論文・出版物 - 2002

Mizuguchi H., Koizumi N., Hosono T., Ishii-Watabe A., Uchida E., Utoguchi N., Watanabe Y., Hayakawa T. CAR- orαv integrin-binding ablated adenovirus vectors, but not fiber-modified vectors containing RGD peptide, do not change the systemic gene transfer properties in mice. Gene Ther., 9, 769-776 (2002) PubMed

 

Mizuguchi H., Hayakawa T. Enhanced antitumor effect and reduced vector dissemination with fiber-modified adenovirus vectors expressing herpes simplex virus thymidine kinase. Cancer Gene Ther., 9, 236-242 (2002) PubMed

 

Mizuguchi H., Hayakawa T. The tet-off system is more effective than the tet-on system for regulating transgene expression in a single adenovirus vector. J. Gene Med., 4, 240-247 (2002) PubMed

 

Mizuguchi H., Hayakawa T. Adenovirus vectors containing chimeric type 5 and type 35 fiber proteins exhibit altered and expanded tropism and increase the size limit of foreign genes. Gene, 285, 69-77 (2002) PubMed

 

Xu Z.L., Mizuguchi H., Ishii-Watabe I., Uchida E., Mayumi T., Hayakawa T. Strength evaluation of transcriptional regulatory elements for transgene expression by adenovirus vector. J.Control. Rel., 81, 155-163 (2002) PubMed

 

Uchida E., Mizuguchi H., Ishi-Watabe A., Hayakawa T. Comparison of the efficiency and safety of non-viral vector-mediated gene transfer into a wide range of human cells. Biol. Pharm. Bull., 25, 891-897 (2002) PubMed

 

Kawamata Y., Nagayama Y., Nakao K., Mizuguchi H., Hayakawa T., Sato T., Ishii N. Receptor-independent augmentation of adenovirus-mediated gene transfer with chitosan in vitro. Biomaterials., 23, 4573-4579 (2002) PubMed

 

Akuta T., Eguchi A., Okuyama H., Senda T., Inokuchi H., Suzuki Y., Nagoshi E., Mizuguchi H., Hayakawa T., Takeda K., Hasegawa M., Nakanishi M. Enhancement of phage-mediated gene transfer by nuclear localization signal. Biochem. Biophys. Res. Commun., 297, 779-786 (2002) PubMed

 

Okada Y., Okada N., Nakagawa S., Mizuguchi H., Takahashi K., Mizuno N., Fujita T., Yamamoto A., Hayakawa T., Mayumi T. Tumor necrosis factor α-gene therapy for an established murine melanoma using RGD (Arg-Gly-Asp) fiber-mutant adenovirus vectors. Jpn. J. Cancer Res., 93, 436-444 (2002) PubMed

 

Nagayama Y, Kita-Furuyama M., Ando T., Nakao K., Mizuguchi H., Hayakawa T., Eguchi K., Niwa M. A Novel murine model of graves’ hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor. J. Immunol., 168, 2789-2794 (2002) PubMed

 

Omori M., Mizuguchi H., Ohsawa K., Kohsaka S., Hayakawa T., Abe K., Shibasaki F. Modification of a fiber protein in an adenovirus vector improves in vitro gene transfer efficiency to microglial cell line. Neurosci. Lett., 324, 145-148 (2002) PubMed

 

Takahashi M., Seki N., Ozaki T., Kato M., Kuno T., Nakagawa T., Watanabe K., Miyazaki K., Ohira M., Hayashi S., Hosoda M., Tokita H., Mizuguchi H., Hayakawa T., Todo S., Nakagawara A. Identification of the p33ING1-regulated genes that include cyclin B1 and proto-oncogene DEK by using cDNA microarray in a mouse mammary epithelial cell line NMuMG.  Cancer Res., 62, 2203-2209 (2002) PubMed

 

Nakagawa T., Takahashi M., Ozaki T., Watanabe K., Todo S., Mizuguchi H., Hayakawa T., Nakagawara A. Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter.  Mol. Cell. Biol., 22, 2575-2585 (2002) PubMed

 

Okada Y., Okada N., Nakagawa S., Mizuguchi H., Kanehira M., Nishino N., Takahashi K., Mizuno N., Hayakawa T., Mayumi T. Fiber-mutant technique can augment gene transduction efficacy and anti-tumor effects against established murine melanoma by cytokine-gene therapy using adenovirus vectors. Cancer Lett., 177, 57-63 (2002) PubMed

Sakurai F, Terada T, Yasuda K, Yamashita F, Takakura Y, and Hashida M. The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes. Gene Ther., 9, 1120-1126 (2002) PubMed

Mizuguchi H., Hayakawa T. Improvement of adenovirus vectors for gene transfer. In: Shirahata S., Teruya K., Katakura Y. (eds) Animal Cell Technology: Basic & Applied Aspects. Springer, vol.12, 1-5 (2002) WebSite

 

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directed by Prof. Hiroyuki Mizuguchi

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