., Jin Y., Manabe T., Kuroda M., Imai S., Mizuguchi H., Taniguchi T. Regulation of IL-27p28 gene by lipopolysacchraide in dendritic DC2.4 cells. Biochem. Biophys. Res. Commun., 349, 1372-1377 (2006) PubMed

 

Komiya E., Kondoh M., Mizuguchi H., Fujii M., Utoguchi N., Nakanishi T., Watanabe Y. Characteristics of transcription-regulatory elements for gene expression from plasmid vectors in human trophoblast cell lines. Placenta, 27, 934-938 (2006) PubMed

 

Fujiwara T., Akita H., Furukawa K., Ushida T., Mizuguchi H., Harashima H. Impact of convective flow on the cellular uptake and transfection activity of lipoplex and adenovirus. Bio. Pharm. Bull., 29, 1511-1515 (2006) PubMed

 

Nukiwa M., Andarini S., Zaini J., Xin H., Kanehira M., Suzuki T., Fukuhara T., Mizuguchi H., Hayakawa T., Saijo Y., Nukiwa T., Kikuchi T. Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors. Eur. J. Immunol., 109, 1019-1027 (2006) PubMed

 

Harui A., Roth MD., Sanghvi M., Vira D., Mizuguchi H., Basak SK. Centrifugation enhances integrin-mediated transduction of dendritic cells by conventional and RGD-modified adenoviral vectors. J. Immunol. Methods, 312, 94-104 (2006) PubMed

 

Harui A., Roth MD., Vira D., Sanghvi M., Mizuguchi H., Basak SK. Adenoviral-encoded antigens are presented by a subset of dendritic cells expressing alpha-v/beta-3 integrins. J. Leukocyte. Biol., 79, 1271-1278 (2006) PubMed

 

Kida S., Maeda M., Hojo K., Eto Y., Gao J.Q., Kurachi S., Mizuguchi H., Hayakawa T., Mayumi T., Nakagawa S., Kawasaki K. Design and synthesis of a Tat-related gene transporter: a tool for carrying the adenovirus vector into cells. Bioorg. Med. Chem. Lett., 16, 743-735 (2006) PubMed

 

Hama S., Akita H., Ito R., Mizuguchi H., Hayakawa T., Harashima H. Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems. Mol. Ther., 13, 786-794 (2006) PubMed

 

Ebihara C., Kondoh M., Hasuike N., Harada M., Mizuguchi H., Horiguchi Y., Fujii M., Watanabe Y. Preparation of a claudin-targeting molecule using a C-terminal fragment of Clostridium perfringens enterotoxin. J. Pharmacol. Exp. Ther., 316, 255-260 (2006) PubMed

 

Okada N., Sasaki A., Niwa M., Okada Y., Hatanaka Y., Tani Y., Mizuguchi H., Nakagawa S., Fujita T., Yamamoto A. Tumor suppressive efficacy through augmentation of tumor-infiltrating immune cells by intratumoral injection of chemokine-expressing adenoviral vector. Cancer Gene Ther., 13, 393-405 (2006) PubMed

 

Gao J-Q., Chen H-L., Nakagawa S., Mizuguchi H., Liang W-Q. Gene expression of tumor cells both in vitro and in vivo enhanced by integrin-targeting adenovirus. Acta Pharmaceutica Sinica, 41, 1116-1120 (2006) PubMed

 

Mizuguchi H. Recent Advance of Development of Viral and Non-viral Vectors for Gene Therapy. Yakugaku Zasshi, 126, 1011 (2006) PubMed

 

Sakurai F., Kawabata K., Mizuguchi H. Characterization of adenovirus serotype 35 vectors using genetically modified animals and nonhuman primates. Yakugaku Zasshi, 126, 1013-1019 (2006) PubMed

 

Akita H., Hama S., Mizuguchi H. Harashima H. Development of non-viral vector based on the quantitative comparison of intracellular trafficking with viral vector. Yakugaku Zasshi, 126, 1047-1057 (2006) PubMed

 

櫻井文教、水口裕之;新しいアデノウイルスベクターの開発、バイオサイエンスとインダストリー、64(5)、11-16(2006)

櫻井文教、川端健二;創薬・創剤人、PHARM TECK JAPAN、22, 18-19 (2006) WebSite

Kawabata K., Sakurai F., Yamaguchi T., Hayakawa T., Mizuguchi H. Efficient gene transfer into mouse embryonic stem cells with adenovirus vectors. Mol. Ther., 12, 547-554 (2005) PubMed

Sakurai F., Kawabata K., Yamaguchi T., Hayakawa T., Mizuguchi H. Optimization of adenovirus serotype 35 vectors for efficient transduction in human hematopoietic progenitors: comparison of promoter activities. Gene Ther., 12, 1424-1433 (2005) PubMed

