論文・出版物 - 2014

Takayama K., Morisaki Y., Kuno S., Nagamoto Y., Harada K., Furukawa N., Ohtaka M., Nishimura K., Imagawa K., Sakurai F., Tachibana M., Sumazaki R., Noguchi E., Nakanishi M., Hirata K., Kawabata K., Mizuguchi H. Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes. Proc. Natl. Acad. Sci. USA., 111, 16772-16777 (2014) PubMed

 

Olszak T., Neves J., Dowds M., Baker K.K., Glickman J., Davidson N., Lin C-Y., Jobin C., Brand S., Sotlar K., Wada K., Katayama K., Nakajima A., Mizuguchi H., Kawasaki K., Nagata K., Müller W., Snapper S., Schreiber S., Kaser A., Zeissig S., Blumberg RS. Protective mucosal immunity mediated by epithelial CD1d and IL-10, Nature, 509, 497-502 (2014) PubMed

 

Hemmi M. #, Tachibana M. #, Tsuzuki S., Shoji M., Sakurai F., Kawabata K., Kobiyama K., Ishii K.J., Akira S., Mizuguchi H. The Early Activation of CD8(+) T Cells is dependent on type I IFN Ssignaling following intramuscular vaccination of adenovirus vector. Biomed Res Int., 158128 (2014) # These authors equally contributed to this work. PubMed

 

Sakurai F. #, Nanjo Y. #, Okamoto S., Tachibana M., Mizuguchi H. Upregulation of RECK gene expression by small double-stranded RNA targeting the promoter region. Cancer Gene Ther., 21, 219-227 (2014) # These authors equally contributed to this work. PubMed

 

Takayama K., Kawabata K., Nagamoto Y., Inamura M., Ohashi K., Okuno H., Yamaguchi T., Tashiro K., Sakurai F., Hayakawa T., Okano T., Furue MK., Mizuguchi H. CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determine the hepatoblast fate decision. Development, 141, 91-100 (2014) PubMed

 

Kuno S., Sakurai F., Shimizu K., Matsumura N., Kim S., Watanabe H., Tashiro K., Tachibana M., Yokoi T., Mizuguchi H. Development of mice exhibiting hepatic microsomal activity of human CYP3A4 comparable to that in human liver microsomes by intravenous administration of an adenovirus vector expressing human CYP3A4. Drug Metab. Pharmacokinet., 29, 296-304 (2014) PubMed

 

Watanabe H. #, Takayama K. #, Inamura M., Tachibana M., Mimura N., Tashiro K., Nagamoto Y., Sakurai F., Kawabata K., Furue MK., Mizuguchi H. HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin. PLoS One, 9, e90791 (2014) # These authors equally contributed to this work. PubMed

 

Tagawa M., Shirane K., Yu L., Sato T., Furukawa S., Mizuguchi H., Kuji R., Kawamura K., Takahashi N., Kato K., Hayakawa S., Sawada S., Furukawa K. Enhanced expression of the β4-galactosyltransferase 2 gene impairs mammalian tumor growth. Cancer Gene Ther., 21, 219-227 (2014) PubMed

 

Yao X, Zhou N, Wan L, Su X, Sun Z, Mizuguchi H., Yoshioka Y, Nakagawa S, Zhao RC, Gao JQ. Polyethyleneimine-coating enhances adenoviral transduction of mesenchymal stem cells. Biochem. Biophys. Res. Commun., 447, 383-387 (2014) PubMed

 

Shimizu K., Sakurai F., Tomita K., Nagamoto Y., Nakamura S., Katayama K., Tachibana M., Kawabata K., Mizuguchi H. Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome. Mol. Ther. Methods Clin. Dev., 1, 14035 (2014) PubMed

 

Tashiro K. #, Nonaka A. #, Hirata N., Yamaguchi T., Mizuguchi H., Kawabata K. Plasma elevation of vascular endothelial growth factor leads to the reduction of mouse hematopoietic and mesenchymal stem/progenitor cells in the bone marrow. Stem Cells Dev., 23, 2202-2210 (2014) # These authors equally contributed to this work.  PubMed

 

Higuchi M, Mizuguchi H. Hepatic differentiation of human embryonic stem cells and induced pluripotent stem cells by two- and three-dimensional culture systems in vitro. Engineered Cell Manipulation for Biomedical Application, the Springer publishing, 147-158, 2014, In: M. Akashi, T. Akagi, M. Matsusaki (eds.) WebSite

 

長基康人、高山和雄、水口裕之;3次元組織化技術を利用したヒトES/iPS細胞から肝細胞への分化誘導法、遺伝子医学MOOK別冊 細胞の3次元組織化 –その最先端技術と材料技術、田畑泰彦編集、244-248 (2014) WebSite

 

水口裕之、高山和雄;iPS細胞由来組織細胞を用いた毒性試験、実験医学別冊 ES・iPS細胞実験スタンダード、羊土社、中辻憲夫監修、末盛博文編集、345-350 (2014) WebSite

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directed by Prof. Hiroyuki Mizuguchi

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