論文・出版物 - 2017

Takayama K. #, Akita N. #, Mimura N., Akahira R., Taniguchi Y., Ikeda M., Sakurai F., Ohara O., Morio T., Sekiguchi K., Mizuguchi H. Generation of safe and therapeutically effective human iPS cell-derived hepatocyte-like cells for regenerative medicine. Hepatol. Commun., 1, 1058-1069 (2017) #These authors equally contributed to this work. PubMed

 

Hemmi M. #, Tachibana M. #, Fujimoto N., Shoji M., Sakurai F., Kobiyama K., Ishii K.J., Akira S., Mizuguchi H. Th17 Promotes Induction of antigen-specific gut-mucosal CTLs following adenovirus vector vaccination. Front Immunol., 8, 1456 (2017) #These authors equally contributed to this work. PubMed

 

Machitani M., Sakurai F., Wakabayashi K., Nakatani K., Tachibana M., Kato N., Fujiwara T., Mizuguchi H. Suppression of Oncolytic Adenovirus-Mediated Hepatotoxicity by Liver-Specific Inhibition of NF-κB. Mol. Ther. Oncolysis., 7, 76-85 (2017) PubMed

 

Mitani S. #, Takayama K. #, Nagamoto Y., Imagawa K., Sakurai F., Tachibana M., Sumazaki R., Mizuguchi H. Human ES/iPS cell-derived hepatocyte-like cells achieve zone-specific hepatic properties by modulation of WNT signaling. Mol. Ther., 25, 1420-1433 (2017) #These authors equally contributed to this work. PubMed

 

Sakurai F. #, Kunito T. #, Takayama K., Hashimoto R., Tachibana M., Sakamoto N., Wakita T., Mizuguchi H. Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells. Virus Res., 242, 7-15 (2017) #These authors equally contributed to this work. PubMed

 

Iizuka S., Sakurai F., Tachibana M., Ohashi K., Mizuguchi H. Neonatal gene therapy for hemophilia B by a novel adenovirus vector showing sustained transgene expression via a reduction in the leaky expression of viral genes. Mol.Ther.Methods.Clin.Dev., 6, 183-193 (2017) PubMed

 

Shimizu K., Okamoto M., Terada T., Sakurai F., Mizuguchi H., Tomita K., Nishinaka T. Adenovirus vector-mediated macrophage erythroblast attacher (MAEA) overexpression in primary mouse hepatocytes attenuates hepatic gluconeogenesis. Biochem. Biophys. Rep., 10, 192-197 (2017) PubMed

 

Sakai E., Miura Y., Suzuki-Kouyama E., Oka K., Tachibana M., Kawabata K., Sakurai F., Mizuguchi H. A mammalian mirtron miR-1224 promotes tube-formation of human primary endothelial cells by targeting anti-angiogenic factor epsin2. Sci. Rep., 7, 5541 (2017) PubMed

 

Togo S., Katagiri N., Namba Y., Tulafu M., Nagahama K., Kadoya K., Takamochi K., Oh S., Suzuki K., Sakurai F., Mizuguchi H., Urata Y., Takahashi K. Sensitive detection of viable circulating tumor cells using a novel conditionally telomerase-selective replicating adenovirus in non-small cell lung cancer patients. Oncotarget, 8, 34884-34895 (2017) PubMed

 

Lim J., Sakai E., Takayama K., Sakurai F., Mizuguchi H. Overexpression of miR-27b negatively regulates expression of pluripotency-associated genes and hepatic differentiation in human induced pluripotent stem cells. Stem Cell Res. Ther., 2, 88-97 (2017) WebSite

 

Sakurai F., Inoue S., Kaminade T., Hotani T., Katayama Y., Hosoyamada E., Terasawa Y., Tachibana M., Mizuguchi H. Cationic liposome-mediated delivery of reovirus enhances the tumor cell-killing efficiencies of reovirus in reovirus-resistant tumor cells. Int. J. Pharm., 524, 238-247 (2017) PubMed

 

Imagawa K., Takayama K., Isoyama S., Tanikawa K., Shinkai M., Harada K., Tachibana M., Sakurai F., Noguchi E., Hirata K., Kage M., Kawabata K., Sumazaki R., Mizuguchi H. Generation of a bile salt export pump deficiency model using patient-specific iPSC-derived hepatocyte-like cells. Sci. Rep., 7, 41806 (2017) PubMed

