論文・出版物 - 2011

Inamura M., Kawabata K., Takayama K., Tashiro K., Sakurai F., Katayama K., Toyoda M., Akutsu H., Miyagawa Y.,Okita H., Kiyokawa N., Umezawa A., Hayakawa T., Furue MK., Mizuguchi H. Efficient generation of hepatoblastsfrom human ES cells and iPS cells by transient overexpression of homeobox gene HEX. Mol. Ther.,19, 400-407 (2011) PubMed

 

Takayama K., Inamura M., Kawabata K., Tashiro K., Katayama K., Hayakawa T., Furue MK., Mizuguchi H. Efficient and directive generation of two distinct endoderm lineages from human ES and iPS cells by differentiation stage-specific SOX17 transduction. PLoS One, 6, e21780 (2011) PubMed

 

Sugio K., Sakurai F., Katayama K., Matsui H., Kawabata K., Kawase A., Iwaki M., Hayakawa T., Fujiwara T., Mizuguchi H. Enhanced safety profiles of the telomerase-specific replication-competent adenovirus by incorporation of normal cell-specific microRNA-targeted sequences. Clin. Cancer Res., 17, 2807-2818 (2011) PubMed

 

Suzuki-Kouyama E., Katayama K., Sakurai F., Yamaguchi T., Kurachi S., Kawabata K., Nakagawa S., Mizuguchi H. Hexon-specific PEGylated adenovirus vectors utilizing avidin-biotin interaction. Biomaterials, 32, 1724-1730 (2011) PubMed

 

Matsui H., Sakurai F., Katayama K., Kurachi S., Tashiro K., Sugio K., Kawabata K., Mizuguchi H. Enhanced transduction efficiency of fiber-substituted adenovirus vectors by the incorporation of RGD peptides in two distinct regions of the adenovirus serotype 35 fiber knob. Virus Res., 155, 48-54 (2011) PubMed

 

Suzuki T., Sasaki T., Yano K., Sakurai F., Kawabata K., Kondoh M., Hayakawa T., Yagi K., Mizuguchi H. Development of a recombinant adenovirus vector production system free of replication-competent adenovirus by utilizing a packaging size limit of the viral genome. Virus Res., 158, 154-160 (2011) PubMed

 

Yoshida T., Takayama K. (Co-first author), Kondoh M. (Co-corresponding author), Sakurai F., Tani H., Sakamoto N., Matsuura Y., Mizuguchi H. (Co-corresponding author), Yagi K. Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection. Biochem. Biophys. Res. Commun., 416, 119-124 (2011) PubMed

 

Motegi Y., Katayama K., Sakurai F., Kato T., Yamaguchi T., Matsui H., Takahashi M., Kawabata K., Mizuguchi H. An effective gene-knockdown using multiple shRNA-expressing adenovirus vectors. J. Cont. Rel., 153, 149-153 (2011) PubMed

 

Shimizu K., Sakurai F., Machitani M., Katayama K., Mizuguchi H. Quantitative analysis of the leaky expression of adenovirus genes in cells transduced with a replication-incompetent adenovirus vector. Mol. Pharmaceutics, 8, 1430-1435 (2011) PubMed

 

Machitani M., Katayama K., Sakurai F., Matsui H., Yamaguchi T., Suzuki T., Miyoshi H., Kawabata K., Mizuguchi H. Development of an adenovirus vector lacking the expression of virus-associated RNAs. J. Cont. Rel., 154, 285-289 (2011) PubMed

 

Katayama K., Furuki R., Yokoyama H., Kaneko M., Tachibana M., Yoshida I., Nagase H., Tanaka K., Sakurai F., Mizuguchi H., Nakagawa S., Nakanishi T. Enhanced in vivo gene transfer into the placenta using RGD fiber-mutant adenovirus vector. Biomaterials, 32, 4185-4193 (2011) PubMed

 

Iwahori K., Serada S., Fujimoto M., Nomura S., Osaki T., Lee C.M., Mizuguchi H. , Takahashi T., Ripley B., Okumura M., Kawase I., Kishimoto T., Naka T. Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma. Int. J. Cancer, 129, 993-1005 (2011) PubMed

 

Yoshida T., Kondoh M., Ojima M., Mizuguchi H., Yamagishi Y., Sakamoto N., Yagi K. Adenovirus vector-mediated assay system for Hepatitis C virus replication. Nucleic. Acid Res., 39, e64 (2011) PubMed

 

Furukawa N., Sakurai F., Katayama K., Seki N., Kawabata K., Mizuguchi H. Optimization of a microRNA expression vector for function analysis of microRNA. J. Cont. Rel., 150, 94-101 (2011) PubMed

 

Kawashima R., Abei M., Fukuda K., Nakamura K., Murata T., Wakayama M., Seo E., Hasegawa N., Mizuguchi H., Obata Y., Hyodo I., Hamada H., Yokoyama K.K. EpCAM- and EGFR- targeted selective gene therapy for biliary cancers using Z33-fiber modified adenovirus. Int. J. Cancer, 129, 1244-53 (2011) PubMed

 

Iwata-Kajihara T., Sumimoto H., Kawamura N., Ueda R., Takahashi T., Mizuguchi H., Miyagishi M., Takeda K., Kawakami Y. Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors. J. Immunol., 187, 27-36 (2011) PubMed

 

Yao X., Yoshioka Y., Morishige T., Eto Y., Narimatsu S., Kawai Y., Mizuguchi H., Gao J.Q., Mukai Y., Okada N., Nakagawa S. Tumor vascular targeted delivery of polymer-conjugated adenovirus vector for cancer gene therapy. Mol. Ther., 19, 1619-1625 (2011) PubMed

 

Machitani M., Yamaguchi T., Shimizu K., Sakurai F., Katayama K., Kawabata K., Mizuguchi H. Adenovirus vector-derived VA-RNA-mediated innate immune responses. Pharmaceutics, 3,338-353 (2011) PubMed

 

Sakurai F., Katayama K., Mizuguchi H. MicroRNA-regulated transgene expression system for gene therapy and virotherapy. Frontier in Bioscience., 17, 2389-2401 (2011) PubMed

 

松井勇人、櫻井文教、形山和史、水口裕之;改良型アデノウイルスベクターの開発と神経系細胞への遺伝子導入、日本薬理学会雑誌、137、70-74 (2011) J-STAGE

 

水口裕之、櫻井文教;ウイルスベクターと遺伝子治療、化学療法の領域、医薬ジャーナル社、27、867-873 (2011) WebSite

 

稲村充、高山和雄、川端健二、水口裕之;ヒトES/iPS細胞から肝細胞への高効率分化誘導と毒性評価系への応用、生産と技術、63、67-69 (2011)

水口裕之、近藤昌夫、八木清仁;iPS細胞分化誘導によるHCV培養モデル、肝胆膵、63、919-924 (2011)

 

水口裕之;スーパー特区研究『ヒトiPS細胞を用いた新規in vitro 毒性評価系の構築』の概要、動物実験代替法学会News Letter、40、21-22 (2011)

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directed by Prof. Hiroyuki Mizuguchi

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