 

Mizuguchi H., Sasaki T., Kawabata K., Sakurai F., Hayakawa T. Fiber-modified adenovirus vectors mediate efficient gene transfer into undifferentiated and adipogenic-differentiated human mesenchymal stem cell. Biochem. Biophys. Res. Commun., 332, 1101-1106 (2005) PubMed

 

Ino A., Naito Y., Mizuguchi H., Handa N., Hayakawa T., Kobayashi I. A trial of somatic gene targeting in vivo with an adenovirus vector. Genetic Vaccines and Therapy, 3:8 (12Oct2005) (2005) PubMed

 

Mizuguchi H., Xu Z-L., Sakurai F., Kawabata K., Yamaguchi T., Hayakawa T. Efficient regulation of gene expression using self-contained fiber-modified adenovirus vectors containing the tet-off system. J. Control. Rel., 110, 202-211 (2005) PubMed

 

Xin K-Q., Jounai N., Someya K., Honma K., Mizuguchi H., Naganawa S., Kitamura K., Hayakawa T., Saha S., Takeshita F., Okuda K., Honda M., Klinman D.M., Okuda K. Prime-boost vaccination with plasmid DNA and a chimeric adenovirus type 5 vector with type 35 fiber induces protective immunity against HIV. Gene Ther., 12, 1769-1777 (2005) PubMed

 

Takahashi A., Kondoh M., Masuyama A. Fujii M., Mizuguchi H., Horiguchi Y., Watanabe Y. Role of C-terminal regions of the C-terminal fragment of Clostridium perfringens enterotoxin in its interaction with claudin-4, J. Control. Rel., 108, 56-62 (2005) PubMed

 

Masuyama A., Kondoh M., Seguchi H., Takahashi A., Harada M., Fujii M., Mizuguchi H., Horiguchi Y., Watanabe Y. Role of N-terminal amino acids in the absorption-enhancing effects of the C-terminal fragment of Clostridium Perfringens enterotoxin. J. Pharmacol. Exp. Ther., 314, 789-795 (2005) PubMed

 

Gao J-Q, Sugita T., Kanagawa N., Iida K., Okada N., Mizuguchi H., Nakayama T., Yoshie O., Tsutsumi Y., Mayumi T., Nakagawa S. Anti-tumor responses induced by chemokine CCL19 transfected into an ovarian carcinoma model via fiber-mutant adenovirus vector. Biol. Pharm. Bull., 28, 1066-1070 (2005) PubMed

 

Okada Y., Okada N., Mizuguchi H., Hayakawa T., Nakagawa S., Mayumi T. Transcriptional targeting of RGD fiber-mutant adenovirus vectors can improve the safety of suicide gene therapy for murine melanoma. Cancer Gene Ther., 12, 608-616 (2005) PubMed

 

Koizumi, N., Kondoh, M., Mizuguchi H., Nakanishi, T., Masuyama, A., Ida, F., Fujii, M., Hayakawa, T., Nakashima, E., Tanaka, K., Watanabe, Y. Comparison of transgene expression mediated by several fiber-modified adenovirus vectors in trophoblast cells. Placenta., 26, 729-734 (2005) PubMed

 

Eto Y., Gao J-Q., Sekiguchi F., Kurachi S., Katayama K., Mizuguchi H., Hayakawa T., Maeda, M., Kawasaki K., Tsutsumi Y., Mayumi T., Nakagawa S. PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody evasion ability. J. Gene Med., 7, 604-612 (2005) PubMed

 

Taki M., Kagawa S., Nishizaki M., Mizuguchi H., Hayakawa T., Kyo S., Nagai K., Urata Y., Tanaka N., Fujiwara T. Enhanced oncolysis by a tropism-modified telomerase-specific replication-selective adenoviral agent OBP-405 ('Telomelysin-RGD'). Oncogene, 24, 3130-3140 (2005) PubMed

 

Maeda M., Kida S., Hojo K., Eto Y., Gao J-Q, Kurachi S., Sekiguchi F., Mizuguchi H., Hayakawa T., Mayumi T., Nakagawa S., Kawasaki K. Design and synthesis of a peptide-PEG transporter tool for carrying adenovirus vector into cells. Bioorg. Medicinal. Chem. Lett., 15, 621-624 (2005) PubMed

 

Gao J-Q, Sugita T., Kanagawa N., Iida K., Eto Y., Motomura Y., Mizuguchi H., Tsutsumi Y., Hayakawa T., Mayumi T., Nakagawa S. A single intratumoral injection of a fiber-mutant adenoviral vector encoding interleukin 12 induces remarkable anti-tumor and anti-metastatic activity in mice with Meth-A fibrosarcoma. Biochem. Biophys. Res. Commun., 328, 1043-1050 (2005) PubMed

