論文・出版物 - 2019

Kawai K., Negoro R., Ichikawa M., Yamashita T., Deguchi S., Harada K., Hirata K., Takayama K., Mizuguchi H. Establishment of SLC15A1/PEPT1-knockout human induced pluripotent stem cell line for intestinal drug absorption studies. Mol. Ther. Methods Clin. Dev., in press.

Tsukamoto T., Sakai E., Nishimae F., Sakurai F., Mizuguchi H. Efficient generation of adenovirus vectors carrying the Clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR associated proteins (Cas)12a system by suppressing Cas12a expression in packaging cells. J. Biotech., 304, 1-9 (2019) PubMed

Takayama K., Negoro R., Yamashita T., Kawai K., Ichikawa M., Mori T., Nakatsu N., Harada K., Ito S., Yamada H., Yamaura Y., Hirata K., Ishida S., Mizuguchi H. Generation of human iPS cell-derived intestinal epithelial cell monolayers by CDX2 transduction. Cell. Mol. Gastroenterol. Hepatol., 8, 513-526 (2019) PubMed

Sakurai F. #, Hashimoto R. #, Inoue C., Wakabayashi K., Tsukamoto T., Taracena-Gándara M., Imaizumi T., Sakai E., Itsuki K., Sakamoto N., Wakita T., Mizuguchi H. miR-27b-mediated suppression of aquaporin-11 expression in hepatocytes reduces HCV genomic RNA levels but not viral titers. Virology Journal, 16, 58 (2019) # These authors contributed equally to this work. PubMed

Deguchi S., Yamashita T., Igai K., Harada K., Toba Y., Hirata K., Takayama K., Mizuguchi H. Modeling of hepatic drug metabolism and responses in CYP2C19 poor metabolizer using genetically manipulated human iPS cells. Drug Metab. Dispos., 47, 632-638 (2019) PubMed

Toba Y., Kiso A., Nakamae S., Sakurai F., Takayama K., Mizuguchi H. FGF signal is not required for hepatoblast differentiation of human iPS cells. Sci. Rep., 9, 3713 (2019) PubMed

Kono K., Sawada R., Kuroda T., Yasuda S., Matsuyama S., Matsuyama A., Mizuguchi H., Sato Y. Development of selective cytotoxic viral vectors for concentration of undifferentiated cells in cardiomyocytes derived from human induced pluripotent stem cells. Sci. Rep., 9, 3630 (2019) PubMed

Wakabayashi K. #, Machitani M. #, Tachibana M., Sakurai F., Mizuguchi H. A microRNA derived from adenovirus virus-associated RNAII promotes virus infection via post-transcriptional gene silencing. J.Virology, 93, e01265-18 (2019) # These authors contributed equally to this work. PubMed

Yamashita T., Takayama K., Hori M., Harada-Shiba M., Mizuguchi H. Pharmaceutical research for inherited metabolic disorders of the liver using human induced pluripotent stem cell and genome editing technologies. Biol. Pharm. Bull., 42, 312-318 (2019) PubMed

Deguchi S., Takayama K., Mizuguchi H., Generation of human iPS cell-derived hepatocyte-like cells for cellular medicine. Biol. Pharm. Bull., in press.

 大阪大学大学院 薬学研究科 分子生物学分野 〒565-0871 大阪府吹田市山田丘1-6 大阪大学 大学院薬学研究科・薬学部 1号館 4階

TEL: 06-6879-8185 FAX: 06-6879-8187

 

Copyright© Laboratory of Biochemistry and Molecular Biology, Graduate School and School of Pharmaceutical Sciences, Osaka University

directed by Prof. Hiroyuki Mizuguchi

  • 大阪大学大学院薬学研究科分子生物学分野公式Twitterアカウント