論文・出版物 - 2005

Kawabata K., Sakurai F., Yamaguchi T., Hayakawa T., Mizuguchi H. Efficient gene transfer into mouse embryonic stem cells with adenovirus vectors. Mol. Ther., 12, 547-554 (2005) PubMed

Sakurai F., Kawabata K., Yamaguchi T., Hayakawa T., Mizuguchi H. Optimization of adenovirus serotype 35 vectors for efficient transduction in human hematopoietic progenitors: comparison of promoter activities. Gene Ther., 12, 1424-1433 (2005) PubMed

 

Mizuguchi H., Sasaki T., Kawabata K., Sakurai F., Hayakawa T. Fiber-modified adenovirus vectors mediate efficient gene transfer into undifferentiated and adipogenic-differentiated human mesenchymal stem cell. Biochem. Biophys. Res. Commun., 332, 1101-1106 (2005) PubMed

 

Ino A., Naito Y., Mizuguchi H., Handa N., Hayakawa T., Kobayashi I. A trial of somatic gene targeting in vivo with an adenovirus vector. Genetic Vaccines and Therapy, 3:8 (12Oct2005) (2005) PubMed

 

Mizuguchi H., Xu Z-L., Sakurai F., Kawabata K., Yamaguchi T., Hayakawa T. Efficient regulation of gene expression using self-contained fiber-modified adenovirus vectors containing the tet-off system. J. Control. Rel., 110, 202-211 (2005) PubMed

 

Xin K-Q., Jounai N., Someya K., Honma K., Mizuguchi H., Naganawa S., Kitamura K., Hayakawa T., Saha S., Takeshita F., Okuda K., Honda M., Klinman D.M., Okuda K. Prime-boost vaccination with plasmid DNA and a chimeric adenovirus type 5 vector with type 35 fiber induces protective immunity against HIV. Gene Ther., 12, 1769-1777 (2005) PubMed

 

Takahashi A., Kondoh M., Masuyama A. Fujii M., Mizuguchi H., Horiguchi Y., Watanabe Y. Role of C-terminal regions of the C-terminal fragment of Clostridium perfringens enterotoxin in its interaction with claudin-4, J. Control. Rel., 108, 56-62 (2005) PubMed

 

Masuyama A., Kondoh M., Seguchi H., Takahashi A., Harada M., Fujii M., Mizuguchi H., Horiguchi Y., Watanabe Y. Role of N-terminal amino acids in the absorption-enhancing effects of the C-terminal fragment of Clostridium Perfringens enterotoxin. J. Pharmacol. Exp. Ther., 314, 789-795 (2005) PubMed

 

Gao J-Q, Sugita T., Kanagawa N., Iida K., Okada N., Mizuguchi H., Nakayama T., Yoshie O., Tsutsumi Y., Mayumi T., Nakagawa S. Anti-tumor responses induced by chemokine CCL19 transfected into an ovarian carcinoma model via fiber-mutant adenovirus vector. Biol. Pharm. Bull., 28, 1066-1070 (2005) PubMed

 

Okada Y., Okada N., Mizuguchi H., Hayakawa T., Nakagawa S., Mayumi T. Transcriptional targeting of RGD fiber-mutant adenovirus vectors can improve the safety of suicide gene therapy for murine melanoma. Cancer Gene Ther., 12, 608-616 (2005) PubMed

 

Koizumi, N., Kondoh, M., Mizuguchi H., Nakanishi, T., Masuyama, A., Ida, F., Fujii, M., Hayakawa, T., Nakashima, E., Tanaka, K., Watanabe, Y. Comparison of transgene expression mediated by several fiber-modified adenovirus vectors in trophoblast cells. Placenta., 26, 729-734 (2005) PubMed

 

Eto Y., Gao J-Q., Sekiguchi F., Kurachi S., Katayama K., Mizuguchi H., Hayakawa T., Maeda, M., Kawasaki K., Tsutsumi Y., Mayumi T., Nakagawa S. PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody evasion ability. J. Gene Med., 7, 604-612 (2005) PubMed

 

Taki M., Kagawa S., Nishizaki M., Mizuguchi H., Hayakawa T., Kyo S., Nagai K., Urata Y., Tanaka N., Fujiwara T. Enhanced oncolysis by a tropism-modified telomerase-specific replication-selective adenoviral agent OBP-405 ('Telomelysin-RGD'). Oncogene, 24, 3130-3140 (2005) PubMed

 

Maeda M., Kida S., Hojo K., Eto Y., Gao J-Q, Kurachi S., Sekiguchi F., Mizuguchi H., Hayakawa T., Mayumi T., Nakagawa S., Kawasaki K. Design and synthesis of a peptide-PEG transporter tool for carrying adenovirus vector into cells. Bioorg. Medicinal. Chem. Lett., 15, 621-624 (2005) PubMed

 

