Yamaguchi, T., Kawabata, K., Kouyama, E., Ishii, K. J., Katayama, K., Suzuki, T., Kurachi, S., Sakurai, F., Akira, S., and Mizuguchi, H. Induction of type I interferon by adenovirus-encoded small RNAs. Proc. Natl. Acad. Sci. USA, 107, 17286-17291 (2010)
Sakurai, F., Nakashima, K., Yamaguchi, T., Ichinose, T., Kawabata, K., Hayakawa, T., and Mizuguchi, H. Adenovirus serotype 35 vector-induced innate immune responses in dendritic cells derived from wild-type and human CD46-transgenic mice: Comparison with a fiber-substituted Ad vector containing fiber proteins of Ad serotype 35. J. Control. Rel., 148, 212-218 (2010)
Tashiro K., Kawabata K., Inamura M., Takayama K., Furukawa N., Sakurai F., Katayama K., Hayakawa H., Furue-Kusuda M., Mizuguchi H., Adenovirus vector-mediated efficient transduction into human embryonic and induced pluripotent stem cells. Cell Reprogram., 12, 501-507 (2010)
Eto Y., Yoshioka Y., Ishida T., Yao X., Morishige T., Narimatsu S., Mizuguchi H., Mukai Y., Okada N., Kiwada H., Nakagawa S. Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer. Biol. Pharm. Bull., 33, 1540-1544 (2010)
Ushitora M., Sakurai F., Yamaguchi T., Nakamura S-I., Kondoh M., Yagi K., Kawabata K., Mizuguchi H. Prevention of hepatic ischemia-reperfusion injury by pre-administration of catalase-expressing adenovirus vectors. J. Control. Rel., 142, 431-437 (2010)
Watanabe Y., Kojima T., Kagawa S., Uno F., Hashimoto Y., Kyo S., Mizuguchi H., Tanaka N., Kawamura H., Ichimaru D., Urata Y., Fujiwara T. A novel translational approach for human malignant pleural mesothelioma: heparanase-assisted dual virotherapy. Oncogene, 29, 1145-1154 (2010)
Van Geer M.A., Brevoord D., Kuhlmann K.F., Bakker C.T., Mizuguchi H., Wesseling J.G., Ten Kate F.J., Gouma D.J., Oude Elferink R.P., Bosma P.J. A fiber modified adenovirus vector that targets to the EphrinA2 receptor reveals enhanced gene transfer to ex vivo pancreatic cancer. Int. J. Oncol., 36, 233-44 (2010)
Morishige T., Yoshioka Y., Tanabe A., Yao X., Mizuguchi H., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S. Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models. Int. Immunopharmacol., 10, 26-33 (2010)
Kojima T., Watanabe Y., Hashimoto Y., Kuroda S., Yamasaki Y., Yano S., Ouchi M., Tazawa H., Uno F., Kagawa S., Kyo S., Mizuguchi H., Urata Y., Tanaka N., Fujiwara T. In vivo biological purging for lymph node metastasis of human colorectal cancer by telomerase-specific oncolytic virotherapy. Ann. Surg., 251, 1079-1086 (2010)
Akita H., Enoto K., Masuda T., Mizuguchi H., Tani T., Harashima H., Particle tracking of intracellular trafficking of octaarginine-modified liposomes: a comparative study with adenovirus. Mol. Ther., 18, 955-964 (2010)
Yashima S., Yoshizaki S., Shinoda K., Yoshida A., Kondo A., Mizuguchi H., Ryo A., Okuda K., Shimada M. Co-administration of viral vector-based vaccines suppresses antigen-specific effector CD8 T cells. Vaccine, 28, 3257-3264 (2010)
Kakutani H., Kondoh M., Saeki R., Fujii M., Watanabe Y., Mizuguchi H., Yagi K. Claudin-4-targeting of diphtheria toxin fragment A using a C-terminal fragment of Clostridium perfringens enterotoxin. Eur. J. Pharm. Biopharm., 75, 213-217 (2010)
Yao X., Yoshioka Y., Morishige T., Eto Y., Narimatsu S., Mizuguchi H., Mukai Y., Okada N., Nakagawa S. Adenovirus vector covalently conjugated to polyethylene glycol with a cancer-specific promoter suppresses the tumor growth through systemic administration. Biol. Pharm. Bull., 35, 1073-1076 (2010)
