論文・出版物 - 2007

Koizumi N., Yamaguchi T., Kawabata K., Sakurai F., Sasaki T., Watanabe Y., Hayakawa T., Mizuguchi H. Fiber-modified adenovirus vectors decrease liver toxicity through reduced interleukin 6 production. J. Immunol., 178, 1767-1773 (2007) PubMed

 

Kurachi S., Koizumi N., Sakurai F., Kawabata K., Sakurai H., Nakagawa S., Hayakawa T., Mizuguchi H. Characterization of capsid-modified adenovirus vectors containing heterologous peptides in the fiber knob, protein IX, or hexon. Gene Ther., 14, 266-274 (2007) PubMed

 

Mizuguchi H., Funakoshi N., Hosono T., Sakurai F., Kawabata K., Yamaguchi T., Hayakawa T. Rapid construction of small interfering RNA-expressing adenovirus vectors on the basis of direct cloning of short hairpin RNA-coding DNAs. Hum. Gene Ther., 18, 74-80 (2007) PubMed

 

Sakurai H., Sakurai F., Kawabata K., Sasaki T., Koizumi N., Huang H., Tashiro K., Kurachi S., Nakagawa S., Mizuguchi H. Comparison of gene expression efficiency and innate immune response induced by Ad vector and lipoplex, J. Control. Release., 117, 430-437 (2007) PubMed

 

Harada M., Kondoh M., Ebihara C., Takahashi A., Komiya E., Fujii M., Mizuguchi H., Tsunoda S-I., Horiguchi Y., Yagi K., Watanabe Y. Role of tyrosine residues in modulation of claudin-4 by the C-terminal fragment of Clostridium perfringens enterotoxin. Biochem Pharmacol., 73, 206-214 (2007) PubMed

Ebihara C., Kondoh M., Harada M., Fujii M., Mizuguchi H., Tsunoda S-I., Horiguchi Y., Yagi K., Watanabe Y. Role of Tyr306 in the C-terminal fragment of Clostridium perfringens enterotoxin for modulation of tight junction. Biochem. Pharmacol., 73, 824-830 (2007) PubMed

Hama S., Akita H., Iida S., Mizuguchi H., Harashima H. Quantitative and mechanism-based investigation of post-nuclear delivery events between adenovirus and lipoplex.  Nuc. Acid Res., 35, 1533-1543 (2007) PubMed

 

Moriuchi A., Yamasaki H., Shimamura M., Kita A., Kuwahara H., Fujishima K., Satoh T., Fukushima K., Fukushima T., Hayakawa T., Mizuguchi H., Nagayama Y., Abiru N., Kawasaki E., Eguchi K. Induction of human adiponectin gene transcription by telmisartan, angiotensin receptor blocker, independently on PPAR-gamma activation. Biochem. Biophys. Res. Commun., 356, 1024-1030 (2007) PubMed

 

Mukai E., Fujimoto S., Sakurai F., Kawabata K., Yamashita M., Inagaki N., Mizuguchi H. Efficient gene transfer into murine pancreatic islets using adenovirus vectors. J. Control. Rel., 119, 136-141 (2007) PubMed

Sakurai F., Akitomo K., Kawabata K., Hayakawa T., Mizuguchi H. Downregulation of human CD46 by adenovirus serotype 35 vectors, Gene Ther., 14, 912-919 (2007) PubMed

 

Xin K-Q., Sekimoto Y., Takahashi T., Mizuguchi H., Ichino M., Yoshida A., Okuda K. Chimeric adenovirus 5/35 vector containing the clade C HIV gag gene induces a cross-reactive immune response against HIV. Vaccine, 25, 3809-3815 (2007) PubMed

 

Gao J-Q., Kanagawa N., Motomura Y., Yanagawa T., Sugita T., Hatanaka Y., Tani Y., Mizuguchi H., Tsutsumi Y., Mayumi T., Okada N., Nakagawa S. Cotransduction of CCL27 gene can improve the efficacy and safety of IL-12 gene therapy for cancer. Gene Ther., 14, 491-502 (2007) PubMed

 

Yamashita M., Ino A., Kawabata K., Sakurai F., Mizuguchi H. Expression of coxsackie and adenovirus receptor reduces the lung metastatic potential of murine tumor cells. Int. J. Cancer, 121, 1690-1696 (2007) PubMed

 

Kurachi S., Tashiro K., Sakurai F., Sakurai H., Kawabata K., Yayama K., Okamoto H., Nakagawa S., Hayakawa T., Mizuguchi H. Fiber-modified adenovirus vectors containing the TAT peptide derived from human immunodeficiency virus in the fiber knob have efficient gene transfer activity. Gene Ther., 14, 1160-1165 (2007) PubMed

