業績|論文・出版物|2003年
Koizumi N., Mizuguchi H., Sakurai F., Yamaguchi T., Watanabe Y., Hayakawa T. Reduction of natural adenovirus tropism to mouse liver by fiber-shaft exchange in combination with both CAR- and αv integrin-binding ablation. J. Virol., 77, 13062-13072 (2003) PubMed
Ishi-Watabe A., Uchida E., Iwata A., Nagata R., Satoh K., Fan K., Murata M., Mizuguchi H., Kawasaki N., Kawanishi T., Yamaguchi T., Hayakawa T. Detection of replication-competent adenoviruses spiked into recombinant adenovirus vector products by infectivity PCR. Mol. Ther., 8, 1009 - 1016 (2003) PubMed
Sakurai F., Mizuguchi H., Yamaguchi T., Hayakawa T. Characterization of in vitro and in vivo gene transfer properties of adenovirus serotype 35 vector. Mol. Ther., 8, 813-821 (2003) PubMed
Mizuguchi H., Xu Z.L., Sakurai F., Mayumi T., Hayakawa T. Tight positive regulation of transgene expression by a single adenovirus vector containing the rtTA and tTS expression cassettes in separate genome regions. Hum. Gene Ther., 14, 1265-1277 (2003) PubMed
Gao J-Q, Tsuda Y., Katayama K., Nakayama T., Hatanaka Y., Tani Y., Mizuguchi H., Hayakawa T., Yoshie O., Tsutsumi Y., Mayumi T., Nakagawa S. Antitumor effect by interleukin-11 receptor alpha-locus chemokine/CCL27, introduced into tumor cells through a recombinant adenovirus vector. Cancer Res., 63, 4420-4425 (2003) PubMed
Sakurai F., Mizuguchi H., Hayakawa T. Efficient gene transfer into human CD34+ cells by an adenovirus type 35 vector. Gene Ther., 10, 1041-1048 (2003) PubMed
Koizumi N., Mizuguchi H., Utoguchi N., Watanabe Y., Hayakawa T. Generation of fiber-modified adenovirus vectors containing heterologous peptides in both the HI loop and C terminus of the fiber knob. J. Gene Med., 5, 267-276 (2003) PubMed
Xu Z.L., Mizuguchi H., Mayumi T., Hayakawa T. Regulated gene expression from adenovirus vectors: a systematic comparison of various inducible systems. Gene, 309, 145-151 (2003) PubMed
Xu Z.L., Mizuguchi H., Mayumi T., Hayakawa T. Woodchuck hepatitis virus post-transcriptional regulation element enhances transgene expression from adenovirus vectors. Biochim. Biophys. Acta, 1621, 266-271 (2003) PubMed
Itoh A., Okada T., Mizuguchi H., Hayakawa T., Mizukami H., Kume A., Takatoku M., Komatsu A., Hanazono Y., Ozawa K. A soluble CAR-SCF fusion protein improves adenoviral vector-mediated gene transfer to c-Kit-positive hematopoietic cells. J. Gene Med., 5, 929-940 (2003) PubMed
Okada N., Masunaga Y., Okada Y., Mizuguchi H., Iiyama S., Mori N., Sasaki A., Nakagawa S., Mayumi T., Hayakawa T., Fujita T., Yamamoto A. Dendritic cells transduced with gp100 gene by RGD fiber-mutant adenovirus vectors are highly efficacious in generating anti-B16BL6 melanoma immunity in mice. Gene Ther., 10, 1891-1902 (2003) PubMed
Kita A., Uotani S., Kuwahara H., Takahashi R., Oshima K., Yamasaki H., Mizuguchi H., Hayakawa T., Nagayama Y., Yamaguchi Y., Eguchi K. Vanadate enhances leptin-induced activation of JAK/STAT pathway in CHO cells. Biochem. Biophys. Res. Commun., 302, 805-809 (2003) PubMed
Li Y., Takemura G., Kosai K.I., Yuge K., Nagano S., Esaki M., Goto K., Takahashi T., Hayakawa K., Koda M., Kawase Y., Maruyama R., Okada H., Minatoguchi S., Mizuguchi H., Fujiwara T., Fujiwara H. Postinfarction treatment with an adenoviral vector expressing hepatocyte growth factor relieves chronic left ventricular remodeling and dysfunction in mice. Circulation, 107, 2499-2506 (2003) PubMed