 

Nasimuzzaman, M., Kuroda, M., Dohno, S., Yamamoto, T., Iwatsuki, K., Matsuzaki, S., Rashel, M., Kumita, W., Mizuguchi, H., Hayakawa, T., Nakamura, H., Taguchi, T., Wakiguchi, H., Imai, S. Eradication of Epstein-Barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1. Mol. Ther., 11, 578-590 (2005) PubMed

 

Hosono T., Mizuguchi H., Katayama K., Koizumi N., Kawabata K., Yamaguchi T., Nakagawa S., Watanabe Y., Mayumi T., Hayakawa T. RNA interference of PPARγ using fiber-modified adenovirus vector efficiently suppresses preadipocyte-to-adipocyte differentiation in 3T3-L1 cells. Gene, 348, 157-165 (2005) PubMed

 

Kondoh, M., Masuyama , A., Takahashi, A., Asano, N., Mizuguchi H., Koizumi, N., Fujii, M., Hayakawa, T., Horiguchi, Y., Watanabe, Y. A novel strategy for the enhancement of drug absorption using a claudin modulator. Mol. Pharmacol., 67, 749-756 (2005) PubMed

 

Sumimoto H., Yamagata S., Shimizu A., Miyoshi H., Mizuguchi H., Hayakawa T., Miyagishi M., Taira K., Kawakami Y. Gene therapy for human small cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference. Gene Ther., 12, 95-100 (2005) PubMed

 

Okada N., Mori N., Koretomo R., Okada Y., Nakayama T., Yoshie O., Mizuguchi H., Hayakawa T., Nakagawa S., Mayumi T., Fujita T., Yamamoto A. Augmentation of the migratory ability of DC-based vaccine into regionalymph nodes by efficient CCR7 gene transduction. Gene Ther., 12, 129-139 (2005) PubMed

 

Okada N., Iiyama S., Okada Y., Mizuguchi H., Hayakawa T., Nakagawa S., Mayumi T., Fujita T., Yamamoto A. Immunological properties and vaccine efficacy of murine dendritic cells simultaneously expressing melanoma-associated antigen and interleukin-12. Cancer Gene Ther., 12, 72-83 (2005) PubMed

 

Imai, J., Katagiri, H., Yamada, T., Ishigaki, Y., Ogihara, T., Uno, K., Hasegawa, Y., Gao, J., Ishihara, H., Sasano, H., Mizuguchi H., Asano, T., Oka, Y. Constitutively active PDX1 induced efficient insulin production in adult murine liver. Biochem. Biophys. Res. Commun., 326, 402-409 (2005) PubMed

 

Xu ZL., Mizuguchi H., Koizumi N., Sakurai F., Hosono T., Kawabata K., Watanabe Y., Yamaguchi T., Hayakawa T. Approaches to improving the kinetics of adenovirus-delivered genes and gene products. Adv. Drug. Deli. Rev., 57, 781-802 (2005) PubMed

 

Sakurai F., Takakura Y., Hashida M. Evaluation of immune response after administration of plasmid DNA-non-viral vector complexes. In: Taira K., Kataoka K (eds) Non-viral Gene Therapy: Gene Design and Delivery. Springer, pp339-347 (2005) WebSite

 

水口裕之;目的遺伝子の抑制レベルを自由に制御するアデノウイルスベクターの開発、実験医学、羊土社、23、2167-2172 (2005) WebSite

水口裕之、川端健二、櫻井文教、早川堯夫;改良型アデノウイルスベクターを用いた造血幹細胞、間葉系幹細胞、ES細胞への高効率遺伝子導入、炎症・再生、25、447-451 (2005) J-STAGE

水口裕之、早川堯夫;カプシドタンパク質を改変した改良型アデノウイルスベクターによる高効率遺伝子導入、BIO INDUSTRY、シーエムシー出版、22(5)、16-21 (2005) WebSite

水口裕之、早川堯夫;ウイルスベクター、Drug Delivery System、20、158-159(2005)

櫻井文教;高性能な遺伝子導入ベクターの開発を目指して、Drug Delivery System、20、474-475 (2005)

水口裕之;ウイルスベクターのDDS:Drug Metabolism And Pharmacokinetics、19(6)、30-32(2005)

Mizuguchi H., Hayakawa T., Targeted adenovirus vectors. Hum. Gene Ther., 15, 1034-1044 (2004) PubMed

Hosono T., Mizuguchi H., Katayama K., Xu ZL., Sakurai F., Ishii-Watabe A., Kawabata K., Yamaguchi T., Nakagawa S., Mayumi T., Hayakawa T. Adenovirus vector-mediated doxycycline-inducible RNA interference. Hum. Gene Ther., 15, 813-819 (2004) PubMed

