業績｜論文・出版物｜2008年

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Suzuki T., Sakurai F., Nakamura S-I., Kouyama E., Kawabata K., kondoh M., Yagi K., Mizuguchi H. miR-122a-regulated expression of a suicide gene prevents hepatotoxicity without altering antitumor effects in suicide gene therapy. Mol. Ther., 16, 1719-1726 (2008) PubMed

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Sakurai H., Tashiro K., Kawabata K., Yamaguchi T., Sakurai F., Nakagawa S., Mizuguchi H. Adenoviral expression of suppressor of cytokine signaling-1 reduces adenovirus vector-induced innate immune response. J. Immunol., 180, 4931-4938 (2008) PubMed

 

Sakurai F., Nakamura S-I., Akitomo K., Shibata H., Terao K., Kawabata K., Hayakawa T., Mizuguchi H. Transduction properties of adenovirus serotype 35 vectors after intravenous administration into nonhuman primates. Mol. Ther., 16, 726-733 (2008) PubMed

 

Tashiro K., Kawabata K., Sakurai H., Kurachi S., Sakurai F., Yamanishi K., Mizuguchi H. Efficient adenovirus vector-mediated PPAR gamma gene transfer into mouse embryoid bodies promotes adipocyte differentiation, J. Gene Med., 10, 498-507 (2008) PubMed

 

Nakashima K., Sakurai F., Kawabata K., Mizuguchi H. Efficient gene delivery in human and rodent mast cells using adenovirus vectors. J. Control. Rel., 129, 215-222 (2008) PubMed

 

Sakurai H., Kawabata K., Sakurai F., Nakagawa S., Mizuguchi H. Innate immune response induced by gene delivery vectors. Int. J. Pharm., 354, 9-15 (2008) PubMed

 

Kurachi S., Koizumi N., Tashiro K., Sakurai H., Sakurai F., Kawabata K., Nakagawa S., Mizuguchi H. Modification of pIX or hexon based on fiberless Ad vectors is not effective for targeted Ad vectors. J. Control. Rel., 127, 88-95 (2008) PubMed

 

Yoshikawa T., Niwa T., Okada N., Mizuguchi H., Nakagawa S. Engineering of highly immunogenic long-lived DC vaccines by antiapoptotic protein gene transfer to enhance cancer vaccine potency. Gene Ther., 15, 1321-1329 (2008) PubMed

 

Gao J-Q., Kanagawa N., Xu D-H., Han M., Sugita T., Hatanaka Y., Tani Y., Mizuguchi H., Tsutsumi Y., Mayumi T., Okada N., Nakagawa S. Combination of two fiber-mutant adenovirus vectors, one encoding the chemokine FKN and another encoding cytokine interleukin 12, elicits notably enhanced anti-tumor responses. Cancer Immunol. Immunother., 57, 1657-64 (2008) PubMed

 

Arita E., Kondoh M., Isoda K., Nishimori H., Yoshida T., Mizuguchi H., Yagi K. Evaluation of promoter strength in mouse and rat primary hepatocytes using adenovirus vectors. Eur. J. Pharm. Biopharm., 70, 1-6 (2008) PubMed

 

Takahashi A., Komiya E., Kakutani H., Yoshida T., Fujii M., Horiguchi Y., Mizuguchi H., Tsutsumi Y., Tsunoda S-I., Koizumi N., Isoda K., Yagi K., Watanabe Y., Kondoh M. Domain mapping of a claudin-4 modulator, the C-terminal region of C-terminal fragment of Clostridium perfringens enterotoxin, by site-directed mutagenesis. Biochem. Pharmacol., 75, 1639-1648 (2008) PubMed

 

Kanagawa N., Koretomo R., Murakami S., Sakurai F., Mizuguchi H., Nakagawa S., Fujita T., Yamamoto A., Okada N. Factors involved in the maturation of murine dendritic cells transduced with adenoviral vector variants. Virology, 374, 411-420 (2008) PubMed

 

Yoshioka Y., Asavatanabodee R., Eto Y., Watanabe H., Morishige T., Yao X., Kida S., Maeda M., Mukai Y., Mizuguchi H., Kawasaki K., Okada N., Nakagawa S. Tat conjugation of adenovirus vector broadens tropism and enhances transduction efficiency. Life Science, 83, 747-755 (2008) PubMed

 

Larochelle N., Deol J., Srivastava V., Allen C., Mizuguchi H., Karpati G., Holland P., Nalbantoglu J. Downregulation of CD46 during muscle differentiation: implications for gene transfer to human skeletal muscle using group B adenoviruses. Hum. Gene Ther., 19, 133-142 (2008) PubMed

 

Sakurai F. Development and evaluation of a novel gene delivery vehicle composed of adenovirus serotype 35. Biol. Pharm. Bull., 31, 1819-1825 (2008) PubMed

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Sakurai F. Development of a replication-incompetent adenovirus vector derived from subgroup B adenovirus serotype 35. Yakugaku Zasshi, 128, 1751-1761 (2008) PubMed

 

衛藤佑介、吉岡靖雄、Asavatanabodee R、水口裕之、向洋平、岡田直貴、中川晋作；標的指向性を有するバイオコンジュゲート化アデノウイルスベクターの開発、薬学雑誌、128、1733-1742 (2008) J-STAGE

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水口裕之；遺伝子治療研究の動向；医薬ジャーナル新薬展望2008、44、235-242 (2008) WebSite

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水口裕之；ウイルスベクター；ウイルスハンドブック、日本医学館、6-7 (2008)

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水口裕之；アデノウイルスベクター；機能性DDSキャリアの製剤設計、シーエムシー出版、岡田弘晃監修、133-141 (2008) WebSite

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