論文・出版物 - 2003

Koizumi N., Mizuguchi H., Sakurai F., Yamaguchi T., Watanabe Y., Hayakawa T. Reduction of natural adenovirus tropism to mouse liver by fiber-shaft exchange in combination with both CAR- and αv integrin-binding ablation. J. Virol., 77, 13062-13072 (2003) PubMed

Ishi-Watabe A., Uchida E., Iwata A., Nagata R., Satoh K., Fan K., Murata M., Mizuguchi H., Kawasaki N., Kawanishi T., Yamaguchi T., Hayakawa T. Detection of replication-competent adenoviruses spiked into recombinant adenovirus vector products by infectivity PCR. Mol. Ther., 8, 1009 - 1016 (2003) PubMed

Sakurai F., Mizuguchi H., Yamaguchi T., Hayakawa T. Characterization of in vitro and in vivo gene transfer properties of adenovirus serotype 35 vector. Mol. Ther., 8, 813-821 (2003) PubMed

Mizuguchi H., Xu Z.L., Sakurai F., Mayumi T., Hayakawa T. Tight positive regulation of transgene expression by a single adenovirus vector containing the rtTA and tTS expression cassettes in separate genome regions. Hum. Gene Ther., 14, 1265-1277 (2003) PubMed

Gao J-Q, Tsuda Y., Katayama K., Nakayama T., Hatanaka Y., Tani Y., Mizuguchi H., Hayakawa T., Yoshie O., Tsutsumi Y., Mayumi T., Nakagawa S. Antitumor effect by interleukin-11 receptor alpha-locus chemokine/CCL27, introduced into tumor cells through a recombinant adenovirus vector. Cancer Res., 63, 4420-4425 (2003) PubMed

Sakurai F., Mizuguchi H., Hayakawa T. Efficient gene transfer into human CD34+ cells by an adenovirus type 35 vector. Gene Ther., 10, 1041-1048 (2003) PubMed

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Koizumi N., Mizuguchi H., Utoguchi N., Watanabe Y., Hayakawa T. Generation of fiber-modified adenovirus vectors containing heterologous peptides in both the HI loop and C terminus of the fiber knob.  J. Gene Med., 5, 267-276 (2003) PubMed

Xu Z.L., Mizuguchi H., Mayumi T., Hayakawa T. Regulated gene expression from adenovirus vectors: a systematic comparison of various inducible systems. Gene, 309, 145-151 (2003) PubMed

Xu Z.L., Mizuguchi H., Mayumi T., Hayakawa T. Woodchuck hepatitis virus post-transcriptional regulation element enhances transgene expression from adenovirus vectors. Biochim. Biophys. Acta, 1621, 266-271 (2003) PubMed

Itoh A., Okada T., Mizuguchi H., Hayakawa T., Mizukami H., Kume A., Takatoku M., Komatsu A., Hanazono Y., Ozawa K. A soluble CAR-SCF fusion protein improves adenoviral vector-mediated gene transfer to c-Kit-positive hematopoietic cells. J. Gene Med., 5, 929-940 (2003) PubMed

Okada N., Masunaga Y., Okada Y., Mizuguchi H., Iiyama S., Mori N., Sasaki A., Nakagawa S., Mayumi T., Hayakawa T., Fujita T., Yamamoto A. Dendritic cells transduced with gp100 gene by RGD fiber-mutant adenovirus vectors are highly efficacious in generating anti-B16BL6 melanoma immunity in mice.  Gene Ther., 10, 1891-1902 (2003) PubMed

Kita A., Uotani S., Kuwahara H., Takahashi R., Oshima K., Yamasaki H., Mizuguchi H., Hayakawa T., Nagayama Y., Yamaguchi Y., Eguchi K. Vanadate enhances leptin-induced activation of JAK/STAT pathway in CHO cells. Biochem. Biophys. Res. Commun., 302, 805-809 (2003) PubMed

Li Y., Takemura G., Kosai K.I., Yuge K., Nagano S., Esaki M., Goto K., Takahashi T., Hayakawa K., Koda M., Kawase Y., Maruyama R., Okada H., Minatoguchi S., Mizuguchi H., Fujiwara T., Fujiwara H. Postinfarction treatment with an adenoviral vector expressing hepatocyte growth factor relieves chronic left ventricular remodeling and dysfunction in mice. Circulation, 107, 2499-2506 (2003) PubMed