Tanaka K., Towata S., Nakao K., Mizuguchi H., Hayakawa T., Niwa M., Ishii N., Nagayama Y. Thyroid cancer immuno-therapy with retroviral and adenoviral vectors expressing granulocyte macrophage colony stimulating factor and interleukin-12 in a rat model. Clin. Endocrinol., 59, 734-742 (2003) PubMed
Nagayama Y, Mizuguchi H., Hayakawa T., Niwa M., McLachlan SM., Rapoport B. Prevention of autoantibody-mediated Graves'-like hyperthyroidism in mice with IL-4, a Th2 cytokine. J. Immunol., 170, 3522-3527 (2003) PubMed
Nagayama Y., Nakao, K., Mizuguchi H., Hayakawa T., Niwa M. Enhanced antitumor effect of combined replicative adenovirus and nonreplicative adenovirus expressing interleukin-12 in an immunocompetent mouse model. Gene Ther., 10, 1400-1403 (2003) PubMed
Morioka T., Koyama H., Yamamura H., Tanaka S., Fujimoto, S., Emoto M., Mizuguchi H., Hayakawa T., Kojima I., Takahashi K., Nishizawa Y. Role of H1-calponin in pancreatic AR42J cell differentiation into insulin-producing cells. Diabetes, 52, 760-766 (2003) PubMed
Nakano R., Nakagawa T., Imazu S., Katayama K., Mizuguchi H., Hayakawa T., Tsutsumi Y., Nakagawa S., Mayumi T. A novel T7 system utilizing mRNA coding for T7 RNA polymerase. Biochem. Biophys. Res. Commun., 301, 974-978 (2003) PubMed
Okada N., Masunaga Y., Okada Y., Iiyama S., Tsuda T., Matsubara A., Mori N., Mizuguchi H., Hayakawa T., Fujita T., Yamamoto A. Gene transduction efficiency and maturation status in mouse bone marrow-derived dendritic cells infected with conventional or RGD fiber-mutant adenovirus vectors. Cancer Gene Ther., 10, 421-431 (2003) PubMed
Katayama K., Wada K., Nakajima A., Yoshida S., Mizuguchi H., Hayakawa T., Nakagawa S., Kadowaki T, Nagai R., Kamisaki Y, Blumberg RS., Mayumi T. A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model. Gastroenterology, 124, 1315-1324 (2003) PubMed
Okada Y., Okada N., Mizuguchi H., Hayakawa T., Mayumi T., Mizuno N. An investigation of adverse effects caused by the injection of high-dose TNFα-expressing adenovirus vector into established murine melanoma. Gene Ther., 10, 700-705 (2003) PubMed
Abiru N., Sun F., Kawasaki E., Yamasaki H., Oshima K., Nagayama Y., Mizuguchi H., Hayakawa T., Miao D., Liu E., Eisenbarth G.S., Eguchi K. In vivo expression of B:9-23 peptide/I-Ag7 complex may abrogate the inhibition of diabetes induced by RGD-fiber-mutant adenovirus in NOD mice. Annals N.Y. Acad. Sci., 1005, 218-221 (2003) PubMed
Ara T., Tokoyoda K., Sugiyama T., Egawa T., Kawabata K., Nagasawa T. Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny. Immunity, 19, 257-267 (2003) PubMed
Ara T., Itoi M., Kawabata K., Egawa T., Tokoyoda K., Sugiyama T., Fujii N., Amagai T., Nagasawa T. A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J. Immunol., 170, 4649-4655 (2003) PubMed
Sakurai F., Terada T., Maruyama M., Yamashita F., Takakura Y., and Hashida M. Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-beta gene and poly I: poly C in a murine lung metastasis model. Cancer Gene Ther., 10, 661-668 (2003) PubMed
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