業績|論文・出版物|2020年

Shimizu K., Sakurai F., Iizuka S., Ono R., Tsukamoto T., Nishimae F., Nakamura SI., Nishinaka T., Terada T., Fujio Y., Mizuguchi H. Adenovirus Vector-Induced IL-6 Promotes Leaky Adenoviral Gene Expression, Leading to Acute Hepatotoxicity. J. Immunol., in press.

 

Takayama K., Ito K., Matsui A., Yamashita T., Kawakami K., Hirayama D., Kishimoto W., Nakase H., Mizuguchi H. In vivo gene expression profile of human intestinal epithelial cells: from the viewpoint of drug metabolism and pharmacokinetics. Drug. Metab. Dispos., in press. 

 

Kiso A., Toba Y., Tsutsumi S., Deguchi S., Igai K., Koshino S., Tanaka Y., Takayama K., Mizuguchi H. Tolloid-like 1 negatively regulates hepatic differentiation of human iPS cells through transforming growth factor beta signaling, Hepatol. Commun., 4, 255-267 (2020) PubMed

 

Hagihara Y., Sakamoto A., Tokuda T., Yamashita T., Ikemoto S., Kimura A., Haruta M., Sasagawa K., Ohta J., Takayama K., Mizuguchi H. Photoactivatable oncolytic adenovirus for optogenetic cancer therapy. Cell Death Dis. 11, 570 (2020) PubMed

 

Negoro R., Kawai K., Ichikawa M., Deguchi S., Takayama K., Mizuguchi H. Establishment of MDR1-knockout human induced pluripotent stem cell line. Drug. Metab. Pharmacokinet., 35, 288-296 (2020) PubMed

 

Koujima T., Tazawa H., Ieda T., Araki H., Fushimi T., Shoji R., Kuroda S., Kikuchi S., Yoshida R., Umeda Y., Teraishi F., Urata Y., Mizuguchi H., Fujiwara T. Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer. Mol. Ther. Oncolysis., 17, 107-117 (2020) PubMed

 

Toba Y., Deguchi S., Mimura N., Sakamoto A., Harada K., Hirata K., Takayama K., Mizuguchi H. Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance. PLoS ONE, 15, e0229654 (2020) PubMed

 

Kanaya N., Kuroda S., Kakiuchi Y., Kumon K., Tsumura T., Hashimoto M., Morihiro T., Kubota T., Aoyama K., Kikuchi S., Nishizaki M., Kagawa S., Tazawa H., Mizuguchi H., Urata Y., Fujiwara T. Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody. Mol. Ther., 28, 794-804 (2020) PubMed

 

Wakabayashi K., Sakurai F., Ono R., Fujiwara T., Mizuguchi H. Development of a Novel Oncolytic Adenovirus Expressing a Short-hairpin RNA Against Cullin 4A. Anticancer Res., 40, 161-168 (2020) PubMed

 

Tachibana M., Watanabe N., Koda Y., Oya Y., Kaminuma O., Katayama K., Fan Z., Sakurai F., Kawabata K., Hiroi T., Mizuguchi H. Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications of myeloid-derived suppressor cells and NO production. Int. Immunol., 32, 187-201 (2020) PubMed

 

Deguchi S., Takayama K., Mizuguchi H., Generation of human induced pluripotent stem cell-derived hepatocyte-like cells for cellular medicine, Biol. Pharm. Bull., 43, 608-615 (2020) PubMed

Yamaguchi T., Uchida E., Okada T., Ozawa K., Onodera M., Kume A., Shimada T., Takahashi S., Tani K., Nasu Y., Mashimo T., Mizuguchi H., Mitani K., Maki K. Aspects of gene therapy products using current genome-editing technology in Japan. Hum. Gene Ther., 31, 1043-1053 (2020) PubMed

 

櫻井文教、水口裕之;ヒトiPS細胞由来肝細胞のB型肝炎ウイルス感染評価系への応用、ファルマシア、56, 1099-1103 (2020) J-STAGE

 

山下智起、横田純平、乾達也、水口裕之;薬物動態評価系としてのヒトiPS細胞由来腸管上皮細胞の可能性、Drug Delivery System、35、309-318 (2020)

 

塚本智仁、酒井英子、櫻井文教、水口裕之;CHOPCHOP v3を用いたCRISPR-Cas9の標的配列検索方法、Drug Delivery System、35、257-259 (2020) J-STAGE

 

鳥羽由希子、水口裕之;ゲノム編集モデルの医薬品評価への応用とその課題、ゲノム編集技術の産業応用技術〜研究動向、課題とその解決、トラブル対策〜、株式会社 技術情報協会、印刷中

 大阪大学大学院 薬学研究科 分子生物学分野 

〒565-0871 大阪府吹田市山田丘1-6 大阪大学 大学院薬学研究科・薬学部 1号館 4階

TEL: 06-6879-8185 FAX: 06-6879-8187

 

Copyright© Laboratory of Biochemistry and Molecular Biology, Graduate School and School of Pharmaceutical Sciences, Osaka University

directed by Prof. Hiroyuki Mizuguchi

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