論文・出版物 - 2018

Hotani T., Mizuguchi H., Sakurai F. Systemically administered reovirus-induced down-regulation of hypoxia inducible factor-1α in subcutaneous tumors. Mol. Ther. Oncolytics, 12, 162-172 (2018) PubMed

Negoro R., Takayama K., Kawai K., Harada K., Sakurai F., Hirata K., Mizuguchi H. Efficient generation of small intestinal epithelial-like cells from human iPS cells for drug absorption and metabolism studies. Stem Cell Reports, 11(6), 1539-1550 (2018) PubMed

Matoba N. #, Yamashita T. #, Takayama K., Sakurai F., Mizuguchi H. Optimal human iPS cell culture method for efficient hepatic differentiation. Differentiation, 104, 13-21 (2018) # These authors contributed equally to this work. PubMed

Morikawa N., Tachibana M., Ago Y., Goda H., Sakurai F., Mizuguchi H. LY341495, an mGluR2/3 antagonist, regulates the immunosuppressive function of myeloid-derived suppressor cells and inhibits melanoma tumor growth. Biol. Pharm. Bull., 41(12), 1866-1869 (2018) PubMed

Tomita K., Sakurai F., Iizuka S., Hemmi M., Wakabayashi K., Tachibana M., Katayama K., Kamada H., Mizuguchi H. Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration. Sci. Rep., 8(1), 12315 (2018) PubMed

 

Tsukamoto T., Sakai E., Iizuka S., Taracena-Gándara M., Sakurai F., Mizuguchi H. Generation of the adenovirus vector-mediated CRISPR/Cpf1 system and the application for primary human hepatocytes prepared from humanized mice with chimeric liver. Biol. Pharm. Bull., 41(7), 1089-1095 (2018) PubMed

Takayama K., Hagihara Y., Toba Y., Sekiguchi K., Sakurai F., Mizuguchi H. Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research. Biomaterials, 161, 24-32 (2018) PubMed

Katayama Y., Tachibana M., Kurisu N., Oya Y., Terasawa Y., Goda H., Kobiyama K., Ishii K., Akira S., Mizuguchi H., Sakurai F. Oncolytic reovirus inhibits immunosuppressive activity of myeloid-derived suppressor cells in a TLR3-dependent manner. J.Immunol., 200(8), 2987-2999 (2018) PubMed

Nakamae S. #, Toba Y. #, Takayama K., Sakurai F., Mizuguchi H. Nanaomycin A treatment promotes hepatoblast differentiation from human iPS cells. Stem Cells Dev., 27(6), 405-414 (2018) # These authors contributed equally to this work. PubMed

Yamashita T., Takayama K., Sakurai F., Mizuguchi H. Billion-scale production of hepatocyte-like cells from human iPS cells. Biochem. Biophys. Res. Commun., 496(4), 1269–1275 (2018) PubMed

Kanayasu-Toyoda T., Ishii-Watabe A., Kikuchi Y., Kitagawa H., Suzuki H., Tamura H., Tada M., Suzuki T., Mizuguchi H., Yamaguchi T. Occludin as a functional marker of vascular endothelial cells on tube-forming activity. J. Cell. Physiol., 233, 1700-1711 (2018) PubMed

Takayama K., Mizuguchi H. Generation of optogenetically modified adenovirus vector for spatiotemporally controllable gene therapy. ACS Chem. Biol., 13(2), 449–454 (2018) PubMed

Takakura M., Matsumoto T., Nakamura M., Mizumoto Y., Myojyo S., Yamazaki R., Iwadare J., Bono Y., Orisaka S., Obata T., Izuka T., Kagami K., Nakayama K., Hayakawa H., Sakurai F., Mizuguchi H., Urata Y., Fujiwara T., Kyo S., Sasagawa T., Fujiwara H. Detection of CTCs in cervical cancer using a conditionally replicative adenovirus targeting telomerase-positive cells. Cancer Sci., 109(1), 231-240 (2018) PubMed

Okamoto R. #, Takayama K. #, Akita N.#, Nagamoto Y., Hosokawa D., Iizuka S., Sakurai F., Suemizu H., Ohashi K., Mizuguchi H. Human iPS cell-based liver-like tissue engineering at extrahepatic sites in mice as a new cell therapy for hemophilia B. Cell Transplant., 27(2), 299-309 (2018) # These authors contributed equally to this work. PubMed

水口裕之・早川堯夫;アデノウイルスベクター、バイオロジクスの開発と品質・安全性確保 ―バイオ医薬品、再生医療等製品、その他のバイオロジクスー、早川堯夫監修、エル・アイ・シー、印刷中

水口裕之、邊見 昌久;組換えアデノウイルス ―特性と最近の話題―、医学のあゆみ、351-358 (2018) WebSite

立花雅史、邊見昌久、水口裕之;粘膜免疫誘導型ワクチンとしてのアデノウイルスベクター、ドラッグデリバリーシステム、シーエムシー出版、(2018) WebSite
 
三谷成二、高山和雄、水口裕之;ヒトiPS細胞由来肝細胞の創出と創薬研究への応用、PHARM STAGE、技術情報協会、(2018) WebSite

 大阪大学大学院 薬学研究科 分子生物学分野 〒565-0871 大阪府吹田市山田丘1-6 大阪大学 大学院薬学研究科・薬学部 1号館 4階

TEL: 06-6879-8185 FAX: 06-6879-8187

 

Copyright© Laboratory of Biochemistry and Molecular Biology, Graduate School and School of Pharmaceutical Sciences, Osaka University

directed by Prof. Hiroyuki Mizuguchi

  • 大阪大学大学院薬学研究科分子生物学分野公式Twitterアカウント