 

Koizumi, N., Mizuguchi H., Kondoh, M., Fujii, M., Hayakawa, T., Watanabe, Y. Efficient gene transfer into human trophoblast cells with adenovirus vector containing chimeric type 5 and 35 fiber protein. Biol. Pharm. Bull., 27, 2046-2048 (2004) PubMed

 

Uchida E., Sato K., Iwata A., Ishii-Watabe A., Mizuguchi H., Hikata M., Murata M., Yamaguchi T., Hayakawa T. An improved method for detection of replication-competent retrovirus in retrovirus vector products. Biologicals, 32, 139-146 (2004) PubMed

 

Gao J-Q., Inoue S., Tsukada Y., Katayama K., Eto Y., Kurachi S., Mizuguchi H., Hayakawa T., Tsutsumi Y., Mayumi T., Nakagawa S. High gene expression of the mutant adenovirus vector, both in vitro and in vivo, with the insertion of integrin-targeting peptide into the fiber. Pharmazie, 59, 571-572 (2004) PubMed

 

Kawai H., Suzuki T., Kobayashi T., Mizuguchi H., Hayakawa T., Kawanishi T. Simultaneous imaging of initiator/effector caspase activity and mitochondrial membrane potential during cell death in living HeLa cells. Biochim. Biophys. Acta., 1693, 101-110 (2004) PubMed

 

Eto Y., Gao J-Q., Sekiguchi F., Kurachi S., Katayama K., Mizuguchi H., Hayakawa T., Tsutsumi Y., Mayumi T., Nakagawa S. Neutralizing antibody evasion ability of adenovirus vector induced by the bioconjugation of methoxypolyethylene glycol succinimidyl propionate (MPEG-SPA). Biol. Pharm. Bull., 27, 936-938 (2004) PubMed

 

Nakamura T., Peng K-W., Vongpunsawad S., Harvey M., Mizuguchi H., Hayakawa T., Cattaneo R., Russell S.J. Antibody-targeted cell fusion. Nat. Biotech., 22, 331-336 (2004) PubMed

 

Okada Y., Okada N., Mizuguchi H., Takahashi K., Hayakawa T., Mayumi T., Mizuno N. Optimization of antitumor efficacy and safety of in vivo cytokine gene therapy using RGD fiber-mutant adenovirus vector for preexisting murine melanoma. Biochim. Biophys. Acta., 1670, 172-180 (2004) PubMed

 

Okada N., Gao J-Q., Sasaki A., Niwa M., Okada Y., Nakayama T., Yoshie O., Mizuguchi H., Hayakawa T., Fujita T., Yamamoto A., Tsutsumi Y., Mayumi T., Nakagawa S. Anti-tumor activity of chemokine is affected by both kinds of tumors and the activation state of the host's immune system: implications for chemokine-based cancer immunotherapy. Biochem. Biophys. Res. Commun., 317, 68-76 (2004) PubMed

 

Anno T., Uehara S., Katagiri H., Ohta Y., Ueda K., Mizuguchi H., Moriyama Y., Oka Y., Tanizawa Y. Overexpression of constitutively activated glutamate dehydrogenase induces insulin secretion through enhanced glutamate oxidation. Am. J. Physiol., 286, E280-285 (2004) PubMed

 

Gao J-Q, Alexandre L.S., Tsuda Y., Katayama K., Eto Y., Sekiguchi F., Mizuguchi H., Hayakawa T., Nakayama T., Yoshie O., Tsutsumi Y., Mayumi T., Nakagawa S. Tumor-suppressive activities by chemokines introduced into OV-HM cells using fiber-mutant adenovirus vectors. Pharmazie, 59, 238-239 (2004) PubMed

 

Katayama K., Wada K., Miyoshi H., Ohashi K., Tachibana M., Furuki R., Mizuguchi H., Hayakawa T., Nakajima A., Kadowaki T., Tsutsumi Y., Nakagawa1 S., Kamisaki Y., Mayumi T. RNA interfering approach for clarifying PPARγ pathway using lentiviral vector expressing short hairpin RNA. FEBS Lett., 560, 178-182 (2004) PubMed

 

Suto R., Tominaga K., Mizuguchi H., Sasaki E., Higuchi K., Kim S., Iwao H., Arakawa T. Dominant negative mutant of c-Jun gene transfer: a novel therapeutic strategy for colorectal cancer. Gene Ther., 11, 187-193 (2004) PubMed

 

水口裕之、早川堯夫;アデノウイルスベクター、Mebio、21(4)、8-16 (2004)

