Yamaguchi, T., Kawabata, K., Kouyama, E., Ishii, K. J., Katayama, K., Suzuki, T., Kurachi, S., Sakurai, F., Akira, S., and Mizuguchi, H. Induction of type I interferon by adenovirus-encoded small RNAs. Proc. Natl. Acad. Sci. USA, 107, 17286-17291 (2010)
Sakurai, F., Nakashima, K., Yamaguchi, T., Ichinose, T., Kawabata, K., Hayakawa, T., and Mizuguchi, H. Adenovirus serotype 35 vector-induced innate immune responses in dendritic cells derived from wild-type and human CD46-transgenic mice: Comparison with a fiber-substituted Ad vector containing fiber proteins of Ad serotype 35. J. Control. Rel., 148, 212-218 (2010)
Tashiro K., Kawabata K., Inamura M., Takayama K., Furukawa N., Sakurai F., Katayama K., Hayakawa H., Furue-Kusuda M., Mizuguchi H., Adenovirus vector-mediated efficient transduction into human embryonic and induced pluripotent stem cells. Cell Reprogram., 12, 501-507 (2010)
Eto Y., Yoshioka Y., Ishida T., Yao X., Morishige T., Narimatsu S., Mizuguchi H., Mukai Y., Okada N., Kiwada H., Nakagawa S. Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer. Biol. Pharm. Bull., 33, 1540-1544 (2010)
Ushitora M., Sakurai F., Yamaguchi T., Nakamura S-I., Kondoh M., Yagi K., Kawabata K., Mizuguchi H. Prevention of hepatic ischemia-reperfusion injury by pre-administration of catalase-expressing adenovirus vectors. J. Control. Rel., 142, 431-437 (2010)
Watanabe Y., Kojima T., Kagawa S., Uno F., Hashimoto Y., Kyo S., Mizuguchi H., Tanaka N., Kawamura H., Ichimaru D., Urata Y., Fujiwara T. A novel translational approach for human malignant pleural mesothelioma: heparanase-assisted dual virotherapy. Oncogene, 29, 1145-1154 (2010)
Van Geer M.A., Brevoord D., Kuhlmann K.F., Bakker C.T., Mizuguchi H., Wesseling J.G., Ten Kate F.J., Gouma D.J., Oude Elferink R.P., Bosma P.J. A fiber modified adenovirus vector that targets to the EphrinA2 receptor reveals enhanced gene transfer to ex vivo pancreatic cancer. Int. J. Oncol., 36, 233-44 (2010)
Morishige T., Yoshioka Y., Tanabe A., Yao X., Mizuguchi H., Tsunoda S., Tsutsumi Y., Mukai Y., Okada N., Nakagawa S. Comparison of the anti-tumor activity of native, secreted, and membrane-bound LIGHT in mouse tumor models. Int. Immunopharmacol., 10, 26-33 (2010)
Kojima T., Watanabe Y., Hashimoto Y., Kuroda S., Yamasaki Y., Yano S., Ouchi M., Tazawa H., Uno F., Kagawa S., Kyo S., Mizuguchi H., Urata Y., Tanaka N., Fujiwara T. In vivo biological purging for lymph node metastasis of human colorectal cancer by telomerase-specific oncolytic virotherapy. Ann. Surg., 251, 1079-1086 (2010)
Akita H., Enoto K., Masuda T., Mizuguchi H., Tani T., Harashima H., Particle tracking of intracellular trafficking of octaarginine-modified liposomes: a comparative study with adenovirus. Mol. Ther., 18, 955-964 (2010)
Yashima S., Yoshizaki S., Shinoda K., Yoshida A., Kondo A., Mizuguchi H., Ryo A., Okuda K., Shimada M. Co-administration of viral vector-based vaccines suppresses antigen-specific effector CD8 T cells. Vaccine, 28, 3257-3264 (2010)
Kakutani H., Kondoh M., Saeki R., Fujii M., Watanabe Y., Mizuguchi H., Yagi K. Claudin-4-targeting of diphtheria toxin fragment A using a C-terminal fragment of Clostridium perfringens enterotoxin. Eur. J. Pharm. Biopharm., 75, 213-217 (2010)
Yao X., Yoshioka Y., Morishige T., Eto Y., Narimatsu S., Mizuguchi H., Mukai Y., Okada N., Nakagawa S. Adenovirus vector covalently conjugated to polyethylene glycol with a cancer-specific promoter suppresses the tumor growth through systemic administration. Biol. Pharm. Bull., 35, 1073-1076 (2010)
櫻井文教、水口裕之；マイクロRNAによる遺伝子発現制御システムを搭載した遺伝子組換えアデノウイルスの開発 、薬学雑誌、130、1497-1504 (2010)
川端健二、田代克久、水口裕之；iPS細胞への遺伝子導入を用いた分化誘導の最適化 、薬学雑誌、130、1527-1534 (2010)
水口裕之；次世代アデノウイルスベクターの開発と生命科学研究への応用、Drug Delivery System、25, 493-503 (2010)
大阪大学大学院 薬学研究科 分子生物学分野
Laboratory of Biochemistry and Molecular Biology
Graduate School of Pharmaceutical Sciences, Osaka University
業績｜論文・出版物｜2008年