Tanaka K., Towata S., Nakao K., Mizuguchi H., Hayakawa T., Niwa M., Ishii N., Nagayama Y. Thyroid cancer immuno-therapy with retroviral and adenoviral vectors expressing granulocyte macrophage colony stimulating factor and interleukin-12 in a rat model. Clin. Endocrinol., 59, 734-742 (2003) PubMed

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Nagayama Y, Mizuguchi H., Hayakawa T., Niwa M., McLachlan SM., Rapoport B. Prevention of autoantibody-mediated Graves'-like hyperthyroidism in mice with IL-4, a Th2 cytokine. J. Immunol., 170, 3522-3527 (2003) PubMed

Nagayama Y., Nakao, K., Mizuguchi H., Hayakawa T., Niwa M. Enhanced antitumor effect of combined replicative adenovirus and nonreplicative adenovirus expressing interleukin-12 in an immunocompetent mouse model.  Gene Ther., 10, 1400-1403 (2003) PubMed

Morioka T., Koyama H., Yamamura H., Tanaka S., Fujimoto, S., Emoto M., Mizuguchi H., Hayakawa T., Kojima I., Takahashi K., Nishizawa Y. Role of H1-calponin in pancreatic AR42J cell differentiation into insulin-producing cells.  Diabetes, 52, 760-766 (2003) PubMed

Nakano R., Nakagawa T., Imazu S., Katayama K., Mizuguchi H., Hayakawa T., Tsutsumi Y., Nakagawa S., Mayumi T. A novel T7 system utilizing mRNA coding for T7 RNA polymerase. Biochem. Biophys. Res. Commun., 301, 974-978 (2003) PubMed

Okada N., Masunaga Y., Okada Y., Iiyama S., Tsuda T., Matsubara A., Mori N., Mizuguchi H., Hayakawa T., Fujita T., Yamamoto A. Gene transduction efficiency and maturation status in mouse bone marrow-derived dendritic cells infected with conventional or RGD fiber-mutant adenovirus vectors.  Cancer Gene Ther., 10, 421-431 (2003) PubMed

Katayama K., Wada K., Nakajima A., Yoshida S., Mizuguchi H., Hayakawa T., Nakagawa S., Kadowaki T, Nagai R., Kamisaki Y, Blumberg RS., Mayumi T. A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model.  Gastroenterology, 124, 1315-1324 (2003) PubMed

Okada Y., Okada N., Mizuguchi H., Hayakawa T., Mayumi T., Mizuno N. An investigation of adverse effects caused by the injection of high-dose TNFα-expressing adenovirus vector into established murine melanoma. Gene Ther., 10, 700-705 (2003) PubMed

Abiru N., Sun F., Kawasaki E., Yamasaki H., Oshima K., Nagayama Y., Mizuguchi H., Hayakawa T., Miao D., Liu E., Eisenbarth G.S., Eguchi K. In vivo expression of B:9-23 peptide/I-Ag7 complex may abrogate the inhibition of diabetes induced by RGD-fiber-mutant adenovirus in NOD mice. Annals N.Y. Acad. Sci., 1005, 218-221 (2003) PubMed

Ara T., Tokoyoda K., Sugiyama T., Egawa T., Kawabata K., Nagasawa T. Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny. Immunity, 19, 257-267 (2003) PubMed

Ara T., Itoi M., Kawabata K., Egawa T., Tokoyoda K., Sugiyama T., Fujii N., Amagai T., Nagasawa T. A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J. Immunol., 170, 4649-4655 (2003) PubMed

Sakurai F., Terada T., Maruyama M., Yamashita F., Takakura Y., and Hashida M. Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-beta gene and poly I: poly C in a murine lung metastasis model.  Cancer Gene Ther., 10, 661-668 (2003) PubMed

水口裕之；次世代遺伝子治療薬の開発基盤研究、薬学雑誌、123、761-771 (2003) J-STAGE

水口裕之、早川堯夫；アデノウイルスベクター：最近の進歩、分子細胞治療、2、200-207 (2003)

水口裕之、早川堯夫；遺伝子機能解析のための遺伝子導入ベクター -ウイルスベクターを中心として-；蛋白質核酸酵素、48、1653-1662 (2003)

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橋田充、水口裕之、山下富義、横山昌幸、原島秀吉、米谷芳枝、松村保広、岡田純一、五十嵐理慧； 21世紀のDDS：発展を担う立場から、Drug Delivery System、18、7-20 (2003)

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