業績｜論文・出版物｜2012年

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Takayama K., Inamura M., Kawabata K., Sugawara M., Kikuchi K., Higuchi M., Nagamoto Y., Watanabe H., Tashiro K., Sakurai F., Hayakawa T., Furue MK., Mizuguchi H. Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction. J. Hepatol., 57, 628-636 (2012) PubMed

 

Takayama K., Inamura M., Kawabata K., Katayama K., Higuchi M., Tashiro K., Nonaka A., Sakurai F., Hayakawa T., Furue MK., Mizuguchi H. Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction. Mol. Ther., 20, 127-137 (2012) PubMed

 

Shoji M., Katayama K., Tachibana M., Tomita K., Sakurai F., Kawabata K., Mizuguchi H. Intramuscular DNA immunization with in vivo electroporation induces antigen-specific cellular and humoral immune responses in both systemic and gut-mucosal compartments. Vaccine, 30, 7278-7285 (2012) PubMed

 

Shoji M., Tachibana M., Katayama K., Tomita K., Tsuzuki S., Sakurai F., Ishii K.J., Akira S., Mizuguchi H. Type-I IFN signaling is required for the induction of antigen-specific CD8＋ T cell responses by adenovirus vector vaccine in the gut-mucosa. Biochem. Biophys. Res. Commun., 425, 89-93 (2012) PubMed

 

Nagamoto Y., Tashiro K., Takayama K., Ohashi K., Kawabata K., Sakurai F., Tachibana M., Hayakawa T., Furue MK., Mizuguchi H. Promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets. Biomaterials, 33, 4526-4534 (2012) PubMed

 

Matsui H., Sakurai F., Katayama K., Yamaguchi T., Okamoto S., Takahira K., Tachibana M., Nakagawa S., Mizuguchi H. A hexon-specific PEGylated adenovirus vector utilizing blood coagulation factor X. Biomaterials, 33, 3743-3755 (2012) PubMed

 

Tashiro K., Omori M., Kawabata K., Hirata N., Yamaguchi T., Sakurai F., Takaki S., Mizuguchi H. Inhibition of Lnk in mouse induced pluripotent stem cells promotes hematopoietic cell generation. Stem Cell Dev., 21, 3381-3390 (2012) PubMed

 

Hiwasa K., Nagaya H., Terao S., Acharya B., Hamada K., Mizuguchi H., Gotoh A. Improved Gene Transfer into Bladder Cancer Cells Using Adenovirus Vector Containing RGD Motif. Anticancer Res., 32, 3137-3140 (2012) PubMed

 

Tashiro K., Kawabata K., Omori M., Yamaguchi T., Sakurai F., Katayama K., Hayakawa H., Mizuguchi H. Promotion of hematopoietic differentiation from mouse induced pluripotent stem cells by transient HoxB4 transduction. Stem Cell Res., 8, 300-311 (2012) PubMed

 

Tomita K., Sakurai F., Tachibana M., Mizuguchi H. Correlation between adenovirus-neutralizing antibody titer and adenovirus vector-mediated transduction efficiency following intratumoral injection. Anticancer Res., 32, 1145-1152 (2012) PubMed

 

Shoji M., Yoshizaki S., Mizuguchi H., Okuda K., Shimada M. Immunogenic Comparison of Chimeric Adenovirus 5/35 Vector Carrying Optimized Human Immunodeficiency Virus Clade C Genes and Various Promoters. PLoS One, 7, e30302 (2012) PubMed

 

Sakurai F., Furukawa N., Higuchi M., Okamoto S., Ono K., Yoshida T., Kondoh M., Yagi K., Sakamoto N., Katayama K., Mizuguchi H. Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-122a. Virus Res., 165, 214-218 (2012) PubMed

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Yao X.L., Yoshioka Y., Ruan G.X., Chen Y.Z., Mizuguchi H., Mukai Y., Okada N., Gao J.Q., Nakagawa S. Optimization and internalization mechanisms of PEGylated adenovirus vector with targeting peptide for cancer gene therapy. Biomacromolecules, 13, 2402-2409 (2012) PubMed

 

Iguchi K., Sakurai F., Tomita K., Katayama K., Yamaguchi T., Tagawa M., Kawabata M., Shirakawa T., Mizuguchi H. Efficient antitumor effects of carrier cells loaded with a fiber-substituted conditionally replicating adenovirus on CAR-negative tumor cells. Cancer Gene Ther., 19, 118-125 (2012) PubMed

 

Yamasaki Y., Tazawa H., Hashimoto Y., Kojima T., Kuroda S., Yano S., Yoshida R., Uno F., Mizuguchi H., Ohtsuru A., Urata Y., Kagawa S., Fujiwara T. A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression. Eur. J. Cancer, 48, 2282-2291 (2012) PubMed

 

Kawabata K., Inamura M., Mizuguchi H. Efficient hepatic differentiation from human iPS cells by gene transfer. Methods Mol. Biol., 826, 115-124 (2012) PubMed

 

Bennett D., Sakurai F., Shimizu K., Matsui H., Tomita K., Suzuki T., Katayama K., Kawabata K., Mizuguchi H. Further reduction in adenovirus vector-mediated liver transduction without largely affecting transgene expression in target organ by exploiting microRNA-mediated regulation and the Cre-loxP recombination system. Mol. Pharm., 9, 3452-63 (2012) PubMed

 

Kawabata K., Takayama K., Nagamoto Y., Saldon M.S., Higuchi M., Mizuguchi H. Endodermal and hepatic differentiation from human embryonic stem cells and human induced pluripotent stem cells. J. Stem Cell Res. Ther., S10 (2012) PubMed

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清水かほり、櫻井文教、立花雅史、水口　裕之；マイクロRNAを利用してウイルス遺伝子の非特異的な発現を抑制可能な新規アデノウイルスベクターの開発、薬学雑誌、132, 1407-1412 (2012) J-STAGE

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水口裕之、高山和雄、長基康人、川端健二；ヒトiPS細胞から肝細胞への分化誘導の現状と創薬応用、医薬品医療機器レギュラトリーサイエンス、医薬品医療機器レギュラトリーサイエンス財団、43、982-987 (2012) WebSite

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早川堯夫、水口裕之；ヒトiPS細胞の再生医療及び創薬研究への応用の現状と展望、Brain and Nerve、64, 47-57 (2012) WebSite

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水口裕之、櫻井文教；ウイルスベクターと遺伝子治療、新編ウイルスの今日的意味、柳雄介・堤裕幸編集、医薬ジャーナル、101-108 (2012) WebSite

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高山和雄、川端健二、水口裕之；多能性幹細胞から肝細胞への分化誘導、再生医療業書、日本再生医療学会監修、後藤満一・大橋一夫編集、朝倉書店、110-116 (2012)

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水口裕之；iPS細胞研究の道しるべ　遺伝子治療研究の貢献と教訓、ファルマシア、日本薬学会、48、827 (2012) J-STAGE

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櫻井文教、水口裕之； microRNAによる遺伝子発現制御システムを搭載した遺伝子発現ベクター、ドラッグデリバリーシステムの新展開II―核酸医薬・抗体医薬・ワクチン医療を支えるDDS技術―、シーエムシー出版、47-53(278) (2012) WebSite

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