Koizumi N., Mizuguchi H., Sakurai F., Yamaguchi T., Watanabe Y., Hayakawa T. Reduction of natural adenovirus tropism to mouse liver by fiber-shaft exchange in combination with both CAR- and αv integrin-binding ablation. J. Virol., 77, 13062-13072 (2003) PubMed

 

Ishi-Watabe A., Uchida E., Iwata A., Nagata R., Satoh K., Fan K., Murata M., Mizuguchi H., Kawasaki N., Kawanishi T., Yamaguchi T., Hayakawa T. Detection of replication-competent adenoviruses spiked into recombinant adenovirus vector products by infectivity PCR. Mol. Ther., 8, 1009 - 1016 (2003) PubMed

 

Sakurai F., Mizuguchi H., Yamaguchi T., Hayakawa T. Characterization of in vitro and in vivo gene transfer properties of adenovirus serotype 35 vector. Mol. Ther., 8, 813-821 (2003) PubMed

 

Mizuguchi H., Xu Z.L., Sakurai F., Mayumi T., Hayakawa T. Tight positive regulation of transgene expression by a single adenovirus vector containing the rtTA and tTS expression cassettes in separate genome regions. Hum. Gene Ther., 14, 1265-1277 (2003) PubMed

 

Gao J-Q, Tsuda Y., Katayama K., Nakayama T., Hatanaka Y., Tani Y., Mizuguchi H., Hayakawa T., Yoshie O., Tsutsumi Y., Mayumi T., Nakagawa S. Antitumor effect by interleukin-11 receptor alpha-locus chemokine/CCL27, introduced into tumor cells through a recombinant adenovirus vector. Cancer Res., 63, 4420-4425 (2003) PubMed

 

Sakurai F., Mizuguchi H., Hayakawa T. Efficient gene transfer into human CD34+ cells by an adenovirus type 35 vector. Gene Ther., 10, 1041-1048 (2003) PubMed

Koizumi N., Mizuguchi H., Utoguchi N., Watanabe Y., Hayakawa T. Generation of fiber-modified adenovirus vectors containing heterologous peptides in both the HI loop and C terminus of the fiber knob.  J. Gene Med., 5, 267-276 (2003) PubMed

 

Xu Z.L., Mizuguchi H., Mayumi T., Hayakawa T. Regulated gene expression from adenovirus vectors: a systematic comparison of various inducible systems. Gene, 309, 145-151 (2003) PubMed

 

Xu Z.L., Mizuguchi H., Mayumi T., Hayakawa T. Woodchuck hepatitis virus post-transcriptional regulation element enhances transgene expression from adenovirus vectors. Biochim. Biophys. Acta, 1621, 266-271 (2003) PubMed

 

Itoh A., Okada T., Mizuguchi H., Hayakawa T., Mizukami H., Kume A., Takatoku M., Komatsu A., Hanazono Y., Ozawa K. A soluble CAR-SCF fusion protein improves adenoviral vector-mediated gene transfer to c-Kit-positive hematopoietic cells. J. Gene Med., 5, 929-940 (2003) PubMed

 

Okada N., Masunaga Y., Okada Y., Mizuguchi H., Iiyama S., Mori N., Sasaki A., Nakagawa S., Mayumi T., Hayakawa T., Fujita T., Yamamoto A. Dendritic cells transduced with gp100 gene by RGD fiber-mutant adenovirus vectors are highly efficacious in generating anti-B16BL6 melanoma immunity in mice.  Gene Ther., 10, 1891-1902 (2003) PubMed

 

Kita A., Uotani S., Kuwahara H., Takahashi R., Oshima K., Yamasaki H., Mizuguchi H., Hayakawa T., Nagayama Y., Yamaguchi Y., Eguchi K. Vanadate enhances leptin-induced activation of JAK/STAT pathway in CHO cells. Biochem. Biophys. Res. Commun., 302, 805-809 (2003) PubMed

 

Li Y., Takemura G., Kosai K.I., Yuge K., Nagano S., Esaki M., Goto K., Takahashi T., Hayakawa K., Koda M., Kawase Y., Maruyama R., Okada H., Minatoguchi S., Mizuguchi H., Fujiwara T., Fujiwara H. Postinfarction treatment with an adenoviral vector expressing hepatocyte growth factor relieves chronic left ventricular remodeling and dysfunction in mice. Circulation, 107, 2499-2506 (2003) PubMed

 

Tanaka K., Towata S., Nakao K., Mizuguchi H., Hayakawa T., Niwa M., Ishii N., Nagayama Y. Thyroid cancer immuno-therapy with retroviral and adenoviral vectors expressing granulocyte macrophage colony stimulating factor and interleukin-12 in a rat model. Clin. Endocrinol., 59, 734-742 (2003) PubMed