 

Kawabata K., Tashiro K., Sakurai F., Osada N., Kusuda J., Hayakawa T., Yamanishi K., Mizuguchi H. Positive and negative regulation of adenovirus infection by CAR-like soluble protein, CLSP. Gene Ther., 14, 1199-1207 (2007) PubMed

 

Yamaguchi T. #, Kawabata K. #, Koizumi N., Sakurai F., Nakashima K., Sasaki T., Okada N, Mizuguchi H. Role of MyD88 and TLR9 in the innate immune response elicited by serotype 5 adenoviral vectors. Hum. Gene Ther., 18, 753-762 (2007) # These authors equally contributed to this work. PubMed

 

Xin H., Kanehira M., Mizuguchi H., Hayakawa T., Kikuchi T., Nukiwa T., Saijo Y. Targeted-delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells. Stem Cells, 25, 1618-1626 (2007) PubMed

 

Sakurai F., Kawabata K., Mizuguchi H. Adenovirus vectors composed of subgroup B adenoviruses. Curr. Gene Ther., 7, 229-238 (2007) PubMed

 

Someya K., Xin K-Q., Ami Y., Izumi Y., Mizuguchi H., Ohta S., Yamamoto N., Honda M., Okuda K. Chimeric adenovirus type 5/35 vector encoding SIV gag and HIV env genes affords protective immunity against the simian/human immunodeficiency virus in monkeys. Virology, 367, 390-397 (2007) PubMed

 

Gao J-Q., Eto Y., Yoshioka Y., Sekiguchi F, Kurachi S., Morishige T., Yao X., Watanabe H., Asavatanabodee R., Sakurai F., Mizuguchi H., Okada Y., Mukai Y., Tsutsumi Y., Mayumi T., Okada N., Nakagawa S. Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration. J. Control. Rel., 122, 102-110 (2007) PubMed

 

Murakami S. #, Sakurai F. #, Kawabata K., Okada N., Fujita T., Yamamoto A., Hayakawa T., Mizuguchi H. Interaction of penton base Arg-Gly-Asp motifs with integrins is crucial for adenovirus serotype 35 vector transduction in human hematopoietic cells.  Gene Ther., 14, 1525-1533 (2007) # These authors equally contributed to this work. PubMed

 

Yao X., Yoshioka Y., Eto Y., Morishige T., Okada Y., Mizuguchi H., Mukai Y., Okada N., Nakagawa S. TERT promoter-driven adenovirus vector for cancer gene therapy via systemic injection. Biochem. Biophys. Res. Commun., 362, 419-424 (2007) PubMed

 

Kanehira M., Xin H., Hoshino K., Maemondo M., Mizuguchi H., Hayakawa T., Matsumoto K., Nakamura T., Nukiwa T., Saijo Y. Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells. Cancer Gene Ther., 14, 894-903 (2007) PubMed

 

Kawabata K. Role of a novel protein, CAR-like soluble protein (CLSP), in adenovirus infection. Yakugaku Zasshi, 127、1091-1096 (2007) PubMed

 

水口裕之;アデノウイルスベクター開発の最前線、バイオテクノロジージャーナル、羊土社、7(2)、168-173 (2007) WebSite

 

川端健二、櫻井文教、水口裕之;改良型アデノウイルスベクターを用いた各種幹細胞への遺伝子デリバリー、Drug Delivery System、22(2)、148-154 (2007) J-STAGE

川端健二;各種幹細胞への高効率遺伝子導入法の開発とその応用、Drug Delivery System、22(6)、668-669 (2007)

水口裕之、早川堯夫;アデノウイルスベクター;バイオ医薬品の開発と品質・安全性確保、早川堯夫監修、エル・アイ・シー、pp563~577 (2007) WebSite

早川堯夫、前田大輔、水口裕之;遺伝子治療用医薬品の品質,安全性等の確保;バイオ医薬品の開発と品質・安全性確保、早川堯夫監修、エル・アイ・シー、pp551~562 (2007) WebSite

水口裕之;遺伝子導入技術開発とその応用、大阪医薬品協会会報、699(4)、21-45 (2007)

水口裕之、櫻井文教、川端健二;カプシドタンパク質改変アデノウイルスベクター、遺伝子医学MOOK別冊 絵で見てわかるナノDDS、メディカルドゥ、235-242 (2007) WebSite

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directed by Prof. Hiroyuki Mizuguchi

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