論文・出版物 - 2006

Koizumi N., Kawabata K., Sakurai F., Watanebe Y., Hayakawa T., Mizuguchi H. Modified adenoviral vectors ablated for coxsackievirus-adenovirus receptor, αv integrin, and heparan sulfate binding reduce in vivo tissue transduction and toxicity. Hum. Gene Ther., 17, 264-279 (2006) PubMed

 

Sakurai F., Kawabata K., Koizumi N., Inoue N., Okabe M., Yamaguchi T., Hayakawa T., Mizuguchi H. Adenovirus serotype 35 vector-mediated transduction into human CD46-transgenic mice. Gene Ther., 13, 1118-1126 (2006) PubMed

 

Sakurai F., Murakami S., Kawabata K., Okada N., Yamamoto A., Seya T., Hayakawa T., Mizuguchi H. The short consensus repeats 1 and 2, not the cytoplasmic domain, of human CD46 are crucial for infection of subgroup B adenovirus serotype 35.  J. Control. Rel., 113, 271-278 (2006) PubMed

 

Kawabata K., Sakurai F., Koizumi N., Hayakawa T., Mizuguchi H. Adenovirus vector-mediated gene transfer into stem cells. Mol. Pharmaceutics, 3, 95-103 (2006) PubMed

 

Koizumi N., Mizuguchi H., Kondoh M., Fujii M., Nakanishi T., Utoguchi N., Watanabe Y. Efficient gene transfer into differentiated human trophoblast cells with adenovirus vector containing RGD motif in the fiber protein. Biol. Pharm. Bull., 29, 1297-1299 (2006) PubMed

 

Kishimoto H., Kojima T., Watanabe Y., Kagawa S., Fujiwara T., Uno F., Teraishi F., Kyo S., Mizuguchi H., Hashimoto Y., Urata Y., Tanaka N., Fujiwara T. In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus.  Nature Med., 12, 1213-1219 (2006) PubMed

 

Uno K., Katagiri H., Yamada T., Ishigaki Y., Ogihara T., Imai J., Hasegawa Y., Gao J., Kaneko K., Iwasaki H., Ishihara H., Sasano H., Inukai K., Mizuguchi H., Asano T., Shiota M., Nakazato M., Oka Y. Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity. Science, 312, 1656-1659 (2006) PubMed

 

Kamakura M., Morisawa K., Komi H., Tomatani A., Saito F., Konishi Y., Jin Y., Manabe T., Kuroda M., Imai S., Mizuguchi H., Taniguchi T. Regulation of IL-27p28 gene by lipopolysacchraide in dendritic DC2.4 cells. Biochem. Biophys. Res. Commun., 349, 1372-1377 (2006) PubMed

 

Komiya E., Kondoh M., Mizuguchi H., Fujii M., Utoguchi N., Nakanishi T., Watanabe Y. Characteristics of transcription-regulatory elements for gene expression from plasmid vectors in human trophoblast cell lines. Placenta, 27, 934-938 (2006) PubMed

 

Fujiwara T., Akita H., Furukawa K., Ushida T., Mizuguchi H., Harashima H. Impact of convective flow on the cellular uptake and transfection activity of lipoplex and adenovirus. Bio. Pharm. Bull., 29, 1511-1515 (2006) PubMed

 

Nukiwa M., Andarini S., Zaini J., Xin H., Kanehira M., Suzuki T., Fukuhara T., Mizuguchi H., Hayakawa T., Saijo Y., Nukiwa T., Kikuchi T. Dendritic cells modified to express fractalkine/CX3CL1 in the treatment of preexisting tumors. Eur. J. Immunol., 109, 1019-1027 (2006) PubMed

 

Harui A., Roth MD., Sanghvi M., Vira D., Mizuguchi H., Basak SK. Centrifugation enhances integrin-mediated transduction of dendritic cells by conventional and RGD-modified adenoviral vectors. J. Immunol. Methods, 312, 94-104 (2006) PubMed

 

Harui A., Roth MD., Vira D., Sanghvi M., Mizuguchi H., Basak SK. Adenoviral-encoded antigens are presented by a subset of dendritic cells expressing alpha-v/beta-3 integrins. J. Leukocyte. Biol., 79, 1271-1278 (2006) PubMed

 

Kida S., Maeda M., Hojo K., Eto Y., Gao J.Q., Kurachi S., Mizuguchi H., Hayakawa T., Mayumi T., Nakagawa S., Kawasaki K. Design and synthesis of a Tat-related gene transporter: a tool for carrying the adenovirus vector into cells. Bioorg. Med. Chem. Lett., 16, 743-735 (2006) PubMed

 

Hama S., Akita H., Ito R., Mizuguchi H., Hayakawa T., Harashima H. Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems. Mol. Ther., 13, 786-794 (2006) PubMed

 

Ebihara C., Kondoh M., Hasuike N., Harada M., Mizuguchi H., Horiguchi Y., Fujii M., Watanabe Y. Preparation of a claudin-targeting molecule using a C-terminal fragment of Clostridium perfringens enterotoxin. J. Pharmacol. Exp. Ther., 316, 255-260 (2006) PubMed

 

Okada N., Sasaki A., Niwa M., Okada Y., Hatanaka Y., Tani Y., Mizuguchi H., Nakagawa S., Fujita T., Yamamoto A. Tumor suppressive efficacy through augmentation of tumor-infiltrating immune cells by intratumoral injection of chemokine-expressing adenoviral vector. Cancer Gene Ther., 13, 393-405 (2006) PubMed

 

Gao J-Q., Chen H-L., Nakagawa S., Mizuguchi H., Liang W-Q. Gene expression of tumor cells both in vitro and in vivo enhanced by integrin-targeting adenovirus. Acta Pharmaceutica Sinica, 41, 1116-1120 (2006) PubMed

 

Mizuguchi H. Recent Advance of Development of Viral and Non-viral Vectors for Gene Therapy. Yakugaku Zasshi, 126, 1011 (2006) PubMed

 

Sakurai F., Kawabata K., Mizuguchi H. Characterization of adenovirus serotype 35 vectors using genetically modified animals and nonhuman primates. Yakugaku Zasshi, 126, 1013-1019 (2006) PubMed

 

Akita H., Hama S., Mizuguchi H. Harashima H. Development of non-viral vector based on the quantitative comparison of intracellular trafficking with viral vector. Yakugaku Zasshi, 126, 1047-1057 (2006) PubMed

 

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directed by Prof. Hiroyuki Mizuguchi

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