Gao J-Q, Sugita T., Kanagawa N., Iida K., Eto Y., Motomura Y., Mizuguchi H., Tsutsumi Y., Hayakawa T., Mayumi T., Nakagawa S. A single intratumoral injection of a fiber-mutant adenoviral vector encoding interleukin 12 induces remarkable anti-tumor and anti-metastatic activity in mice with Meth-A fibrosarcoma. Biochem. Biophys. Res. Commun., 328, 1043-1050 (2005) PubMed

 

Nasimuzzaman, M., Kuroda, M., Dohno, S., Yamamoto, T., Iwatsuki, K., Matsuzaki, S., Rashel, M., Kumita, W., Mizuguchi, H., Hayakawa, T., Nakamura, H., Taguchi, T., Wakiguchi, H., Imai, S. Eradication of Epstein-Barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1. Mol. Ther., 11, 578-590 (2005) PubMed

 

Hosono T., Mizuguchi H., Katayama K., Koizumi N., Kawabata K., Yamaguchi T., Nakagawa S., Watanabe Y., Mayumi T., Hayakawa T. RNA interference of PPARγ using fiber-modified adenovirus vector efficiently suppresses preadipocyte-to-adipocyte differentiation in 3T3-L1 cells. Gene, 348, 157-165 (2005) PubMed

 

Kondoh, M., Masuyama , A., Takahashi, A., Asano, N., Mizuguchi H., Koizumi, N., Fujii, M., Hayakawa, T., Horiguchi, Y., Watanabe, Y. A novel strategy for the enhancement of drug absorption using a claudin modulator. Mol. Pharmacol., 67, 749-756 (2005) PubMed

 

Sumimoto H., Yamagata S., Shimizu A., Miyoshi H., Mizuguchi H., Hayakawa T., Miyagishi M., Taira K., Kawakami Y. Gene therapy for human small cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference. Gene Ther., 12, 95-100 (2005) PubMed

 

Okada N., Mori N., Koretomo R., Okada Y., Nakayama T., Yoshie O., Mizuguchi H., Hayakawa T., Nakagawa S., Mayumi T., Fujita T., Yamamoto A. Augmentation of the migratory ability of DC-based vaccine into regionalymph nodes by efficient CCR7 gene transduction. Gene Ther., 12, 129-139 (2005) PubMed

 

Okada N., Iiyama S., Okada Y., Mizuguchi H., Hayakawa T., Nakagawa S., Mayumi T., Fujita T., Yamamoto A. Immunological properties and vaccine efficacy of murine dendritic cells simultaneously expressing melanoma-associated antigen and interleukin-12. Cancer Gene Ther., 12, 72-83 (2005) PubMed

 

Imai, J., Katagiri, H., Yamada, T., Ishigaki, Y., Ogihara, T., Uno, K., Hasegawa, Y., Gao, J., Ishihara, H., Sasano, H., Mizuguchi H., Asano, T., Oka, Y. Constitutively active PDX1 induced efficient insulin production in adult murine liver. Biochem. Biophys. Res. Commun., 326, 402-409 (2005) PubMed

 

Xu ZL., Mizuguchi H., Koizumi N., Sakurai F., Hosono T., Kawabata K., Watanabe Y., Yamaguchi T., Hayakawa T. Approaches to improving the kinetics of adenovirus-delivered genes and gene products. Adv. Drug. Deli. Rev., 57, 781-802 (2005) PubMed

 

Sakurai F., Takakura Y., Hashida M. Evaluation of immune response after administration of plasmid DNA-non-viral vector complexes. In: Taira K., Kataoka K (eds) Non-viral Gene Therapy: Gene Design and Delivery. Springer, pp339-347 (2005) WebSite

 

水口裕之;目的遺伝子の抑制レベルを自由に制御するアデノウイルスベクターの開発、実験医学、羊土社、23、2167-2172 (2005) WebSite

水口裕之、川端健二、櫻井文教、早川堯夫;改良型アデノウイルスベクターを用いた造血幹細胞、間葉系幹細胞、ES細胞への高効率遺伝子導入、炎症・再生、25、447-451 (2005) J-STAGE

水口裕之、早川堯夫;カプシドタンパク質を改変した改良型アデノウイルスベクターによる高効率遺伝子導入、BIO INDUSTRY、シーエムシー出版、22(5)、16-21 (2005) WebSite

水口裕之、早川堯夫;ウイルスベクター、Drug Delivery System、20、158-159(2005)

櫻井文教;高性能な遺伝子導入ベクターの開発を目指して、Drug Delivery System、20、474-475 (2005)

水口裕之;ウイルスベクターのDDS:Drug Metabolism And Pharmacokinetics、19(6)、30-32(2005)

 大阪大学大学院 薬学研究科 分子生物学分野 〒565-0871 大阪府吹田市山田丘1-6 大阪大学 大学院薬学研究科・薬学部 1号館 4階

TEL: 06-6879-8185 FAX: 06-6879-8187

 

Copyright© Laboratory of Biochemistry and Molecular Biology, Graduate School and School of Pharmaceutical Sciences, Osaka University

directed by Prof. Hiroyuki Mizuguchi

  • 大阪大学大学院薬学研究科分子生物学分野公式Twitterアカウント