 

Machitani M., Sakurai F., Wakabayashi K., Nakatani K., Tachibana M., Mizuguchi H. MicroRNA miR-27 inhibits adenovirus infection by suppressing the expression of SNAP25 and TXN2. J. Virol., 91, e00159-17 (2017) PubMed

 

Sakurai F. #, Mitani S. #, Yamamoto T. #, Takayama K., Tachibana M., Watashi K., Wakita T., Iijima S., Tanaka Y., Mizuguchi H. Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection. Sci. Rep., 7, 45698 (2017) #These authors equally contributed to this work. PubMed

 

Machitani M. #, Sakurai F. #, Wakabayashi K., Nakatani K., Takayama K., Tachibana M., Mizuguchi H. Inhibition of CRISPR/Cas9-mediated genome engineering by a type I interferon-induced reduction in guide RNA expression. Biol. Pharm. Bull., 40, 272-277 (2017) Highlighted paper selected by Editor-in-Chief PubMed

 

Machitani M. #, Sakurai F. #, Wakabayashi K., Tachibana M., Fujiwara T., Mizuguchi H. Enhanced oncolytic activities of the telomerase-specific replication-competent adenovirus expressing short-hairpin RNA against Dicer. Mol. Cancer Ther., 16, 251-259 (2017) #These authors contributed equally to this work. PubMed

 

Nakamori D. #, Akamine H. #, Takayama K. #, Sakurai F., Mizuguchi H. Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction. Sci. Rep., 7(1), 16675 (2017) #These authors contributed equally to this work. PubMed

 

Fukuda T., Takayama K., Hirata M., Liu Y-J, Yanagihara K., Suga M., Mizuguchi H., Furue M.K. Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions. Exp. Cell Res., 352, 333-345 (2017) PubMed

 

Hirai T., Yamagishi Y., Koizumi N., Nonaka M., Mochida R., Shida K., Nomura T., Fujii M., Sakurai F., Mizuguchi H., Watanabe Y., Utoguchi N. Identification of adenovirus-derived cell-penetrating peptide. Biol. Pharm. Bull., 40, 195-204 (2017) PubMed

 

Takehara K., Yano S., Tazawa H., Okada N., Kishimoto H., Narii N., Mizuguchi H., Urata Y., Kagawa S., Fujiwara T., Hoffman R.M. Eradication of melanoma in vitro and in vivo via targeting with a Killer-Red-containing telomerase-dependent adenovirus. Cell Cycle, 16, 1502-1508 (2017) PubMed

 

Takayama K., Igai K., Hagihara Y., Hashimoto R., Hanawa M., Sakuma T., Tachibana M., Sakurai F., Yamamoto T., Mizuguchi H. Highly efficient biallelic genome editing of human ES/iPS cells Using a CRISPR/Cas9 or TALEN system. Nuc. Acid Res., 45, 5198-5207 (2017) PubMed

 

Machitani M. #, Sakurai F. #, Wakabayashi K., Takayama K., Tachibana M., Mizuguchi H. Type I interferons impede short-hairpin RNA-mediated RNA interference via inhibition of dicer-mediated processing to small interfering RNA. Mol. Ther. Nucleic Acids, 6, 173-182 (2017)  #These authors contributed equally to this work. PubMed

 

Hanawa M., Takayama K., Sakurai F., Tachibana M., Mizuguchi H. Hepatocyte Nuclear Factor 4 alpha promotes definitive endoderm differentiation from human induced pluripotent stem cells. Stem Cell Rev., 13, 542-551 (2017) PubMed

 

Takayama K., Mizuguchi H. Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening. cells. Drug. Metab. Pharmacokinet., 32, 12-20 (2017) PubMed

 

Yamashita T., Takayama K., Mizuguchi H. Generation of hepatocytes from human ES/iPS cells for regenerative medicine, Springer Book: Cell-Inspired Materials and Engineering (edited by Dr. Dan Ohtan Wang), in press.

 

三谷成二、高山和雄、水口裕之;zone特異的性質を有するヒトES/iPS細胞由来肝細胞の作製法の開発、肝細胞研究会HP・研究交流http://hepato.umin.jp/kouryu/kouryu42.html)(2017)

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directed by Prof. Hiroyuki Mizuguchi

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