業績|論文・出版物|2012年
Takayama K., Inamura M., Kawabata K., Sugawara M., Kikuchi K., Higuchi M., Nagamoto Y., Watanabe H., Tashiro K., Sakurai F., Hayakawa T., Furue MK., Mizuguchi H. Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction. J. Hepatol., 57, 628-636 (2012) PubMed
Takayama K., Inamura M., Kawabata K., Katayama K., Higuchi M., Tashiro K., Nonaka A., Sakurai F., Hayakawa T., Furue MK., Mizuguchi H. Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction. Mol. Ther., 20, 127-137 (2012) PubMed
Shoji M., Katayama K., Tachibana M., Tomita K., Sakurai F., Kawabata K., Mizuguchi H. Intramuscular DNA immunization with in vivo electroporation induces antigen-specific cellular and humoral immune responses in both systemic and gut-mucosal compartments. Vaccine, 30, 7278-7285 (2012) PubMed
Shoji M., Tachibana M., Katayama K., Tomita K., Tsuzuki S., Sakurai F., Ishii K.J., Akira S., Mizuguchi H. Type-I IFN signaling is required for the induction of antigen-specific CD8+ T cell responses by adenovirus vector vaccine in the gut-mucosa. Biochem. Biophys. Res. Commun., 425, 89-93 (2012) PubMed
Nagamoto Y., Tashiro K., Takayama K., Ohashi K., Kawabata K., Sakurai F., Tachibana M., Hayakawa T., Furue MK., Mizuguchi H. Promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets. Biomaterials, 33, 4526-4534 (2012) PubMed
Matsui H., Sakurai F., Katayama K., Yamaguchi T., Okamoto S., Takahira K., Tachibana M., Nakagawa S., Mizuguchi H. A hexon-specific PEGylated adenovirus vector utilizing blood coagulation factor X. Biomaterials, 33, 3743-3755 (2012) PubMed
Tashiro K., Omori M., Kawabata K., Hirata N., Yamaguchi T., Sakurai F., Takaki S., Mizuguchi H. Inhibition of Lnk in mouse induced pluripotent stem cells promotes hematopoietic cell generation. Stem Cell Dev., 21, 3381-3390 (2012) PubMed
Hiwasa K., Nagaya H., Terao S., Acharya B., Hamada K., Mizuguchi H., Gotoh A. Improved Gene Transfer into Bladder Cancer Cells Using Adenovirus Vector Containing RGD Motif. Anticancer Res., 32, 3137-3140 (2012) PubMed
Tashiro K., Kawabata K., Omori M., Yamaguchi T., Sakurai F., Katayama K., Hayakawa H., Mizuguchi H. Promotion of hematopoietic differentiation from mouse induced pluripotent stem cells by transient HoxB4 transduction. Stem Cell Res., 8, 300-311 (2012) PubMed
Tomita K., Sakurai F., Tachibana M., Mizuguchi H. Correlation between adenovirus-neutralizing antibody titer and adenovirus vector-mediated transduction efficiency following intratumoral injection. Anticancer Res., 32, 1145-1152 (2012) PubMed
Shoji M., Yoshizaki S., Mizuguchi H., Okuda K., Shimada M. Immunogenic Comparison of Chimeric Adenovirus 5/35 Vector Carrying Optimized Human Immunodeficiency Virus Clade C Genes and Various Promoters. PLoS One, 7, e30302 (2012) PubMed
Sakurai F., Furukawa N., Higuchi M., Okamoto S., Ono K., Yoshida T., Kondoh M., Yagi K., Sakamoto N., Katayama K., Mizuguchi H. Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-122a. Virus Res., 165, 214-218 (2012) PubMed
Yao X.L., Yoshioka Y., Ruan G.X., Chen Y.Z., Mizuguchi H., Mukai Y., Okada N., Gao J.Q., Nakagawa S. Optimization and internalization mechanisms of PEGylated adenovirus vector with targeting peptide for cancer gene therapy. Biomacromolecules, 13, 2402-2409 (2012) PubMed
Iguchi K., Sakurai F., Tomita K., Katayama K., Yamaguchi T., Tagawa M., Kawabata M., Shirakawa T., Mizuguchi H. Efficient antitumor effects of carrier cells loaded with a fiber-substituted conditionally replicating adenovirus on CAR-negative tumor cells. Cancer Gene Ther., 19, 118-125 (2012) PubMed
Yamasaki Y., Tazawa H., Hashimoto Y., Kojima T., Kuroda S., Yano S., Yoshida R., Uno F., Mizuguchi H., Ohtsuru A., Urata Y., Kagawa S., Fujiwara T. A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression. Eur. J. Cancer, 48, 2282-2291 (2012) PubMed
Kawabata K., Inamura M., Mizuguchi H. Efficient hepatic differentiation from human iPS cells by gene transfer. Methods Mol. Biol., 826, 115-124 (2012) PubMed
Bennett D., Sakurai F., Shimizu K., Matsui H., Tomita K., Suzuki T., Katayama K., Kawabata K., Mizuguchi H. Further reduction in adenovirus vector-mediated liver transduction without largely affecting transgene expression in target organ by exploiting microRNA-mediated regulation and the Cre-loxP recombination system. Mol. Pharm., 9, 3452-63 (2012) PubMed
Kawabata K., Takayama K., Nagamoto Y., Saldon M.S., Higuchi M., Mizuguchi H. Endodermal and hepatic differentiation from human embryonic stem cells and human induced pluripotent stem cells. J. Stem Cell Res. Ther., S10 (2012) PubMed
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