櫻井文教、水口裕之；マイクロRNAによる遺伝子発現制御システムを搭載した遺伝子組換えアデノウイルスの開発 、薬学雑誌、130、1497-1504 (2010)
川端健二、田代克久、水口裕之；iPS細胞への遺伝子導入を用いた分化誘導の最適化 、薬学雑誌、130、1527-1534 (2010)
水口裕之；次世代アデノウイルスベクターの開発と生命科学研究への応用、Drug Delivery System、25, 493-503 (2010)
大阪大学大学院 薬学研究科 分子生物学分野
Laboratory of Biochemistry and Molecular Biology
Graduate School of Pharmaceutical Sciences, Osaka University
業績｜論文・出版物｜2015年
Ozawa T., Takayama K., Okamoto R., Negoro R., Sakurai F., Tachibana M., Kawabata K., Mizuguchi H. Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine. Sci. Rep., 5:16479, (2015) PubMed
Mori J., Kawabata A., Tang H., Tadagaki K., Mizuguchi H., Kuroda K., Mori Y.. Human Herpesvirus-6 U14 induces cell-cycle arrest in G2/M phase by associating with a cellular protein, EDD. PLoS One, 10, e0137420 (2015) PubMed
Koizumi N., Yamagishi Y., Hirai T., Fujii M., Mizuguchi H., Watanabe Y. Efficient Adenovirus gene transfer methods in human colonic Caco-2 epithelial cells using capric acid. Biol. Pharm. Bull., 38, 1240-1244 (2015) PubMed
Tashiro K., Hirata N., Okada A., Yamaguchi T., Takayama K., Mizuguchi H., Kawabata K. Expression of coxsackievirus and adenovirus receptor separates hematopoietic and cardiac progenitor cells in Flk1-expressing mesoderm. Stem Cells Transl. Med., 4, 424-436 (2015) PubMed
Terasawa Y., Hotani T., Katayama Y., Tachibana M., Mizuguchi H., Sakurai F. Activity levels of cathepsins B and L in tumor cells are a biomarker for efficacy of reovirus-mediated tumor cell killing. Cancer Gene Ther., 22, 188-97 (2015) PubMed
Wakabayashi K., Machitani M., Shimizu K., Tachibana M., Sakurai F., Mizuguchi H. Quantitative analysis of virus-associated RNAI expression following transduction with a replication-incompetent adenovirus vector in vitro and in vivo. J. Mol. Genet. Med., 9:169 (2015) WebSite
Minami H., Tashiro K., Okada A., Hirata N., Yamaguchi T., Takayama K., Mizuguchi H., Kawabata K. Generation of brain microvascular endothelial-like cells from human induced pluripotent stem cells by co-culture with C6 glioma cells. PLOS ONE, 10, e0128890 (2015) PubMed
Iizuka S., Sakurai F., Shimizu K., Ohashi K., Nakamura S-I., Tachibana M., Mizuguchi H. Evaluation of transduction properties of an adenovirus vector in neonatal mice. BioMed Res.Int., Article ID 685374 (2015) PubMed
Hotani T., Tachibana M., Mizuguchi H., Sakurai F. Reovirus double-stranded RNA genomes and polyI:C induce down-regulation of hypoxia-inducible factor-alpha. Biochem. Biophys. Res. Commun., 460, 1041-1046 (2015) PubMed
Nagamoto Y., Takayama K., Tashiro K., Tateno C., Sakurai F., Tachibana M., Kawabata K., Ikeda K., Tanaka Y., Mizuguchi H. Efficient engraftment of human iPS cell-derived hepatocyte-like cells in uPA/SCID mice by overexpression of FNK, a Bcl-xLmutant gene. Cell Transplant., 24, 1127-1138 (2015) PubMed
Katayama Y., Terasawa Y., Tachibana M., Mizuguchi H., Sakurai F. Proteolytic disassembly of viral outer capsid proteins is crucial for reovirus-mediated type-I interferon induction in both reovirus-susceptible and reovirus-refractory tumor cells. BioMed Res.Int., Article ID 468457 (2015) PubMed
水口裕之；ヒトiPS細胞から肝細胞への高効率分化誘導法の開発とその実用化に関する研究、バイオサイエンスとインダストリー、73, 104-109 (2015)
高山和雄、水口裕之；ヒトiPS細胞由来肝細胞の創薬研究・非臨床試験への応用を目指して、薬剤学、75, 369-373(2015) J-STAGE