Nagayama Y, Mizuguchi H., Hayakawa T., Niwa M., McLachlan SM., Rapoport B. Prevention of autoantibody-mediated Graves'-like hyperthyroidism in mice with IL-4, a Th2 cytokine. J. Immunol., 170, 3522-3527 (2003) PubMed

 

Nagayama Y., Nakao, K., Mizuguchi H., Hayakawa T., Niwa M. Enhanced antitumor effect of combined replicative adenovirus and nonreplicative adenovirus expressing interleukin-12 in an immunocompetent mouse model.  Gene Ther., 10, 1400-1403 (2003) PubMed

 

Morioka T., Koyama H., Yamamura H., Tanaka S., Fujimoto, S., Emoto M., Mizuguchi H., Hayakawa T., Kojima I., Takahashi K., Nishizawa Y. Role of H1-calponin in pancreatic AR42J cell differentiation into insulin-producing cells.  Diabetes, 52, 760-766 (2003) PubMed

 

Nakano R., Nakagawa T., Imazu S., Katayama K., Mizuguchi H., Hayakawa T., Tsutsumi Y., Nakagawa S., Mayumi T. A novel T7 system utilizing mRNA coding for T7 RNA polymerase. Biochem. Biophys. Res. Commun., 301, 974-978 (2003) PubMed

 

Okada N., Masunaga Y., Okada Y., Iiyama S., Tsuda T., Matsubara A., Mori N., Mizuguchi H., Hayakawa T., Fujita T., Yamamoto A. Gene transduction efficiency and maturation status in mouse bone marrow-derived dendritic cells infected with conventional or RGD fiber-mutant adenovirus vectors.  Cancer Gene Ther., 10, 421-431 (2003) PubMed

 

Katayama K., Wada K., Nakajima A., Yoshida S., Mizuguchi H., Hayakawa T., Nakagawa S., Kadowaki T, Nagai R., Kamisaki Y, Blumberg RS., Mayumi T. A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model.  Gastroenterology, 124, 1315-1324 (2003) PubMed

 

Okada Y., Okada N., Mizuguchi H., Hayakawa T., Mayumi T., Mizuno N. An investigation of adverse effects caused by the injection of high-dose TNFα-expressing adenovirus vector into established murine melanoma. Gene Ther., 10, 700-705 (2003) PubMed

 

Abiru N., Sun F., Kawasaki E., Yamasaki H., Oshima K., Nagayama Y., Mizuguchi H., Hayakawa T., Miao D., Liu E., Eisenbarth G.S., Eguchi K. In vivo expression of B:9-23 peptide/I-Ag7 complex may abrogate the inhibition of diabetes induced by RGD-fiber-mutant adenovirus in NOD mice. Annals N.Y. Acad. Sci., 1005, 218-221 (2003) PubMed

 

Ara T., Tokoyoda K., Sugiyama T., Egawa T., Kawabata K., Nagasawa T. Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny. Immunity, 19, 257-267 (2003) PubMed

 

Ara T., Itoi M., Kawabata K., Egawa T., Tokoyoda K., Sugiyama T., Fujii N., Amagai T., Nagasawa T. A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J. Immunol., 170, 4649-4655 (2003) PubMed

 

Sakurai F., Terada T., Maruyama M., Yamashita F., Takakura Y., and Hashida M. Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-beta gene and poly I: poly C in a murine lung metastasis model.  Cancer Gene Ther., 10, 661-668 (2003) PubMed

 

水口裕之;次世代遺伝子治療薬の開発基盤研究、薬学雑誌、123、761-771 (2003) J-STAGE

 

水口裕之、早川堯夫;アデノウイルスベクター:最近の進歩、分子細胞治療、2、200-207 (2003)

 

水口裕之、早川堯夫;遺伝子機能解析のための遺伝子導入ベクター -ウイルスベクターを中心として-;蛋白質核酸酵素、48、1653-1662 (2003)

橋田充、水口裕之、山下富義、横山昌幸、原島秀吉、米谷芳枝、松村保広、岡田純一、五十嵐理慧; 21世紀のDDS:発展を担う立場から、Drug Delivery System、18、7-20 (2003)

Mizuguchi H., Koizumi N., Hosono T., Ishii-Watabe A., Uchida E., Utoguchi N., Watanabe Y., Hayakawa T. CAR- orαv integrin-binding ablated adenovirus vectors, but not fiber-modified vectors containing RGD peptide, do not change the systemic gene transfer properties in mice. Gene Ther., 9, 769-776 (2002) PubMed

 

Mizuguchi H., Hayakawa T. Enhanced antitumor effect and reduced vector dissemination with fiber-modified adenovirus vectors expressing herpes simplex virus thymidine kinase. Cancer Gene Ther., 9, 236-242 (2002) PubMed

 