Suzuki T., Sakurai F., Nakamura S-I., Kouyama E., Kawabata K., kondoh M., Yagi K., Mizuguchi H. miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy. Mol. Ther., 16, 1719-1726 (2008) PubMed
Sakurai H., Tashiro K., Kawabata K., Yamaguchi T., Sakurai F., Nakagawa S., Mizuguchi H. Adenoviral expression of suppressor of cytokine signaling-1 reduces adenovirus vector-induced innate immune response. J. Immunol., 180, 4931-4938 (2008) PubMed
Sakurai F., Nakamura S-I., Akitomo K., Shibata H., Terao K., Kawabata K., Hayakawa T., Mizuguchi H. Transduction properties of adenovirus serotype 35 vectors after intravenous administration into nonhuman primates. Mol. Ther., 16, 726-733 (2008) PubMed
Tashiro K., Kawabata K., Sakurai H., Kurachi S., Sakurai F., Yamanishi K., Mizuguchi H. Efficient adenovirus vector-mediated PPAR gamma gene transfer into mouse embryoid bodies promotes adipocyte differentiation, J. Gene Med., 10, 498-507 (2008) PubMed
Nakashima K., Sakurai F., Kawabata K., Mizuguchi H. Efficient gene delivery in human and rodent mast cells using adenovirus vectors. J. Control. Rel., 129, 215-222 (2008) PubMed
Sakurai H., Kawabata K., Sakurai F., Nakagawa S., Mizuguchi H. Innate immune response induced by gene delivery vectors. Int. J. Pharm., 354, 9-15 (2008) PubMed
Kurachi S., Koizumi N., Tashiro K., Sakurai H., Sakurai F., Kawabata K., Nakagawa S., Mizuguchi H. Modification of pIX or hexon based on fiberless Ad vectors is not effective for targeted Ad vectors. J. Control. Rel., 127, 88-95 (2008) PubMed
Yoshikawa T., Niwa T., Okada N., Mizuguchi H., Nakagawa S. Engineering of highly immunogenic long-lived DC vaccines by antiapoptotic protein gene transfer to enhance cancer vaccine potency. Gene Ther., 15, 1321-1329 (2008) PubMed
Gao J-Q., Kanagawa N., Xu D-H., Han M., Sugita T., Hatanaka Y., Tani Y., Mizuguchi H., Tsutsumi Y., Mayumi T., Okada N., Nakagawa S. Combination of two fiber-mutant adenovirus vectors, one encoding the chemokine FKN and another encoding cytokine interleukin 12, elicits notably enhanced anti-tumor responses. Cancer Immunol. Immunother., 57, 1657-64 (2008) PubMed
Arita E., Kondoh M., Isoda K., Nishimori H., Yoshida T., Mizuguchi H., Yagi K. Evaluation of promoter strength in mouse and rat primary hepatocytes using adenovirus vectors. Eur. J. Pharm. Biopharm., 70, 1-6 (2008) PubMed
Takahashi A., Komiya E., Kakutani H., Yoshida T., Fujii M., Horiguchi Y., Mizuguchi H., Tsutsumi Y., Tsunoda S-I., Koizumi N., Isoda K., Yagi K., Watanabe Y., Kondoh M. Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis. Biochem. Pharmacol., 75, 1639-1648 (2008) PubMed
Kanagawa N., Koretomo R., Murakami S., Sakurai F., Mizuguchi H., Nakagawa S., Fujita T., Yamamoto A., Okada N. Factors involved in the maturation of murine dendritic cells transduced with adenoviral vector variants. Virology, 374, 411-420 (2008) PubMed
Yoshioka Y., Asavatanabodee R., Eto Y., Watanabe H., Morishige T., Yao X., Kida S., Maeda M., Mukai Y., Mizuguchi H., Kawasaki K., Okada N., Nakagawa S. Tat conjugation of adenovirus vector broadens tropism and enhances transduction efficiency. Life Science, 83, 747-755 (2008) PubMed
Larochelle N., Deol J., Srivastava V., Allen C., Mizuguchi H., Karpati G., Holland P., Nalbantoglu J. Downregulation of CD46 during muscle differentiation: implications for gene transfer to human skeletal muscle using group B adenoviruses. Hum. Gene Ther., 19, 133-142 (2008) PubMed
Sakurai F. Development and evaluation of a novel gene delivery vehicle composed of adenovirus serotype 35. Biol. Pharm. Bull., 31, 1819-1825 (2008) PubMed
Sakurai F. Development of a replication-incompetent adenovirus vector derived from subgroup B adenovirus serotype 35. Yakugaku Zasshi, 128, 1751-1761 (2008) PubMed
衛藤佑介、吉岡靖雄、Asavatanabodee R、水口裕之、向洋平、岡田直貴、中川晋作；標的指向性を有するバイオコンジュゲート化アデノウイルスベクターの開発、薬学雑誌、128、1733-1742 (2008) J-STAGE
水口裕之；遺伝子治療研究の動向；医薬ジャーナル新薬展望2008、44、235-242 (2008) WebSite
水口裕之；ウイルスベクター；ウイルスハンドブック、日本医学館、6-7 (2008)
水口裕之；アデノウイルスベクター；機能性DDSキャリアの製剤設計、シーエムシー出版、岡田弘晃監修、133-141 (2008) WebSite