Mizuguchi H., Hayakawa T. The tet-off system is more effective than the tet-on system for regulating transgene expression in a single adenovirus vector. J. Gene Med., 4, 240-247 (2002) PubMed

 

Mizuguchi H., Hayakawa T. Adenovirus vectors containing chimeric type 5 and type 35 fiber proteins exhibit altered and expanded tropism and increase the size limit of foreign genes. Gene, 285, 69-77 (2002) PubMed

 

Xu Z.L., Mizuguchi H., Ishii-Watabe I., Uchida E., Mayumi T., Hayakawa T. Strength evaluation of transcriptional regulatory elements for transgene expression by adenovirus vector. J.Control. Rel., 81, 155-163 (2002) PubMed

 

Uchida E., Mizuguchi H., Ishi-Watabe A., Hayakawa T. Comparison of the efficiency and safety of non-viral vector-mediated gene transfer into a wide range of human cells. Biol. Pharm. Bull., 25, 891-897 (2002) PubMed

 

Kawamata Y., Nagayama Y., Nakao K., Mizuguchi H., Hayakawa T., Sato T., Ishii N. Receptor-independent augmentation of adenovirus-mediated gene transfer with chitosan in vitro. Biomaterials., 23, 4573-4579 (2002) PubMed

 

Akuta T., Eguchi A., Okuyama H., Senda T., Inokuchi H., Suzuki Y., Nagoshi E., Mizuguchi H., Hayakawa T., Takeda K., Hasegawa M., Nakanishi M. Enhancement of phage-mediated gene transfer by nuclear localization signal. Biochem. Biophys. Res. Commun., 297, 779-786 (2002) PubMed

 

Okada Y., Okada N., Nakagawa S., Mizuguchi H., Takahashi K., Mizuno N., Fujita T., Yamamoto A., Hayakawa T., Mayumi T. Tumor necrosis factor α-gene therapy for an established murine melanoma using RGD (Arg-Gly-Asp) fiber-mutant adenovirus vectors. Jpn. J. Cancer Res., 93, 436-444 (2002) PubMed

 

Nagayama Y, Kita-Furuyama M., Ando T., Nakao K., Mizuguchi H., Hayakawa T., Eguchi K., Niwa M. A Novel murine model of graves’ hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor. J. Immunol., 168, 2789-2794 (2002) PubMed

 

Omori M., Mizuguchi H., Ohsawa K., Kohsaka S., Hayakawa T., Abe K., Shibasaki F. Modification of a fiber protein in an adenovirus vector improves in vitro gene transfer efficiency to microglial cell line. Neurosci. Lett., 324, 145-148 (2002) PubMed

 

Takahashi M., Seki N., Ozaki T., Kato M., Kuno T., Nakagawa T., Watanabe K., Miyazaki K., Ohira M., Hayashi S., Hosoda M., Tokita H., Mizuguchi H., Hayakawa T., Todo S., Nakagawara A. Identification of the p33ING1-regulated genes that include cyclin B1 and proto-oncogene DEK by using cDNA microarray in a mouse mammary epithelial cell line NMuMG.  Cancer Res., 62, 2203-2209 (2002) PubMed

 

Nakagawa T., Takahashi M., Ozaki T., Watanabe K., Todo S., Mizuguchi H., Hayakawa T., Nakagawara A. Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter.  Mol. Cell. Biol., 22, 2575-2585 (2002) PubMed

 

Okada Y., Okada N., Nakagawa S., Mizuguchi H., Kanehira M., Nishino N., Takahashi K., Mizuno N., Hayakawa T., Mayumi T. Fiber-mutant technique can augment gene transduction efficacy and anti-tumor effects against established murine melanoma by cytokine-gene therapy using adenovirus vectors. Cancer Lett., 177, 57-63 (2002) PubMed

Sakurai F, Terada T, Yasuda K, Yamashita F, Takakura Y, and Hashida M. The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes. Gene Ther., 9, 1120-1126 (2002) PubMed

Mizuguchi H., Hayakawa T. Improvement of adenovirus vectors for gene transfer. In: Shirahata S., Teruya K., Katakura Y. (eds) Animal Cell Technology: Basic & Applied Aspects. Springer, vol.12, 1-5 (2002) WebSite

 

水口裕之、早川堯夫;in vitroライゲーションを利用したアデノウイルスベクターの作製・増殖法、実験医学、羊土社、20、1799-1804 (2002) WebSite

水口裕之;遺伝子治療とDDS、Drug Delivery System、17、60-61(2002)

Mizuguchi H., Koizumi N., Hosono T., Utoguchi N., Watanabe Y., Kay MA., Hayakawa T. A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob. Gene Ther., 8, 730-735 (2001) PubMed

 

Mizuguchi H., Kay MA., Hayakawa T. In vitro ligation-based cloning of foreign DNAs into the E3 and E1 deletion regions for generation of recombinant adenovirus vectors.  BioTechniques, 30, 1112-1114, 1116 (2001) PubMed

 

Mizuguchi H., Hayakawa T. Characteristics of adenovirus-mediated tetracycline-controllable expression system. Biochim. Biophys. Acta, 1568, 21-29 (2001) PubMed

 

Koizumi N., Mizuguchi H., Hosono T., Ishii-Watabe A., Uchida E., Utoguchi N., Watanabe Y., Hayakawa T. Efficient gene transfer by fiber-mutant adenoviral vectors containing RGD peptide. Biochim. Biophys. Acta, 1568, 13-20 (2001) PubMed

 

Xu ZL., Mizuguchi H., Ishii-Watabe A., Uchida E., Mayumi T., Hayakawa T. Optimization of transcriptional regulatory elements for constructing plasmid vectors. Gene, 272, 149-156 (2001) PubMed

 

Mizuguchi H., Kay M.A., Hayakawa T. Approaches for generating recombinant adenovirus vectors. Adv. Drug. Deli. Rev., 52, 165-176 (2001) PubMed

 

Maruyama K., Akiyama Y., Nara-Ashizawa N., Hojo T., Cheng JY., Mizuguchi H., Hayakawa T., Yamaguchi K. Adenovirus-mediated MUC1 gene transduction into human blood-derived dendritic cells. J. Immunother., 24, 345-353 (2001) PubMed

 

Okada N., Saito T., Masunaga Y., Tsukada Y., Nakagawa S., Mizuguchi H., Mori K., Okada Y., Fujita T., Hayakawa T., Mayumi T., Yamamoto A. Efficient antigen gene transduction using Arg-Gly-Asp fiber-mutant adenovirus vectors can potentiate antitumor vaccine efficacy and maturation of murine dendritic cells.  Cancer Res., 61, 7913-7919 (2001) PubMed

 

Okada N., Tsukada Y., Nakagawa S., Mizuguchi H., Mori K., Saito T., Fujita T., Yamamoto A., Hayakawa T., Mayumi T. Efficient gene delivery into dendritic cells by fiber-mutant adenovirus vectors. Biochem. Biophys. Res. Commun., 282, 173-179 (2001) PubMed

 

Ishii-Watabe A., Uchida E., Mizuguchi H., Hayakawa T. Involvement of a calcium-independent pathway in plasmin-induced platelet shape change.  Life Science, 69, 945-960 (2001) PubMed

 

Nagayama Y., Nishihara E., Namba H., Yokoi H., Hasegawa M., Mizuguchi H., Hayakawa T., Hamada H., Yamashita S., Niwa M. Targeting the replication of adenovirus to p53-defective thyroid carcinoma with a p53-regulated cre/loxP system. Cancer Gene Ther., 8, 36-44 (2001) PubMed

 

Nakanishi M., Akuta T., Nagoshi E., Eguchi A., Mizuguchi H., Senda T. Nuclear targeting of DNA. Eur. J. Pharm. Sci., 13, 17-24 (2001) PubMed

 

Sakurai F, Nishioka T, Yamashita F, Takakura Y, and Hashida M. Effects of erythrocytes and serum proteins on lung accumulation of lipoplexes containing cholesterol or DOPE as a helper lipid in the single-pass rat lung perfusion system. Eur. J. Pharm. Biopharm., 52, 165-172 (2001) PubMed

 

Sakurai F, Nishioka T, Saito H, Baba T, Okuda A, Matsumoto O, Taga T, Yamashita F, Takakura Y, and Hashida M. Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid. Gene Ther., 8, 677-686 (2001) PubMed

 

Egawa T, Kawabata K, Kawamoto H, Amada K, Okamoto R, Fujii N, Kishimoto T, Katsura Y, Nagasawa T. The earliest stages of B cell development require a chemokine stromal cell-derived factor/pre-B cell growth-stimulating factor. Immunity, 15, 323-334 (2001) PubMed

 

水口裕之、早川堯夫;プラスミド構築に基づいた組換えアデノウイルスベクター作製技術、BIO INDUSTRY、18(7)、5-14 (2001)

早川堯夫、水口裕之;遺伝子治療用医薬品の実用化と一層の進展に向けて-新世代アデノウイルスベクターの開発-、医薬ジャーナル、医薬ジャーナル社、37、101-107 (2001) WebSite

水口裕之、早川堯夫;アデノウイルスベクター、バイオ医薬品の品質・安全性評価、早川堯夫、山崎修道、延原正弘編、エル・アイ・シー、pp383-393 (2001)

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directed by Prof. Hiroyuki Mizuguchi

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